LOCUS HSU01877 9046 bp mRNA linear HUM 06-JUN-1994
DEFINITION Human p300 protein mRNA, complete cds.
ACCESSION U01877
VERSION U01877.1
KEYWORDS p300; transcriptional adaptor protein; E1A-binding protein; cell
cycle regulatory protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9046)
AUTHORS Eckner,R., Ewen,M.E., Newsome,D., Gerdes,M., DeCaprio,J.A.,
Lawrence,J.B. and Livingston,D.M.
TITLE Molecular cloning and functional analysis of the adenovirus
E1A-associated 300-kD protein (p300) reveals a protein with
properties of a transcriptional adaptor
JOURNAL Genes Dev. 8 (8), 869-884 (1994)
PUBMED 7523245
REFERENCE 2 (bases 1 to 9046)
AUTHORS Eckner,R.
TITLE Direct Submission
JOURNAL Submitted (16-SEP-1993) Richard Eckner, Neoplastic Disease
Mechanisms, Dana-Farber Cancer Institute, 44 Binney Street, Boston,
MA 02115, USA
FEATURES Location/Qualifiers
source 1..9046
/db_xref="H-InvDB:HIT000217430"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q13.2."
/clone="p300"
/cell_line="293, Akata, Nalm-6, HeLa"
/clone_lib="from several different cDNA libraries"
5'UTR 1..1199
CDS 1200..8444
/codon_start=1
/product="p300 protein"
/protein_id="AAA18639.1"
/translation="MAENVVEPGPPSAKRPKLSSPALSASASDGTDFGSLFDLEHDLP
DELINSTELGLTNGGDINQLQTSLGMVQDAASKHKQLSELLRSGSSPNLNMGVGGPGQ
VMASQAQQSSPGLGLINSMVKSPMTQAGLTSPNMGMGTSGPNQGPTQSTGMMNSPVNQ
PAMGMNTGTNAGMNPGMLAAGNGQGIMPNQVMNGSIGAGRGRQDMQYPNPGMGSAGNL
LTEPLQQGSPQMGGQTGLRGPQPLKMGMMNNPNPYGSPYTQNPGQQIGASGLGLQIQT
KTVLSNNLSPFAMDKKAVPGGGMPNMGQQPAPQVQQPGLVTPVAQGMGSGAHTADPEK
RKLIQQQLVLLLHAHKCQRREQANGEVRQCNLPHCRTMKNVLNHMTHCQSGKSCQVAH
CASSRQIISHWKNCTRHDCPVCLPLKNAGDKRNQQPILTGAPVGLGNPSSLGVGQQSA
PNLSTVSQIDPSSIERAYAALGLPYQVNQMPTQPQVQAKNQQNQQPGQSPQGMRPMSN
MSASPMGVNGGVGVQTPSLLSDSMLHSAINSQNPMMSENASVPSLGPMPTAAQPSTTG
IRKQWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESAN
NRAEYYHLLAEKIYKIQKELEEKRRTRLQKQNMLPNAAGMVPVSMNPGPNMGQPQPGM
TSNGPLPDPSMIRGSVPNQMMPRITPQSGLNQFGQMSMAQPPIVPRQTPPLQHHGQLA
QPGALNPPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSS
SSCPVNSPIMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPA
TTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQVQPSLPAAPSADQPQQQP
RSQQSTAASVPTPNAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQP
SQEVKMEAKMEVDQPEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQP
STSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPD
YFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLS
EVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKC
FNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQICVLHH
EIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGE
VTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHV
QEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIW
ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDR
LTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNESTDVTKGDSKNAKKKN
NKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLP
PIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVY
TCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKMEKLGLGLDDESNNQQAAATQS
PGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQ
LIALCCYHAKHCQENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVG
QQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPYLPRTQAAGPVSQGK
AAGQVTPPTPPQTAQPPLPGPPPTAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPP
MTPMAPMGMNPPPMTRGPSGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMM
SVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQQQQVLSIL
HANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQN
MNPMQAGVQRAGLPQQQPQQQLQPPMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQ
QQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQPQQRMQHHMQQMQQGNMGQIGQLPQA
LGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQ
VRSPQPVPSPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLVAAQANPMEQGHF
ASPDQNSMLSQLASNPGMANLHGASATDLGLSTDNSDLNSNLSQSTLDIH"
misc_feature 1230..1250
/note="nuclear location signal"
misc_feature 2238..2431
/note="zinc-finger like structure (cys/his rich region 1)"
misc_feature 4430..4650
/note="bromodomain"
misc_feature 4686..5552
/note="cys/his rich region 2"
regulatory 6156..6650
/regulatory_class="other"
/note="cys/his rich region 3, binding site of adenovirus
E1A oncoprotein"
3'UTR 8445..9046
BASE COUNT 2392 a 2552 c 2243 g 1859 t
ORIGIN
1 ccttgtttgt gtgctaggct gggggggaga gagggcgaga gagagcgggc gagagtgggc
61 aagcaggacg ccgggctgag tgctaactgc gggacgcaga gagtgcggag gggagtcggg
121 tcggagagag gcggcagggg ccagaacagt ggcagggggc ccggggcgca cgggctgagg
181 cgacccccag ccccctcccg tccgcacaca cccccaccgc ggtccagcag ccgggccggc
241 gtcgacgcta ggggggacca ttacataacc cgcgccccgg ccgtcttctc ccgccgccgc
301 ggcgcccgaa ctgagcccgg ggcgggcgct ccagcactgg ccgccggcgt ggggcgtagc
361 agcggccgta ttattatttc gcggaaagga aggcgaagga ggggagcgcc ggcgcgagga
421 ggggccgcct gcgcccgccg ccggagcggg gcctcctcgg tgggctccgc gtcggcgcgg
481 gcgtgcgggc ggcgctgctc ggcccggccc cctcggccct ctggtccggc cagctccgct
541 cccggcgtcc ttgccgcgcc tccgccggcc gccgcgcgat gtgaggcggc ggcgccagcc
601 tggctctcgg ctcgggcgag ttctctgcgg ccattagggg ccggtgcggc ggcggcgcgg
661 agcgcggcgg caggaggagg gttcggaggg tgggggcgca ggcccgggag ggggcaccgg
721 gaggaggtga gtgtctcttg tcgcctcctc ctctcccccc ttttcgcccc cgcctccttg
781 tggcgatgag aaggaggagg acagcgccga ggaggaagag gttgatggcg gcggcggagc
841 tccgagagac ctcggctggg caggggccgg ccgtggcggg ccggggactg cgcctctaga
901 gccgcgagtt ctcgggaatt cgccgcagcg gaccggcctc ggcgaatttg tgctcttgtg
961 ccctcctccg ggcttgggcc aggccggccc ctcgcacttg cccttacctt ttctatcgag
1021 tccgcatccc tctccagcca ctgcgacccg gcgaagagaa aaaggaactt cccccacccc
1081 ctcgggtgcc gtcggagccc cccagcccac ccctgggtgc ggcgcgggga ccccgggccg
1141 aagaagagat ttcctgagga ttctggtttt cctcgcttgt atctccgaaa gaattaaaaa
1201 tggccgagaa tgtggtggaa ccggggccgc cttcagccaa gcggcctaaa ctctcatctc
1261 cggccctctc ggcgtccgcc agcgatggca cagattttgg ctctctattt gacttggagc
1321 acgacttacc agatgaatta atcaactcta cagaattggg actaaccaat ggtggtgata
1381 ttaatcagct tcagacaagt cttggcatgg tacaagatgc agcttctaaa cataaacagc
