LOCUS HUMPTPRZ 7941 bp mRNA linear HUM 08-JAN-1995
DEFINITION Human protein tyrosine phosphatase zeta-polypeptide (PTPRZ) mRNA,
complete cds.
ACCESSION M93426
VERSION M93426.1
KEYWORDS carbonic anhydrase-related transmembrane protein; protein tyrosine
phosphatase zeta-polypeptide.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7941)
AUTHORS Krueger,N.X. and Saito,H.
TITLE A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is
expressed in brain and has an N-terminal receptor domain homologous
to carbonic anhydrases
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (16), 7417-7421 (1992)
PUBMED 1323835
COMMENT Original source text: Homo sapiens (tissue library: lambda gt10 and
gt11) fetus brain cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..7941
/db_xref="H-InvDB:HIT000196852"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Unassigned"
/tissue_type="brain"
/dev_stage="fetus"
/tissue_lib="lambda gt10 and gt11"
gene 1..7941
/gene="PTPRZ"
CDS 148..7092
/gene="PTPRZ"
/note="carbonic anhydrase-like domain"
/codon_start=1
/product="protein tyrosine phosphatase zeta-polypeptide"
/protein_id="AAA60225.1"
/db_xref="GDB:G00-127-353"
/translation="MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGAL
NQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTV
EINLTNDYRVSGGVSEMVFKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDA
DRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILL
NLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVM
LMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLLVTWER
PRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAIC
TNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEGKDIEEGAIVNPGRDSA
TNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEFSGKGDVPNTSLNSTSQPVT
KLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSIT
EYEEESLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFSSENPETITYDVLIP
ESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESFLQTNYTEIR
VDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVST
VNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSALHATP
VFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPL
HASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSD
AMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQGSLFSGPSHIPIP
KSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYT
TSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQET
SVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSLKPVLSA
NSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPS
DPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTI
SYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID
EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITA
VSPHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDRDSDGL
SIHKCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQ
TGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQ
GTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHV
SEAEASNSSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTA
HFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEF
YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINA
NYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPD
MGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTV
NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGP
AGKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGT
DYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV
YWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKW
PNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSV
DVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALPDGNI
AESLESLV"
BASE COUNT 2406 a 1651 c 1598 g 2286 t
ORIGIN
1 cacacatacg cacgcacgat ctcacttcga tctatacact ggaggattaa aacaaacaaa
61 caaaaaaaac atttccttcg ctccccctcc ctctccactc tgagaagcag aggagccgca
121 cggcgagggg ccgcagaccg tctggaaatg cgaatcctaa agcgtttcct cgcttgcatt
181 cagctcctct gtgtttgccg cctggattgg gctaatggat actacagaca acagagaaaa
241 cttgttgaag agattggctg gtcctataca ggagcactga atcaaaaaaa ttggggaaag
301 aaatatccaa catgtaatag cccaaaacaa tctcctatca atattgatga agatcttaca
361 caagtaaatg tgaatcttaa gaaacttaaa tttcagggtt gggataaaac atcattggaa
421 aacacattca ttcataacac tgggaaaaca gtggaaatta atctcactaa tgactaccgt
481 gtcagcggag gagtttcaga aatggtgttt aaagcaagca agataacttt tcactgggga
541 aaatgcaata tgtcatctga tggatcagag catagtttag aaggacaaaa atttccactt
601 gagatgcaaa tctactgctt tgatgcggac cgattttcaa gttttgagga agcagtcaaa
661 ggaaaaggga agttaagagc tttatccatt ttgtttgagg ttgggacaga agaaaatttg
721 gatttcaaag cgattattga tggagtcgaa agtgttagtc gttttgggaa gcaggctgct
781 ttagatccat tcatactgtt gaaccttctg ccaaactcaa ctgacaagta ttacatttac
841 aatggctcat tgacatctcc tccctgcaca gacacagttg actggattgt ttttaaagat
901 acagttagca tctctgaaag ccagttggct gttttttgtg aagttcttac aatgcaacaa
961 tctggttatg tcatgctgat ggactactta caaaacaatt ttcgagagca acagtacaag
1021 ttctctagac aggtgttttc ctcatacact ggaaaggaag agattcatga agcagtttgt
1081 agttcagaac cagaaaatgt tcaggctgac ccagagaatt ataccagcct tcttgttaca
1141 tgggaaagac ctcgagtcgt ttatgatacc atgattgaga agtttgcagt tttgtaccag
1201 cagttggatg gagaggacca aaccaagcat gaatttttga cagatggcta tcaagacttg
1261 ggtgctattc tcaataattt gctacccaat atgagttatg ttcttcagat agtagccata
1321 tgcactaatg gcttatatgg aaaatacagc gaccaactga ttgtcgacat gcctactgat
1381 aatcctgaac ttgatctttt ccctgaatta attggaactg aagaaataat caaggaggag
1441 gaagagggaa aagacattga agaaggcgct attgtgaatc ctggtagaga cagtgctaca
1501 aaccaaatca ggaaaaagga accccagatt tctaccacaa cacactacaa tcgcataggg
1561 acgaaataca atgaagccaa gactaaccga tccccaacaa gaggaagtga attctctgga
1621 aagggtgatg ttcccaatac atctttaaat tccacttccc aaccagtcac taaattagcc
1681 acagaaaaag atatttcctt gacttctcag actgtgactg aactgccacc tcacactgtg
1741 gaaggtactt cagcctcttt aaatgatggc tctaaaactg ttcttagatc tccacatatg
1801 aacttgtcgg ggactgcaga atccttaaat acagtttcta taacagaata tgaggaggag
1861 agtttattga ccagtttcaa gcttgatact ggagctgaag attcttcagg ctccagtccc
1921 gcaacttctg ctatcccatt catctctgag aacatatccc aagggtatat attttcctcc
1981 gaaaacccag agacaataac atatgatgtc cttataccag aatctgctag aaatgcttcc
2041 gaagattcaa cttcatcagg ttcagaagaa tcactaaagg atccttctat ggagggaaat
2101 gtgtggtttc ctagctctac agacataaca gcacagcccg atgttggatc aggcagagag
2161 agctttctcc agactaatta cactgagata cgtgttgatg aatctgagaa gacaaccaag
2221 tccttttctg caggcccagt gatgtcacag ggtccctcag ttacagatct ggaaatgcca
2281 cattattcta cctttgccta cttcccaact gaggtaacac ctcatgcttt taccccatcc
2341 tccagacaac aggatttggt ctccacggtc aacgtggtat actcgcagac aacccaaccg
2401 gtatacaatg gtgagacacc tcttcaacct tcctacagta gtgaagtctt tcctctagtc
