LOCUS AH002818 6114 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens FKBP12C (FKBP12) gene, FK506-binding protein 12
(FKBP12) gene, complete cds; and FKBP12A (FKBP12) gene, complete
sequence.
ACCESSION AH002818 M80706 M92422 M92423 M93060
VERSION AH002818.2
KEYWORDS FK506-binding protein 12.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6114)
AUTHORS Maki,N., Sekiguchi,F., Nishimaki,J., Miwa,K., Hayano,T.,
Takahashi,N. and Suzuki,M.
TITLE Complementary DNA encoding the human T-cell FK506-binding protein,
a peptidylprolyl cis-trans isomerase distinct from cyclophilin
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87 (14), 5440-5443 (1990)
PUBMED 1695378
REFERENCE 2 (bases 1 to 6114)
AUTHORS Standaert,R.F., Galat,A., Verdine,G.L. and Schreiber,S.L.
TITLE Molecular cloning and overexpression of the human FK506-binding
protein FKBP
JOURNAL Nature 346 (6285), 671-674 (1990)
PUBMED 1696686
REFERENCE 3 (bases 1 to 6114)
AUTHORS Peattie,D.A.
TITLE The human FKBP12 gene encodes different FKBP12 mRNAs
JOURNAL Unpublished
COMMENT On or before Jun 10, 2016 this sequence version replaced M92422.1,
M92423.1, M93060.1, AH002818.1.
FEATURES Location/Qualifiers
source 1..6114
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/sex="male"
/tissue_type="placenta"
/note="caucasian"
gene 299..>6114
/gene="FKBP12"
mRNA join(299..365,446..493,1206..1318,4567..4731,5537..>6113)
/gene="FKBP12"
/product="FKBP12B"
/note="alternate mRNA"
mRNA join(299..365,446..493,1206..1318,4567..4731,5537..5747)
/gene="FKBP12"
/product="FKBP12C"
/note="alternate mRNA"
mRNA join(299..365,446..493,1206..1318,4567..5069)
/gene="FKBP12"
/product="FKBP12A"
/note="alternate mRNA"
exon 299..365
/gene="FKBP12"
/number=1
5'UTR 299..328
/gene="FKBP12"
CDS join(329..365,446..493,1206..1318,4567..4695)
/gene="FKBP12"
/note="three mRNA's (FKBP12A, FKBP12B and FKBP12C) code
for this cds. The cds has been reported by Peattie et al.
1992, Maki et al. 1990 and Standaert et al., 1990)"
/citation=[1]
/citation=[2]
/citation=[3]
/codon_start=1
/product="FK506-binding protein 12"
/protein_id="AAA58476.1"
/translation="MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRN
KPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDV
ELLKLE"
intron 366..445
/gene="FKBP12"
/number=1
exon 446..493
/gene="FKBP12"
/number=2
intron 494..>748
/gene="FKBP12"
/note="9.4 Kb gap"
/number=2
gap 749..848
/estimated_length=unknown
intron <849..1205
/gene="FKBP12"
/note="9.4 Kb gap"
/number=2
exon 1206..1318
/gene="FKBP12"
/number=3
intron 1319..4566
/gene="FKBP12"
/number=3
exon 4567..5069
/gene="FKBP12"
/note="FKBP12A alternate"
/number=4A
exon 4567..4731
/gene="FKBP12"
/note="FKBP12B and FKBP12C alternate"
/number=4
3'UTR 4696..5069
/gene="FKBP12"
/note="3'UTR for FKBP12A"
misc_feature 4731^4732
/gene="FKBP12"
/note="3'splice site for FKBP12B and FKBP12C mRNA's"
3'UTR join(4732..5069,5537..>6114)
/gene="FKBP12"
/note="FKBP12B 3'UTR"
3'UTR join(4732..5069,5537..5747)
/gene="FKBP12"
/note="FKBP12C 3'UTR"
intron 4732..>5069
/gene="FKBP12"
/note="intron for alternate mRNA's FKBP12B and FKBP12C;
1.5 Kb gap"
/number=4
polyA_site 5069
/gene="FKBP12"
/note="for FKBP12A"
gap 5070..5169
/estimated_length=unknown
intron <5170..5536
/gene="FKBP12"
/note="intron for alternate mRNA's FKBP12B and FKBP12C;
1.5 Kb gap"
/number=4
exon 5537..>6114
/gene="FKBP12"
/note="alternate for FKBP12B"
/number=5B
exon 5537..5747
/gene="FKBP12"
/note="alternate for FKBP12C"
/number=5C
polyA_site 5747
/gene="FKBP12"
/note="polyA site for FKBP12B is 518 bases downstream of
the last base of this sequence (as defined by Maki et al.
