LOCUS HUMACTN1A 3081 bp mRNA linear HUM 30-OCT-1994
DEFINITION Human non-muscle alpha-actinin mRNA, complete cds.
ACCESSION M95178 M31300
VERSION M95178.1
KEYWORDS alpha-actinin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3081)
AUTHORS Youssoufian,H., McAfee,M. and Kwiatkowski,D.J.
TITLE Cloning and chromosomal localization of the human cytoskeletal
alpha-actinin gene reveals linkage to the beta-spectrin gene
JOURNAL Am. J. Hum. Genet. 47 (1), 62-71 (1990)
PUBMED 2349951
COMMENT Original source text: Homo sapiens (individual_isolate p5aA)
umbilical vein cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3081
/db_xref="H-InvDB:HIT000196890"
/organism="Homo sapiens"
/mol_type="mRNA"
/isolate="p5aA"
/db_xref="taxon:9606"
/map="14q24.1-q24.2"
/cell_type="endothelial cell"
/tissue_type="umbilical vein"
gene 1..3081
/gene="ACTN1"
CDS 112..2790
/gene="ACTN1"
/codon_start=1
/product="alpha-actinin"
/protein_id="AAA51582.1"
/db_xref="GDB:G00-125-187"
/translation="MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSH
LRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIAS
KGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAP
YKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDI
PKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLM
EDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQL
EINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERL
DHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDR
VEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETID
QLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERL
AILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHAR
QQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYK
PKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDA
KGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSI
VDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQ
AEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL"
polyA_site 3081
/gene="ACTN1"
/note="G00-125-187"
BASE COUNT 789 a 880 c 857 g 555 t
ORIGIN
1 cccgccagcc cagcccagcc caaccctact ccctccccac gccagggcag cagccgttgc
61 tcagagagaa ggtggaggaa gaaatccaga ccctagcacg cgcgcaccat catggaccat
121 tatgattctc agcaaaccaa cgattacatg cagccagaag aggactggga ccgggacctg
181 ctcctggacc cggcctggga gaagcagcag agaaagacat tcacggcatg gtgtaactcc
241 cacctccgga aggcggggac acagatcgag aacatcgaag aggacttccg ggatggcctg
301 aagctcatgc tgctgctgga ggtcatctca ggtgaacgct tggccaagcc agagcgaggc
361 aagatgagag tgcacaagat ctccaacgtc aacaaggccc tggatttcat agccagcaaa
421 ggcgtcaaac tggtgtccat cggagccgaa gaaatcgtgg atgggaatgt gaagatgacc
481 ctgggcatga tctggaccat catcctgcgc tttgccatcc aggacatctc cgtggaagag
541 acttcagcca aggaagggct gctcctgtgg tgtcagagaa agacagcccc ttacaaaaat
601 gtcaacatcc agaacttcca cataagctgg aaggatggcc tcggcttctg tgctttgatc
661 caccgacacc ggcccgagct gattgactac gggaagctgc ggaaggatga tccactcaca
721 aatctgaata cggcttttga cgtggcagag aagtacctgg acatccccaa gatgctggat
781 gccgaagaca tcgttggaac tgcccgaccg gatgagaaag ccatcatgac ttacgtgtct
841 agcttctacc acgccttctc tggagcccag aaggcggaga cagcagccaa tcgcatctgc
901 aaggtgttgg ccgtcaacca ggagaacgag cagcttatgg aagactacga gaagctggcc
961 agtgatctgt tggagtggat ccgccgcaca atcccgtggc tggagaaccg ggtgcccgag
1021 aacaccatgc atgccatgca acagaagctg gaggacttcc gggactaccg gcgcctgcac
1081 aagccgccca aggtgcagga gaagtgccag ctggagatca acttcaacac gctgcagacc
1141 aagctgcggc tcagcaaccg gcctgccttc atgccctctg agggcaggat ggtctcggac
1201 atcaacaatg cctggggctg cctggagcag gtggagaagg gctatgagga gtggttgctg
1261 aatgagatcc ggaggctgga gcgactggac cacctggcag agaagttccg gcagaaggcc
1321 tccatccacg aggcctggac tgacggcaaa gaggccatgc tgcgacagaa ggactatgag
1381 accgccaccc tctcggagat caaggccttg ctcaagaagc atgaggcctt cgagagtgac
1441 ctggctgccc accaggaccg tgtggagcag attgccgcca tcgcacagga gctcaatgag
1501 ctggactatt atgactcacc cagtgtcaac gcccgttgcc aaaagatctg tgaccagtgg
1561 gacaatctgg gggccctaac tcagaagcga agggaagctc tggagcggac cgagaaactg
1621 ctggagacca ttgaccagct gtacttggag tatgccaagc gggctgcacc cttcaacaac
1681 tggatggagg gggccatgga ggacctgcag gacaccttca ttgtgcacac cattgaggag
1741 atccagggac tgaccacagc ccatgagcag ttcaaggcca ccctccctga tgccgacaag
1801 gagcgcctgg ccatcctggg catccacaat gaggtgtcca agattgtcca gacctaccac
1861 gtcaatatgg cgggcaccaa cccctacaca accatcacgc ctcaggagat caatggcaaa
1921 tgggaccacg tgcggcagct ggtgcctcgg agggaccaag ctctgacgga ggagcatgcc
1981 cgacagcagc acaatgagag gctacgcaag cagtttggag cccaggccaa tgtcatcggg
2041 ccctggatcc agaccaagat ggaggagatc gggaggatct ccattgagat gcatgggacc
2101 ctggaggacc agctcagcca cctgcggcag tatgagaaga gcatcgtcaa ctacaagcca
2161 aagattgatc agctggaggg cgaccaccag ctcatccagg aggcgctcat cttcgacaac
2221 aagcacacca actacaccat ggagcacatc cgtgtgggct gggagcagct gctcaccacc
2281 atcgccagga ccatcaatga ggtagagaac cagatcctga cccgggatgc caagggcatc
2341 agccaggagc agatgaatga gttccgggcc tccttcaacc actttgaccg ggatcactcc
2401 ggcacactgg gtcccgagga gttcaaagcc tgcctcatca gcttgggtta tgatattggc
2461 aacgaccccc agggagaagc agaatttgcc cgcatcatga gcattgtgga ccccaaccgc
2521 ctgggggtag tgacattcca ggccttcatt gacttcatgt cccgcgagac agccgacaca
2581 gatacagcag accaagtcat ggcttccttc aagatcctgg ctggggacaa gaactacatt
2641 accatggacg agctgcgccg cgagctgcca cccgaccagg ctgagtactg catcgcgcgg
2701 atggccccct acaccggccc cgactccgtg ccaggtgctc tggactacat gtccttctcc
2761 acggcgctgt acggcgagag tgacctctaa tccaccccgc ccggccgccc tcgtcttgtg
2821 cgccgtgccc acagatgtga aatgaatgta atctaataga agcctaatca gcccaccatg
2881 ttctccactg aaaaatcctc tttctttggg gtttttcttt ctttcttttt tgattttgca
2941 ctggacggtg acgtcagcct gtacaggctc ccaggggtgg cgtcaaatgc tattgaaatt
3001 gcgctgaatc gtatgctttt tccttttgat aaataaacaa tgtaaaaatg tttcaaaaac
3061 ctaataaaat aaataaatac g
//