LOCUS HUM130LEU 4782 bp mRNA linear HUM 11-FEB-2002
DEFINITION Homo sapiens leucine-rich PPR-motif containing protein (LRPPRC)
mRNA, complete cds.
ACCESSION M92439
VERSION M92439.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 2 (bases 1 to 4782)
AUTHORS McKeehan,W.L.
TITLE Direct Submission
JOURNAL Submitted (07-MAY-1992) Wallace L. McKeehan, Albert B. Alkek
Institute of Biosciences and Technology, Texas A&M University, 2121
Holcombe Blvd., Houston, TX 77030, USA
REFERENCE 3 (bases 1 to 4782)
AUTHORS Hou,J., Wang,F. and McKeehan,W.L.
TITLE Molecular cloning and expression of the gene for a major
leucine-rich protein from human hepatoblastoma cells (HepG2)
JOURNAL In Vitro Cell. Dev. Biol. Anim. 30A (2), 111-114 (1994)
PUBMED 8012652
REFERENCE 4 (bases 1 to 4782)
AUTHORS Liu,L. and McKeehan,W.L.
TITLE Sequence analysis of LRPPRC and its SEC1 domain interaction
partners suggests roles in cytoskeletal organization, vesicular
trafficking, nucleocytosolic shuttling, and chromosome activity
JOURNAL Genomics 79 (1), 124-136 (2002)
PUBMED 11827465
FEATURES Location/Qualifiers
source 1..4782
/db_xref="H-InvDB:HIT000196825"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="terminal hepatoma"
gene 1..4782
/gene="LRPPRC"
CDS 46..3867
/gene="LRPPRC"
/inference="non-experimental evidence, no additional
details recorded"
/note="130kD; GP130; may play roles in cytoskeletal
organization, vesicular trafficking, nucleocytosolic
shuttling and chromosome activity"
/codon_start=1
/product="leucine-rich PPR-motif containing protein"
/protein_id="AAA67549.1"
/translation="MPCFYLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHY
NALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFM
KTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKG
DIDHVKQTLEKVEKFELHLMDRDLLQIIFSFSKAGYLSMSQKFWKKFTCERRYIPDAM
NLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKL
KEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNV
QGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLR
SEAANGNLDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINVWSEITELLYKDGRYC
QEPRGPTEAVGNFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNL
LESYHVPELIKDAHLLVERKNLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLIL
VLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAV
LDTGNYLGLVRVLAKHGKLQDAIKILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIE
TVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDV
LCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRAR
SARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAV
WNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDF
QKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFA
ETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAM
KGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENK
VIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKV
DDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLM
KSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFEFYA
QQLRKLRENSS"
misc_feature 157..258
/gene="LRPPRC"
/note="Region: LRP01; LRP/PPR-like repeat 1"
misc_feature 259..369
/gene="LRPPRC"
/note="Region: LRP02; LRP/PPR-like repeat 2"
misc_feature 370..474
/gene="LRPPRC"
/note="Region: LRP03; LRP/PPR-like repeat 3"
misc_feature 475..579
/gene="LRPPRC"
/note="Region: LRP04; LRP/PPR-like repeat 4"
misc_feature 580..687
/gene="LRPPRC"
/note="Region: LRP05; LRP/PPR-like repeat 5"
misc_feature 1537..1647
/gene="LRPPRC"
/note="Region: LRP06; LRP/PPR-like repeat 6"
misc_feature 1705..1818
/gene="LRPPRC"
/note="Region: LRP07; LRP/PPR-like repeat 7"
misc_feature 1816..1911
/gene="LRPPRC"
