LOCUS HUMPDE2A 3871 bp mRNA linear HUM 12-JUN-1993
DEFINITION Human rolipram-sebsitive, cAMP-specific phosphodiesterase (PDE2)
mRNA, complete cds.
ACCESSION M97515
VERSION M97515.1
KEYWORDS cAMP-specific phosphodiesterase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3871)
AUTHORS McLaughlin,M.M., Cieslinski,L.B., Burman,M., Torphy,T.J. and
Livi,G.P.
TITLE A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from
human brain. Cloning and expression of cDNA, biochemical
characterization of recombinant protein, and tissue distribution of
mRNA
JOURNAL J. Biol. Chem. 268 (9), 6470-6476 (1993)
PUBMED 8384210
COMMENT Original source text: Homo sapiens brain, frontal cortex cDNA to
mRNA.
FEATURES Location/Qualifiers
source 1..3871
/db_xref="H-InvDB:HIT000196961"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain, frontal cortex"
CDS 282..1976
/note="rolipram-sensitive, cAMP-specific"
/codon_start=1
/product="phosphodiesterase"
/protein_id="AAA36426.1"
/translation="MKEHGGTFSSTGISGGSGDSAMDSLQPLQPNYMPVCLFAEESYQ
KLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEY
ISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNT
ENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFIT
YMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDV
DHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTL
RKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCAD
LSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI
VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQF
ELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT"
polyA_site 1371
BASE COUNT 1108 a 847 c 851 g 1065 t
ORIGIN
1 ggcacgagcc taaagaaccc tgggatgact aaggcagaga gagtctgaga aaactctttg
61 gtgcttctgc ctttagtttt aggacacatt tatgcagatg agcttataag agaccgttcc
121 ctccgccttc ttcctcagag gaagtttctt ggtagatcac cgacacctca tccaggcggg
181 gggttggggg gaaacttggc accagccatc ccaggcagag caccactgtg atttgttctc
241 ctggtggaga gagctggaag gaaggagcca gcgtgcaaat aatgaaggag cacgggggca
301 ccttcagtag caccggaatc agcggtggta gcggtgactc tgctatggac agcctgcagc
361 cgctccagcc taactacatg cctgtgtgtt tgtttgcaga agaatcttat caaaaattag
421 caatggaaac gctggaggaa ttagactggt gtttagacca gctagagacc atacagacct
481 accggtctgt cagtgagatg gcttctaaca agttcaaaag aatgctgaac cgggagctga
541 cacacctctc agagatgagc cgatcaggga accaggtgtc tgaatacatt tcaaatactt
601 tcttagacaa gcagaatgat gtggagatcc catctcctac ccagaaagac agggagaaaa
661 agaaaaagca gcagctcatg acccagataa gtggagtgaa gaaattaatg catagttcaa
721 gcctaaacaa tacaagcatc tcacgctttg gagtcaacac tgaaaatgaa gatcacctgg
781 ccaaggagct ggaagacctg aacaaatggg gtcttaacat ctttaatgtg gctggatatt
841 ctcacaatag acccctaaca tgcatcatgt atgctatatt ccaggaaaga gacctcctaa
901 agacattcag aatctcatct gacacattta taacctacat gatgacttta gaagaccatt
961 accattctga cgtggcatat cacaacagcc tgcacgctgc tgatgtagcc cagtcgaccc
1021 atgttctcct ttctacacca gcattagacg ctgtcttcac agatttggag atcctggctg
1081 ccatttttgc agctgccatc catgacgttg atcatcctgg agtctccaat cagtttctca
1141 tcaacacaaa ttcagaactt gctttgatgt ataatgatga atctgtgttg gaaaatcatc
1201 accttgctgt gggtttcaaa ctgctgcaag aagaacactg tgacatcttc atgaatctca
