LOCUS HSU01873 1590 bp mRNA linear HUM 27-SEP-1993
DEFINITION Human tyrosinase mRNA, complete cds.
ACCESSION U01873
VERSION U01873.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1590)
AUTHORS Brichard,V., Van Pel,A., Wolfel,T., Wolfel,C., De Plaen,E.,
Lethe,B., Coulie,P. and Boon,T.
TITLE The tyrosinase gene codes for an antigen recognized by autologous
cytolytic T lymphocytes on HLA-A2 melanomas
JOURNAL J. Exp. Med. 178 (2), 489-495 (1993)
PUBMED 8340755
REFERENCE 2 (bases 1 to 1590)
AUTHORS Bouchard,B., Fuller,B.B., Vijayasaradhi,S. and Houghton,A.N.
TITLE Induction of pigmentation in mouse fibroblasts by expression of
human tyrosinase cDNA
JOURNAL J. Exp. Med. 169 (6), 2029-2042 (1989)
PUBMED 2499655
REFERENCE 3 (bases 1 to 1590)
AUTHORS Kwon,B.S., Haq,A.K., Pomerantz,S.H. and Halaban,R.
TITLE Isolation and sequence of a cDNA clone for human tyrosinase that
maps at the mouse c-albino locus
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (21), 7473-7477 (1987)
PUBMED 2823263
REFERENCE 4 (bases 1 to 1590)
AUTHORS Brichard,V.G.
TITLE Direct Submission
JOURNAL Submitted (16-SEP-1993) Vincent G Brichard, Ludwig Institute for
Cancer Research, Avenue Hippocrate, 74, Brussels B-1200 Belgium
FEATURES Location/Qualifiers
source 1..1590
/db_xref="H-InvDB:HIT000217428"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS 1..1590
/codon_start=1
/product="tyrosinase"
/protein_id="AAB60319.1"
/translation="MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRS
PCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGN
CKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMK
NGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRW
EQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVC
SRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDK
AANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAF
VDSIFEQWLQRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYS
YLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLP
EEKQPLLMEKEDYHSLYQSHL"
misc_difference 537
/note="conflict; amino acid change (I in Bouchard to M in
Brichard)"
/replace="c"
misc_difference 575
/note="conflict; amino acid change (Y in Bouchard and Kwon
to S in Brichard)"
/replace="a"
misc_difference 1205
/note="conflict; amino acid change (R in Bouchard to Q in
Brichard)"
/replace="g"
BASE COUNT 411 a 387 c 369 g 423 t
ORIGIN
1 atgctcctgg ctgttttgta ctgcctgctg tggagtttcc agacctccgc tggccatttc
61 cctagagcct gtgtctcctc taagaacctg atggagaagg aatgctgtcc accgtggagc
121 ggggacagga gtccctgtgg ccagctttca ggcagaggtt cctgtcagaa tatccttctg
181 tccaatgcac cacttgggcc tcaatttccc ttcacagggg tggatgaccg ggagtcgtgg
241 ccttccgtct tttataatag gacctgccag tgctctggca acttcatggg attcaactgt
301 ggaaactgca agtttggctt ttggggacca aactgcacag agagacgact cttggtgaga
361 agaaacatct tcgatttgag tgccccagag aaggacaaat tttttgccta cctcacttta
421 gcaaagcata ccatcagctc agactatgtc atccccatag ggacctatgg ccaaatgaaa
481 aatggatcaa cacccatgtt taacgacatc aatatttatg acctctttgt ctggatgcat
541 tattatgtgt caatggatgc actgcttggg ggatctgaaa tctggagaga cattgatttt
601 gcccatgaag caccagcttt tctgccttgg catagactct tcttgttgcg gtgggaacaa
661 gaaatccaga agctgacagg agatgaaaac ttcactattc catattggga ctggcgggat
721 gcagaaaagt gtgacatttg cacagatgag tacatgggag gtcagcaccc cacaaatcct
781 aacttactca gcccagcatc attcttctcc tcttggcaga ttgtctgtag ccgattggag
841 gagtacaaca gccatcagtc tttatgcaat ggaacgcccg agggaccttt acggcgtaat
901 cctggaaacc atgacaaatc cagaacccca aggctcccct cttcagctga tgtagaattt
961 tgcctgagtt tgacccaata tgaatctggt tccatggata aagctgccaa tttcagcttt
1021 agaaatacac tggaaggatt tgctagtcca cttactggga tagcggatgc ctctcaaagc
1081 agcatgcaca atgccttgca catctatatg aatggaacaa tgtcccaggt acagggatct
1141 gccaacgatc ctatcttcct tcttcaccat gcatttgttg acagtatttt tgagcagtgg
1201 ctccaaaggc accgtcctct tcaagaagtt tatccagaag ccaatgcacc cattggacat
1261 aaccgggaat cctacatggt tccttttata ccactgtaca gaaatggtga tttctttatt
1321 tcatccaaag atctgggcta tgactatagc tatctacaag attcagaccc agactctttt
1381 caagactaca ttaagtccta tttggaacaa gcgagtcgga tctggtcatg gctccttggg
1441 gcggcgatgg taggggccgt cctcactgcc ctgctggcag ggcttgtgag cttgctgtgt
1501 cgtcacaaga gaaagcagct tcctgaagaa aagcagccac tcctcatgga gaaagaggat
1561 taccacagct tgtatcagag ccatttataa
//