LOCUS U01134 2651 bp mRNA linear HUM 02-FEB-1994
DEFINITION Human soluble vascular endothelial cell growth factor receptor
(sflt) mRNA, complete cds.
ACCESSION U01134
VERSION U01134.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2651)
AUTHORS Kendall,R.L. and Thomas,K.A.
TITLE Inhibition of vascular endothelial cell growth factor activity by
an endogenously encoded soluble receptor
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (22), 10705-10709 (1993)
PUBMED 8248162
REFERENCE 2 (bases 1 to 2651)
AUTHORS Kendall,R.L.
TITLE Direct Submission
JOURNAL Submitted (30-AUG-1993) Richard L. Kendall, Growth Factors
Research, Merck, Room 80W-243, Rahway, New Jersey, 07065, USA
FEATURES Location/Qualifiers
source 1..2651
/db_xref="H-InvDB:HIT000217415"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/clone="7"
/cell_type="vascular endothelial"
/tissue_type="umbilical vein"
/clone_lib="HL1070b Clonetech"
gene 1..2651
/gene="sflt"
CDS 250..2313
/gene="sflt"
/standard_name="soluble VEGF receptor"
/codon_start=1
/product="soluble vascular endothelial cell growth factor
receptor"
/protein_id="AAC50060.1"
/translation="MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQ
AGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHT
GFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRV
TSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKT
NYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRA
SVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFI
TVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLII
KDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ
ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQR
MAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKM
PTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIM
NVSLQDSGTYACRARNVYTGEEILQKKEITIRGEHCNKKAVFSRISKFKSTRNDCTTQ
SNVKH"
BASE COUNT 773 a 621 c 620 g 637 t
ORIGIN
1 gcggacactc ctctcggctc ctccccggca gcggcggcgg ctcggagcgg gctccggggc
61 tcgggtgcag cggccagcgg gcctggcggc gaggattacc cggggaagtg gttgtctcct
121 ggctggagcc gcgagacggg cgctcagggc gcggggccgg cggcggcgaa cgagaggacg
181 gactctggcg gccgggtcgt tggccggggg agcgcgggca ccgggcgagc aggccgcgtc
241 gcgctcacca tggtcagcta ctgggacacc ggggtcctgc tgtgcgcgct gctcagctgt
301 ctgcttctca caggatctag ttcaggttca aaattaaaag atcctgaact gagtttaaaa
361 ggcacccagc acatcatgca agcaggccag acactgcatc tccaatgcag gggggaagca
421 gcccataaat ggtctttgcc tgaaatggtg agtaaggaaa gcgaaaggct gagcataact
481 aaatctgcct gtggaagaaa tggcaaacaa ttctgcagta ctttaacctt gaacacagct
541 caagcaaacc acactggctt ctacagctgc aaatatctag ctgtacctac ttcaaagaag
601 aaggaaacag aatctgcaat ctatatattt attagtgata caggtagacc tttcgtagag
661 atgtacagtg aaatccccga aattatacac atgactgaag gaagggagct cgtcattccc
721 tgccgggtta cgtcacctaa catcactgtt actttaaaaa agtttccact tgacactttg
781 atccctgatg gaaaacgcat aatctgggac agtagaaagg gcttcatcat atcaaatgca
841 acgtacaaag aaatagggct tctgacctgt gaagcaacag tcaatgggca tttgtataag
901 acaaactatc tcacacatcg acaaaccaat acaatcatag atgtccaaat aagcacacca
961 cgcccagtca aattacttag aggccatact cttgtcctca attgtactgc taccactccc
1021 ttgaacacga gagttcaaat gacctggagt taccctgatg aaaaaaataa gagagcttcc
1081 gtaaggcgac gaattgacca aagcaattcc catgccaaca tattctacag tgttcttact
1141 attgacaaaa tgcagaacaa agacaaagga ctttatactt gtcgtgtaag gagtggacca
1201 tcattcaaat ctgttaacac ctcagtgcat atatatgata aagcattcat cactgtgaaa
1261 catcgaaaac agcaggtgct tgaaaccgta gctggcaagc ggtcttaccg gctctctatg
1321 aaagtgaagg catttccctc gccggaagtt gtatggttaa aagatgggtt acctgcgact
1381 gagaaatctg ctcgctattt gactcgtggc tactcgttaa ttatcaagga cgtaactgaa
1441 gaggatgcag ggaattatac aatcttgctg agcataaaac agtcaaatgt gtttaaaaac
1501 ctcactgcca ctctaattgt caatgtgaaa ccccagattt acgaaaaggc cgtgtcatcg
1561 tttccagacc cggctctcta cccactgggc agcagacaaa tcctgacttg taccgcatat
1621 ggtatccctc aacctacaat caagtggttc tggcacccct gtaaccataa tcattccgaa
1681 gcaaggtgtg acttttgttc caataatgaa gagtccttta tcctggatgc tgacagcaac
1741 atgggaaaca gaattgagag catcactcag cgcatggcaa taatagaagg aaagaataag
1801 atggctagca ccttggttgt ggctgactct agaatttctg gaatctacat ttgcatagct
1861 tccaataaag ttgggactgt gggaagaaac ataagctttt atatcacaga tgtgccaaat
1921 gggtttcatg ttaacttgga aaaaatgccg acggaaggag aggacctgaa actgtcttgc
1981 acagttaaca agttcttata cagagacgtt acttggattt tactgcggac agttaataac
2041 agaacaatgc actacagtat tagcaagcaa aaaatggcca tcactaagga gcactccatc
2101 actcttaatc ttaccatcat gaatgtttcc ctgcaagatt caggcaccta tgcctgcaga
2161 gccaggaatg tatacacagg ggaagaaatc ctccagaaga aagaaattac aatcagaggt
2221 gagcactgca acaaaaaggc tgttttctct cggatctcca aatttaaaag cacaaggaat
2281 gattgtacca cacaaagtaa tgtaaaacat taaaggactc attaaaaagt aacagttgtc
2341 tcatatcatc ttgatttatt gtcactgttg ctaactttca ggctcggagg agatgctcct
2401 cccaaaatga gttcggagat gatagcagta ataatgagac ccccgggctc cagctctggg
2461 ccccccattc aggccgaggg ggctgctccg gggggccgac ttggtgcacg tttggatttg
2521 gaggatccct gcactgcctt ctctgtgttt gttgctcttg ctgttttctc ctgcctgata
2581 aacaacaact tgggatgatc ctttccattt tgatgccaac ctctttttat ttttaagcgg
2641 cgccctatag t
//