LOCUS HSU02687 3475 bp mRNA linear HUM 11-JUN-1994
DEFINITION Human growth factor receptor tyrosine kinase (STK-1) mRNA, complete
cds.
ACCESSION U02687
VERSION U02687.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3475)
AUTHORS Small,D., Levenstein,M., Kim,E., Carow,C., Amin,S., Rockwell,P.,
Witte,L., Burrow,C., Ratajczak,M.Z., Gewirtz,A.M. et al.
TITLE STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed
in CD34+ human bone marrow cells and is involved in the
proliferation of early progenitor/stem cells
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 91 (2), 459-463 (1994)
PUBMED 7507245
REFERENCE 2 (bases 1 to 3475)
AUTHORS Small,D.
TITLE Direct Submission
JOURNAL Submitted (25-OCT-1993) Donald Small, Oncology, Johns Hopkins
University School of Medicine, 600 N. Wolfe St., Baltimore, MD
21287 USA
FEATURES Location/Qualifiers
source 1..3475
/db_xref="H-InvDB:HIT000217477"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="13q12"
/cell_type="stem cell"
/tissue_type="bone marrow"
CDS 58..3039
/codon_start=1
/product="serine/threonine protein kinase"
/protein_id="AAA18947.1"
/translation="MPALARDAGTVPLLVVFSAMIFGTITNQDLPVIKCVLINHKNND
SSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNIS
CLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSI
RNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEE
KVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVH
VNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSK
HPSQSALVTIVGKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPC
EQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQA
SCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIK
GFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKY
KKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKV
MNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACT
LSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGS
REVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKG
MEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMA
PESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYA
TEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNR
RPFSREMDLGLLSPQAQVEDS"
BASE COUNT 1042 a 709 c 784 g 940 t
ORIGIN
1 cgaggcggca tccgagggct gggccggcgc cctgggggac cccgggctcc ggaggccatg
61 ccggcgttgg cgcgcgacgc gggcaccgtg ccgctgctcg ttgttttttc tgcaatgata
121 tttgggacta ttacaaatca agatctgcct gtgatcaagt gtgttttaat caatcataag
181 aacaatgatt catcagtggg gaagtcatca tcatatccca tggtatcaga atccccggaa
241 gacctcgggt gtgcgttgag accccagagc tcagggacag tgtacgaagc tgccgctgtg
301 gaagtggatg tatctgcttc catcacactg caagtgctgg tcgatgcccc agggaacatt
361 tcctgtctct gggtctttaa gcacagctcc ctgaattgcc agccacattt tgatttacaa
421 aacagaggag ttgtttccat ggtcattttg aaaatgacag aaacccaagc tggagaatac
481 ctacttttta ttcagagtga agctaccaat tacacaatat tgtttacagt gagtataaga
541 aataccctgc tttacacatt aagaagacct tactttagaa aaatggaaaa ccaggacgcc
601 ctggtctgca tatctgagag cgttccagag ccgatcgtgg aatgggtgct ttgcgattca
661 cagggggaaa gctgtaaaga agaaagtcca gctgttgtta aaaaggagga aaaagtgctt
721 catgaattat ttgggacgga cataaggtgc tgtgccagaa atgaactggg cagggaatgc
781 accaggctgt tcacaataga tctaaatcaa actcctcaga ccacattgcc acaattattt
