LOCUS HUMTDGF1A 7355 bp DNA linear HUM 14-JAN-1995
DEFINITION Human (clone CR) teratocarcinoma-derived growth factor 1 (TDGF1)
gene, complete cds.
ACCESSION M96955 M37099
VERSION M96955.1
KEYWORDS epidermal growth factor family; teratocarcinoma-derived growth
factor 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Ciccodicola,A., Dono,R., Obici,S., Simeone,A., Zollo,M. and
Persico,M.G.
TITLE Molecular characterization of a gene of the 'EGF family' expressed
in undifferentiated human NTERA2 teratocarcinoma cells
JOURNAL EMBO J. 8 (7), 1987-1991 (1989)
PUBMED 2792079
REFERENCE 2 (bases 1 to 7355)
AUTHORS Dono,R., Montuori,N., Rocchi,M., De Ponti-Zilli,L., Ciccodicola,A.
and Persico,M.G.
TITLE Isolation and characterization of the CRIPTO autosomal gene and its
X-linked related sequence
JOURNAL Am. J. Hum. Genet. 49 (3), 555-565 (1991)
PUBMED 1882841
COMMENT Original source text: Homo sapiens blood DNA.
FEATURES Location/Qualifiers
source 1..7355
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="Unassigned"
/tissue_type="blood"
exon 2244..2514
/gene="TDGF1"
/note="G00-125-188"
/number=1
gene join(2480..2514,3605..3657,3741..3875,4246..4360,
4459..4568,5643..5761)
/gene="TDGF1"
CDS join(2480..2514,3605..3657,3741..3875,4246..4360,
4459..4568,5643..5761)
/gene="TDGF1"
/standard_name="CRIPTO-1"
/codon_start=1
/product="teratocarcinoma-derived growth factor 1"
/protein_id="AAA61134.1"
/db_xref="GDB:G00-125-188"
/translation="MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYL
AFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFY
GRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVA
SRTPELPPSARTTTFMLVGICLSIQSYY"
intron 2515..3604
/note="G00-125-188"
/number=1
exon 3605..3657
/gene="TDGF1"
/note="G00-125-188"
/number=2
intron 3658..3740
/note="G00-125-188"
/number=2
exon 3741..3875
/gene="TDGF1"
/note="G00-125-188"
/number=3
intron 3876..4245
/note="G00-125-188"
/number=3
exon 4246..4360
/gene="TDGF1"
/note="G00-125-188"
/number=4
intron 4361..4458
/note="G00-125-188"
/number=4
exon 4459..4568
/gene="TDGF1"
/note="G00-125-188"
/number=5
intron 4569..5642
/note="G00-125-188"
/number=5
exon 5643..6972
/gene="TDGF1"
/note="G00-125-188"
/number=6
BASE COUNT 1955 a 1686 c 1638 g 2075 t
ORIGIN chromosome 3.
1 ctgcagtcag tacctatggg gaatgggaat ctcttcaggg ggttctggtc cttagagaag
61 ggattttgtg tggctgaaaa gctggcatcc tggggttctg gtcccgtcaa tgacaacatc
121 gccagactgg agacctcagt tacttcctct gaaaatgcag tgatttccag gggtcctatt
181 taagcctcta aaaattccac aagagcttta gataaggaaa tagcaacgca ggggtgtgtt
241 cttttgccag ttctgccaca ggctgcccag tctctaaaga caagacatcc aaatccccca
301 atagaactag ttgtcttgtc cataaagtga gactaatatt gtgggcgcta cttatctact
361 tagcaccttg gactggtgag gactgtggtg cacaagctac cttacaaatg taccacactg
