LOCUS S73751 1767 bp mRNA linear HUM 05-JUN-2000
DEFINITION Homo sapiens acyl coenzyme A:cholesterol acyltransferase mRNA,
complete cds.
ACCESSION S73751
VERSION S73751.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1767)
AUTHORS Becker,A., Bottcher,A., Lackner,K.J., Fehringer,P., Notka,F.,
Aslanidis,C. and Schmitz,G.
TITLE Purification, cloning, and expression of a human enzyme with acyl
coenzyme A: cholesterol acyltransferase activity, which is
identical to liver carboxylesterase
JOURNAL Arterioscler. Thromb. 14 (8), 1346-1355 (1994)
PUBMED 8049197
REMARK GenBank staff at the National Library of Medicine created this
entry [NCBI gibbsq 156480] from the original journal article.
FEATURES Location/Qualifiers
source 1..1767
/db_xref="H-InvDB:HIT000216491"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
CDS 28..1734
/note="carboxylesterase; ACAT; conceptual translation
presented here differs from translation in publication"
/codon_start=1
/product="acyl coenzyme A:cholesterol acyltransferase"
/protein_id="AAC60631.2"
/translation="MWLRAFILATLSASAAWGAHPSSPPVVDTVHGKVLGKFVSLEGF
AQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELF
TNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA
HENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTI
FGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCK
TTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPE
ELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCI
AKELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEF
QYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNG
NPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHI
EL"
BASE COUNT 432 a 452 c 485 g 398 t
ORIGIN
1 ctaaagcgag aactgtcgcc cttcacgatg tggctccgtg cctttatcct ggccactctc
61 tctgcttccg cggcttgggg ggcacatccg tcctcgccac ctgtggtgga caccgtgcat
121 ggcaaagtgc tggggaagtt cgtcagctta gaaggatttg cacagcctgt ggccattttc
181 ctgggaatcc cttttgccaa gccgcctctt ggacccctga ggtttactcc accgcagcct
241 gcagaaccat ggagctttgt gaagaatgcc acctcgtacc ctcctatgtg cacccaagat
301 cccaaggcgg ggcagttact ctcagagcta tttacaaacc gaaaggagaa cattcctctc
361 aagctttctg aagactgtct ttacctcaat atttacactc ctgctgactt gaccaagaaa
421 aacaggctgc cggtgatggt gtggatccac ggaggggggc tgatggtggg tgcggcatca
481 acctatgatg ggctggccct tgctgcccat gaaaacgtgg tggtggtgac cattcaatat
541 cgcctgggca tctggggatt cttcagcaca ggggatgaac acagccgggg gaactggggt
601 cacctggacc aggtggctgc cctgcgctgg gtccaggaca acattgccag ctttggaggg
661 aacccaggct ctgtgaccat ctttggagag tcagcgggag gagaaagtgt ctctgttctt
721 gttttgtctc cattggccaa gaacctcttc caccgggcca tttctgagag tggcgtggcc
781 ctcacttctg ttctggtgaa gaaaggtgat gtcaagccct tggctgagca aattgctatc
841 actgctgggt gcaaaaccac cacctctgct gtcatggttc actgcctgcg acagaagacg
901 gaagaggagc tcttggagac gacattgaaa atgaaattct tatctctgga cttacaggga
961 gaccccagag agagtcaacc ccttctgggc actgtgattg atgggatgct gctgctgaaa
1021 acacctgaag agcttcaagc tgaaaggaat ttccacactg tcccctacat ggtcggaatt
1081 aacaagcagg agtttggctg gttgattcca atgcagttga tgagctatcc actctccgaa
1141 gggcaactgg accagaagac agccatgtca ctcctgtgga agtcctatcc ccttgtttgc
1201 attgctaagg aactgattcc agaagccact gagaaatact taggaggaac agacgacact
1261 gtcaaaaaga aagacctgtt cctggacttg atagcagatg tgatgtttgg tgtcccatct
1321 gtgattgtgg cccggaacca cagagatgct ggagcaccca cctacatgta tgagtttcag
1381 taccgtccaa gcttctcatc agacatgaaa cccaagacgg tgataggaga ccacggggat
1441 gagctcttct ccgtctttgg ggccccattt ttaaaagagg gtgcctcaga agaggagatc
1501 agacttagca agatggtgat gaaattctgg gccaactttg ctcgcaatgg aaaccccaat
1561 ggggaagggc tgccccactg gccagagtac aaccagaagg aagggtatct gcagattggt
1621 gccaacaccc aggcggccca gaagctgaag gacaaagaag tagctttctg gaccaacctc
1681 tttgccaaga aggcagtgga gaagccaccc cagacagaac acatagagct gtgaatgaag
1741 atccagccgg ccttgggagc ctggagg
//