LOCUS HUMMSADHA 1423 bp mRNA linear HUM 27-APR-1993
DEFINITION Human methylmalonate semialdehyde dehydrogenase gene, complete cds.
ACCESSION M93405
VERSION M93405.1
KEYWORDS aldehyde dehydrogenase superfamily; methylmalonate semialdehyde
dehydrogenase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1423)
AUTHORS Kedishvili,N.Y., Popov,K.M., Rougraff,P.M., Zhao,Y., Crabb,D.W. and
Harris,R.A.
TITLE CoA-dependent methylmalonate-semialdehyde dehydrogenase, a unique
member of the aldehyde dehydrogenase superfamily. cDNA cloning,
evolutionary relationships, and tissue distribution
JOURNAL J. Biol. Chem. 267 (27), 19724-19729 (1992)
PUBMED 1527093
COMMENT Original source text: Homo sapiens adult liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1423
/db_xref="H-InvDB:HIT000196849"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="liver"
/dev_stage="adult"
CDS <1..1293
/EC_number="1.2.1.27"
/function="oxidation of semialdehyde"
/codon_start=1
/product="methylmalonate semialdehyde dehydrogenase"
/protein_id="AAA36328.1"
/translation="LRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHAC
SVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFL
MKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKA
GEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTA
VLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASI
LLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVN
NNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNF
YGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR"
3'UTR 1291..1423
BASE COUNT 401 a 324 c 334 g 364 t
ORIGIN
1 ctccgctatc aacaacttat taaagaaaac ttgaaagaaa ttgccaagtt aatcacattg
61 gaacaaggga agaccctagc tgatgctgaa ggagatgtat ttcgaggcct tcaggtggtt
121 gagcatgcct gtagtgtgac atccctcatg atgggagaga ccatgccatc catcaccaaa
181 gacatggacc tttattccta ccgtctgcct ctgggagtgt gtgcaggcat tgctccattc
241 aattttcctg ccatgatccc cctttggatg tttcccatgg ccatggtgtg tggaaatacc
301 ttcctaatga aaccatctga gcgagtccct ggagcaacta tgcttcttgc taagttgctc
361 caggattctg gtgcccctga tggaacatta aacatcatcc atggacagca tgaagctgta
421 aattttattt gcgatcatcc ggacatcaaa gcaatcagct ttgtgggatc caacaaggca
481 ggagagtata tcttcgagag aggatcaaga catggcaaga gggttcaagc caatatggga
541 gccaagaacc atggggtagt catgccagat gccaataagg aaaataccct gaaccagctg
601 gttggggcag catttggagc tgctggtcag cgctgcatgg ctctttcaac agcagtcctt
661 gtgggagaag ccaagaagtg gctgccagag ctggtggagc atgccaaaaa cctgagagtc
721 aatgcaggag atcagcctgg agctgatctt ggccctctga tcactcccca ggccaaagag
781 cgagtctgta atctgattga tagtggaaca aaggagggag cttccatcct tcttgatgga
841 cgaaaaatta aagtgaaagg ctatgaaaat ggcaactttg ttggaccaac catcatctcg
901 aatgtcaagc caaatatgac ctgttacaaa gaggagattt ttggtccagt tcttgtggtt
961 ctggagacag aaacattgga tgaagccatc cagattgtaa ataacaaccc atatggaaat
1021 ggaactgcca tcttcaccac caatggagcc actgctcgga aatatgccca cttggtggat
1081 gttggacagg tgggagtgaa tgtccccatt ccagtgcctt tgccaatgtt ctcattcacc
1141 ggctctcgat cctccttcag gggagacacc aatttctatg gcaaacaggg catccaattc
1201 tacactcagt taaagaccat tacttctcag tggaaagaag aagatgctac tctttcctca
1261 cctgctgttg tcatgcctac catgggccgt tagaaacaag tttgtttaag actgactcca
1321 tcctgagtaa tctcccttta tttttgacca gcttcatttg tcagctttgc tcagatcaga
1381 tcgatgggat tggaatacat tgtaactaaa atcttaaaaa aaa
//