1441 tgtcagaatt gctgcgatct ggtagttccc ctaacctcaa tatgggagtt ggtggcccag
1501 gtcaagtcat ggccagccag gcccaacaga gcagtcctgg attaggtttg ataaatagca
1561 tggtcaaaag cccaatgaca caggcaggct tgacttctcc caacatgggg atgggcacta
1621 gtggaccaaa tcagggtcct acgcagtcaa caggtatgat gaacagtcca gtaaatcagc
1681 ctgccatggg aatgaacaca gggacgaatg cgggcatgaa tcctggaatg ttggctgcag
1741 gcaatggaca agggataatg cctaatcaag tcatgaacgg ttcaattgga gcaggccgag
1801 ggcgacagga tatgcagtac ccaaacccag gcatgggaag tgctggcaac ttactgactg
1861 agcctcttca gcagggctct ccccagatgg gaggacaaac aggattgaga ggcccccagc
1921 ctcttaagat gggaatgatg aacaacccca atccttatgg ttcaccatat actcagaatc
1981 ctggacagca gattggagcc agtggccttg gtctccagat tcagacaaaa actgtactat
2041 caaataactt atctccattt gctatggaca aaaaggcagt tcctggtgga ggaatgccca
2101 acatgggtca acagccagcc ccgcaggtcc agcagccagg tctggtgact ccagttgccc
2161 aagggatggg ttctggagca catacagctg atccagagaa gcgcaagctc atccagcagc
2221 agcttgttct ccttttgcat gctcacaagt gccagcgccg ggaacaggcc aatggggaag
2281 tgaggcagtg caaccttccc cactgtcgca caatgaagaa tgtcctaaac cacatgacac
2341 actgccagtc aggcaagtct tgccaagtgg cacactgtgc atcttctcga caaatcattt
2401 cacactggaa gaattgtaca agacatgatt gtcctgtgtg tctccccctc aaaaatgctg
2461 gtgataagag aaatcaacag ccaattttga ctggagcacc cgttggactt ggaaatccta
2521 gctctctagg ggtgggtcaa cagtctgccc ccaacctaag cactgttagt cagattgatc
2581 ccagctccat agaaagagcc tatgcagctc ttggactacc ctatcaagta aatcagatgc
2641 cgacacaacc ccaggtgcaa gcaaagaacc agcagaatca gcagcctggg cagtctcccc
2701 aaggcatgcg gcccatgagc aacatgagtg ctagtcctat gggagtaaat ggaggtgtag
2761 gagttcaaac gccgagtctt ctttctgact caatgttgca ttcagccata aattctcaaa
2821 acccaatgat gagtgaaaat gccagtgtgc cctccctggg tcctatgcca acagcagctc
2881 aaccatccac tactggaatt cggaaacagt ggcacgaaga tattactcag gatcttcgaa
2941 atcatcttgt tcacaaactc gtccaagcca tatttcctac gccggatcct gctgctttaa
3001 aagacagacg gatggaaaac ctagttgcat atgctcggaa agttgaaggg gacatgtatg
3061 aatctgcaaa caatcgagcg gaatactacc accttctagc tgagaaaatc tataagatcc
3121 agaaagaact agaagaaaaa cgaaggacca gactacagaa gcagaacatg ctaccaaatg
3181 ctgcaggcat ggttccagtt tccatgaatc cagggcctaa catgggacag ccgcaaccag
3241 gaatgacttc taatggccct ctacctgacc caagtatgat ccgtggcagt gtgccaaacc
3301 agatgatgcc tcgaataact ccacaatctg gtttgaatca atttggccag atgagcatgg
3361 cccagccccc tattgtaccc cggcaaaccc ctcctcttca gcaccatgga cagttggctc
3421 aacctggagc tctcaacccg cctatgggct atgggcctcg tatgcaacag ccttccaacc
3481 agggccagtt ccttcctcag actcagttcc catcacaggg aatgaatgta acaaatatcc
3541 ctttggctcc gtccagcggt caagctccag tgtctcaagc acaaatgtct agttcttcct
3601 gcccggtgaa ctctcctata atgcctccag ggtctcaggg gagccacatt cactgtcccc
3661 agcttcctca accagctctt catcagaatt caccctcgcc tgtacctagt cgtaccccca
3721 cccctcacca tactccccca agcatagggg ctcagcagcc accagcaaca acaattccag
3781 cccctgttcc tacaccacca gccatgccac ctgggccaca gtcccaggct ctacatcccc
3841 ctccaaggca gacacctaca ccaccaacaa cacaacttcc ccaacaagtg cagccttcac
3901 ttcctgctgc accttctgct gaccagcccc agcagcagcc tcgctcacag cagagcacag
3961 cagcgtctgt tcctacccca aacgcaccgc tgcttcctcc gcagcctgca actccacttt