/note="Region: LRP08; LRP/PPR-like repeat 8"
misc_feature 1912..2025
/gene="LRPPRC"
/note="Region: LRP09; LRP/PPR-like repeat 9"
misc_feature 2026..2136
/gene="LRPPRC"
/note="Region: LRP10; LRP/PPR-like repeat 10"
misc_feature 2248..2331
/gene="LRPPRC"
/note="Region: LRP11; LRP/PPR-like repeat 11"
misc_feature 2332..2433
/gene="LRPPRC"
/note="Region: LRP12; LRP/PPR-like repeat 12"
misc_feature 2434..2535
/gene="LRPPRC"
/note="Region: LRP13; LRP/PPR-like repeat 13"
misc_feature 2536..3096
/gene="LRPPRC"
/note="Region: interacts with UXT, CECR2 and C19ORF5"
misc_feature 2536..2643
/gene="LRPPRC"
/note="Region: LRP14; LRP/PPR-like repeat 14"
misc_feature 2782..2877
/gene="LRPPRC"
/note="Region: LRP15; LRP/PPR-like repeat 15"
misc_feature 2878..2979
/gene="LRPPRC"
/note="Region: LRP16; LRP/PPR-like repeat 16"
misc_feature 2980..3084
/gene="LRPPRC"
/note="Region: LRP17; LRP/PPR-like repeat 17"
misc_feature 3085..3195
/gene="LRPPRC"
/note="Region: LRP18; LRP/PPR-like repeat 18"
misc_feature 3208..3306
/gene="LRPPRC"
/note="Region: LRP19; LRP/PPR-like repeat 19"
misc_feature 3430..3531
/gene="LRPPRC"
/note="Region: LRP20; LRP/PPR-like repeat 20"
misc_feature 3532..3627
/gene="LRPPRC"
/note="Region: LRP21; LRP/PPR-like repeat 21"
misc_feature 3628..3738
/gene="LRPPRC"
/note="Region: LRP22; LRP/PPR-like repeat 22"
misc_feature 3739..3852
/gene="LRPPRC"
/note="Region: LRP23; LRP/PPR-like repeat 23"
misc_feature 244..247
/gene="LRPPRC"
/note="alternative start codon"
BASE COUNT 1531 a 856 c 1018 g 1377 t
ORIGIN
1 aagtttttaa tgatacctgc cgctcaggtg gcctaggtgg tagtcatgcc ttgcttctac
61 ttacgtagtt gtggttctct cttgcctgaa ctaaagcttg aagagagaac agaatttgct
121 cataggatat gggacacact tcagaaatta ggtgctgtgt atgatgtgag tcactataat
181 gctttactta aagtctatct tcaaaatgaa tataaattct caccaactga tttcctggca
241 aaaatggagg aagcaaacat tcaaccaaat cgagtgacat accagagatt gattgcttct
301 tattgtaatg taggagatat tgaaggtgcc agcaagattc ttggatttat gaaaactaag
361 gatctcccag ttacagaggc agtattcagt gcccttgtga cagggcatgc cagagctggt
421 gatatggaga atgcagaaaa cattctcaca gtgatgagag atgccggaat tgagcctggt
481 ccagacacat acctcgcatt attgaatgca tatgctgaga agggcgacat tgaccatgtt
541 aagcagactc tggagaaggt ggagaagttc gagcttcacc ttatggaccg tgatttactg
601 caaattattt ttagcttcag taaagctggg tatctcagta tgtctcagaa attttggaaa
661 aagtttacat gtgaaagaag atatattcca gatgcaatga acctcatttt acttttagtc
721 actgaaaaat tggaagatgt agcgttgcaa attttactag catgccccgt atcaaaggaa
781 gatggcccaa gtgtctttgg cagtttcttt ttacaacact gtgtgactat gaatacgcct
841 gtggagaagc taacagacta ctgtaagaag ttaaaggaag tccagatgca ctcctttcct
901 ctgcagttca ccctccattg tgctttactc gccaataaaa ctgatttggc aaaagcctta
961 atgaaggctg tgaaggagga aggttttcct atcagacctc actatttctg gccattgcta
1021 gttggacgtc ggaaggaaaa aaatgttcaa ggtataattg aaatcctcaa aggaatgcaa
1081 gaattgggag tacatcctga tcaggaaaca tatacagatt atgtgattcc atgctttgat
1141 agtgtaaact cagcacgagc cattttgcag gaaaatggat gtctgtctga tagtgatatg
1201 ttttctcaag ctggattgag aagtgaagca gcaaatggga acttagactt tgtattatca
1261 tttttgaaat caaatacatt gcccatctcg ctgcagtcta taagaagtag cctactgcta
1321 ggcttcagga ggtctatgaa tataaatgtt tggagcgaga taacagaatt attgtacaag
1381 gatggacgtt attgccagga gcctcgagga ccgacggaag ctgttggcaa ttttctttat
1441 aacttgattg acagcatgag tgactcagag gtacaggcca aggaggagca tttgagacaa
1501 tacttccatc agctggagaa gatgaatgta aaaattcctg aaaatatcta cagaggcatt
1561 cgtaatctcc tggaaagcta ccatgttcct gaattgatta aggatgctca cttgttggtt
1621 gagcgtaaga atttagactt tcaaaaaact gtgcaactta catcatctga attggagtca
1681 acacttgaaa cactaaaagc tgaaaatcaa cctataagag atgtcctaaa gcaactcata
