LOCUS HUMBP180AA 4669 bp mRNA linear HUM 07-MAY-1993
DEFINITION Human Bullous pemphigoid autoantigen BP180 gene, 3' end.
ACCESSION M91669
VERSION M91669.1
KEYWORDS BP180 autoantigen; autoantigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4669)
AUTHORS Giudice,G.J., Emery,D.J. and Diaz,L.A.
TITLE Cloning and primary structural analysis of the bullous pemphigoid
autoantigen BP180
JOURNAL J. Invest. Dermatol. 99 (3), 243-250 (1992)
PUBMED 1324962
COMMENT Original source text: Homo sapiens (library: lambda gt11, Clonetech
Lab., Inc.,) neonatal foreskin cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..4669
/db_xref="H-InvDB:HIT000196811"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Giesma band"
/cell_type="keratinocyte"
/tissue_type="foreskin"
/dev_stage="neonatal"
/tissue_lib="lambda gt11, Clonetech Lab., Inc."
gene 1..4669
/gene="BP180"
CDS <1..4599
/gene="BP180"
/standard_name="BP180 autoantigen"
/note="(1504..1572) transmembrane domain; (1804..4550)
collagenous domain"
/codon_start=1
/product="autoantigen"
/protein_id="AAA35605.1"
/translation="PLQISRRKHQEKKERGGFIQSCFQFLQNLKPGGYGMDVTKKNKR
DGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTASLGGGSRLEKQSLTHGSSGYINS
TGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKTHVTRHAYEGSSSGNSSPEYPRKE
FASSSTRGRSQTRESEIRVRLQSASPSTRWTELDDVKRLLKGSRSASVSPTRNSSNTL
PIPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTTQ
SSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLSTSSSVFGMQNNLAPSLTTLSHGTT
TTSTAYGVKKNMPQSPAAVNTGVSTSAACTTSVQSDDLLHKDCKFLILEKDNTPAKKE
MELLIMTKDSGKVFTASPASIAATSFSEDTLKKEKQAAYNADSGLKAEANGDLKTVST
KGKTTTADIHSYSSSGGGGSGGGGGVGGAGGGPWGPAPAWCPCGSCCSWWKWLLGLLL
TWLLLLGLLFGLIALAEEVRKLKARVDELERIRRSILPYGDSMDRIEKDRLQGMAPAA
GADLDKIGLHSDSQEELWMFVRKKLMMEQENGNLRGSPGPKGDMGSPGPKGDRGFPGT
PGIPGPLGHPGPQGPKGQKGSVGDPGMEGPMGQRGREGPMGPRGEAGPPGSGEKGERG
AAGEPGPHGPPGVPGSVGPKGSSGSPGPQGPPGPVGLQGLRGEVGLPGVKGDKGPMGP
PGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKGAMGPAGPDGHQGPRGEQGLTGMP
GIRGPPGPSGDPGKPGLTGPQGPQGLPGTPGRPGIKGEPGAPGKIVTSEGSSMLTVPG
PPGPPGAMGPPGPPGAPGPAGPAGLPGHQEVLNLQGPPGPPGPRGPPGPSIPGPPGPR
GPPGEGLPGPPGPPGSFLSNSETFLFGPPGPPGPPGPKGDQGPPGPRGHQGEQGLPGF
STSGSSSFGLNLQGPPGPPGPQGPKGDKGDPGVPGALGIPSGPSEGGSSSTMYVSGPP
GPPGPPGPPGSISSSGQEIQQYISEYMQSDSIRSYLSGVQGPPGPPGPPGPVTTITGE
TFDYSELASHVVSYLRTSGYGVSLFSSSISSEDILAVLQRDDVRQYLRQYLMGPRGPP
GPPGASGDGSLLSLDYAELSSRILSYMSSSGISIGLPGPPGPPGLPGTSYEELLSLLR
GSEFRGIVGPPGPPGPPGIPGNVWSSISVEDLSSYLHTAGLSFIPGPPGPPGPPGPRG
PPGVSGALATYAAENSDSFRSELISYLTSPDVRSFIVGPPGPPGPQGPPGDSRLLSTD
ASHSRGSSSSSHSSSVRRGSSYSSSMSTGGGGAGSLGAGGAFGEAAGDRGPYGTDIGP
GGGYGAAAEGGMYAGNGGLLGADFAGDLDYNELAVRVSESMQRQGLLQGMAYTVQGPP
GQPGPQGPPGISKVFSAYSNVTADLMDFFQTYGAIQGPPGQKGEMGTPGPKGDRGPAG
PPGHPGPPGPRGHKGEKGDKGDQVYAGRRRRRSIAVKP"
BASE COUNT 1072 a 1402 c 1350 g 845 t