1261 ccaagaagca gcgtcagaca ctcaggaaga tggttattga catggtgtta gcaactgata
1321 tgtctaaaca tatgagcctg ctggcagacc tgaagacaat ggtagaaacg aagaaagtta
1381 caagttcagg cgttcttctc ctagacaact ataccgatcg cattcaggtc cttcgcaaca
1441 tggtacactg tgcagacctg agcaacccca ccaagtcctt ggaattgtat cggcaatgga
1501 cagaccgcat catggaggaa tttttccagc agggagacaa agagcgggag aggggaatgg
1561 aaattagccc aatgtgtgat aaacacacag cttctgtgga aaaatcccag gttggtttca
1621 tcgactacat tgtccatcca ttgtgggaga catgggcaga tttggtacag cctgatgctc
1681 aggacattct cgatacctta gaagataaca ggaactggta tcagagcatg atacctcaaa
1741 gtccctcacc accactggac gagcagaaca gggactgcca gggtctgatg gagaagtttc
1801 agtttgaact gactctcgat gaggaagatt ctgaaggacc tgagaaggag ggagagggac
1861 acagctattt cagcagcaca aagacgcttt gtgtgattga tccagaaaac agagattccc
1921 tgggagagac tgacatagac attgcaacag aagacaagtc ccccgtggat acataatccc
1981 cctctccctg tggagatgaa cattctatcc ttgatgagca tgccagctat gtggtagggc
2041 cagcccacca tgggggccaa gacctgcaca ggacaagggc cacctggctt tcagttactt
2101 gagtttggag tcagaaagca agaccaggaa gcaaatagca gctcaggaaa tcccacggtt
2161 gacttgcctt gatggcaagc ttggtggaga gggctgaagc tgttgctggg ggccgattct
2221 gatcaagaca catggcttga aaatggaaga cacaaaactg agagatcatt ctgcactaag
2281 tttcgggaac ttatccccga cagtgactga actcactgac taataacttc atttatgaat
2341 cttctcactt gtccctttgt ctgccaacct gtgtgccttt tttgtaaaac attttcatgt
2401 ctttaaaatg cctgttgaat acctggagtt tagtatcaac ttctacacag ataagctttc
2461 aaagttgaca aacttttttg actctttctg gaaaagggaa agaaaatagt cttccttctt
2521 tcttgggcaa tatccttcac tttactacag ttacttttgc aaacagacag aaaggataca
2581 cttctaacca cattttactt ccttcccctg ttgtccagtc caactccaca gtcactctta
2641 aaacttctct ctgtttgcct gcctccaaca gtacttttaa ctttttgctg taaacagaat
2701 aaaattgaac aaattagggg gtagaaagga gcagtggtgt cgttcaccgt gagagtctgc
2761 atagaactca gcagtgtgcc ctgctgtgtc ttggaccctg ccccccacag gagttgtaca
2821 gtccctggcc ctgctcccta cctcctctct tcaccccgtt aggctgtttt caatgtaatg
2881 ctgccgtcct tctcttgcac tgccttctgc gctaacacct ccattcctgt ttataaccgt
2941 gtatttatta cttaatgtat ataatgtaat gttttgtaag ttattaattt atatatctaa
3001 cattgcctgc caatggtggt gttaaatttg tgtagaaaac tctgcctaag agttacgact
3061 ttttcttgta atgttttgta ttgtgtatta tataacccaa acgtcactta gtagagacat
3121 atggccccct tggcagagag gacaggggtg ggcttttgtt caaagggtct gccctttccc
3181 tgcctgagtt gctacttctg cacaacccct ttatgaacca gttttggaaa caatattcta
3241 cacattagat actaaatggt ttatactgag cttttacttt tgtatagctt gataggggca
3301 gggggcaatg gatgtagttt ttacccaggt tctatccaaa tctatgtggg catgagttgg
3361 gttataactg gatcctacta tcattgtggc tttggttcaa aaggaaacac tacatttgct
3421 cacagatgat tcttctgaat gctcccgaac tactgacttt gaagaggtag cctcctgcct
3481 gccattaagc aggaatgtca tgttccagtt cattacaaaa gaaaacaata aaacaatgtg
3541 aatttttata ataaaatgtg aactgatgta gcaaattacg caaatgtgaa gcctcttctg
3601 ataacacttg ttaggcctct tactgatgtc agtttcagtt tgtaaaatat gtttcatgct
3661 ttcagttcag cattgtgact cagtaaatac agaaaatggc acaaatgtgc atgaccaatg
3721 tatgtctatg aacactgcat tgtttcaggt ggacatttta tcgattttca aatgtttctc
3781 acaatgtatg ttatagtgtt attattatat attgtgttca aatgcattct aaagagactt
3841 ttatatgagg tgaataaaga aaagcataat t
//