LOCUS HUMSPTBN1A 7561 bp mRNA linear HUM 13-JAN-1995
DEFINITION Human general beta-spectrin (SPTBN1) mRNA, complete cds.
ACCESSION M96803
VERSION M96803.1
KEYWORDS beta-spectrin; membrane skeleton protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7561)
AUTHORS Hu,R.J., Watanabe,M. and Bennett,V.
TITLE Characterization of human brain cDNA encoding the general isoform
of beta-spectrin
JOURNAL J. Biol. Chem. 267 (26), 18715-18722 (1992)
PUBMED 1527002
COMMENT Original source text: Homo sapiens (tissue library: lambda gt11 and
lambda ZAPII) 2-year old brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..7561
/db_xref="H-InvDB:HIT000196936"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="2p21"
/tissue_type="brain"
/dev_stage="2-year old"
/tissue_lib="lambda gt11 and lambda ZAPII"
gene 1..7561
/gene="SPTBN1"
CDS 311..7405
/gene="SPTBN1"
/codon_start=1
/product="beta-spectrin"
/protein_id="AAA60580.1"
/db_xref="GDB:G00-120-386"
/translation="MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSR
IKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPK
PTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ
DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPD
LIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHY
FSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSL
VGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDI
NKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNF
GFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIR
LWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDL
LQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELC
QLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRA
FEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL
EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP
TLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS
EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ
LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIR
EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQA
QAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE
DMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQA
LDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGA
EAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE
TASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM
AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD
ANKAELFTQSCADLDKWLHGLESQIQSDDYGKHLTSVNILLKKQQMLENQMEVRKKEI
EELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV
EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIV
TDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE
QELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESER
ISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHEL
GQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLN
EAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETL
QRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDAC
ESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKA
EIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLI
LEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS
ALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGL
PAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPA
RTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTAASGIP
YHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKDDEEMNTWIQAISSAI
SSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEKDKEKRFSLFGKKK
"
BASE COUNT 2146 a 1894 c 2136 g 1385 t
ORIGIN
1 gtgagctgaa gcagggcagg gcatcaactc acccaggaag tgcaaggggt ttggggattt
61 tcctttccta gccaagggaa ggcatgacag actgtacctg gaaaaacagg acactcttgc
121 ccaaatactg cactttttgc acagtcttag caactggcag accaggagat tctctcctgt
181 gcctgattca ttgggtccca cacccatagg gccttgctta ctgccagtgc agcagtctga
241 gattaacacc ccatccccgg gagaactcta agaaggagct gatgtggagg agcagctgag
301 acagttcaag atgacgacca cagtagccac agactatgac aacattgaga tccagcagca
361 gtacagtgat gtcaacaacc gctgggatgt cgacgactgg gacaatgaga acagctctgc
421 gcggcttttt gagcggtccc gcatcaaggc tctggcagat gagcgtgaag ccgtgcagaa
481 gaagaccttc accaagtggg tcaattccca ccttgcccgt gtgtcctgcc ggatcacaga
541 cctgtacact gaccttcgag atggacggat gctcatcaag ctgctggagg tcctctctgg
601 agagaggctg cctaaaccca ccaagggacg aatgcgcatc cactgcttag agaatgtgga
661 caaggccctt cagttcctga aggagcagag agtccatctt gagaacatgg ggtcccatga
721 catcgtggat ggaaaccacc ggctgaccct tggcctcatc tggaccatca tcctgcgctt
781 ccagatccag gatatcagtg tggaaactga agacaacaaa gagaagaaat ctgccaagga
841 tgcattgctg ttgtggtgcc agatgaagac agctgggtac cccaatgtca acattcacaa
901 tttcaccact agctggaggg acggcatggc cttcaatgca ctgatacaca aacaccggcc
961 tgacctgata gattttgaca aactaaagaa atctaacgca cactacaacc tgcagaatgc
1021 atttaatctg gcagaacagc acctcggcct cactaaactg ttggaccccg aagacatcag
1081 cgtggaccat cctgatgaga agtccataat cacttatgtg gtgacttatt accactactt
1141 ctctaagatg aaggccttag ctgttgaagg aaaacgaatt ggaaaggtgc ttgacaatgc
1201 tattgaaaca gaaaaaatga ttgaaaagta tgaatcactt gcctctgacc ttctggaatg
1261 gattgaacaa accatcatca ttctgaacaa tcgcaaattt gccaattcac tggtcggggt
1321 tcaacagcag cttcaggcat tcaacactta ccgcactgtg gagaaaccac ccaaatttac
1381 tgagaagggg aacttggaag tgctgctctt caccattcag agcaagatga gggccaacaa
1441 ccagaaggtc tacatgcccc gggaggggaa gctcatctct gacatcaaca aggcctggga
1501 aagactggaa aaagcggaac acgaaagaga actggctttg cggaatgagc tcataagaca
1561 ggagaaactg gaacagctcg cccgcagatt tgatcgcaag gcagctatga gggagacttg
1621 gctgagcgaa aaccagcgtc tggtgtctca ggacaacttt gggtttgacc ttcctgcagt
1681 tgaggccgcc acaaaaaagc acgaggccat tgagacagac attgccgcat acgaggagcg
1741 tgtgcaggct gtggtagccg tggccaggga gctcgaggcc gagaattacc acgacatcaa
1801 gcgcatcaca gcgaggaagg acaatgtcat ccggctctgg gaatacctac tggaactgct
1861 cagggcccgg agacagcggc tcgagatgaa cctggggctg cagaagatat tccaggaaat
1921 gctctacatt atggactgga tggatgaaat gaaggtgcta gtattgtctc aagactatgg
1981 caaacactta cttggtgtgg aagacctgtt acagaagcac accctggttg aagcagacat
2041 tggcatccag gcagagcggg tgagaggtgt caatgcctcc gcccagaagt tcgcaacaga
2101 cggggaaggt tacaagccct gtgaccccca ggtgatccga gaccgcgtgg cccacatgga
2161 gttctgttat caagagcttt gccagctggc ggctgagcgc agggcccgtc tggaagagtc
2221 ccgccgcctc tggaagttct tctgggagat ggcagaagag gaaggctgga tacgggagaa
2281 ggagaagatc ctgtcctcgg acgattacgg gaaagacctg accagcgtca tgcgcctgct
