LOCUS S76822 1673 bp mRNA linear HUM 27-JUL-1995
DEFINITION squalene synthase=farnesyl diphosphate:farnesyl diphosphate
farnesyltransferase [human, liver, mRNA, 1673 nt].
ACCESSION S76822
VERSION S76822.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1673)
AUTHORS Soltis,D.A., McMahon,G., Caplan,S.L., Dudas,D.A., Chamberlin,H.A.,
Vattay,A., Dottavio,D., Rucker,M.L., Engstrom,R.G.,
Cornell-Kennon,S.A. et al.
TITLE Expression, purification, and characterization of the human
squalene synthase: use of yeast and baculoviral systems
JOURNAL Arch. Biochem. Biophys. 316 (2), 713-723 (1995)
PUBMED 7864626
REMARK GenBank staff at the National Library of Medicine created this
entry [NCBI gibbsq 163636] from the original journal article.
FEATURES Location/Qualifiers
source 1..1673
/db_xref="H-InvDB:HIT000216693"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1673
/gene="squalene synthase"
CDS 66..1319
/gene="squalene synthase"
/note="farnesyl diphosphate:farnesyl diphosphate
farnesyltransferase"
/codon_start=1
/product="squalene synthase"
/protein_id="AAB33404.1"
/translation="MEFVKCLGHPEEFYNLVRFRIGGKRKVMPKMDQDSLSSSLKTCY
RYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLEDDMTISVEKKVPLLHNFHS
FLYQPDWRFMESKEKDRQVLEDFPTISLEFRNLAEKYQTVIADICRRMGIGMAEFLDK
HVTSEQEWDKYCHYVAGLVGIGLSRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIR
DYLEDQQGGREFWPQEVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITY
LSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAV
KAIIYQYMEEIYHRIPDSNPSSSKTRQIISTIRTQNLPNCQLISRSHYSPIYLSFVML
LAALSWQYLTTLSQVTEDYVQTGEH"
BASE COUNT 449 a 393 c 419 g 412 t
ORIGIN
1 gccggtgagc gcctggggac cgcagaggtg agagtcgcgc ccgggagtcc gccgcctgcg
61 ccaggatgga gttcgtgaaa tgccttggcc accccgaaga gttctacaac ctggtgcgct
121 tccggatcgg gggcaagcgg aaggtgatgc ccaagatgga ccaggactcg ctcagcagca
181 gcctgaaaac ttgctacagg tatctcaatc agaccagtcg cagtttcgca gctgttatcc
241 aggcgctgga tggggaaatg cgcaacgcag tgtgcatatt ttatctggtt ctccgagctc
301 tggacacact ggaagatgac atgaccatca gtgtggaaaa gaaggtcccg ctgttacaca
361 actttcactc tttcctttac caaccagact ggcggttcat ggagagcaag gagaaggatc
421 gccaggtgct ggaggacttc ccaacgatct cccttgagtt tagaaatctg gctgagaaat
481 accaaacagt gattgccgac atttgccgga gaatgggcat tgggatggca gagtttttgg
541 ataagcatgt gacctctgaa caggagtggg acaagtactg ccactatgtt gctgggctgg
601 tcggaattgg cctttcccgt cttttctcag cctcagagtt tgaagacccc ttagttggtg
661 aagatacaga acgtgccaac tctatgggcc tgtttctgca gaaaacaaac atcatccgtg
721 actatctgga agaccagcaa ggaggaagag agttctggcc tcaagaggtt tggagcaggt
781 atgttaagaa gttaggggat tttgctaagc cggagaatat tgacttggcc gtgcagtgcc
841 tgaatgaact tataaccaat gcactgcacc acatcccaga tgtcatcacc tacctttcga
901 gactcagaaa ccagagtgtg tttaacttct gtgctattcc acaggtgatg gccattgcca
961 ctttggctgc ctgttataat aaccagcagg tgttcaaagg ggcagtgaag attcggaaag
1021 ggcaagcagt gaccctgatg atggatgcca ccaatatgcc agctgtcaaa gccatcatat
1081 atcagtatat ggaagagatt tatcatagaa tccccgactc aaacccatct tctagcaaaa
1141 caaggcagat catctccacc atccggacgc agaatcttcc caactgtcag ctgatttccc
1201 gaagccacta ctcccccatc tacctgtcgt ttgtcatgct tttggctgcc ctgagctggc
1261 agtacctgac cactctctcc caggtaacag aagactatgt tcagactgga gaacactgat
1321 cccaaatttg tccatagctg aagtccacca taaagtggat ttactttttt tctctttatt
1381 tttttcctac tactttaatc cctaaaagaa cgctgtgtgg ctgggacctt taggaaagtg
1441 aaatgcaggt gagaagaacc taaacatgaa aggtaaaggg tgcctcatcc cagcaacctg
1501 tccttgtggg tgatgatcac tgtgctgctt gtggctcatg gcagagcatt cagtgccacg
1561 gtttaggtga agtcgctgca tatgtgactg tcatgagatc ctacttagta tgatcctggc
1621 tagaatgata attaaaagta tttaatttga agcaaaaaaa aaaaaaaaaa aaa
//