4021 cccagccagc tgtaagcatt gaaggacagg tatcaaatcc tccatctact agtagcacag
4081 aagtgaattc tcaggccatt gctgagaagc agccttccca ggaagtgaag atggaggcca
4141 aaatggaagt ggatcaacca gaaccagcag atacgcagcc ggaggatatt tcagagtcta
4201 aagtggaaga ctgtaaaatg gaatctaccg aaacagaaga gagaagcact gagttaaaaa
4261 ctgaaataaa agaggaggaa gaccagccaa gtacttcagc tacccagtca tctccggctc
4321 caggacagtc aaagaaaaag attttcaaac cagaagaact acgacaggca ctgatgccaa
4381 cattggaggc actttaccgt caggatccag aatcccttcc ctttcgtcaa cctgtggacc
4441 ctcagctttt aggaatccct gattactttg atattgtgaa gagccccatg gatctttcta
4501 ccattaagag gaagttagac actggacagt atcaggagcc ctggcagtat gtcgatgata
4561 tttggcttat gttcaataat gcctggttat ataaccggaa aacatcacgg gtatacaaat
4621 actgctccaa gctctctgag gtctttgaac aagaaattga cccagtgatg caaagccttg
4681 gatactgttg tggcagaaag ttggagttct ctccacagac actgtgttgc tacggcaaac
4741 agttgtgcac aatacctcgt gatgccactt attacagtta ccagaacagg tatcatttct
4801 gtgagaagtg tttcaatgag atccaagggg agagcgtttc tttgggggat gacccttccc
4861 agcctcaaac tacaataaat aaagaacaat tttccaagag aaaaaatgac acactggatc
4921 ctgaactgtt tgttgaatgt acagagtgcg gaagaaagat gcatcagatc tgtgtccttc
4981 accatgagat catctggcct gctggattcg tctgtgatgg ctgtttaaag aaaagtgcac
5041 gaactaggaa agaaaataag ttttctgcta aaaggttgcc atctaccaga cttggcacct
5101 ttctagagaa tcgtgtgaat gactttctga ggcgacagaa tcaccctgag tcaggagagg
5161 tcactgttag agtagttcat gcttctgaca aaaccgtgga agtaaaacca ggcatgaaag
5221 caaggtttgt ggacagtgga gagatggcag aatcctttcc ataccgaacc aaagccctct
5281 ttgcctttga agaaattgat ggtgttgacc tgtgcttctt tggcatgcat gttcaagagt
5341 atggctctga ctgccctcca cccaaccaga ggagagtata catatcttac ctcgatagtg
5401 ttcatttctt ccgtcctaaa tgcttgagga ctgcagtcta tcatgaaatc ctaattggat
5461 atttagaata tgtcaagaaa ttaggttaca caacagggca tatttgggca tgtccaccaa
5521 gtgagggaga tgattatatc ttccattgcc atcctcctga ccagaagata cccaagccca
5581 agcgactgca ggaatggtac aaaaaaatgc ttgacaaggc tgtatcagag cgtattgtcc
5641 atgactacaa ggatattttt aaacaagcta ctgaagatag attaacaagt gcaaaggaat
5701 tgccttattt cgagggtgat ttctggccca atgttctgga agaaagcatt aaggaactgg
5761 aacaggagga agaagagaga aaacgagagg aaaacaccag caatgaaagc acagatgtga
5821 ccaagggaga cagcaaaaat gctaaaaaga agaataataa gaaaaccagc aaaaataaga
5881 gcagcctgag taggggcaac aagaagaaac ccgggatgcc caatgtatct aacgacctct
5941 cacagaaact atatgccacc atggagaagc ataaagaggt cttctttgtg atccgcctca
6001 ttgctggccc tgctgccaac tccctgcctc ccattgttga tcctgatcct ctcatcccct
6061 gcgatctgat ggatggtcgg gatgcgtttc tcacgctggc aagggacaag cacctggagt
6121 tctcttcact ccgaagagcc cagtggtcca ccatgtgcat gctggtggag ctgcacacgc
6181 agagccagga ccgctttgtc tacacctgca atgaatgcaa gcaccatgtg gagacacgct
6241 ggcactgtac tgtctgtgag gattatgact tgtgtatcac ctgctataac actaaaaacc
6301 atgaccacaa aatggagaaa ctaggccttg gcttagatga tgagagcaac aaccagcagg
6361 ctgcagccac ccagagccca ggcgattctc gccgcctgag tatccagcgc tgcatccagt
6421 ctctggtcca tgcttgccag tgtcggaatg ccaattgctc actgccatcc tgccagaaga
6481 tgaagcgggt tgtgcagcat accaagggtt gcaaacggaa aaccaatggc gggtgcccca