ORIGIN
1 ccgctgcaaa tttctagaag aaaacatcag gagaagaaag agagaggggg atttattcaa
61 agttgtttcc aattccttca aaacctcaaa ccaggtggct atggtatgga tgtaaccaag
121 aaaaacaaac gagatggaac tgaagtcact gagagaattg tcactgaaac agtaaccaca
181 agacttacat ccttaccacc aaaaggcggg accagcaatg gctatgctaa aacagcctct
241 cttggtggag ggagccggct ggagaaacaa agcctgactc atggcagcag cggctacata
301 aactcaactg gaagcacacg aggccatgcc tccacctcta gttacaggag ggctcactca
361 cctgcctcca ctctgcccaa ctccccaggc tcaacctttg aaaggaaaac tcacgttacc
421 cgccatgcgt atgaagggag ctccagtggc aactcttctc cggagtaccc tcggaaggaa
481 tttgcatctt cttcaaccag aggacggagt caaacacgag agagtgaaat tcgagttcga
541 ctgcagagtg cgtccccatc cacccgatgg acagaattgg atgatgttaa gcgtttgctc
601 aaggggagtc gatcggcaag tgtgagcccc acccggaatt cctccaacac actccccatc
661 cccaagaaag gcactgtgga gaccaaaatt gtgacagcga gctcccagtc ggtgtcaggc
721 acctacgatg caacgatcct ggatgccaac cttccctccc atgtgtggtc ctccaccctg
781 cccgcggggt cctccatggg gacctatcac aacaacatga caacccagag ctcatccctc
841 ctcaacacca atgcctactc tgcgggatca gtcttcggag ttccaaacaa catggcgtcc
901 tgctcaccca ctttgcaccc tggactcagc acatcctcct cagtgtttgg catgcagaac
961 aatctggccc ccagcttgac caccctgtcc catggcacca ccaccacttc cacagcatat
1021 ggggtgaaga aaaacatgcc ccagagtcct gcggctgtga acactggcgt ttccacctcc
1081 gccgcctgca ccacaagtgt gcagagcgat gaccttttgc acaaggactg caagttcctg
1141 atcctagaga aagacaacac acctgctaag aaggagatgg agctgctcat catgaccaag
1201 gacagcggga aggtctttac agcctcccct gccagcatcg ctgcaacttc tttttcagaa
1261 gacaccctaa aaaaagaaaa gcaagctgcc tacaatgctg actcaggcct aaaagccgaa
1321 gctaatggag acctgaagac tgtgtccaca aagggcaaga ccaccactgc agatatccac
1381 agctacagca gcagtggtgg tggtggcagt ggaggaggtg gcggtgttgg tggcgctggc
1441 ggcggccctt ggggaccagc gccagcctgg tgcccctgcg gctcctgctg cagctggtgg
1501 aagtggctgc tgggcctgct gctcacctgg ctgctactcc tggggctgct cttcggcctc
1561 attgctctgg cggaggaggt gaggaagctg aaggcgcgtg tggatgagct ggagaggatc
1621 aggaggagca tactgcccta tggggacagc atggatagaa tagaaaagga ccgcctccag
1681 ggcatggcac ccgcggcggg agcagacctg gacaaaattg ggctgcacag tgacagccag
1741 gaggagctct ggatgttcgt gaggaagaag ctaatgatgg aacaggaaaa tggaaatctc
1801 cgaggaagcc ctggccctaa aggtgacatg ggaagtccag gccctaaagg agatcgaggg
1861 ttccctggga ctccaggtat ccctgggccc ttgggccacc caggtccaca aggaccaaag
1921 ggtcaaaaag gcagcgtggg agatcctggc atggaaggcc ccatgggcca gagagggcga
1981 gaaggcccca tgggacctcg tggtgaggca gggcctcctg gatctggaga gaaaggggaa
2041 agaggggctg ctggtgaacc aggtcctcat ggcccacctg gtgtcccagg ttctgtgggt
2101 cccaaaggtt ccagcggctc tcctggccca cagggccctc caggtcctgt aggtctccaa
2161 gggctccgag gtgaagtagg acttcctggt gtcaaaggtg acaaaggacc aatgggacca
2221 ccaggaccca aaggtgacca gggtgagaaa ggacctcgag gcctcacagg cgagcctggc
2281 atgagaggtt tgcctggtgc tgttggtgag cccggggcta aaggagcaat gggtcctgct
