LOCUS HUMPMCA2A 4030 bp mRNA linear HUM 27-APR-1993
DEFINITION Human plasma membrane Ca2+-ATPase isoform PMCA2a mRNA, complete
cds.
ACCESSION M97260
VERSION M97260.1
KEYWORDS Ca2+-ATPase; isoform PMCA2a; plasma membrane.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4030)
AUTHORS Brandt,P., Ibrahim,E., Bruns,G.A. and Neve,R.L.
TITLE Determination of the nucleotide sequence and chromosomal
localization of the ATP2B2 gene encoding human Ca(2+)-pumping
ATPase isoform PMCA2
JOURNAL Genomics 14 (2), 484-487 (1992)
PUBMED 1427863
COMMENT Original source text: Homo sapiens male fetus brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4030
/db_xref="H-InvDB:HIT000196954_01"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="male"
/tissue_type="brain"
/dev_stage="fetus"
5'UTR 1..420
/note="putative"
CDS 421..4017
/note="plasma membrane isoform PMCA2a; putative"
/codon_start=1
/product="Ca2+-ATPase"
/protein_id="AAA36456.1"
/translation="MGDMTNSDFYSKNQRNESSHGGEFGCTMEELRSLMELRGTEAVV
KIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIPPKKAKPFLQLVWEA
LQDVTLIILEIAAIISLGLSFYHPPGEGNEGCATAQGGAEDEGEAEAGWIEGAAILLS
VICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKY
GDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMLVTAV
GVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGGDADDRKKASMH
KKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVYV
QYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA
ICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKIL
PPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMST
VIKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACEWL
RTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITV
RMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKL
RVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTD
VAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQ
DSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHA
VYQLALIFTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIH
GERNVFDGIFRNPIFCTIVLGTFAIQIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGEL
VWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELNEDVEEIDHAERELRRGQILWFRG
LNRIQTQIRVVKAFRSSLYEGLEKPESRTSIHNFMAHPEFRIEDSQPHIPLIDDTDLE
EDAALKQNSSPPSSLNKNNSSIDSGINLTTDTSKSATSSSPGSPIHSLETSL"
BASE COUNT 931 a 1205 c 1177 g 717 t
ORIGIN
1 gaattccccg ctggctgggc tcagccgcgg caccagctgc cgcaccgcga ttacggggct
61 gcccgccggg aaaccgtgca ggattggtgg tgattttcat agccaagagc caccacccct
121 gaccatgtag atgccagttc cagggagcag catgggcccc actgaatgga gactcctggg
181 tctacagccc tgagcccctc cggcccctgg acctcgtccc acaccggagg acacctcttg
241 gagctcacca ccactgtcac cagcccgcct aggccacccc caccccccgg gacccggagt
301 cggccgcctg gtgccacagc tgaccagtga gggtgtgctg aggacagcca caagcagcca
361 tcacccggca gcctcttgtc agcgctgacc ttgggcccag ccgagcaagg accgagaaac
421 atgggtgaca tgaccaacag cgacttttac tccaaaaacc aaagaaatga gtcgagccat
481 gggggcgagt tcgggtgcac aatggaggag ctccgctccc tcatggagct gcggggcact
541 gaggctgtgg tcaagatcaa ggagacttat ggggacaccg aagccatctg ccggcgcctc
601 aaaacctcac ctgttgaagg tttgccgggc accgctccag acctggaaaa gagaaagcaa
661 atttttgggc aaaactttat acctccaaag aaagcaaaac ccttcctgca gctcgtgtgg
721 gaggcgctgc aggacgtgac cctcatcatc ctggagattg ccgccatcat ctccctgggg
781 ctgtccttct accacccgcc cggcgagggc aacgaaggat gtgcgacggc ccagggtggg
841 gcagaggatg aaggagaggc agaggcaggt tggatcgagg gggccgccat tctcctctca
901 gttatctgtg tggtcctggt cacggccttc aatgactgga gcaaagagaa acagttccgg
961 ggcctgcaga gccgcatcga gcaggaacag aaatttaccg tggtccgggc tggccaggtg
1021 gtgcagatcc ctgtggctga gatcgtggtt ggggacatag cccaggtcaa atatggtgac
