LOCUS S62904 2742 bp mRNA linear HUM 25-AUG-1993
DEFINITION thiopurine methyltransferase [human, T84 colon carcinoma cell,
mRNA, 2742 nt].
ACCESSION S62904
VERSION S62904.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2742)
AUTHORS Honchel,R., Aksoy,I.A., Szumlanski,C., Wood,T.C., Otterness,D.M.,
Wieben,E.D. and Weinshilboum,R.M.
TITLE Human thiopurine methyltransferase: molecular cloning and
expression of T84 colon carcinoma cell cDNA
JOURNAL Mol. Pharmacol. 43 (6), 878-887 (1993)
PUBMED 8316220
REMARK GenBank staff at the National Library of Medicine created this
entry [NCBI gibbsq 134246] from the original journal article.
FEATURES Location/Qualifiers
source 1..2742
/db_xref="H-InvDB:HIT000216014"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..2742
/gene="thiopurine methyltransferase, TPMT"
CDS 66..803
/gene="thiopurine methyltransferase, TPMT"
/note="Method: conceptual translation with partial peptide
sequencing; TPMT"
/codon_start=1
/product="thiopurine methyltransferase"
/protein_id="AAB27277.1"
/translation="MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQ
GHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTE
QNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINP
GDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLE
KVDAFEERHKSWGIDCLFEKLYLLTEK"
BASE COUNT 784 a 524 c 595 g 839 t
ORIGIN
1 cggcaaccag ctgtaagcga ggcacggaag acatatgctt gtgagacaaa ggtgtctctg
61 aaactatgga tggtacaaga acttcacttg acattgaaga gtactcggat actgaggtac
121 agaaaaacca agtactaact ctggaagaat ggcaagacaa gtgggtgaac ggcaagactg
181 cttttcatca ggaacaagga catcagctat taaagaagca tttagatact ttccttaaag
241 gcaagagtgg actgagggta ttttttcctc tttgcggaaa agcggttgag atgaaatggt
301 ttgcagaccg gggacacagt gtagttggtg tggaaatcag tgaacttggg atacaagaat
361 tttttacaga gcagaatctt tcttactcag aagaaccaat caccgaaatt cctggaacca
421 aagtatttaa gagttcttcg gggaacattt cattgtactg ttgcagtatt tttgatcttc
481 ccaggacaaa tattggcaaa tttgacatga tttgggatag aggagcatta gttgccatta
541 atccaggtga tcgcaaatgc tatgcagata caatgttttc cctcctggga aagaagtttc
601 agtatctcct gtgtgttctt tcttatgatc caactaaaca tccaggtcca ccattttatg
661 ttccacatgc tgaaattgaa aggttgtttg gtaaaatatg caatatacgt tgtcttgaga
721 aggttgatgc ttttgaagaa cgacataaaa gttggggaat tgactgtctt tttgaaaagt
781 tatatctact tacagaaaag taaatgagac atagataaaa taaaatcaca ctgacatgtt
841 tttgaggaat tgaaaattat gctaaagcct gaaaatgtaa tggatgaatt tttaaaattg
901 tttataaatc atatgataga tctttactaa aaatggcttt ttagtaaagc catttacttt
961 ttctaaaaaa gttttagaag aaaaagatgt aactaaactt ttaaagtagc tcctttggag
1021 aggagattat gatgtgaaag attatgccta tgtgtcttgc agattgcaag atattttacc
1081 aatcagcatg tgttacctgt acaattaaaa aaatatttca aaatgcaatg catattaaat
1141 ataatacaca cagaaaaact ggcatttatt ttgttttatt tttttgagat ggagtttcgt
1201 tcttgttgcc caacctggag tgcagtggtg cggtctcggc tcactgcaac ctctgcctcc
1261 cgggttcggg tggttctcct gcctcggcct cctgagtggc tgggattgca ggtgtgcgcc
1321 accacgcccg gctagttttt tgtgttttta gtggagacgg ggtttcacca tgttggtcag
1381 gctgatctcg agctcctgac ctcaggtgat ctacccacct cggcctccca aagtgctggg
1441 attacaggcg tgagccactg cacctggcct gacattcttt atgaaattta gaattgttga
1501 agaactataa catttcagta gggttcaagg tggtcccaaa agttatataa aagattagtt
1561 tttactataa acccttgtct tttactcaga tcctagcatc ccttttcaca tggtttctcc
1621 atgtatataa cagaatcaag aaacaaattt taattaaaca atctgtaaca gaatcaagaa
1681 acaaatacat tttaattaaa caatctatat ggaacaaaca ttcccaaatt ctaagaataa
1741 atttttcttt aagttttctc tgagtttggc aattgttgtt ttttataatt taatctgttt
1801 aaatcatcag gtcttataaa atataatgta cttagagctg gattcatggc tgtttattat
1861 gaaaggttag atttctcagt tcttctttaa ccacattttg ttatatcaga cagtcctcta
1921 taactctgta ctacccaaca actaaatggt ttagattgtt tagctcatgt taataggatg
1981 gttgtgtatt ataaaaaacg agttacgtgt gtgtgtgcac gcatgcacgc acatgtgctg
2041 gcttaaaggt tgttaatgca aggtttgggg tcccctttaa cactggtgaa agctacggta
2101 ctctccccag agatatgtct tgtcagcctc tctagttccc cttggcctgc atgtacaaac
2161 ttctacccta gaagctctct gccatcgatg tattctaata gatttgtaag gctattaatt
2221 tgaagcaact ccttgctcac agtgattctt gcttctctga gacctgctcc cagtcgatac
2281 tgtgggcttc agaagccatg actccccaac tctgcctgta tcaccggttg aatggacaac
2341 taacccgagc tggaccaaca caattctctc cagagacttt tgattttact tttatgtaga
2401 gacagggtct cactttgttg cccacgctga tgttgaactt gacgtgaggc ctcaagcagt
2461 cctcctgtct tggccaccca aagtgctagg attacaggta tgagccattg cgctggccct
2521 cttcataggc ttttggactt gggaatagaa aagcaacccc gtctctactg aaagtgcaga
2581 aggattggcc gggcgtggtg gcgcgtgcct gtggtcccag ctgcttgggg ggctgaggcg
2641 ggagaatcac ttggacctgg ggggcggagg ttgcagtgag ctgagatcgt gccactgcac
2701 gccagcctgg gcaacagagc aagactctgt ctcaaaagaa ag
//