LOCUS HUMNACH 5389 bp mRNA linear HUM 07-JAN-1995 DEFINITION Human voltage-gated sodium channel mRNA, complete cds. ACCESSION M91556 VERSION M91556.1 KEYWORDS Na+ channel; sodium channel. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 5389) AUTHORS George,A.L. Jr., Knittle,T.J. and Tamkun,M.M. TITLE Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (11), 4893-4897 (1992) PUBMED 1317577 COMMENT Original source text: Homo sapiens (tissue library: of M.Tamkun) ventricular heart muscle cDNA to mRNA. FEATURES Location/Qualifiers source 1..5389 /db_xref="H-InvDB:HIT000196807" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="ventricular heart muscle" /tissue_lib="of M.Tamkun" gene 1..5389 /gene="Na+ channel" CDS 140..5188 /gene="Na+ channel" /codon_start=1 /product="Na+ channel" /protein_id="AAA59899.1" /translation="MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPNPDL EVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLS PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEIL VKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIP LNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFT NFDSFGWALFALFRLMAQDYPEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGI LAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSL DVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTD LFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ VGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSW VALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVF RILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAE ENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSEL SNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSK SGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGAS KKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYIDQRKTIKILLEYAD MIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMK FLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECI DPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWIT IMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLG GSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLIC FQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLP ALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGW DGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVV VMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMA KPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFK ITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAY FDKAKEKSPIQSQI" BASE COUNT 1642 a 961 c 1074 g 1712 t ORIGIN 1 gcggccgcgc aagtcctcca ccatgtgaat gccaacatgg ccaggtcatt agagctgagg 61 gaaaactagt gcccaaagat atgaaaagag tgtggatctt ctggagaagt gctgttgttc 121 aacaggtaca aaattggaaa tgttggcttc accagaacct aagggccttg ttcccttcac 181 taaagagtct tttgaactta taaaacagca tattgctaaa acacataatg aagaccatga 241 agaagaagac ttaaagccaa atcctgattt ggaagttggc aaaaagcttc catttattta 301 tggaaacctt tctcaaggaa tggtgtcaga gcccttggaa gatgtggacc catattacta 361 caagaaaaaa aatactttca tagtattaaa taaaaataga acaatcttca gattcaatgc 421 ggcttccatc ttgtgtacat tgtctccttt caattgtatt agaagaacaa ctatcaaggt 481 tttggtacat ccctttttcc aactgtttat tctaattagt gtcctgattg attgcgtatt 541 catgtccctg actaatttgc caaaatggag accagtatta gagaatactt tgcttggaat 601 ttacacattt gaaatacttg taaaactctt tgcaagaggt gtctgggcag gatcattttc 661 cttcctcggt gatccatgga actggctcga tttcagcgta actgtgtttg aggttattat 721 aagatactca cctctggact tcattccaac gcttcaaact gcaagaactt tgagaatttt 781 aaaaattatt cctttaaatc aaggtctgaa atcccttgta ggggtcctga tccactgctt 841 gaagcagctt attggtgtca ttatcctaac tctgtttttt ctgagcatat tttctctaat 901 tgggatgggg ctcttcatgg gcaacttgaa acacaaatgt tttcgatggc cccaagagaa 961 tgaaaatgaa accctgcaca acagaactgg aaacccatat tatattcgag aaacagaaaa 1021 cttttattat ttggaaggag aaagatatgc tctcctttgt ggcaacagga cagatgctgg 1081 tcagtgtcct gaaggatatg tgtgtgtaaa agctggcata aatcctgatc aaggcttcac 1141 aaattttgac agttttggct gggccttatt tgccctattt cggttaatgg ctcaggatta 1201 ccctgaagta ctttatcacc tgatacttta tgcttctggg aaggtctaca tgatattttt 1261 tgtggtggta agttttttgt tttcctttta tatggcaagt ttgttcttag gcatacttgc 1321 catggcctat gaagaagaaa agcagagagt tggtgaaata tctaagaaga ttgaaccaaa 1381 atttcaacag actggaaaag aacttcaaga aggaaatgaa acagatgagg ccaagaccat 1441 acaaatagaa atgaagaaaa ggtcaccaat ttccacagac acatcattgg atgtgttgga 1501 agatgctact ctcagacata aggaagaact tgaaaaatcc aagaagatat gcccattata 1561 ctggtataag tttgctaaaa ctttcttgat ctggaattgt tctccctgtt ggttaaaatt 1621 gaaagagttt gtccatagga