LOCUS S67334 3213 bp mRNA linear HUM 18-FEB-1994
DEFINITION phosphatidylinositol 3-kinase p110 beta isoform=110 kda catalytic
subunit [human, mRNA Partial, 3213 nt].
ACCESSION S67334
VERSION S67334.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3213)
AUTHORS Hu,P., Mondino,A., Skolnik,E.Y. and Schlessinger,J.
TITLE Cloning of a novel, ubiquitously expressed human
phosphatidylinositol 3-kinase and identification of its binding
site on p85
JOURNAL Mol. Cell. Biol. 13 (12), 7677-7688 (1993)
PUBMED 8246984
REMARK GenBank staff at the National Library of Medicine created this
entry [NCBI gibbsq 140879] from the original journal article.
FEATURES Location/Qualifiers
source 1..3213
/db_xref="H-InvDB:HIT000216195"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..3213
/gene="phosphatidylinositol 3-kinase p110 beta isoform, PI
3-kinase p110 beta"
CDS 1..3213
/gene="phosphatidylinositol 3-kinase p110 beta isoform, PI
3-kinase p110 beta"
/note="110 kda catalytic subunit; PI 3-kinase p110 beta"
/codon_start=1
/product="phosphatidylinositol 3-kinase p110 beta isoform"
/protein_id="AAB29081.1"
/translation="MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQL
EVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDV
RPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKI
LSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNM
NPIKVNELAIQKRLTIHGKEDEVSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNR
ALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQ
IVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINIC
DLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG
QLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPF
DKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCR
EIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAV
GCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEV
HIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKE
AMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGED
SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVST
SETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYV
LGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGK
TGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLAL
GKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS"
BASE COUNT 979 a 612 c 704 g 918 t
ORIGIN
1 atgtgcttca gtttcataat gcctcctgct atggcagaca tccttgacat ctgggcggtg
61 gattcacaga tagcatctga tggctccata cctgtggatt tccttttgcc cactgggatt
121 tatatccagt tggaggtacc tcgggaagct accatttctt atattaagca gatgttatgg
181 aagcaagttc acaattaccc aatgttcaac ctccttatgg atattgactc ctatatgttt
241 gcatgtgtga atcagactgc tgtatatgag gagcttgaag atgaaacacg aagactctgt
301 gatgtcagac cttttcttcc agttctcaaa ttagtgacaa gaagttgtga cccaggggaa
361 aaattagact caaaaattgg agtccttata ggaaaaggtc tgcatgaatt tgattccttg
421 aaggatcctg aagtaaatga atttcgaaga aaaatgcgca aattcagcga ggaaaaaatc
481 ctgtcacttg tgggattgtc ttggatggac tggctaaaac aaacatatcc accagagcat
541 gaaccatcca tccctgaaaa cttagaagat aaactttatg ggggaaagct catcgtagct
601 gttcattttg aaaactgcca ggacgtgttt agctttcaag tgtctcctaa tatgaatcct
661 atcaaagtaa atgaattggc aatccaaaaa cgtttgacta ttcatgggaa ggaagatgaa
721 gttagcccct atgattatgt gttgcaagtc agcgggagag tagaatatgt ttttggtgat
781 catccactaa ttcagttcca gtatatccgg aactgtgtga tgaacagagc cctgccccat
841 tttatacttg tggaatgctg caagatcaag aaaatgtatg aacaagaaat gattgccata
901 gaggctgcca taaatcgaaa ttcatctaat cttcctcttc cattaccacc aaagaaaaca
961 cgaattattt ctcatgtttg ggaaaataac aaccctttcc aaattgtctt ggttaaggga
1021 aataaactta acacagagga aactgtaaaa gttcatgtca gggctggtct ttttcatggt
1081 actgagctcc tgtgtaaaac catcgtaagc tcagaggtat cagggaaaaa tgatcatatt
1141 tggaatgaac cactggaatt tgatattaat atttgtgact taccaagaat ggctcgatta
1201 tgttttgctg tttatgcagt tttggataaa gtaaaaacga agaaatcaac gaaaactatt
1261 aatccctcta aatatcagac catcaggaaa gctggaaaag tgcattatcc tgtagcgtgg
1321 gtaaatacga tggtttttga ctttaaagga caattgagaa ctggagacat aatattacac
1381 agctggtctt catttcctga tgaactcgaa gaaatgttga atccaatggg aactgttcaa
1441 acaaatccat atactgaaaa tgcaacagct ttgcatgtta aatttccaga gaataaaaaa
1501 caaccttatt attaccctcc cttcgataag attattgaaa aggcagctga gattgcaagc
1561 agtgatagtg ctaatgtgtc aagtcgaggt ggaaaaaagt ttcttcctgt attgaaagaa
1621 atcttggaca gggatccctt gtctcaactg tgtgaaaatg aaatggatct tatttggact
1681 ttgcgacaag actgccgaga gattttccca caatcactgc caaaattact gctgtcaatc
1741 aagtggaata aacttgagga tgttgctcag cttcaggcgc tgcttcagat ttggcctaaa
1801 ctgccccccc gggaggccct agagcttctg gatttcaact atccagacca gtacgttcga
1861 gaatatgctg taggctgcct gcgacagatg agtgatgaag aactttctca atatctttta
1921 caactggtgc aagtgttaaa atatgagcct tttcttgatt gtgccctctc tagattccta
1981 ttagaaagag cacttggtaa tcggaggata gggcagtttc tattttggca tcttaggtca
2041 gaagtgcaca ttcctgctgt ctcagtacaa tttggtgtca tccttgaagc atactgccgg
2101 ggaagtgtgg ggcacatgaa agtgctttct aagcaggttg aagcactcaa taagttaaaa
2161 actttaaata gtttaatcaa actgaatgcc gtgaagttaa acagagccaa agggaaggag
2221 gccatgcata cctgtttaaa acagagtgct taccgggaag ccctctctga cctgcagtca
2281 cccctgaacc catgtgttat cctctcagaa ctctatgttg aaaagtgcaa atacatggat
2341 tccaaaatga agcctttgtg gctggtatac aataacaagg tatttggtga ggattcagtt
2401 ggagtgattt ttaaaaatgg tgatgattta cgacaggata tgttgacact ccaaatgttg
2461 cgcttgatgg atttactctg gaaagaagct ggtttggatc ttcggatgtt gccttatggc
2521 tgtttagcaa caggagatcg ctctggcctc attgaagttg tgagcacctc tgaaacaatt
2581 gctgacattc agctgaacag tagcaatgtg gctgctgcag cagccttcaa caaagatgcc
2641 cttctgaact ggcttaaaga atacaactct ggggatgacc tggaccgagc cattgaggaa
2701 tttacactgt cctgtgctgg ctactgtgta gcttcttatg tccttgggat tggtgacaga
2761 catagtgaca acatcatggt caaaaaaact ggccagctct tccacattga ctttggacat
2821 attcttggaa atttcaaatc taagtttggc attaaaaggg agcgagtgcc ttttattctt
2881 acctatgatt tcatccatgt cattcaacaa ggaaaaacag gaaatacaga aaagtttggc
2941 cggttccgcc agtgttgtga ggatgcatat ctgattttac gacggcatgg gaatctcttc
3001 atcactctct ttgcgctgat gttgactgca gggcttcctg aactcacatc agtcaaagat
3061 atacagtatc ttaaggactc tcttgcatta gggaagagtg aagaagaagc actcaaacag
3121 tttaagcaaa aatttgatga ggcgctcagg gaaagctgga ctactaaagt gaactggatg
3181 gcccacacag ttcggaaaga ctacagatct taa
//