6541 tctgcaagca gctcattgcc ctctgctgct accatgccaa gcactgccag gagaacaaat
6601 gcccggtgcc gttctgccta aacatcaagc agaagctccg gcagcaacag ctgcagcacc
6661 gactacagca ggcccaaatg cttcgcagga ggatggccag catgcagcgg actggtgtgg
6721 ttgggcagca acagggcctc ccttccccca ctcctgccac tccaacgaca ccaactggcc
6781 aacagccaac caccccgcag acgccccagc ccacttctca gcctcagcct acccctccca
6841 atagcatgcc accctacttg cccaggactc aagctgctgg ccctgtgtcc cagggtaagg
6901 cagcaggcca ggtgacccct ccaacccctc ctcagactgc tcagccaccc cttccagggc
6961 ccccacctac agcagtggaa atggcaatgc agattcagag agcagcggag acgcagcgcc
7021 agatggccca cgtgcaaatt tttcaaaggc caatccaaca ccagatgccc ccgatgactc
7081 ccatggcccc catgggtatg aacccacctc ccatgaccag aggtcccagt gggcatttgg
7141 agccagggat gggaccgaca gggatgcagc aacagccacc ctggagccaa ggaggattgc
7201 ctcagcccca gcaactacag tctgggatgc caaggccagc catgatgtca gtggcccagc
7261 atggtcaacc tttgaacatg gctccacaac caggattggg ccaggtaggt atcagcccac
7321 tcaaaccagg cactgtgtct caacaagcct tacaaaacct tttgcggact ctcaggtctc
7381 ccagctctcc cctgcagcag caacaggtgc ttagtatcct tcacgccaac ccccagctgt
7441 tggctgcatt catcaagcag cgggctgcca agtatgccaa ctctaatcca caacccatcc
7501 ctgggcagcc tggcatgccc caggggcagc cagggctaca gccacctacc atgccaggtc
7561 agcagggggt ccactccaat ccagccatgc agaacatgaa tccaatgcag gcgggcgttc
7621 agagggctgg cctgccccag cagcaaccac agcagcaact ccagccaccc atgggaggga
7681 tgagccccca ggctcagcag atgaacatga accacaacac catgccttca caattccgag
7741 acatcttgag acgacagcaa atgatgcaac agcagcagca acagggagca gggccaggaa
7801 taggccctgg aatggccaac cataaccagt tccagcaacc ccaaggagtt ggctacccac
7861 cacagccgca gcagcggatg cagcatcaca tgcaacagat gcaacaagga aatatgggac
7921 agataggcca gcttccccag gccttgggag cagaggcagg tgccagtcta caggcctatc
7981 agcagcgact ccttcagcaa cagatggggt cccctgttca gcccaacccc atgagccccc
8041 agcagcatat gctcccaaat caggcccagt ccccacacct acaaggccag cagatcccta
8101 attctctctc caatcaagtg cgctctcccc agcctgtccc ttctccacgg ccacagtccc
8161 agccccccca ctccagtcct tccccaagga tgcagcctca gccttctcca caccacgttt
8221 ccccacagac aagttcccca catcctggac tggtagctgc ccaggccaac cccatggaac
8281 aagggcattt tgccagcccg gaccagaatt caatgctttc tcagcttgct agcaatccag
8341 gcatggcaaa cctccatggt gcaagcgcca cggacctggg actcagcacc gataactcag
8401 acttgaattc aaacctctca cagagtacac tagacataca ctagagacac cttgtatttt
8461 gggagcaaaa aaattatttt ctcttaacaa gactttttgt actgaaaaca atttttttga
8521 atctttcgta gcctaaaaga caattttcct tggaacacat aagaactgtg cagtagccgt
8581 ttgtggttta aagcaaacat gcaagatgaa cctgagggat gatagaatac aaagaatata
8641 tttttgttat gggctggtta ccaccagcct ttcttcccct ttgtgtgtgt ggttcaagtg
8701 tgcactggga ggaggctgag gcctgtgaag ccaaacaata tgctcctgcc ttgcacctcc
8761 aataggtttt attatttttt ttaaattaat gaacatatgt aatattaatg aacatatgta
8821 atattaatag ttattattta ctggtgcaga tggttgacat ttttccctat tttcctcact
8881 ttatggaaga gttaaaacat ttctaaacca gaggacaaaa ggggttaatg ttactttgaa
8941 attacattct atatatatat aaatatatat aaatatatat taaaatacca gttttttttc
9001 tctgggtgca aagatgttca ttcttttaaa aaatgtttaa aaaaaa
//