1741 ttagtgcttt gttcagaaga gaatatgcaa aaagcccttg aattgaaagc aaaatatgaa
1801 tccgacatgg ttactggtgg ctatgcagct ttaataaatt tatgctgtcg acatgataaa
1861 gtagaagatg ccttgaactt gaaagaagaa tttgaccgct tagattcatc tgctgtcctt
1921 gacaccggca actatctagg ccttgtaaga gtattggcaa agcatggcaa gctccaagat
1981 gctattaaga ttctgaagga gatgaaagag aaggatgttc ttatcaaaga tacaacagcc
2041 ttgtcctttt tccacatgct aaatggcgca gctttaagag gtgaaattga aacagtaaaa
2101 cagttgcatg aagccatcgt gactctaggg ttagcagaac catccaccaa cataagtttc
2161 ccattggtca ctgtacactt ggaaaagggc gacctatcta ctgctcttga ggtcgccatt
2221 gactgctatg aaaagtataa agtattacca aggattcatg atgtcttgtg taaactggta
2281 gagaaaggcg agactgatct aattcagaaa gcaatggact ttgtgagcca agaacaaggt
2341 gaaatggtga tgctctatga tctcttcttt gccttcctac aaacaggaaa ttacaaagag
2401 gccaagaaga tcattgagac tccagggatt agagctcgat ctgcaaggct tcagtggttt
2461 tgtgacagat gtgttgcaaa taatcaggtt gaaactctgg aaaaattagt ggagctgaca
2521 cagaagctat ttgaatgtga tagagaccag atgtactaca atctgctaaa actgtataaa
2581 ataaacggtg actggcaaag agctgatgca gtctggaata aaatccaaga agaaaatgtt
2641 attcctcgtg aaaagacatt aagattatta gcagaaatcc ttagagaggg taaccaggaa
2701 gttccgtttg acgtacctga gttgtggtat gaagatgaaa aacattccct gaattcttcg
2761 tcagcctcaa ccacagaacc tgatttccag aaagatatat tgattgcctg ccgattgaac
2821 caaaaaaaag gggcatatga tattttcctg aatgcaaaag agcaaaacat tgtgtttaat
2881 gctgaaacct acagcaatct cattaaatta ctgatgtcag aagattattt tacacaagca
2941 atggaagtga aagcattcgc ggagacccac atcaagggct tcacactgaa cgatgctgcc
3001 aacagccgcc tcatcataac gcaagttagg cgggattatt tgaaagaggc tgtgacaaca
3061 ctgaaaacag tattggatca gcagcagacc ccttctaggt tagcagtgac ccgtgtcatc
3121 caggcattgg ccatgaaggg tgatgttgaa aacatagaag tagttcagaa gatgttaaat
3181 ggactcgaag actccattgg actttcaaaa atggttttca tcaataacat tgctttggct
3241 caaataaaga ataataacat agatgccgca atagaaaaca ttgaaaatat gcttacttca
3301 gagaataaag tcattgaacc ccaatacttc ggcttggcat acttattcag aaaagtaata
3361 gaggagcagt tggaaccagc agttgaaaag ataagcatca tggcggagag attggccaat
3421 cagtttgcaa tttataaacc tgtcactgat tttttccttc aacttgtgga tgcaggcaag
3481 gtggatgatg ccagagctct cctacagaga tgtggtgcaa ttgctgaaca aaccccgatt
3541 ttgttgttgt tcctccttag gaattctagg aaacaaggaa aggcatcaac tgtgaaatct
3601 gtgttagaat tgattcctga attaaatgaa aaggaagaag catacaattc cctcatgaaa
3661 agctatgtct cagagaaaga tgtcacatct gctaaagcac tgtatgaaca tttgactgca
3721 aagaatacaa aattggatga tctgtttcta aagcgttacg catctttgct gaagtatgct
3781 ggagagcctg tccctttcat tgaaccccct gaaagctttg aattttatgc acagcagcta
3841 agaaaattga gggaaaactc ttcttgaaat aaccaggcga tactttgttt tgtatatatt
3901 tgtgattctg tgtctacatg ttattttgaa gtatatctga gggaaaaata aatgaaaatt
3961 ttctttatgt acttatgtat gtgtgatgca tgttcaaagt cttattgacc ataactctgt
4021 gcacttggtt attggacatt tttggagttt tttctctggg aaaaatcgat agtgttttct
4081 tcaatgctgc tgctgtgtga agccatactt ttcaggattc ttccctaatt ggctctttgg
4141 tttccctgct ctgtttcatt tatttcatta aaatgttatt cctttattta agattcactt
4201 attagtctgc tgtttctctg aaaaatttta gagctaggta tagtgaccgt gaacttctaa
4261 cgcataatat ctgtgataca gccattccgt acatgtgtga gtctgcataa ctttcgaact
4321 ttcgaacttt gttaaatgtt ggcactagga gtcatcagat ctaggattca tcattttcca
4381 gtgagaagca gagacccaaa ggcctgttac ttgtgcttgg tcaggggact gtctgtcatg
4441 cctggaggct cttcggcaca cttccccatc tttcccttct gccactgtgg cttcaagcac
4501 ctctgttcat agagcgtctc tgaaattgag tctcggtcat gacttatccc gaagtagagc
4561 aatgtgtttc ctctcattgt agtttcagga ctttgtcagt acaagctctg ccctaggctt
4621 cttactttat actcatatcc tgaaaagatg tgatttcatc tatgaagggg taaaatattg
4681 gtttgtattt aattgtttga aataaaagtg atccctataa aaaaaaaaaa aaaaaaaaaa
4741 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//