1990); polyA site for FKBP12C (as defined by Standaert et
al., 1990)"
/citation=[1]
/citation=[2]
BASE COUNT 1431 a 1332 c 1446 g 1705 t
ORIGIN
1 ttctttgggc agggagtctt aaccggctgg aacacagagg aagggcagga gaacgaagca
61 agtcacccgg caaacacagc tgtatccgga ggcctccggg cttccggagg tctcggggct
121 tctgggcttc cggtccctct tccggaggcc tgggtttccg ggacgtcgcg cgccgtgtgg
181 ggcgcgcacg cagggctggg cgtgaggggg cgtgcgcgtg cgcaggcgac gcgccgaggt
241 actaggcaga gccgtggaac cgccgccagg tcgctgttgg tccacgccgc ccgtcgcgcc
301 gcccgcccgc tcagcgtccg ccgccgccat gggagtgcag gtggaaacca tctccccagg
361 agacggtgag tagtggcgcg cggcggctcg gagtacctct gccgccgcgc gcatcggctc
421 agcatgcccg tctctgtctc ctcagggcgc accttcccca agcgcggcca gacctgcgtg
481 gtgcactaca ccggtgagtc gggggcccag cggggagggg gcccgggccg cagtccgcag
541 cccgggtgcg gctggccgtc gaggcctggg ggcccggggc ctggggtccg gggcgtggcg
601 gcggcgaggt ccgcatggcc cgaggctgag gcctgggcgg tggctcaggg gcagcctggg
661 gcttgcggaa cccgggcggg tctgaatcgg cggctgtgag cgtcggctgc ggctaggtgt
721 tatctgaccc gtcagagcat ttctgcacnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
841 nnnnnnnngg gaccacagtt atttttagct ggggagaaaa tccacggggt gctgggagag
901 tcagggcagg aggaagttta tactccccat ctccagaaga aggtggactg ccgctcatct
961 ctggtacgcg gggtcctttt gtagtcgagt tattgcttgg agtcagggaa gagcattcac
1021 aggtctggag taggactgtc gcaactcctt agatgtccag tgaggtcaca ggaaaccctc
1081 cctagatact gcagttcctg ccagactctt cagcactggc atctctgatg agtgctctgc
1141 tgctggtttc tgacttgtct tgtgtcatta ctctgctgct catgttacag tggtcttttt
1201 cacagggatg cttgaagatg gaaagaaatt tgattcctcc cgggacagaa acaagccctt
1261 taagtttatg ctaggcaagc aggaggtgat ccgaggctgg gaagaagggg ttgcccaggt
1321 atgctctctc atttgttttg ttttgctttc tagtatttac cttttatatt tttttatagg
1381 tggcatattt atacggttca aaaataaaaa aagtgaaaag tctcaccctc atgccatccc
1441 atctgaccaa tacccccaca agaagctcct gttgttaatg tttcttgtac tgtggtttaa
1501 gcacatataa aaacataact ttttttcttg ctttcacaca catactgttt tgcagtttac
1561 tttttcactt aatgcatttt tgacacttgc aataccacta cataaaagag gagtaggctg
1621 ggcgcggtgg ctcatgcctg taattccagc actttgggag gccaagatgg gtggatcacc
1681 tgaggtcagg agttcctgta atcccagcac tttgggaggc caagatggat ggatcacctg
1741 aggtccggag tttgagacca gcctggccaa catggcgaaa ccccatctcc attaaaaata
1801 caaaaattag ccgggcgtgg tggcaggtgc ctgtaatccc agctacttgg gaggccgagg
1861 caggagaatc acttgaaccc agcaggcgga ggttgtagtg agccaagatt gtgccattgc
1921 gctccagcct ggatgacgag agcgaaactc catttcaaaa aagaaagaaa aaatgaggag
