LOCUS       HUMNACH                 5389 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human voltage-gated sodium channel mRNA, complete cds.
ACCESSION   M91556
VERSION     M91556.1
KEYWORDS    Na+ channel; sodium channel.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5389)
  AUTHORS   George,A.L. Jr., Knittle,T.J. and Tamkun,M.M.
  TITLE     Molecular cloning of an atypical voltage-gated sodium channel
            expressed in human heart and uterus: evidence for a distinct gene
            family
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (11), 4893-4897 (1992)
   PUBMED   1317577
COMMENT     Original source text: Homo sapiens (tissue library: of M.Tamkun)
            ventricular heart muscle cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..5389
                     /db_xref="H-InvDB:HIT000196807"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="ventricular heart muscle"
                     /tissue_lib="of M.Tamkun"
     gene            1..5389
                     /gene="Na+ channel"
     CDS             140..5188
                     /gene="Na+ channel"
                     /codon_start=1
                     /product="Na+ channel"
                     /protein_id="AAA59899.1"
                     /translation="MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPNPDL
                     EVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLS
                     PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEIL
                     VKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIP
                     LNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN
                     ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFT
                     NFDSFGWALFALFRLMAQDYPEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGI
                     LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSL
                     DVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTD
                     LFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ
                     VGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSW
                     VALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVF
                     RILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAE
                     ENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSEL
                     SNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSK
                     SGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGAS
                     KKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYIDQRKTIKILLEYAD
                     MIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMK
                     FLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECI
                     DPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWIT
                     IMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLG
                     GSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLIC
                     FQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM
                     VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLP
                     ALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGW
                     DGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVV
                     VMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMA
                     KPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFK
                     ITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAY
                     FDKAKEKSPIQSQI"
BASE COUNT         1642 a          961 c         1074 g         1712 t
ORIGIN      
        1 gcggccgcgc aagtcctcca ccatgtgaat gccaacatgg ccaggtcatt agagctgagg
       61 gaaaactagt gcccaaagat atgaaaagag tgtggatctt ctggagaagt gctgttgttc
      121 aacaggtaca aaattggaaa tgttggcttc accagaacct aagggccttg ttcccttcac
      181 taaagagtct tttgaactta taaaacagca tattgctaaa acacataatg aagaccatga
      241 agaagaagac ttaaagccaa atcctgattt ggaagttggc aaaaagcttc catttattta
      301 tggaaacctt tctcaaggaa tggtgtcaga gcccttggaa gatgtggacc catattacta
      361 caagaaaaaa aatactttca tagtattaaa taaaaataga acaatcttca gattcaatgc
      421 ggcttccatc ttgtgtacat tgtctccttt caattgtatt agaagaacaa ctatcaaggt
      481 tttggtacat ccctttttcc aactgtttat tctaattagt gtcctgattg attgcgtatt
      541 catgtccctg actaatttgc caaaatggag accagtatta gagaatactt tgcttggaat
      601 ttacacattt gaaatacttg taaaactctt tgcaagaggt gtctgggcag gatcattttc
      661 cttcctcggt gatccatgga actggctcga tttcagcgta actgtgtttg aggttattat
      721 aagatactca cctctggact tcattccaac gcttcaaact gcaagaactt tgagaatttt
      781 aaaaattatt cctttaaatc aaggtctgaa atcccttgta ggggtcctga tccactgctt
      841 gaagcagctt attggtgtca ttatcctaac tctgtttttt ctgagcatat tttctctaat
      901 tgggatgggg ctcttcatgg gcaacttgaa acacaaatgt tttcgatggc cccaagagaa
      961 tgaaaatgaa accctgcaca acagaactgg aaacccatat tatattcgag aaacagaaaa
     1021 cttttattat ttggaaggag aaagatatgc tctcctttgt ggcaacagga cagatgctgg
     1081 tcagtgtcct gaaggatatg tgtgtgtaaa agctggcata aatcctgatc aaggcttcac
     1141 aaattttgac agttttggct gggccttatt tgccctattt cggttaatgg ctcaggatta
     1201 ccctgaagta ctttatcacc tgatacttta tgcttctggg aaggtctaca tgatattttt
     1261 tgtggtggta agttttttgt tttcctttta tatggcaagt ttgttcttag gcatacttgc
     1321 catggcctat gaagaagaaa agcagagagt tggtgaaata tctaagaaga ttgaaccaaa
     1381 atttcaacag actggaaaag aacttcaaga aggaaatgaa acagatgagg ccaagaccat
     1441 acaaatagaa atgaagaaaa ggtcaccaat ttccacagac acatcattgg atgtgttgga
     1501 agatgctact ctcagacata aggaagaact tgaaaaatcc aagaagatat gcccattata
     1561 ctggtataag tttgctaaaa ctttcttgat ctggaattgt tctccctgtt ggttaaaatt
     1621 gaaagagttt gtccatagga ttataatggc accatttact gatcttttcc ttatcatatg
     1681 cataatttta aacgtatgtt ttctgacctt ggagcattat ccaatgagta aacaaactaa
     1741 cactcttctc aacattggaa acctggtttt cattggaatt ttcacagcag aaatgatttt
     1801 taaaataatt gcaatgcatc catatgggta tttccaagta ggttggaaca tttttgatag
     1861 catgatagtg ttccatggtt taatagaact ttgtctagca aatgttgcag gaatggctct
     1921 tcttcgatta ttcaggatgt taagaatttt caagttggga aagtattggc caacattcca
     1981 gattttgatg tggtctctta gtaactcatg ggtggccctg aaagacttgg tcctgttgtt
     2041 gttcacattc atcttctttt ctgctgcatt cggcatgaag ctgtttggta agaattatga
     2101 agaatttgtc tgccacatag acaaagactg tcaactccca cgctggcaca tgcatgactt
     2161 tttccactcc ttcctgaatg tgttccgaat tctctgtgga gagtgggtag agaccttgtg
     2221 ggactgtatg gaggttgcag gccaatcctg gtgtattcct ttttacctga tggtcatttt
     2281 aattggaaat ttactggtac tttacctgtt tctggcattg gtgagctcat ttagttcatg
     2341 caaggatgta acagctgaag agaataatga agcaaaaaat ctccagcttg cagtggcaag
     2401 aattaaaaaa ggaataaact atgtgcttct taaaatacta tgcaaaacac aaaatgtccc
     2461 aaaggacaca atggaccatg taaatgaggt atatgttaaa gaagatattt ctgaccatac
     2521 cctttctgaa ttgagcaaca cccaagattt tctcaaagat aaggaaaaaa gcagtggcac
     2581 agagaaaaac gctactgaaa atgagagcca atcacttatc cccagtccta gtgtctcaga
