LOCUS S79639 3183 bp mRNA linear HUM 27-JAN-1996
DEFINITION EXT1=putative tumour suppressor/hereditary multiple exostoses
candidate gene [human, placenta, mRNA, 3183 nt].
ACCESSION S79639
VERSION S79639.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3183)
AUTHORS Ahn,J., Ludecke,H.J., Lindow,S., Horton,W.A., Lee,B., Wagner,M.J.,
Horsthemke,B. and Wells,D.E.
TITLE Cloning of the putative tumour suppressor gene for hereditary
multiple exostoses (EXT1)
JOURNAL Nat. Genet. 11 (2), 137-143 (1995)
PUBMED 7550340
REMARK GenBank staff at the National Library of Medicine created this
entry [NCBI gibbsq 171344] from the original journal article.
FEATURES Location/Qualifiers
source 1..3183
/db_xref="H-InvDB:HIT000216859"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3183
/gene="EXT1"
/note="putative tumour suppressor/hereditary multiple
exostoses candidate gene"
CDS 652..2892
/gene="EXT1"
/note="putative tumour suppressor/hereditary multiple
exostoses candidate gene"
/codon_start=1
/protein_id="AAB62283.1"
/translation="MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRN
GLHHPSPDHFWPRFPEPLRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMES
CFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDT
LDRDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAK
ASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIG
SDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFC
LVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPST
IRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPG
GLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQ
YCAQIIVLWNCDKPLPAKHRWPATAVPVVVIEGESKVMSSRFLPYDNIITDAVLSLDE
DTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAA
IYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETM
MGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKY
RDIERL"
BASE COUNT 815 a 805 c 803 g 760 t
ORIGIN
1 cctccaggcc ccgccgcgcg tcccgggggc cggccccgcg agcgcaggag taaacaccgc
61 cggagtcttg gagccgctgc agaagggaat aaagagagat gcagggattt gtgaggttac
121 ggcgccccag ctgcaagatg cactagccgg ctgaacccgg gatcggctga cttgttggaa
181 ccggagtgct ctgcacggag agtggtggat gagttgaagt tgccttcccg gggctcattt
241 tccacgctgc cgagaggaat ccgagaggca aggcaatcac ttcgtcttgc cattgattgg
301 gtatcgggag cttttttttt ctcccctctc tctttctttt cctccgtctt gttgcatgca
361 agaaaattac agtccgctgc tcgcccgccc tgggtgcgag atattcagcc ccgctctctc
421 ccgtgcattg tgcaacccaa agatgaaaga ccgaagggga gaaagttaaa gaaatcgccc
481 acatgcgctg gatcagtcca cggcttgggg aaaggcatcc agagaaggtg ggagcggaga
541 gtttgaagtc tttacaggcg ggaagatggc ggactggagc tgaaagtgtt gattgggaaa
601 cttgggtgat tcttgtgttt atttacaatc ctcttgaccc aggcaggaca catgcaggcc
661 aaaaaacgct atttcatcct gctctcagct ggctcttgtc tcgccctttt gttttatttc
721 ggaggcttgc agtttagggc atcgaggagc cacagccgga gagaagaaca cagcggtagg
781 aatggcttgc accaccccag tccggatcat ttctggcccc gcttcccgga gcctctgcgc
841 cccttcgttc cttgggatca attggaaaac gaggattcca gcgtgcacat ttccccccgg
901 cagaagcgag atgccaactc cagcatctac aaaggcaaga agtgccgcat ggagtcctgc
961 ttcgatttca ccctttgcaa gaaaaacggc ttcaaagtct acgtataccc acagcaaaaa
1021 ggggagaaaa tcgccgaaag ttaccaaaac attctagcgg ccatcgaggg ctccaggttc
1081 tacacctcgg accccagcca ggcgtgcctc tttgtcctga gtctggatac tttagacaga
1141 gaccagttgt cacctcagta tgtgcacaat ttgagatcca aagtgcagag tctccacttg
1201 tggaacaatg gtaggaatca tttaattttt aatttatatt ccggcacttg gcctgactac
1261 accgaggacg tggggtttga catcggccag gcgatgctgg ccaaagccag catcagtact
1321 gaaaacttcc gacccaactt tgatgtttct attcccctct tttctaagga tcatcccagg
1381 acaggagggg agagggggtt tttgaagttc aacaccatcc ctcctctcag gaagtacatg
1441 ctggtattca aggggaagag gtacctgaca gggataggat cagacaccag gaatgcctta
1501 tatcacgtcc ataacgggga ggacgttgtg ctcctcacca cctgcaagca tggcaaagac
1561 tggcaaaagc acaaggattc tcgctgtgac agagacaaca ccgagtatga gaagtatgat
1621 tatcgggaaa tgctgcacaa tgccactttc tgtctggttc ctcgtggtcg caggcttggg
1681 tccttcagat tcctggaggc tttgcaggct gcctgcgtcc ctgtgatgct cagcaatgga
1741 tgggagttgc cattctctga agtgattaat tggaaccaag ctgccgtcat aggcgatgag
1801 agattgttat tacagattcc ttctacaatc aggtctattc atcaggataa aatcctagca
1861 cttagacagc agacacaatt cttgtgggag gcttattttt cttcagttga gaagattgta
1921 ttaactacac tagagattat tcaggacaga atattcaagc acatatcacg taacagttta
1981 atatggaaca aacatcctgg aggattgttc gtactaccac agtattcatc ttatctggga
2041 gattttcctt actactatgc taatttaggt ttaaagcccc cctccaaatt cactgcagtc
2101 atccatgcgg tgacccccct ggtctctcag tcccagccag tgttgaagct tctcgtggct
2161 gcagccaagt cccagtactg tgcccagatc atagttctat ggaattgtga caagccccta
2221 ccagccaaac accgctggcc tgccactgct gtgcctgtcg tcgtcattga aggagagagc
2281 aaggttatga gcagccgttt tctgccctac gacaacatca tcacagacgc cgtgctcagc
2341 cttgacgagg acacggtgct ttcaacaaca gaggtggatt tcgccttcac agtgtggcag
2401 agcttccctg agaggattgt ggggtacccc gcgcgcagcc acttctggga taactctaag
2461 gagcggtggg gatacacatc aaagtggacg aacgactact ccatggtgtt gacaggagct
2521 gctatttacc acaaatatta tcactaccta tactcccatt acctgccagc cagcctgaag
2581 aacatggtgg accaattggc caattgtgag gacattctca tgaacttcct ggtgtctgct
2641 gtgacaaaat tgcctccaat caaagtgacc cagaagaagc agtataagga gacaatgatg
2701 ggacagactt ctcgggcttc ccgttgggct gaccctgacc actttgccca gcgacagagc
2761 tgcatgaata cgtttgccag ctggtttggc tacatgccgc tgatccactc tcagatgagg
2821 ctcgaccccg tcctctttaa agaccaggtc tctattttga ggaagaaata ccgagacatt
2881 gagcgacttt gaggaatccg gctgagtggg ggaggggaag caagaaggga tgggggtcaa
2941 gctgctctct cttcccagtg cagatccact catcagcaga gccagattgt gccaactatc
3001 caaaaactta gatgagcaga atgacaaaaa aaaaaaaggc caatgagaac tcaactcctg
3061 gctcctggga ctgcaccaga ctgctccaaa ctcacctcac tggcttctgt gtcccaagac
3121 taggttggta cagtttaatt atggaacatt aaataattat ttttgaaaaa aaaaaaaaaa
3181 aaa
//