ttataatggc accatttact gatcttttcc ttatcatatg 1681 cataatttta aacgtatgtt ttctgacctt ggagcattat ccaatgagta aacaaactaa 1741 cactcttctc aacattggaa acctggtttt cattggaatt ttcacagcag aaatgatttt 1801 taaaataatt gcaatgcatc catatgggta tttccaagta ggttggaaca tttttgatag 1861 catgatagtg ttccatggtt taatagaact ttgtctagca aatgttgcag gaatggctct 1921 tcttcgatta ttcaggatgt taagaatttt caagttggga aagtattggc caacattcca 1981 gattttgatg tggtctctta gtaactcatg ggtggccctg aaagacttgg tcctgttgtt 2041 gttcacattc atcttctttt ctgctgcatt cggcatgaag ctgtttggta agaattatga 2101 agaatttgtc tgccacatag acaaagactg tcaactccca cgctggcaca tgcatgactt 2161 tttccactcc ttcctgaatg tgttccgaat tctctgtgga gagtgggtag agaccttgtg 2221 ggactgtatg gaggttgcag gccaatcctg gtgtattcct ttttacctga tggtcatttt 2281 aattggaaat ttactggtac tttacctgtt tctggcattg gtgagctcat ttagttcatg 2341 caaggatgta acagctgaag agaataatga agcaaaaaat ctccagcttg cagtggcaag 2401 aattaaaaaa ggaataaact atgtgcttct taaaatacta tgcaaaacac aaaatgtccc 2461 aaaggacaca atggaccatg taaatgaggt atatgttaaa gaagatattt ctgaccatac 2521 cctttctgaa ttgagcaaca cccaagattt tctcaaagat aaggaaaaaa gcagtggcac 2581 agagaaaaac gctactgaaa atgagagcca atcacttatc cccagtccta gtgtctcaga 2641 aactgtacca attgcttcag gagaatctga tatagaaaat ctggataata aggagattca 2701 gagtaagtct ggtgatggag gcagcaaaga gaaaataaag caatctagct catctgaatg 2761 cagtactgtt gatattgcta tctctgaaga agaagaaatg ttctatggag gtgaaagatc 2821 aaagcatctg aaaaatggtt gcagacgcgg atcttcactt ggtcaaatca gtggagcatc 2881 caagaaagga aaaatctggc agaacatcag gaaaacctgc tgcaagattg tagagaacaa 2941 ttggtttaag tgttttattg ggcttgttac tctgctcagc actggcactc tggcttttga 3001 agatatatat attgatcaga gaaagacaat taaaatttta ttagaatatg ctgacatgat 3061 ctttacttat atcttcattc tggaaatgct tctaaaatgg atggcatatg gttttaaggc 3121 ctatttctct aatggctggt acaggctgga cttcgtggtt gttattgtgt tttgtcttag 3181 cttaataggc aaaactcggg aagaactaaa acctcttatt tccatgaaat tccttcggcc 3241 cctcagagtt ctatctcaat ttgaaagaat gaaggtggtt gtgagagctt tgatcaaaac 3301 aaccttaccc actttgaatg tgtttcttgt ctgcctgatg atctggctga tttttagtat 3361 catgggagta gacttatttg ctggcagatt ctatgaatgc attgacccaa caagtggaga 3421 aaggtttcct tcatctgaag tcatgaataa gagtcggtgt gaaagccttc tgtttaacga 3481 atccatgcta tgggaaaatg caaaaatgaa ctttgataat gttggaaatg gtttcctttc 3541 tctgcttcaa gtagcaacat ttaatggatg gatcactatt atgaattcag caattgattc 3601 tgttgctgtt aatatacagc ctcattttga agtcaacatc tacatgtatt gttactttat 3661 caactttatt atatttggag tatttctccc tctgagtatg ctgattactg ttattattga 3721 taatttcaac aagcataaaa taaagctggg aggctcaaat atctttataa cggttaaaca 3781 gagaaaacag taccgcaggc tgaagaagct aatgtatgag gattctcaaa gaccagtacc 3841 tcgcccatta aacaagctcc aaggattcat ctttgatgtg gtaacaagcc aagcttttaa 3901 tgtcattgtt atggttctta tatgtttcca agcaatagcc atgatgatag acactgatgt 3961 tcagagtcta caaatgtcca ttgctctcta ctggattaac tcaatttttg ttatgctata 4021 tactatggaa tgtatactga agctcatcgc tttccgttgt ttttatttca ccattgcgtg 4081 gaacattttt gattttatgg tggttatttt ctccatcaca ggactatgtc tgcctatgac 4141 agtaggatcc taccttgtgc ctccttcact tgtgcaactg atacttctct cacggatcat 4201 tcacatgctg cgtcttggaa aaggaccaaa ggtgtttcat aatctgatgc ttcctttgat 4261 gctgtccctc ccagcattat tgaacatcat tcttctcatc ttcctggtca tgttcatcta 4321 tgccgtattt ggaatgtata attttgccta tgttaaaaaa gaagctggaa ttaatgatgt 4381 gtctaatttt gaaacctttg gcaacagtat gctctgtctt tttcaagttg caatatttgc 4441 tggttgggat gggatgcttg atgcaatttt caacagtaaa tggtctgact gtgatcctga 4501 taaaattaac cctgggactc aagttagagg agattgtggg aacccctctg ttgggatttt 4561 ttattttgtc agttatatcc tcatatcatg gctgatcatt gtaaatatgt acattgttgt 4621 tgtcatggag tttttaaata ttgcttctaa gaagaaaaac aagaccttga gtgaagatga 4681 ttttaggaaa ttctttcagg tatggaaaag gtttgatcct gataggaccc agtacataga 4741 ctctagcaag ctttcagatt ttgcagctgc tcttgatcct cctcttttca tggcaaaacc 4801 aaacaagggc cagctcattg ctttggacct ccccatggct gttggggaca gaattcattg 4861 cctcgatatc ttacttgctt ttacaaagag agttatgggt caagatgtga ggatggagaa 4921 agttgtttca gaaatagaat cagggttttt gttagccaac ccttttaaga tcacatgtga 4981 gccaattacg actactttga aacgaaaaca agaggcagtt tcagcaacca tcattcaacg 5041 tgcttataaa aattaccgct tgaggcgaaa tgacaaaaat acatcagata ttcatatgat 5101 agatggtgac agagatgttc atgctactaa agaaggtgcc tattttgaca aagctaagga 5161 aaagtcacct attcaaagcc agatctaata ccacttacca cctcttttca tatttcttca 5221 catatctgaa aaatgttgaa agcctaagcc aggaataaaa gaaaagtaga gataataatc 5281 agttctttac aaccgatggt aattaagctt gtattcacaa gacttcatgc caaattcact 5341 ttttagcatt atatctaaca aatcaagaga atccttaata ttgctgcag //