LOCUS HSU02571 1222 bp mRNA linear HUM 16-APR-1994
DEFINITION Human tissue inhibitor of metalloproteinase-3 precursor (TIMP-3)
mRNA, complete cds.
ACCESSION U02571
VERSION U02571.1
KEYWORDS metalloproteinase inhibitor, extracellular matrix, collagenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1222)
AUTHORS Silbiger,S.M., Jacobsen,V.L., Cupples,R.L. and Koski,R.A.
TITLE Cloning of cDNAs encoding human TIMP-3, a novel member of the
tissue inhibitor of metalloproteinase family
JOURNAL Gene 141 (2), 293-297 (1994)
PUBMED 8163205
REFERENCE 2 (bases 1 to 1222)
AUTHORS Silbiger,S.M.
TITLE Direct Submission
JOURNAL Submitted (18-OCT-1993) Scott M. Silbiger, Molecular and Cellular
Biology Department, Amgen Inc., Amgen Center, Thousand Oaks, CA
91320, USA
FEATURES Location/Qualifiers
source 1..1222
/db_xref="H-InvDB:HIT000217469"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="TIMP-3clone7"
/tissue_type="kidney"
/clone_lib="human cDNA library, lambda gt11, Clontech"
/dev_stage="fetus"
CDS 282..917
/standard_name="TIMP-3 precursor"
/codon_start=1
/product="tissue inhibitor of metalloproteinase-3
precursor"
/protein_id="AAA17672.1"
/translation="MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRA
KVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQY
LLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSK
NECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP"
sig_peptide 282..350
mat_peptide 351..914
/product="tissue inhibitor of metalloproteinase-3"
/standard_name="TIMP-3"
regulatory 1203..1209
/regulatory_class="polyA_signal_sequence"
/note="sequence varient"
BASE COUNT 238 a 391 c 336 g 257 t
ORIGIN
1 ggcggcgggc gctcagacgg cttctcctcc tcctcttgct cctccaagct cctgctcctt
61 cgccgggagc ccgcccgccg agtcctgcgc cagcgccgag gcagcctcgc tgcgccccat
121 cccgtcccgc cgggcactcg gagggcagcg cgccggaggc caaggttgcc ccgcacggcc
181 cggcgggcga gcgagctcgg gctgcagcag ccccgccggc ggcgcgcacg gcaactttgg
241 agaggcgagc agcagccccg gcagcggcgg cagcagcggc aatgacccct tggctcgggc
301 tcatcgtgct cctgggcagc tggagcctgg gggactgggg cgccgaggcg tgcacatgct
361 cgcccagcca cccccaggac gccttctgca actccgacat cgtgatccgg gccaaggtgg
421 tggggaagaa gctggtaaag gaggggccct tcggcacgct ggtctacacc atcaagcaga
481 tgaagatgta ccgaggcttc accaagatgc cccatgtgca gtacatccat acggaagctt
541 ccgagagtct ctgtggcctt aagctggagg tcaacaagta ccagtacctg ctgacaggtc
601 gcgtctatga tggcaagatg tacacggggc tgtgcaactt cgtggagagg tgggaccagc
661 tcaccctctc ccagcgcaag gggctgaact atcggtatca cctgggttgt aactgcaaga
721 tcaagtcctg ctactacctg ccttgctttg tgacttccaa gaacgagtgt ctctggaccg
781 acatgctctc caatttcggt taccctggct accagtccaa acactacgcc tgcatccggc
841 agaagggcgg ctactgcagc tggtaccgag gatgggcccc cccggataaa agcatcatca
901 atgccacaga cccctgagcg ccagaccctg ccccacctca cttccctccc ttcccgctga
961 gcttcccttg gacactaact cttcccagat gatgacaatg aaattagtgc ctgttttctt
1021 gcaaatttag cacttggaac atttaaagaa aggtctatgc tgtcatatgg ggtttattgg
1081 gaactatcct cctggcccca ccctgcccct tctttttggt tttgacatca ttcatttcca
1141 cctgggaatt tctggtgcca tgccagaaag aatgaggaac ctgtattcct cttcttcgtg
1201 ataatataat ctctattttt tt
//