     2641 aactgtacca attgcttcag gagaatctga tatagaaaat ctggataata aggagattca
     2701 gagtaagtct ggtgatggag gcagcaaaga gaaaataaag caatctagct catctgaatg
     2761 cagtactgtt gatattgcta tctctgaaga agaagaaatg ttctatggag gtgaaagatc
     2821 aaagcatctg aaaaatggtt gcagacgcgg atcttcactt ggtcaaatca gtggagcatc
     2881 caagaaagga aaaatctggc agaacatcag gaaaacctgc tgcaagattg tagagaacaa
     2941 ttggtttaag tgttttattg ggcttgttac tctgctcagc actggcactc tggcttttga
     3001 agatatatat attgatcaga gaaagacaat taaaatttta ttagaatatg ctgacatgat
     3061 ctttacttat atcttcattc tggaaatgct tctaaaatgg atggcatatg gttttaaggc
     3121 ctatttctct aatggctggt acaggctgga cttcgtggtt gttattgtgt tttgtcttag
     3181 cttaataggc aaaactcggg aagaactaaa acctcttatt tccatgaaat tccttcggcc
     3241 cctcagagtt ctatctcaat ttgaaagaat gaaggtggtt gtgagagctt tgatcaaaac
     3301 aaccttaccc actttgaatg tgtttcttgt ctgcctgatg atctggctga tttttagtat
     3361 catgggagta gacttatttg ctggcagatt ctatgaatgc attgacccaa caagtggaga
     3421 aaggtttcct tcatctgaag tcatgaataa gagtcggtgt gaaagccttc tgtttaacga
     3481 atccatgcta tgggaaaatg caaaaatgaa ctttgataat gttggaaatg gtttcctttc
     3541 tctgcttcaa gtagcaacat ttaatggatg gatcactatt atgaattcag caattgattc
     3601 tgttgctgtt aatatacagc ctcattttga agtcaacatc tacatgtatt gttactttat
     3661 caactttatt atatttggag tatttctccc tctgagtatg ctgattactg ttattattga
     3721 taatttcaac aagcataaaa taaagctggg aggctcaaat atctttataa cggttaaaca
     3781 gagaaaacag taccgcaggc tgaagaagct aatgtatgag gattctcaaa gaccagtacc
     3841 tcgcccatta aacaagctcc aaggattcat ctttgatgtg gtaacaagcc aagcttttaa
     3901 tgtcattgtt atggttctta tatgtttcca agcaatagcc atgatgatag acactgatgt
     3961 tcagagtcta caaatgtcca ttgctctcta ctggattaac tcaatttttg ttatgctata
     4021 tactatggaa tgtatactga agctcatcgc tttccgttgt ttttatttca ccattgcgtg
     4081 gaacattttt gattttatgg tggttatttt ctccatcaca ggactatgtc tgcctatgac
     4141 agtaggatcc taccttgtgc ctccttcact tgtgcaactg atacttctct cacggatcat
     4201 tcacatgctg cgtcttggaa aaggaccaaa ggtgtttcat aatctgatgc ttcctttgat
     4261 gctgtccctc ccagcattat tgaacatcat tcttctcatc ttcctggtca tgttcatcta
     4321 tgccgtattt ggaatgtata attttgccta tgttaaaaaa gaagctggaa ttaatgatgt
     4381 gtctaatttt gaaacctttg gcaacagtat gctctgtctt tttcaagttg caatatttgc
     4441 tggttgggat gggatgcttg atgcaatttt caacagtaaa tggtctgact gtgatcctga
     4501 taaaattaac cctgggactc aagttagagg agattgtggg aacccctctg ttgggatttt
     4561 ttattttgtc agttatatcc tcatatcatg gctgatcatt gtaaatatgt acattgttgt
     4621 tgtcatggag tttttaaata ttgcttctaa gaagaaaaac aagaccttga gtgaagatga
     4681 ttttaggaaa ttctttcagg tatggaaaag gtttgatcct gataggaccc agtacataga
     4741 ctctagcaag ctttcagatt ttgcagctgc tcttgatcct cctcttttca tggcaaaacc
     4801 aaacaagggc cagctcattg ctttggacct ccccatggct gttggggaca gaattcattg
     4861 cctcgatatc ttacttgctt ttacaaagag agttatgggt caagatgtga ggatggagaa
     4921 agttgtttca gaaatagaat cagggttttt gttagccaac ccttttaaga tcacatgtga
     4981 gccaattacg actactttga aacgaaaaca agaggcagtt tcagcaacca tcattcaacg
     5041 tgcttataaa aattaccgct tgaggcgaaa tgacaaaaat acatcagata ttcatatgat
     5101 agatggtgac agagatgttc atgctactaa agaaggtgcc tattttgaca aagctaagga
     5161 aaagtcacct attcaaagcc agatctaata ccacttacca cctcttttca tatttcttca
     5221 catatctgaa aaatgttgaa agcctaagcc aggaataaaa gaaaagtaga gataataatc
     5281 agttctttac aaccgatggt aattaagctt gtattcacaa gacttcatgc caaattcact
     5341 ttttagcatt atatctaaca aatcaagaga atccttaata ttgctgcag
//