421 agtaaccatc tttaaacctt cctttgcagc tccagggcta gccttctcct ttgcgagccc
481 tccccacctc ggcctcctag agcttcaggc catgttcccc tgtccctgtg aatctcagca
541 tgctacctga agcatttcac ctgaaaaggc cacacaggga ggaggcgaag cgcagcagga
601 atgaaatagt caactgctgt ggagttggaa atgttgctgc atcccaccat tgactggatg
661 gggccctcac tcccccaata caaattattt tacgtttgct tctcccaaga tcatgtgtaa
721 ggccgggcgc ggtagctcat gcctgtaatc ccagcacttt gggaggccga ggcgggtgga
781 tcatgaggtc aggaatttga gaccagactg accaacatgg tgaaaccctg tctctactga
841 aaatacaaaa attagccggg cgttgtgcgg gcgcctgtaa tcccagctac tcaggaggtt
901 gaggcaggag aatgaggcag gagaatcact tgaacccagg aggtggaggt tgcagtgagc
961 caagatcgtg ccattgcact ccagcccggg taacagaggg agactctgtc gcaaaaaaaa
1021 aaaaaaaaaa aaaaaaaaaa tcatgtgtag aagtaaataa cacctcttcc cagcacctgt
1081 ggatccatgg cattcacaca ggtaggcact gacgctgaaa tggcctcaga tgctaccaat
1141 tctttctgcc gaggcctaaa tccaataaac agagacaact atctaataaa gtttcgcatt
1201 gtgtgcctgg caacattaag taaccgtcag gctttccttt agaaattgga attaaatgcg
1261 atttagaaac tattaacgac tttgggcgta tttaataaca catgaaataa cccggaggat
1321 tgaaatgtta ggtgaggcga ctccggctca tagacgcgcc tctccatctg gggcgtctgg
1381 cacttagtgg aaccactcaa taaacacgtt tacccctgca agcggcacat cagagtccgg
1441 gggtaattct cggtgtcgtg gggccaggac ggcgaggggc tggaagaggc cgccctgtgg
1501 gagctgggag gctgagataa attcccgtga ttgggtgctg aaatggcctc ccatgccgga
1561 ctgccgtggt tctagaactt tttcctggaa caggccggca ctcccactgg agagtcccag
1621 ctgcctctgg ccgcccctcc cctctcccgg gcacctggcg ccgctcccgc gtcctttcag
1681 gaattcacgt ccgcctggaa tttgcacttc aagtctggag cccccaagga acccctcctg
1741 accctgaact tctatctcag tttcaagctt cctagtcttc cccacacaca cacacctagc
1801 tcctcaggcg gagagcaccc ctttcttggc cacccgggta tcccccaggg agtacggggc
1861 tcaaaacacc cttctggaaa aaacaaaggt ggaagcaaat ttcaggaagt aaaacttctg
1921 aaataaaata aaatatcgaa tgccttgaga cccatacatt ttcaggtttt cctaattaaa
1981 gcaattactt tccaccaccc ctccaacctg gaatcaccaa cttgattaga gaaactgatt
2041 tttctttttt cttttttttt cccgaaaaga gtacctctga tcattttagc ctgcaactaa
2101 tgatagagat attagggcta gttaaccaca gttttacaag actcctcttc ccgcgtgtgg
2161 gccattgtca tgctgtcggt cccgcccacc tgaaaggtct ccccgccccg actggggttt
2221 gttgttgaag aaggagaatc cccggaaagg ctgagtctcc agctcaaggt caaaacgtcc
2281 aaggccgaaa gccctccagt ttcccctgga cgccttgctc ctgcttctgc tacgaccttc
2341 tggggaaaac gaatttctca ttttcttctt aaattgccat tttcgcttta ggagatgaat
2401 gttttccttt ggctgttttg gcaatgactc tgaattaaag cgatgctaac gcctcttttc
2461 cccctaattg ttaaaagcta tggactgcag gaagatggcc cgcttctctt acaggtatga
2521 gctaatctta gaatagtgaa ctttttttga ttgctagaga ttgccagctt aggaagtaat
2581 gttctacact gtcatttgat ttttctcctt gctcaagcct taaaagagct gccaaccgac
2641 tgctgttttt cctgaaagac ctggaatttc acatggttac ttctaacttt gccattggct
2701 tttaacattt tcgtgttaat gttaattttc attttatgtt aatgactctg cctatgaaat