1981 taagctctgt tacagctgcc tagtattcgt ttatgtaagt gtgctataat ttacttggct
2041 agtgccctat taatgagtat ttgagtcatt tccagtattt tgctattata aacaatgctg
2101 cagtaactca ccttgtacag acttcatttt ccacgtgtgc acatgttgcc ataggactta
2161 ctctcagaag tgggatgagg ggctcaaaag ctgtgtgtag tgtttttgag aggtcttgtc
2221 aagttaccat ctctaggggt tgcactctgg actgccacca ccaggctata aaggtgcaat
2281 ctcctcccag ccccagcatc acagtatatt gttaaatctt tggcctctgg acaataagag
2341 taaaacatga tatcagtggt tttaatttgt atttatctat tacccatatt gtgtgagacc
2401 acttctgaga cgtcatactt atggagaaag tcatttcgtt tgtcttgagt gtgtttccta
2461 atctctttcc tccccatttg tggaaacagc ttttgttctg ccaacactac aaaattccca
2521 ggagacaata gggacccagg gttgccaaat tttagttgga ttctgtcttt ccatcaaacc
2581 taggaatttt ttcttggctc taaccaggta aagggatgtt tttcagtgac ctgagaccca
2641 aggaacttta taattaggct ctgcatgatg ggtaattagt ctgcttccct ctcacccagg
2701 agaattagaa atttaaccaa gatgaaaaga cagatttctg tctctctctt ttccagaata
2761 cacattgctc tacttcctct ataaaatatc actgatttat ctccaaataa actgctcaac
2821 tttcaggaac ttgaagccat cccactccca ggtgtctggg tttctgttcc tgcagggcag
2881 agggttggca gtgtgaggaa gaggctttgt agtttacttc ccttgggaaa ccttgccaac
2941 catagctttt tgcctctgtc tccctagtct gtctggctct tggatctgta gcccatcccc
3001 catctttcat gccagccatt gttcatacca caacccatct tctgtgactg ctccagcatt
3061 ggaacaatca ctgcgttgta tgtactgagt gctgtatctg ccatcgagat agtgttatcg
3121 gcctacttca cttcccaggc ttggagaggc atggtcgagt attggacaga tgcctactcc
3181 ccctttaact ggtattttgg ggtcagtcac agccctgtca tttgtgagaa gtctgggtag
3241 tttgagatct acataaaata tcttttaaat tcttcatagc atattttttc accaagtgag
3301 ttaaaaacac aggaagaagg ggagattgac ttgtgaccct tttcctttcc ttttgatatt
3361 gttttggttt tacatgtttg caggcgtgga gtcctgcctg ccacaaggac cattttggca
3421 gctttctttc atccatcttg gacatctttt catgttaata catttaaagc caccactata
3481 tgatttctca tgactaatcc ctggtgtgga tatgcctatg aaaccactcc ttctgtgatg
3541 gacttttgag ttgttagcag aatattctgg aaatagaatt gctgagtcaa ggaatatgat
3601 tgttttgaat tgtacaaggt aaagccatac ctcactatcc ttaccacctt ggtccaacat
3661 gtcccagctt ctgaggggag caaggactag acgcttcaca gcctggagct tcctctttat
3721 tcatcctctg tctggtggag ttggaaagtc gggaacatac acatggagac caaaagcaga
3781 gataagtcaa aggatggaaa tactgcagag aacctgctca ctgttcagaa agtagatatt
3841 ttatacttat ttgtgtattt aatttgaaac tgaaaatata cacaaatata ttttttaaag
3901 tagaaatctc tccttactgg tcactcacta tccatactgt tctcctcaca gcaaatgtct
3961 ggtatgtcct tccaaagatg ttttctgttg taggcatatc aatattttca caaatggtat