2341 cagcaagcac cgggcgttcg aggacgagat gagcggccgc agtggccact ttgagcaggc
2401 catcaaggaa ggcgaagaca tgatcgcgga ggagcacttc gggtcggaga agatccgtga
2461 gaggatcatt tacatccggg agcagtgggc caacctagag cagctctcgg ccattcggaa
2521 gaagcgcctg gaggaggcct ccctgctgca ccagttccag gcagatgctg atgacattga
2581 tgcctggatg ctggacatcc tcaagattgt ctccagcagc gacgtgggcc acgatgagta
2641 ttccacacag tctctggtca agaaacacaa ggacgtggcg gaagagatcg ccaattacag
2701 gcccaccctt gacacgctgc acgaacaagc cagcgccctc ccccaggagc atgccgagtc
2761 tccagacgtg aggggcaggc tgtcgggcat cgaggagcgg tataaggagg tggcagagct
2821 gacgcggctg cggaagcagg cactccagga cactctggcc ctgtacaaga tgttcagcga
2881 ggctgatgcc tgtgagctct ggatcgacga gaaggagcag tggctcaaca acatgcagat
2941 cccagagaag ctggaggatc tggaggtcat ccagcacaga tttgagagcc tagaaccaga
3001 aatgaacaac caggcttccc gggttgcagt ggtgaaccag attgcacgcc agctgatgca
3061 cagcggccac ccaagtgaga aggaaatcaa agcccagcag gacaaactca acacaaggtg
3121 gagccagttc agagaactgg ttgacaggaa gaaggatgcc ctcctgtctg ccctgagcat
3181 ccagaactac cacctcgagt gcaatgaaac caaatcctgg attcgggaaa agaccaaggt
3241 catcgagtcc acccaggacc tgggcaatga cctggctggc gtcatggccc tgcagcgcaa
3301 gctgaccggc atggagcggg acttggtggc cattgaggca aagctgagtg acctgcagaa
3361 ggaggcggag aagctggagt ccgagcaccc cgaccaggcc caggccatcc tgtctcggct
3421 ggccgagatc agcgacgtgt gggaggagat gaagaccacc ctgaaaaacc gagaggcctc
3481 cctgggagag gccagcaagc tgcagcagtt cctacgggac ttggacgact tccagtcctg
3541 gctctctagg acccagacag cgatcgcctc ggaggacatg ccaaacaccc tgaccgaggc
3601 tgagaagctg ctcacgcagc acgagaacat caagaatgag atcgacaact acgaggagga
3661 ctaccagaag atgagggaca tgggcgagat ggtcacccag gggcagaccg atgcccagta
3721 catgtttctg cggcagcggc tgcaggccct ggacactgga tggaacgagc tccacaagat
3781 gtgggagaac agacaaaatc tcctatccca gtcacatgcc taccagcagt tcctcagaga
3841 cacgaagcaa gccgaagcct ttcttaacaa ccaggagtat gttctggctc acactgaaat
3901 gcctaccacc ttggaaggag ctgaagcagc aattaaaaag caagaggact tcatgaccac
3961 catggacgcc aatgaggaga agatcaatgc tgtggtggag actggccgga ggctggtgag
4021 cgatgggaac atcaactcag atcgcatcca ggagaaggtg gactctattg atgacagaca
4081 taggaagaat cgtgagacag ccagtgaact tttgatgagg ttgaaggaca acagggatct
4141 acagaaattc ctgcaagatt gtcaagagct gtctctctgg atcaatgaga agatgctcac
4201 agcccaggac atgtcttacg atgaagccag aaatctgcac agtaaatggt tgaagcatca
4261 agcatttatg gcagaacttg catccaacaa agaatggctt gacaaaatcg agaaggaagg
4321 aatgcagctc atttcagaaa agcctgagac ggaagctgtg gtgaaggaga aactcactgg
4381 tttacataaa atgtgggaag tccttgaatc cactacccag acaaaggccc agcggctctt
4441 tgatgcaaac aaggccgaac ttttcaccca gagctgtgca gatctagaca aatggctgca
4501 cggcctggag agtcagattc agtctgatga ctatggcaaa cacctgacca gtgtcaatat
4561 cctgctgaaa aagcaacaga tgctggagaa tcagatggaa gtgcggaaga aggagatcga
4621 agagctccaa agccaagccc aggccctgag tcaggaaggg aagagcaccg acgaggtaga
4681 cagcaagcgc ctcaccgtgc agaccaagtt catggagttg ctggagccct tgaacgagag
4741 gaagcataac ctgctggcct ccaaagagat ccatcagttc aacagggatg tggaggacga
4801 gatcttgtgg gttggagaga ggatgccttt ggcaacttcc acggatcatg gccacaacct
4861 ccagactgtg cagctgttaa taaagaaaaa tcagaccctc cagaaagaaa tccaggggca
4921 ccagcctcgc attgacgaca tctttgagag gagccaaaac atcgtcactg acagcagcag