2341 ggcccagacg gacaccaagg cccaagaggt gaacaaggtc ttactgggat gcctggaatc
2401 cgtggcccac caggaccttc tggagaccca ggaaagccag gtctcacagg accccaggga
2461 cctcagggac ttcccggtac ccctggccga ccaggaataa aaggtgaacc aggagctcca
2521 ggcaagatcg tgacttcgga ggggtcatcg atgctcactg tcccaggccc cccaggacct
2581 cctggagcca tgggaccccc aggacctcca ggtgccccag gccctgccgg cccagctggt
2641 ctcccaggac atcaagaagt tcttaattta caaggtcccc caggcccacc cggcccacgt
2701 gggccaccag ggccttccat tccaggccca ccaggacccc gaggcccacc aggggagggt
2761 ttgccaggcc caccaggccc accaggatcg ttcctgtcca actcagaaac cttcctcttc
2821 ggccccccag gcccacctgg ccccccaggt cccaagggag accaaggtcc cccaggcccc
2881 agaggacacc aaggcgagca aggcctccca ggtttctcaa cctcagggtc cagttctttc
2941 ggactcaacc ttcagggacc accaggccca cctggccccc agggaccaaa aggtgacaaa
3001 ggtgatccgg gtgttccagg ggctcttggc attcctagtg gtccttctga agggggatca
3061 tcaagtacca tgtacgtgtc aggcccgcca gggccccctg ggccccctgg gcctccgggc
3121 tctatcagca gctctggcca ggagattcag cagtacatct ctgagtacat gcagagtgac
3181 agtattagat cttacctatc cggagttcag ggtcccccag gcccacctgg tcccccagga
3241 cctgtcacca ccatcacagg cgagactttc gactactcag agctggcaag ccacgttgtg
3301 agctacttac ggacttcggg gtacggtgtc agcttgttct cgtcctccat ctcttctgaa
3361 gacatcctgg ctgtgctgca gcgggatgac gtgcgtcagt acctacgtca gtacttgatg
3421 ggccctcggg gtccgccagg gccaccagga gccagtggag atgggtccct cctgtctttg
3481 gactatgcag agctgagtag tcgcattctc agctacatgt cgagttctgg gatcagcatt
3541 gggcttcctg gtcccccggg gccccctggc ttgccgggaa cctcctatga ggagctcctc
3601 tccttgctgc gagggtctga attcagaggc atcgttggac ccccaggtcc cccgggtcca
3661 ccagggatcc caggcaatgt gtggtccagc atcagcgtgg aggacctctc gtcttactta
3721 catactgccg gcttgtcatt catcccaggc cctccaggac ctcctggtcc cccagggcct
3781 cgagggcccc cgggtgtctc aggagccctg gcaacctatg cagctgaaaa cagcgacagc
3841 ttccggagcg agctgatcag ctacctcaca agtcctgatg tgcgcagctt cattgttggc
3901 cccccaggcc ctcctgggcc gcagggaccc cctggggaca gccgcctcct gtccacggat
3961 gcctcccaca gtcggggtag cagctcctcc tcacacagct catctgtcag gcggggcagc
4021 tcctacagct cttccatgag cacaggagga ggtggtgcag gctccctggg tgcaggcggt
4081 gcctttggtg aagctgcagg agacaggggt ccctatggca ctgacatcgg cccaggcgga
4141 ggctatgggg cagcagcaga aggcggcatg tatgctggca atggcggact attgggagct
4201 gactttgctg gagatctgga ttacaatgag ctggctgtga gggtgtcaga gagcatgcag
4261 cgtcagggcc tactgcaagg gatggcctac actgtccagg gcccaccagg ccagcctggg
4321 ccacaggggc cacccggcat cagcaaggtc ttctctgcct acagcaacgt gactgcggac
4381 ctcatggact tcttccaaac ttatggagcc attcaaggac cccctgggca aaaaggagag
4441 atgggcactc caggacccaa aggtgacagg ggccctgctg ggccaccagg tcatcctggg
4501 ccacctggcc ctcgaggaca caagggagaa aaaggagaca aaggtgacca agtctatgct
4561 gggcggagaa ggagaagaag tattgctgtc aagccgtgag ctagccatgg caggacagct
4621 cctggaccag gtctcataat gcatgtggca cttaggtcca aggtctcca
//