LOCUS U01184 4105 bp mRNA linear HUM 26-JUL-2016
DEFINITION Human homolog of D. melanogaster flightless-I gene product mRNA,
partial cds.
ACCESSION U01184
VERSION U01184.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4105)
AUTHORS Campbell,H.D., Schimansky,T., Claudianos,C., Ozsarac,N.,
Kasprzak,A.B., Cotsell,J.N., Young,I.G., de Couet,H.G. and
Miklos,G.L.
TITLE The Drosophila melanogaster flightless-I gene involved in
gastrulation and muscle degeneration encodes gelsolin-like and
leucine-rich repeat domains and is conserved in Caenorhabditis
elegans and humans
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (23), 11386-11390 (1993)
PUBMED 8248259
REFERENCE 2 (bases 1 to 4105)
AUTHORS Campbell,H.D.
TITLE Direct Submission
JOURNAL Submitted (02-SEP-1993) Hugh D. Campbell, Centre for Molec.
Structure & Function, RSBS, Australian National University, Biology
Place, Acton, Canberra, ACT, 2601, Australia
FEATURES Location/Qualifiers
source 1..4105
/db_xref="H-InvDB:HIT000217420"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="hippocampus"
/clone_lib="cDNA library in lambda ZAP II vector,
Stratagene, catalog # 936205"
CDS <1..3808
/note="leucine-rich repeat domain towards the N-terminus,
likely to be involved in protein-protein interactions, is
linked to a gelsolin-like, putative actin-binding domain"
/codon_start=2
/product="flightless-I homolog"
/protein_id="AAC03568.1"
/translation="EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGL
CYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKL
DDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSEN
RLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSL
EGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLS
RNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPES
LCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNID
FSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSD
VAQEKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENF
VPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVN
LRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVY
GKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNE
RKGKAEITLLVQGQELPEFWEALGGEPSEIKKHVPEDFWPPQPKLYKVGLGLGYLELP
QINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAA
ALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQSP
GLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGFVLEGK
KFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAEAEE
KQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFL
SHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILK
VPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVG
IGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVY
MWVGTQTSQVEIKLSLKACQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSA
FCKALA"
3'UTR 3809..4105
regulatory 4081..4086
/regulatory_class="polyA_signal_sequence"
/note="differs from canonical sequence by one base (ATTAAA
instead of AATAAA)."
polyA_site 4105
BASE COUNT 944 a 1207 c 1222 g 732 t
ORIGIN
1 ggaggccacc ggggtgctgc cgttcgtgcg tggcgtggac ctcagcggca acgacttcaa
61 gggcggctac ttccctgaga atgtcaaggc catgaccagc ctgcggtggc tgaagctgaa
121 ccgcactggc ctctgctacc tgcccgagga gctggccgcc ctgcagaagc tggaacactt
181 gtctgtgagc cacaacaacc tgaccacgct tcatggggag ctgtccagcc tgccatcgct
241 gcgcgccatc gtggcccgag ccaacagtct gaagaattcc ggagtccccg atgacatctt
301 caagctagat gatctctcag tcctggactt gagccacaac cagctgacag agtgcccgcg
361 ggagctggag aacgccaaga acatgctggt gctgaacctc agccacaaca gcatcgacac
421 catccccaac cagctcttca tcaacctcac tgacctacta tacctggacc tcagcgagaa
481 ccgcctggag agcctgcccc cgcagatgcg ccgcctggtg cacctgcaga cgctcgtgct
541 caatggaaac cccctgctgc atgcacagct ccggcagctc ccagcgatga cggccctgca
601 gaccctgcac ctgcggagca cccagcgcac ccagagcaac ctgcccacca gcctggaggg
661 tctgagcaac ctcgcagacg tggatctgtc ctgcaatgac ctgacacggg tgcccgagtg
721 tctgtacacc ctccccagcc tgcgccgcct caacctcagc agcaaccaga tcacggagct