4021 tcagtaaatg ctattttgta gcccagaaaa tcatattgtc ttttttgaag ttttcctata
4081 tgggtaaaag agtataaata gaaaaaatac agaaaaaata gactaccctc aagtattact
4141 tcctgtgtat atattttttt aaagcaaagt tgagtattcc tttttcaaga agagcataga
4201 tggcacttaa catgtccttt aagtgacaga tcactgaagg ggactaggtg gtgagacatc
4261 tggaatgtta cctgcctagc attagtcatt aagacttgcg tagaaggttg agggcctgac
4321 cgttctgaga gtcaggaggg gttttgaact gccattgggc tcttggagtg agatgcaggg
4381 gtgatggaat atgactgcca acctccaagt cctgcacaag gaggtggtga tgcctgggca
4441 gctgcaaagt cactggaaag tcaataccat cctggccaag gaacacctag gtaaacagct
4501 ctttttctta cagagacagt tggggcatgt gtccagctga gtctgtcttc cttgttcttt
4561 tcacagatga gtgtgggtca gagagccaaa ctgactatat ctccagatta tgcctatggt
4621 gccactgggc acccaggcat catcccacca catgccactc tcgtcttcga tgtggagctt
4681 ctaaaactgg aatgacagga atggcctcct cccttagctc cctgttcttg ggtaaggaaa
4741 tggaatactg aagggccctt cactgccttt gctcctccca tgttatgccc agcgtttgat
4801 gggtagcaga gagaacaaaa aacaccacaa ggctattttt ccccctgcat tctttctgta
4861 ttgagtatcc tttcagtgtt attagtgtat gctttgaatg taaaaattgg tcaccctaag
4921 gaaaggaatt ggcatgtgta tgttccagtt caactcatgg agatggcagc tgtttaaatg
4981 tttttctatg tagtttataa attaaaactg aattgaggac tatggaaatg taggccaaat
5041 ttgtagtgcc aacattttag ttctttggan nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5161 nnnnnnnnna aataagactc ttaatgaatg actttgttct accctgtgtt tctagaagct
5221 agagggggaa aaaaaaaccc tttggatatg aatatcatgt cctagcttct gcggctctct
5281 cttcactgtg gtttgtggtt actgcctatt agatggtatg agggaggcat tcctgcatcg
5341 gtccacctgc tcagggtcca cacccaggac acttgaggcc ccaggcagct tatcagtgag
5401 tgaagtggaa aaatgaagtc cagaggatgc ttgtgaagtt gaaggatgct cttagatcag
5461 acagttctag gagggcgcca ctgcacacaa agaacactga gttgctggaa actcacagat
5521 tttctgtccc caacagatct gccgtggagg gatctggtgc ctccagacat gtgcacatga
5581 gtccatatgg agcttttcct gatgttccac tccactttgt atagacatct gccctgactg
5641 aatgtgttct gtcactcagc tttgcttccg acacctctgt ttcctcttcc cctttctcct
5701 cgtatgtgtg tttacctaaa ctatatgcca taaacctcaa gttattcatt ttattttgtt
5761 ttcattttgg ggtgaagatt cagtttcagt cttttggata taggtttcca attaagtaca
5821 tggtcaagta ttaacagcac aagtggtagg ttaacattag aataggaatt ggtgttgggg
5881 ggggggtttg caagaatatt ttattttaat tttttggatg aaatttttat ctattatata
5941 ttaaacattc ttgctgctgc gctgcaaagc catagcagat ttgaggcgct gttgaggact
6001 gaattactct ccaagttgag agatgtcttt gggttaaatt aaaagcccta cctaaaactg
6061 aggtggggat ggggagagcc tttgcctcca ccattcccac ccaccctccc ctta
//