LOCUS HUMOP2A 1842 bp mRNA linear HUM 28-MAY-1996
DEFINITION Homo sapiens osteogenic protein-2 (OP-2) mRNA, complete cds.
ACCESSION M97016
VERSION M97016.1
KEYWORDS TGF beta-like protein; osteogenic protein-2.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1842)
AUTHORS Ozkaynak,E., Schnegelsberg,P.N., Jin,D.F., Clifford,G.M.,
Warren,F.D., Drier,E.A. and Oppermann,H.
TITLE Osteogenic protein-2. A new member of the transforming growth
factor-beta superfamily expressed early in embryogenesis
JOURNAL J. Biol. Chem. 267 (35), 25220-25227 (1992)
PUBMED 1460021
COMMENT Original source text: Homo sapiens embryo hippocampus cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1842
/db_xref="H-InvDB:HIT000196948"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="hippocampus"
/dev_stage="embryo"
gene 1..1842
/gene="OP-2"
CDS 497..1705
/gene="OP-2"
/standard_name="pre-pro peptide"
/codon_start=1
/product="osteogenic protein-2"
/protein_id="AAB01360.1"
/translation="MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDV
QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRA
DLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRT
LHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL
YVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKS
NELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGEC
SFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVLYYDSSNNVILRKHR
NMVVKACGCH"
sig_peptide 497..553
/gene="OP-2"
mat_peptide 1286..1702
/gene="OP-2"
/product="osteogenic protein-2"
/note="putative"
BASE COUNT 290 a 664 c 605 g 283 t
ORIGIN
1 ccacagtggc gccggcagag caggagtggc tggaggagct gtggttggag caggaggtgg
61 cacggcaggg ctggagggct ccctatgagt ggcggagacg gcccaggagg cgctggagca
121 acagctccca caccgcacca agcggtggct gcaggagctc gcccatcgcc cctgcgctgc
181 tcggaccgcg gccacagccg gactggcggg tacggcggcg acagacggat tggccgagag
241 tcccagtccg cagagtagcc ccggcctcga ggcggtggcg tcccggtcct ctccgtccag
301 gagccaggac aggtgtcgcg cggcggggct ccagggaccg cgcctgaggc cggctgcccg
361 cccgtcccgc cccgccccgc cgcccgccgc ccgccgagcc cagcctcctt gccgtcgggg
421 cgtccccagg ccctgggtcg gccgcggagc cgatgcgcgc ccgctgagcg ccccagctga
481 gcgcccccgg cctgccatga ccgcgctccc cggcccgctc tggctcctgg gcctggcgct
541 atgcgcgctg ggcgggggcg gccccggcct gcgacccccg cccggctgtc cccagcgacg
601 tctgggcgcg cgcgagcgcc gggacgtgca gcgcgagatc ctggcggtgc tcgggctgcc
661 tgggcggccc cggccccgcg cgccacccgc cgcctcccgg ctgcccgcgt ccgcgccgct
721 cttcatgctg gacctgtacc acgccatggc cggcgacgac gacgaggacg gcgcgcccgc
781 ggagcggcgc ctgggccgcg ccgacctggt catgagcttc gttaacatgg tggagcgaga
841 ccgtgccctg ggccaccagg agccccattg gaaggagttc cgctttgacc tgacccagat
901 cccggctggg gaggcggtca cagctgcgga gttccggatt tacaaggtgc ccagcatcca
961 cctgctcaac aggaccctcc acgtcagcat gttccaggtg gtccaggagc agtccaacag
1021 ggagtctgac ttgttctttt tggatcttca gacgctccga gctggagacg agggctggct
1081 ggtgctggat gtcacagcag ccagtgactg ctggttgctg aagcgtcaca aggacctggg
1141 actccgcctc tatgtggaga ctgaggacgg gcacagcgtg gatcctggcc tggccggcct
1201 gctgggtcaa cgggccccac gctcccaaca gcctttcgtg gtcactttct tcagggccag
1261 tccgagtccc atccgcaccc ctcgggcagt gaggccactg aggaggaggc agccgaagaa
1321 aagcaacgag ctgccgcagg ccaaccgact cccagggatc tttgatgacg tccacggctc
1381 ccacggccgg caggtctgcc gtcggcacga gctctacgtc agcttccagg acctcggctg
1441 gctggactgg gtcatcgctc cccaaggcta ctcggcctat tactgtgagg gggagtgctc
1501 cttcccactg gactcctgca tgaatgccac caaccacgcc atcctgcagt ccctggtgca
1561 cctgatgaag ccaaacgcag tccccaaggc gtgctgtgca cccaccaagc tgagcgccac
1621 ctctgtgctc tactatgaca gcagcaacaa cgtcatcctg cgcaagcacc gcaacatggt
1681 ggtcaaggcc tgcggctgcc actgagtcag cccgcccagc cctactgcag ccacccttct
1741 catctggatc gggccctgca gaggcagaaa acccttaaat gctgtcacag ctcaagcagg
1801 agtgtcaggg gccctcactc tctgtgccta cttcctgtca gg
//