781 gtccctgtgc atagaccagt gggtgcacgt ggaaactctg aacctgtccc gaaatcagct
841 cacctcactg ccctcagcca tttgcaagct gagcaagctg aagaagctgt acctgaattc
901 caacaagctg gactttgacg ggctgccctc aggcattggc aagctcacca acctggaaga
961 gttcatggct gccaacaaca acctggagct ggtccctgaa agtctctgca ggtgcccaaa
1021 gctgaggaaa cttgtcctga acaagaacca cctggtgacc ctcccagaag ccatccattt
1081 cctgacggag atcgaggtcc tggatgtgcg ggagaacccc aacctggtca tgccgcccaa
1141 gcccgcagac cgtgccgctg agtggtacaa catcgacttc tcgctgcaga accagctgcg
1201 gctagcgggt gcctctcctg ctaccgtggc tgcagctgca gctgcaggga gtgggcccaa
1261 ggaccctatg gctcgcaaga tgcgactgcg gaggcgcaag gattcagccc aggatgacca
1321 ggccaagcag gtgctgaagg gcatgtcaga tgttgcccag gagaagaaca aaaagcagga
1381 ggagagcgca gatgcccggg cccccagcgg gaaggtgcgg cgttgggacc agggcctgga
1441 gaagccccgc cttgactact ccgagttctt cacggaggac gtgggccagc tgcccggact
1501 gaccatctgg cagatagaga acttcgtgcc tgtgctggtg gaggaagcct tccacggcaa
1561 gttctacgag gctgactgct acattgtgct caagaccttt ctggatgaca gcggctccct
1621 caactgggag atctactact ggattggcgg ggaggccaca ctcgacaaga aagcttgctc
1681 tgccatccac gctgtcaact tgcgcaacta cctgggtgct gagtgccgca ctgtccggga
1741 ggagatgggc gatgagagcg aggagttcct gcaggtgttt gacaacgaca tctcctacat
1801 tgagggtgga acagccagtg gcttctacac tgtggaagac acacactatg tcaccaggat
1861 gtatcgtgtg tatgggaaaa agaacatcaa gttggagcct gtgcccctca aggggacctc
1921 tctggaccca aggtttgttt tcctgctgga ccgagggcta gacatctacg tatggcgggg
1981 ggcccaggcc acactgagca gcaccaccaa ggccaggctc tttgcagaga aaattaacaa
2041 gaatgagcgg aaagggaagg ctgagatcac actgctggtg cagggccagg agctcccaga
2101 gttctgggag gcactgggtg gggagccctc tgagatcaag aagcacgtgc ctgaagactt
2161 ctggccgccg cagcccaagc tgtacaaggt gggcctgggc ttgggctacc tggagctgcc
2221 acagatcaac tacaagctct ccgtggaaca taagcagcgt cccaaggtgg agctgatgcc
2281 aagaatgcgg ctgctgcaga gtctgctgga cacgcgctgc gtgtacattc tggactgttg
2341 gtccgacgtg ttcatctggc tcggccgcaa gtccccgcgc ctggtgcgcg ctgccgccct
2401 caagctgggt caggagctgt gcgggatgct gcaccggcca cgccatgcca cggtcagccg
2461 cagcctcgag ggcaccgagg cgcaggtgtt caaggccaag ttcaagaatt gggacgatgt
2521 gttgacggtg gactacacac gcaatgcgga ggccgtgctg cagagcccgg gtctctccgg
2581 gaaggtgaaa cgcgacgccg agaagaaaga ccagatgaag gctgacctca ctgcgctttt
2641 cctgccgcgg cagccgccca tgtcgctggc cgaggcggag cagctgatgg aggagtggaa
2701 cgaagaccta gacggcatgg agggtttcgt gctggagggc aagaagtttg cgcggctgcc
2761 ggaagaggag tttggccact tctacacgca ggactgctac gtcttcctct gcaggtactg
2821 ggtgcctgtg gagtacgagg aggaggaaaa gaaggaagac aaggaggaga aggccgaggg
2881 caaagaaggc gaggaagcaa ccgctgaggc agaggagaag cagccagagg aggacttcca
2941 gtgcatcgtg tacttctggc agggccgtga agcctccaat atgggctggc tcaccttcac
3001 cttcagcctg caaaagaagt tcgagagcct cttccctggg aagctggagg tggtacgcat
3061 gacgcagcag caggagaacc ccaagttcct gtcccatttc aagaggaagt tcatcatcca
3121 ccggggcaag aggaaggcgg tccagggcgc ccaacagccc agcctctacc agatccgcac
3181 caacggcagc gccctctgca cccggtgcat ccagatcaac accgactcca gcctcctcaa
3241 ctccgagttc tgcttcatcc tcaaggttcc ctttgagagt gaggacaacc agggcatcgt
3301 gtatgcctgg gtgggccggg catcagaccc tgacgaagcc aagttggcag aagacatcct
3361 gaacaccatg tttgacacct cctacagcaa gcaggttatc aacgaaggtg aggagcctga
3421 gaacttcttc tgggtgggca ttggggcaca gaagccctat gatgacgatg ccgagtacat
3481 gaaacacaca cgtctcttcc ggtgctccaa cgagaagggc tactttgcag tgactgagaa
3541 atgctccgac ttttgccaag atgacctggc agatgatgac atcatgttgc tagacaatgg
3601 ccaagaggtc tacatgtggg tggggaccca gactagccag gtggagatca agctgagcct
3661 gaaggcctgc caggtatata tccagcacat gcggtccaag gaacatgagc ggccgcgccg
3721 gctgcgcctg gtccgcaagg gcaatgagca gcacgccttt acccgctgct tccacgcctg
3781 gagcgccttc tgcaaggccc tggcctaaga caggctggca cagccccagg cttggtgagg
3841 aagaggaagg ggcctcatcc actgtctgct agcaaagaat gtactcaggt gacaccacct
3901 gctccagcca cgtccagtgc cacagtcccc agtagcctca agcagcacca atggggatga
3961 ccctgacagg tgccctcagg ggtctgggaa atccaactct ctccacagtg tgagtgcacg
4021 tgtgaagccc cctcactctt ccgctaggga taaagcagat gtggatgccc tttaagagat
4081 attaaatgct tttattttca atatt
//