LOCUS       HUMCNC                  3250 bp    mRNA    linear   HUM 27-APR-1993
DEFINITION  Human Na+/Ca+ exchanger (CNC) mRNA, complete cds.
ACCESSION   M91368
VERSION     M91368.1
KEYWORDS    Na+/Ca+ exchanger.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Komuro,I., Wenninger,K.E., Philipson,K.D. and Izumo,S.
  TITLE     Molecular cloning and characterization of the human cardiac
            Na+/Ca2+ exchanger cDNA
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (10), 4769-4773 (1992)
   PUBMED   1374913
COMMENT     Original source text: Homo sapiens adult heart cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..3250
                     /db_xref="H-InvDB:HIT000196805"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="heart"
                     /dev_stage="adult"
     gene            1..3250
                     /gene="CNC"
     CDS             81..3002
                     /gene="CNC"
                     /codon_start=1
                     /product="Na+/Ca+ exchanger"
                     /protein_id="AAA35702.1"
                     /translation="MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGN
                     ETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSS
                     IEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHN
                     FTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWL
                     YIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMII
                     EHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELK
                     QKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVS
                     MHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT
                     ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDG
                     ILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGA
                     RGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFL
                     EIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEY
                     DDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVG
                     TNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYW
                     NGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVA
                     ATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLF
                     TIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKG
                     F"
     sig_peptide     81..161
                     /gene="CNC"
BASE COUNT          884 a          670 c          816 g          880 t
ORIGIN      
        1 ccggaggatt ttgaggacac ttgtggagag ctcgaattcc agaatgatga aattgttagg
       61 ttgtgacagt tggaagtgtc atgtacaaca tgcggcgatt aagtctttca cccacctttt
      121 caatgggatt tcatctgtta gttactgtga gtctcttatt ttcccatgtg gaccatgtaa
      181 ttgctgagac agaaatggaa ggagaaggaa atgaaactgg tgaatgtact ggatcatatt
      241 actgtaagaa aggggtgatt ttgcccattt gggaacccca agacccttct tttggggaca
      301 aaattgctag agctactgtg tattttgtgg ccatggtcta catgtttctt ggagtctcta
      361 tcatagctga tcggttcatg tcctctatag aagtcatcac atctcaagaa aaagaaataa
      421 ccataaagaa acccaatgga gagaccacca agacaactgt gaggatctgg aatgaaacag
      481 tttctaacct gaccttgatg gccctgggat cttctgctcc tgagattctc ctttcagtaa
      541 ttgaagtgtg tggccataac ttcactgcag gagacctcgg tcctagcacc atcgtgggaa
      601 gtgctgcatt caatatgttc atcattattg cactctgtgt ttatgtggtg cctgacggag
      661 agacaaggaa gattaagcat ttgcgtgtct tctttgtgac agcagcctgg agcatctttg
      721 cctacacctg gctttacatt attttgtctg tcatatctcc tggtgttgtg gaggtctggg
      781 aaggtttgct tactttcttc ttctttccca tctgtgttgt gttcgcttgg gtagcggata
      841 ggagacttct gttttacaag tatgtctaca agaggtatcg agctggcaag cagaggggga
      901 tgattattga acatgaagga gacaggccat cttctaagac tgaaattgaa atggacggga
      961 aagtggtcaa ttctcatgtt gaaaatttct tagatggtgc tctggttctg gaggtggatg
     1021 agagggacca agatgatgaa gaagctaggc gagaaatggc taggattctg aaggaactta
     1081 agcagaagca tccagataaa gaaatagagc aattaataga attagctaac taccaagtcc
     1141 taagtcagca gcaaaaaagt agagcatttt atcgcattca agctactcgc ctcatgactg
     1201 gagctggcaa cattttaaag aggcatgcag ctgaccaagc aaggaaggct gtcagcatgc
     1261 acgaggtcaa cactgaagtg actgaaaatg accctgttag taagatcttc tttgaacaag
     1321 ggacatatca gtgtctggag aactgtggta ctgtggccct taccattatc cgcagaggtg
     1381 gtgatttgac taacactgtg tttgttgact tcagaacaga ggatggcaca gcaaatgctg
     1441 ggtctgatta tgaatttact gaaggaactg tggtgtttaa gcctggtgat acccagaagg
     1501 aaatcagagt gggtatcata gatgatgata tctttgagga ggatgaaaat ttccttgtgc
     1561 atctcagcaa tgtcaaagta tcttctgaag cttcagaaga tggcatactg gaagccaatc
     1621 atgtttctac acttgcttgc ctcggatctc cctccactgc cactgtaact atttttgatg
     1681 atgaccacgc aggcattttt acttttgagg aacctgtgac tcatgtgagt gagagcattg
     1741 gcatcatgga ggtgaaagta ttgagaacat ctggagctcg aggaaatgtt atcgttccat
     1801 ataaaaccat cgaagggact gccagaggtg gaggggagga ttttgaggac acttgtggag
     1861 agctcgaatt ccagaatgat gaaattgtca aaacaatatc agtcaaggta attgatgatg
     1921 aggagtatga gaaaaacaag accttcttcc ttgagattgg agagccccgc ctggtggaga
     1981 tgagtgagaa gaaagccctg ttattgaatg agcttggtgg cttcacaata acaggaaaat
     2041 acctgtttgg ccaacctgtc ttcaggaagg ttcatgctag agaacatccg attctctcta
     2101 ctgtaatcac cattgcagac gaatatgatg acaagcagcc actgaccagc aaagaggaag
     2161 aggagaggcg cattgcagaa atggggcgcc ccatcctggg agagcacacc aagttggaag
     2221 tgatcattga agaatcctat gaattcaaga gtactgtgga caaactcatt aagaagacaa
     2281 acctggccct tgtggttggg actaacagct ggagagaaca gttcattgaa gctatcactg
     2341 tcagtgctgg ggaagatgat gacgacgatg aatgtgggga agagaagctg ccctcctgtt
     2401 tcgattacgt gatgcacttt ctgactgtgt tctggaaggt cctgtttgcc ttcgtccccc
     2461 ctactgaata ctggaatggc tgggcgtgtt tcattgtctc catcctcatg attggcctac
     2521 tgacagcttt cattggagac ctggcttccc actttggctg caccattggc ctgaaagatt
     2581 ctgtgactgc agtcgtgttc gtcgcacttg gaacatcagt gccagacaca tttgccagca
     2641 aagtggcagc cacccaggac cagtatgcag acgcctccat aggtaacgtc acgggcagca
     2701 acgcggtgaa tgtcttcctg ggaatcggtg tggcctggtc catcgctgcc atctaccacg
     2761 cagccaatgg ggaacagttc aaagtgtccc ctggcacact agctttctct gtcactctct
     2821 tcaccatttt tgctttcatc aatgtggggg tgctgctgta tcggcggagg ccagaaatcg
     2881 gaggtgagct gggtgggccc cggactgcca agctcctcac atcctgcctc tttgtgctcc
     2941 tatggctctt gtacattttc ttctcctccc tggaggccta ctgccacata aaaggcttct
     3001 aaaggaacta tcagatatag taaatttata tatatacata tatatacata aaaattatgt
     3061 ataatggaca gaggaaactg acatttgtca tgttcactta cctgctgatg gaatccagct
     3121 tcaagagcat actctgtact agggccgaag taaaaaacca tcacctccca ttcccagggg
     3181 catcatcatg ttcaacaagg catggaggca gggccatctt tgcagctcag tctagaaggg
     3241 ctgcactctc
//