1081 ctcctccctg ccgacggcct cttcatccag ggcaatgacc tcaagattga tgaaagctcc
1141 ctaactggag agtctgacca ggtgcgcaag tccgtggaca aggaccccat gctgctgtca
1201 ggaacccacg tgatggaggg ctcaggacgg atgttggtga ctgctgtggg tgtgaactct
1261 cagactggca tcatctttac cctcctgggg gctggtggtg aagaggaaga gaagaaagac
1321 aaaaaagcca aacagcagga cggggcagcc gccatggaga tgcagcccct caagagtgcc
1381 gagggcggcg acgctgacga caggaagaag gccagcatgc acaagaagga gaagtccgtg
1441 ctgcagggca agctcaccaa gctggctgtg cagatcggga aggcgggctt ggtgatgtca
1501 gccatcacgg tgatcatcct ggtgctctac ttcactgtgg acaccttcgt ggtcaacaag
1561 aagccgtggc tgcctgagtg cacgcccgtc tacgtgcagt actttgtcaa gttcttcatc
1621 attggcgtga cggtgctggt ggtcgccgtg cccgaggggc tccctctggc cgtcaccatc
1681 tcgttggcct attcggtgaa gaaaatgatg aaggacaaca atctggtacg ccacctggat
1741 gcctgtgaga ccatgggcaa tgccacagcc atctgctcag acaagacagg cacgctgacc
1801 accaatcgca tgacagtggt acaggcctat gtcggtgacg tccactataa agagatcccc
1861 gaccccagct ccatcaacac caagaccatg gagctgctga tcaatgccat cgccatcaac
1921 agcgcctaca ccaccaagat tctgccccca gagaaggagg gcgccctgcc tcggcaggtg
1981 ggcaacaaga cggagtgcgg cctgctgggc ttcgtgctgg acctgaagca ggactacgag
2041 cccgtgcgca gccagatgcc agaggagaag ttgtacaaag tgtacacctt caactccgtg
2101 cgcaagtcca tgagcactgt catcaagctg cccgacgaga gcttccgcat gtacagcaag
2161 ggggcttctg agatcgtgct caagaagtgc tgcaaaatcc tcaatggggc gggagagcct
2221 cgtgtcttcc ggccccgcga ccgggacgag atggtaaaga aggtgattga gcccatggct
2281 tgcgagtggc tccgcactat ctgcgtggcc taccgcgact tccccagcag cccggagccg
2341 gactgggaca atgagaatga catcctcaac gaactcacct gcatctgcgt ggtgggcatc
2401 gaggacccgg tgcggccaga ggtcccagaa gccatccgca agtgccagcg ggcaggcatc
2461 acggtccgca tggtcactgg cgacaatatc aacacggctc gggccatcgc catcaagtgt
2521 ggcatcatcc atcctgggga ggactttctg tgcctcgagg gcaaggagtt caacaggagg
2581 atccgcaacg agaaggggga gattgagcag gagcgaattg acaagatctg gccaaagctg
2641 cgggtgctgg ctcgctcctc cccaacggac aagcataccc tggttaaagg catcatcgac
2701 agcacacaca ctgagcagcg gcaggtggtg gccgtgacgg gggacgggac caacgacggg
2761 cctgcactca agaaggccga cgtgggcttc gccatgggca tcgcaggcac tgacgtggcc
2821 aaggaggcct cagacatcat cctgacagac gacaatttca gcagcatcgt caaggcagtg
2881 atgtggggcc gcaacgtcta tgacagcatc tccaaattct tgcagttcca gctcaccgtc
2941 aacgtggtgg ccgtgattgt ggccttcaca ggcgcctgca tcacgcagga ctcccctctg
3001 aaggccgtgc agatgctctg ggtgaacctc atcatggaca cgtttgcctc gctggcactg
3061 gccactgagc cgcccacgga gaccctgctg ctgaggaagc cgtacggccg caacaagccg
3121 ctcatctcca ggaccatgat gaagaacatc ctgggccatg ctgtctacca gcttgccctc
3181 atcttcaccc tgctctttgt tggcgagaag atgttccaga tcgacagcgg gaggaacgcg
3241 cccctgcatt cgccaccctc agaacattac accatcatct tcaacacctt cgtcatgatg
3301 cagctcttca acgagatcaa cgcccgcaag atccacggcg agcgcaatgt ctttgacggc
3361 atcttccgga accccatctt ctgcaccatc gtgctgggca cctttgccat ccagatagtg
3421 atcgtgcagt ttggagggaa gccattcagc tgctctccac tgcagctgga ccagtggatg
3481 tggtgcatat tcattgggtt aggagagctc gtttggggcc aggtcatcgc caccatcccg
3541 accagcagac tcaagttcct caaggaggca ggcaggctca cacagaagga ggagatcccg
3601 gaggaggagc tcaacgagga cgtggaggag atcgaccacg cggagcggga gctgcggcgg
3661 ggccagatcc tgtggttccg aggcctgaat cggatccaga cacagatccg cgtcgtgaag
3721 gcgttccgta gctctctcta tgaaggttta gaaaagcctg aatctcgaac ctccatccat
3781 aacttcatgg ctcatcctga attccggatc gaagattccc agccccacat ccccctcatt
3841 gatgacaccg acctggaaga agatgccgcg ctcaagcaga actcgagccc gccgtcatcc
3901 ctcaacaaga acaacagcag catcgacagt gggatcaacc tgacgaccga cacaagcaaa
3961 tcagctacct cttcaagccc agggagcccc atccacagcc tggagacgtc gctttagctg
4021 aggaccctct
//