4981 cctcagcgct gaggccatca gacagaggct tgccgacctg aagcagctgt ggggtctcct
5041 cattgaggag acagagaaac gccacaggcg gctggaggag gcgcacaggg cccagcagta
5101 ctactttgac gctgctgagg ccgaagcctg gatgagcgag caggagctgt acatgatgtc
5161 agaggagaag gccaaggatg agcagagtgc tgtctccatg ttgaagaagc accagatctt
5221 agaacaagct gtggaggact atgcagagac cgtgcatcag ctctccaaga ccagccgggc
5281 cctggtggcc gacagccatc ctgaaagtga gcgcattagc atgcggcagt ccaaagtgga
5341 taaactgtac gctggtctga aagaccttgc tgaagagaga agaggcaagc tggatgagag
5401 acacaggtta ttccagctca accgggaggt ggacgacctg gagcagtgga tcgctgagag
5461 ggaggtggtc gcagggtccc atgaactggg acaggactat gagcatgtca cgatgttaca
5521 agaacgattc cgggagtttg cccgagacac cgggaacatt gggcaggagc gcgtggacac
5581 ggtcaatcac ctggcagatg agctcatcaa ctctggacat tcagatgccg ccaccatcgc
5641 tgaatggaag gatggcctca atgaagcctg ggccgacctc ctggagctca ttgacacaag
5701 aacacagatt cttgccgctt cctatgaact gcacaagttt taccacgatg ccaaggagat
5761 ctttgggcgt atacaggaca aacacaagaa actccctgag gagcttggga gagatcagaa
5821 cacagtggag accttacaga gaatgcacac tacatttgag catgacatcc aggctctggg
5881 cacacaggtg aggcagctgc aggaggatgc agcccgcctc caggcggcct atgcgggtga
5941 caaggccgac gatatccaga agcgcgagaa cgaggtcctg gaagcctgga agtccctcct
6001 ggacgcctgt gagagccgca gggtgcggct ggtggacaca ggggacaagt tccgcttctt
6061 cagcatggtg cgcgacctca tgctctggat ggaggatgtc atccggcaga tcgaggccca
6121 ggagaagcca agggatgtat catctgttga actcttaatg aataatcatc aaggcatcaa
6181 agctgaaatt gatgcacgta atgacagttt cacaacctgc attgaacttg ggaaatccct
6241 gttggcgaga aaacactatg catctgagga gatcaaggaa aaattactgc agttgacgga
6301 aaagaggaaa gaaatgatcg acaagtggga agaccgatgg gaatggttaa gactgattct
6361 ggaggtccat cagttctcaa gagacgccag tgtggccgag gcctggctgc ttggacagga
6421 gccgtaccta tccagccgag agataggcca gagcgtggac gaggtggaga agctcatcaa
6481 gcgccacgag gcatttgaaa agtctgcagc aacctgggat gagaggttct ctgccctgga
6541 aaggctgact acattggagt tactggaagt gcgcagacag caagaggaag aggagaggaa
6601 gaggcggccg ccttctcccg agccgagcac gaaggtttca gaggaagccg agtcccagca
6661 gcagtgggat acttcaaaag gagaacaagt ttcccaaaac ggtttgccag ctgaacaggg
6721 atctccacgg atggcagaaa cggtggacac aagcgaaatg gtcaacggcg ctacagaaca
6781 aaggacgagc tctaaagagt ccagccccat cccctccccg acctctgatc gtaaagccaa
6841 gactgccctc ccagcccaga gtgccgccac cttaccagcc agaacccagg agacaccttc
6901 ggcccagatg gaaggcttcc tcaatcggaa acacgagtgg gaggcccaca ataagaaagc
6961 ctcaagcagg tcctggcaca atgtttattg tgtcataaat aaccaagaaa tgggtttcta
7021 caaagatgca aagactgctg cttctggaat tccctaccac agcgaggtcc ctgtgagttt
7081 gaaagaagct gtctgcgaag tggcccttga ttacaaaaag aagaaacacg tattcaagct
7141 aagactaaat gatggcaatg agtacctctt ccaagccaaa gacgatgagg aaatgaacac
7201 atggatccag gctatctctt ccgccatctc ctctgataaa cacgaggtgt ctgccagcac
7261 ccagagcacg ccagcatcca gccgcgcgca gaccctcccc accagcgtcg tcaccatcac
7321 cagcgagtcc agtcccggca agcgggaaaa ggacaaagag aaagacaaag agaagcggtt
7381 cagccttttt ggcaaaaaga aatgaactcc tttccttcac ctcctgccct tctcttacct
7441 tttcagtgaa attccagcat gcaagctcag aaccaacaca ttactctctg tgcctaatgt
7501 tcctcaatgt ggttgattta tttttttttt taatttatag agcatttcgg ggggggtggg
7561 g
//