2761 agtgtttctt tacttcttgt acaaataaag gtcagtacta caaccaaatt taaatcttcc
2821 gaaaagatta aaggtataag cagattcaat acttggcaaa actattaaga taatagcaaa
2881 aaaaaaaaaa aaacccacat tttttaccta aaaacctttt aagtgattgg ttaaaatagt
2941 ttggccgggt gcggtggctc acgcctgtaa tcctagcact ttgggaggca gaggcgggtg
3001 gatcactgag gtcaggagac cagcctggcc aacatggcaa aaccccgtct ctattaaaaa
3061 tacaaaaatt agccaagcat ggtggcgggc acctgtaatc ccagctactc tggaggctga
3121 ggcaggagaa ttgcttgaac tggggagggg aggncagtga gccgagatcg caccattgca
3181 ctccagcctg ggtgaaaaac cgaaactccc tctcaaaaat aaataaataa atacagtagt
3241 ttgtaaaatg attcatcggt aacatgggat gcagctattt tttaatcctt atatgaaaat
3301 tgtatgcagg ggaaaacatg tgaaatagaa gataaaagac atatacctac ttaaaattag
3361 gtacttatgt gaggacaggg cctaagaaat aataatatat attaaaaaga cttggatatt
3421 ggtgactttt tttcaacatt tttctttgtt acatgaatta gccattaaaa aaagaaagat
3481 ggtgctctac aatttctttt cagtgatctg tggtcttgtc cttgtgatga gaggacctgg
3541 gtgttaactt gtaaggtttt atttcctttg tttggctaac tcatgtttga cttcctcttc
3601 ctagtgtgat ttggatcatg gccatttcta aagtctttga actgggatta gttgccggtg
3661 agagaccttt tgtttctttt gatcactctc aattttatgt ggcctaaaat acagactcca
3721 tgaattgatt tgtcgttaag ggctgggcca tcaggaattt gctcgtccat ctcggggata
3781 cctggccttc agagatgaca gcatttggcc ccaggaggag cctgcaattc ggcctcggtc
3841 ttcccagcgt gtgccgccca tggggataca gcacagtaag aactgcctga cttcgatgct
3901 tctgccctgg cccttcatgt gtctcctgac tatctttcca acactctttc acctaaaagg
3961 gcacctggtt ctggaactgt gcaggtgctg gactgctttg gttttggaag tgagacaagg
4021 attgtgtatt ttacttccct agagtgcagt ttcctcccct gagtccactt cacactggga
4081 acccagaacc accactggcc tatgcatgaa aatgacttct ctgctcaaag gcacagagtc
4141 ttactctgat acaacacatt ggtgttgtat taaccttcgc ttacaggaat tgcccttgca
4201 cttttccatc cctacacctc agtcattctg ttcttacctt tcaaggtaag gagctaaaca
4261 gaacctgctg cctgaatggg ggaacctgca tgctggggtc cttttgtgcc tgccctccct
4321 ccttctacgg acggaactgt gagcacgatg tgcgcaaaga gtaagcaatt cagaggggcg
4381 gggagccgtg gagaggagag agaaagggaa gtggaaattt cagacccaag ctatcgcagc
4441 ttacctgttc attctcagga actgtgggtc tgtgccccat gacacctggc tgcccaagaa
4501 gtgttccctg tgtaaatgct ggcacggtca gctccgctgc tttcctcagg catttctacc
4561 cggctgtggt aagcggaggt tctcctcttt cttttgccct ttgaagttac gtagttgcct
4621 tggggggtgc ttagttagca ggctctcctt gtacctcttg tcttgctaga gcctggcagc
4681 caaagttctg cttataaaag catcgcagac tcctgatgag atagttgcct tggcctcttt
4741 gatatttatt tcctcgggaa cctggctagt cctgctgcct ttcagataga gatgtatttc
4801 aagtctattt gacattttat ggtctgaact tctattgagg aaaataaaca agtctcggtc
4861 tcttgttaaa ccaagagatg ttctctggtg ttcctttcct ttgggtaggg gggacccaaa
4921 ccaggatggg cagctcattt agagcccacc ctgacgacaa attctatcag aggcttggcc
4981 ccttgctagt cctttagaaa cttccagagt cctaaaagtc cctggtaacc ccctccccat