841 cttaaagtag gggaaccctt atggataagg tgcaaagctg ttcatgtgaa ccatggattc
901 gggctcacct gggaattaga aaacaaagca ctcgaggagg gcaactactt tgagatgagt
961 acctattcaa caaacagaac tatgatacgg attctgtttg cttttgtatc atcagtggca
1021 agaaacgaca ccggatacta cacttgttcc tcttcaaagc atcccagtca atcagctttg
1081 gttaccatcg taggaaaggg atttataaat gctaccaatt caagtgaaga ttatgaaatt
1141 gaccaatatg aagagttttg tttttctgtc aggtttaaag cctacccaca aatcagatgt
1201 acgtggacct tctctcgaaa atcatttcct tgtgagcaaa agggtcttga taacggatac
1261 agcatatcca agttttgcaa tcataagcac cagccaggag aatatatatt ccatgcagaa
1321 aatgatgatg cccaatttac caaaatgttc acgctgaata taagaaggaa acctcaagtg
1381 ctcgcagaag catcggcaag tcaggcgtcc tgtttctcgg atggataccc attaccatct
1441 tggacctgga agaagtgttc agacaagtct cccaactgca cagaagagat cacagaagga
1501 gtctggaata gaaaggctaa cagaaaagtg tttggacagt gggtgtcgag cagtactcta
1561 aacatgagtg aagccataaa agggttcctg gtcaagtgct gtgcatacaa ttcccttggc
1621 acatcttgtg agacgatcct tttaaactct ccaggcccct tccctttcat ccaagacaac
1681 atctcattct atgcaacaat tggtgtttgt ctcctcttca ttgtcgtttt aaccctgcta
1741 atttgtcaca agtacaaaaa gcaatttagg tatgaaagcc agctacagat ggtacaggtg
1801 accggctcct cagataatga gtacttctac gttgatttca gagaatatga atatgatctc
1861 aaatgggagt ttccaagaga aaatttagag tttgggaagg tactaggatc aggtgctttt
1921 ggaaaagtga tgaacgcaac agcttatgga attagcaaaa caggagtctc aatccaggtt
1981 gccgtcaaaa tgctgaaaga aaaagcagac agctctgaaa gagaggcact catgtcagaa
2041 ctcaagatga tgacccagct gggaagccac gagaatattg tgaacctgct gggggcgtgc
2101 acactgtcag gaccaattta cttgattttt gaatactgtt gctatggtga tcttctcaac
2161 tatctaagaa gtaaaagaga aaaatttcac aggacttgga cagagatttt caaggaacac
2221 aatttcagtt tttaccccac tttccaatca catccaaatt ccagcatgcc tggttcaaga
2281 gaagttcaga tacacccgga ctcggatcaa atctcagggc ttcatgggaa ttcatttcac
2341 tctgaagatg aaattgaata tgaaaaccaa aaaaggctgg aagaagagga ggacttgaat
2401 gtgcttacat ttgaagatct tctttgcttt gcatatcaag ttgccaaagg aatggaattt
2461 ctggaattta agtcgtgtgt tcacagagac ctggccgcca ggaacgtgct tgtcacccac
2521 gggaaagtgg tgaagatatg tgactttgga ttggctcgag atatcatgag tgattccaac
2581 tatgttgtca ggggcaatgc ccgtctgcct gtaaaatgga tggcccccga aagcctgttt
2641 gaaggcatct acaccattaa gagtgatgtc tggtcatatg gaatattact gtgggaaatc
2701 ttctcacttg gtgtgaatcc ttaccctggc attccggttg atgctaactt ctacaaactg
2761 attcaaaatg gatttaaaat ggatcagcca ttttatgcta cagaagaaat atacattata
2821 atgcaatcct gctgggcttt tgactcaagg aaacggccat ccttccctaa tttgacttcg
2881 tttttaggat gtcagctggc agatgcagaa gaagcgatgt atcagaatgt ggatggccgt
2941 gtttcggaat gtcctcacac ctaccaaaac aggcgacctt tcagcagaga gatggatttg
3001 gggctactct ctccgcaggc tcaggtcgaa gattcgtaga ggaacaattt agttttaagg
3061 acttcatccc tccacctatc cctaacaggc tgtagattac caaaacaaga ttaatttcat
3121 cactaaaaga aaatctatta tcaactgctg cttcaccaga cttttctcta gaagccgtct
3181 gcgtttactc ttgttttcaa agggactttt gtaaaatcaa atcatcctgt cacaaggcag
3241 gaggagctga taatgaactt tattggagca ttgatctgca tccaaggcct tctcaggccg
3301 gcttgagtga attgtgtacc tgaagtacag tatattcttg taaatacata aaacaaaagc
3361 attttgctaa ggagaagcta atatgatttt ttaagtctat gttttaaaat aatatgtaaa
3421 tttttcagct atttagtgat atattttatg ggtgggaata aaatttctac tacag
//