2461 acccctttgt tgcttgacaa tcagatcctc aacactaccc ctgctgcttc aagtagtgat
2521 tcggccttgc atgctacgcc tgtatttccc agtgtcgatg tgtcatttga atccatcctg
2581 tcttcctatg atggtgcacc tttgcttcca ttttcctctg cttccttcag tagtgaattg
2641 tttcgccatc tgcatacagt ttctcaaatc cttccacaag ttacttcagc taccgagagt
2701 gataaggtgc ccttgcatgc ttctctgcca gtggctgggg gtgatttgct attagagccc
2761 agccttgctc agtattctga tgtgctgtcc actactcatg ctgcttcaga gacgctggaa
2821 tttggtagtg aatctggtgt tctttataaa acgcttatgt tttctcaagt tgaaccaccc
2881 agcagtgatg ccatgatgca tgcacgttct tcagggcctg aaccttctta tgccttgtct
2941 gataatgagg gctcccaaca catcttcact gtttcttaca gttctgcaat acctgtgcat
3001 gattctgtgg gtgtaactta tcagggttcc ttatttagcg gccctagcca tataccaata
3061 cctaagtctt cgttaataac cccaactgca tcattactgc agcctactca tgccctctct
3121 ggtgatgggg aatggtctgg agcctcttct gatagtgaat ttcttttacc tgacacagat
3181 gggctgacag cccttaacat ttcttcacct gtttctgtag ctgaatttac atatacaaca
3241 tctgtgtttg gtgatgataa taaggcgctt tctaaaagtg aaataatata tggaaatgag
3301 actgaactgc aaattccttc tttcaatgag atggtttacc cttctgaaag cacagtcatg
3361 cccaacatgt atgataatgt aaataagttg aatgcgtctt tacaagaaac ctctgtttcc
3421 atttctagca ccaagggcat gtttccaggg tcccttgctc ataccaccac taaggttttt
3481 gatcatgaga ttagtcaagt tccagaaaat aacttttcag ttcaacctac acatactgtc
3541 tctcaagcat ctggtgacac ttcgcttaaa cctgtgctta gtgcaaactc agagccagca
3601 tcctctgacc ctgcttctag tgaaatgtta tctccttcaa ctcagctctt attttatgag
3661 acctcagctt cttttagtac tgaagtattg ctacaacctt cctttcaggc ttctgatgtt
3721 gacaccttgc ttaaaactgt tcttccagct gtgcccagtg atccaatatt ggttgaaacc
3781 cccaaagttg ataaaattag ttctacaatg ttgcatctca ttgtatcaaa ttctgcttca
3841 agtgaaaaca tgctgcactc tacatctgta ccagtttttg atgtgtcgcc tacttctcat
3901 atgcactctg cttcacttca aggtttgacc atttcctatg caagtgagaa atatgaacca
3961 gttttgttaa aaagtgaaag ttcccaccaa gtggtacctt ctttgtacag taatgatgag
4021 ttgttccaaa cggccaattt ggagattaac caggcccatc ccccaaaagg aaggcatgta
4081 tttgctacac ctgttttatc aattgatgaa ccattaaata cactaataaa taagcttata
4141 cattccgatg aaattttaac ctccaccaaa agttctgtta ctggtaaggt atttgctggt
4201 attccaacag ttgcttctga tacatttgta tctactgatc attctgttcc tataggaaat
4261 gggcatgttg ccattacagc tgtttctccc cacagagatg gttctgtaac ctcaacaaag
4321 ttgctgtttc cttctaaggc aacttctgag ctgagtcata gtgccaaatc tgatgccggt
4381 ttagtgggtg gtggtgaaga tggtgacact gatgatgatg gtgatgatga tgatgacaga
4441 gatagtgatg gcttatccat tcataagtgt atgtcatgct catcctatag agaatcacag
4501 gaaaaggtaa tgaatgattc agacacccac gaaaacagtc ttatggatca gaataatcca
4561 atctcatact cactatctga gaattctgaa gaagataata gagtcacaag tgtatcctca
4621 gacagtcaaa ctggtatgga cagaagtcct ggtaaatcac catcagcaaa tgggctatcc
4681 caaaagcaca atgatggaaa agaggaaaat gacattcaga ctggtagtgc tctgcttcct
4741 ctcagccctg aatctaaagc atgggcagtt ctgacaagtg atgaagaaag tggatcaggg
4801 caaggtacct cagatagcct taatgagaat gagacttcca cagatttcag ttttgcagac
4861 actaatgaaa aagatgctga tgggatcctg gcagcaggtg actcagaaat aactcctgga
4921 ttcccacagt ccccaacatc atctgttact agcgagaact cagaagtgtt ccacgtttca
4981 gaggcagagg ccagtaatag tagccatgag tctcgtattg gtctagctga ggggttggaa
5041 tccgagaaga aggcagttat accccttgtg atcgtgtcag ccctgacttt tatctgtcta
5101 gtggttcttg tgggtattct catctactgg aggaaatgct tccagactgc acacttttac
5161 ttagaggaca gtacatcccc tagagttata tccacacctc caacacctat ctttccaatt