5041 accttaccat gactggtcac agaaccctta ccatgactgg tcacagaacc ctttcacctt
5101 cttgattttt tactgatttg aggaatacaa tgaaaagaag ggcagcacct ggagaggaaa
5161 agaggcgaca gtcctctctc caccctagcc tgagccaggt ttctagggcc ccccaaattc
5221 agagacctat tatagttctg ggccttggag atgtagaaat ggaaaatatt caagcccagg
5281 aagtaaatga aagcaaacat ttcactgaga acaggaagga attccccaat ccagacaggg
5341 attgtgtctt tgccatttgc atcctgggtg tcaggctcag gataggtgtt tgataagtgt
5401 gggttgggtg attggatgtg tagggaacat ttgctcttcc tggaacatgg ggcccaagtc
5461 agaatctaac ccaggttgtg ctcattcctg caagtgaagg catcaccact gggctaggtt
5521 ccaggtgtga gtgtcctgag aagagcaggt tcacagtagc gtatagatat gccacatttg
5581 tgggcagcag gatgaactgc cagagaggtt tgctttaatg accaagcatc cctaccttcc
5641 agatggcctt gtgatggatg agcacctcgt ggcttccagg actccagaac taccaccgtc
5701 tgcacgtact accactttta tgctagttgg catctgcctt tctatacaaa gctactatta
5761 atcgacattg acctatttcc agaaatacaa ttttagatat catgcaaatt tcatgaccag
5821 taaaggctgc tgctacaatg tcctaactga aagatgatca tttgtagttg ccttaaaata
5881 atgaatacaa tttccaaaat ggtctctaac atttccttac agaactactt cttacttctt
5941 tgccctgccc tctcccaaaa aactacttct tttttcaaaa gaaagtcagc catatctcca
6001 ttgtgcctaa gtccagtgtt tctttttttt tttttttttg agacggagtc tcactctgtc
6061 acccaggctg gactgcaatg acgcgatctt ggttcactgc aacctccgca tccggggttc
6121 aagccattct cctgcctaag cctcccaagt aactgggatt acaggcatgt gtcaccatgc
6181 ccagctaatt tttttgtatt tttagtagag atgggggttt caccatattg gccagtctgg
6241 tctcgaactc ctgaccttgt gatccactcg cctcagcctc tcgaagtgct gagattacac
6301 acgtgagcaa ctgtgcaagg cctggtgttt cttgatacat gtaattctac caaggtcttc
6361 ttaatatgtt cttttaaatg attgaattat atgttcagat tattggagac taattctaat
6421 gtggacctta gaatacagtt ttgagtagag ttgatcaaaa tcaattaaaa tagtctcttt
6481 aaaaggaaag aaaacatctt taaggggagg aaccagagtg ctgaaggaat ggaagtccat
6541 ctgcgtgtgt gcagggagac tgggtaggaa agaggaagca aatagaagag agaggttgaa
6601 aaacaaaatg ggttacttga ttggtgatta ggtggtggta gagaagcaag taaaaaggct
6661 aaatggaagg gcaagtttcc atcatctata gaaagctata taagacaaga actccccttt
6721 ttttcccaaa ggcattataa aaagaatgaa gcctccttag aaaaaaaatt atacctcaat
6781 gtccccaaca agattgctta ataaattgtg tttcctccaa gctattcaat tcttttaact
6841 gttgtagaag acaaaatgtt cacaatatat ttagttgtaa accaagtgat caaactacat
6901 attgtaaagc ccatttttaa aatacattgt atatatgtgt atgcacagta aaaatggaaa
6961 ctatattgac ctaaatgtga actggttatt tctaggtggt gaggtgcttt atggtggtgg
7021 gtttttgctc ttgatgccct ttttgcattt tccaaagtac catggtgagg atgtgttata
7081 tcttttccag ggtcctaaaa gtccctggca actccctccc cataccctac catgactggt
7141 cacagaaccc tttcacctta ttgatttgta ctgatttcat atggaatatg gcaactacat
7201 ctggctcaaa acaaaggaaa ccagaagagc caagtcccag gtgagtgctc agttctgttt
7261 ctagctttga cgtgtgtgtt cttctgtgaa ggacaaaatt tgcttctatt atttaggtac
7321 cataatttgt gtttttccaa attaattccc tgcag
//