5221 tcagatgatg tcggagcaat tccaataaag cactttccaa agcatgttgc agatttacat
5281 gcaagtagtg ggtttactga agaatttgag acactgaaag agttttacca ggaagtgcag
5341 agctgtactg ttgacttagg tattacagca gacagctcca accacccaga caacaagcac
5401 aagaatcgat acataaatat cgttgcctat gatcatagca gggttaagct agcacagctt
5461 gctgaaaagg atggcaaact gactgattat atcaatgcca attatgttga tggctacaac
5521 agaccaaaag cttatattgc tgcccaaggc ccactgaaat ccacagctga agatttctgg
5581 agaatgatat gggaacataa tgtggaagtt attgtcatga taacaaacct cgtggagaaa
5641 ggaaggagaa aatgtgatca gtactggcct gccgatggga gtgaggagta cgggaacttt
5701 ctggtcactc agaagagtgt gcaagtgctt gcctattata ctgtgaggaa ttttactcta
5761 agaaacacaa aaataaaaaa gggctcccag aaaggaagac ccagtggacg tgtggtcaca
5821 cagtatcact acacgcagtg gcctgacatg ggagtaccag agtactccct gccagtgctg
5881 acctttgtga gaaaggcagc ctatgccaag cgccatgcag tggggcctgt tgtcgtccac
5941 tgcagtgctg gagttggaag aacaggcaca tatattgtgc tagacagtat gttgcagcag
6001 attcaacacg aaggaactgt caacatattt ggcttcttaa aacacatccg ttcacaaaga
6061 aattatttgg tacaaactga ggagcaatat gtcttcattc atgatacact ggttgaggcc
6121 atacttagta aagaaactga ggtgctggac agtcatattc atgcctatgt taatgcactc
6181 ctcattcctg gaccagcagg caaaacaaag ctagagaaac aattccagct cctgagccag
6241 tcaaatatac agcagagtga ctattctgca gccctaaagc aatgcaacag ggaaaagaat
6301 cgaacttctt ctatcatccc tgtggaaaga tcaagggttg gcatttcatc cctgagtgga
6361 gaaggcacag actacatcaa tgcctcctat atcatgggct attaccagag caatgaattc
6421 atcattaccc agcaccctct ccttcatacc atcaaggatt tctggaggat gatatgggac
6481 cataatgccc aactggtggt tatgattcct gatggccaaa acatggcaga agatgaattt
6541 gtttactggc caaataaaga tgagcctata aattgtgaga gctttaaggt cactcttatg
6601 gctgaagaac acaaatgtct atctaatgag gaaaaactta taattcagga ctttatctta
6661 gaagctacac aggatgatta tgtacttgaa gtgaggcact ttcagtgtcc taaatggcca
6721 aatccagata gccccattag taaaactttt gaacttataa gtgttataaa agaagaagct
6781 gccaataggg atgggcctat gattgttcat gatgagcatg gaggagtgac ggcaggaact
6841 ttctgtgctc tgacaaccct tatgcaccaa ctagaaaaag aaaattccgt ggatgtttac
6901 caggtagcca agatgatcaa tctgatgagg ccaggagtct ttgctgacat tgagcagtat
6961 cagtttctct acaaagtgat cctcagcctt gtgagcacaa ggcaggaaga gaatccatcc
7021 acctctctgg acagtaatgg tgcagcattg cctgatggaa atatagctga gagcttagag
7081 tctttagttt aacacagaaa ggggtggggg gactcacatc tgagcattgt tttcctcttc
7141 ctaaaattag gcaggaaaat cagtctagtt ctgttatctg ttgatttccc atcacctgac
7201 agtaactttc atgacatagg attctgccgc caaatttata tcattaacaa tgtgtgcctt
7261 tttgcaagac ttgtaattta cttattatgt ttgaactaaa atgattgaat tttacagtat
7321 ttctaagaat ggaattgtgg tatttttttc tgtattgatt ttaacagaaa atttcaattt
7381 atagaggtta ggaattccaa actacagaaa atgtttgttt ttagtgtcaa atttttagct
7441 gtatttgtag caattatcag gtttgctaga aatataactt ttaatacagt agcctgtaaa
7501 taaaacactc ttccatatga tattcaacat tttacaactg cagtattcac ctaaagtaga
7561 aataatctgt tacttattgt aaatactgcc ctagtgtctc catggaccaa atttatattt
7621 ataattgtag atttttatat tttactactg agtcaagttt tctagttctg tgtaattgtt
7681 tagtttaatg acgtagttca ttagctggtc ttactctacc agttttctga cattgtattg
7741 tgttacctaa gtcattaact ttgtttcagc atgtaatttt aacttttgtg gaaaatagaa
7801 ataccttcat tttgaaagaa gtttttatga gaataacacc ttaccaaaca ttgttcaaat
7861 ggtttttatc caaggaattg caaaaataaa tataaatatt gccattaaaa aaaaaaaaaa
7921 aaaaaaaaaa aaaaaaaaaa a
//