LOCUS HUMCATS 1763 bp mRNA linear HUM 19-OCT-2000
DEFINITION Homo sapiens cathepsin S (CTSS) mRNA, complete cds.
ACCESSION M90696 S39127
VERSION M90696.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Ritonja,A., Colic,A., Dolenc,I., Ogrinc,T., Podobnik,M. and Turk,V.
TITLE The complete amino acid sequence of bovine cathepsin S and a
partial sequence of bovine cathepsin L
JOURNAL FEBS Lett. 283 (2), 329-331 (1991)
PUBMED 2044774
REFERENCE 2 (bases 1 to 1763)
AUTHORS Wiederanders,B., Bromme,D., Kirschke,H., von Figura,K., Schmidt,B.
and Peters,C.
TITLE Phylogenetic conservation of cysteine proteinases. Cloning and
expression of a cDNA coding for human cathepsin S
JOURNAL J. Biol. Chem. 267 (19), 13708-13713 (1992)
PUBMED 1377692
COMMENT On or before Oct 19, 2000 this sequence version replaced S39127.1,
gi:179956.
FEATURES Location/Qualifiers
source 1..1763
/db_xref="H-InvDB:HIT000196792"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="testis"
/tissue_lib="lambda gt11 (Clontech #HL10106)"
gene 1..1763
/gene="CTSS"
CDS 137..1132
/gene="CTSS"
/note="cysteine proteinase; lysosomal enzyme"
/codon_start=1
/product="cathepsin S"
/protein_id="AAC37592.1"
/translation="MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNE
EAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQ
RNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLV
SLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDLKCQYDSK
YRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNV
NHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI"
sig_peptide 137..478
/gene="CTSS"
mat_peptide 479..1129
/gene="CTSS"
/product="cathepsin S"
BASE COUNT 525 a 345 c 400 g 493 t
ORIGIN
1 ggggtacctc atgtgacaag ttccaatttc ttttcaagtc aattgaactg aaatctcctt
61 gttgctttga aatcttagaa gagagcccac taattcaagg actcttactg taggagcaac
121 tgctggttct atcacaatga aacggctggt ttgtgtgctc ttggtgtgct cctctgcagt
181 ggcacagttg cataaagatc ctaccctgga tcaccactgg catctctgga agaaaaccta
241 tggcaaacaa tacaaggaaa agaatgaaga agcagtacga cgtctcatct gggaaaagaa
301 tctaaagttt gtgatgcttc acaacctgga gcattcaatg ggaatgcact catacgatct
361 gggcatgaac cacctgggag acatgaccag tgaagaagtg atgtctttga tgagttccct
421 gagagttccc agccagtggc agagaaatat cacatataag tcaaacccta atcggatatt
481 gcctgattct gtggactgga gagagaaagg gtgtgttact gaagtgaaat atcaaggttc
541 ttgtggtgct tgctgggctt tcagtgctgt gggggccctg gaagcacagc tgaagctgaa
601 aacaggaaag ctggtgtctc tcagtgccca gaacctggtg gattgctcaa ctgaaaaata
661 tggaaacaaa ggctgcaatg gtggcttcat gacaacggct ttccagtaca tcattgataa
721 caagggcatc gactcagacg cttcctatcc ctacaaagcc atggatctga aatgtcaata
781 tgactcaaaa tatcgtgctg ccacatgttc aaagtacact gaacttcctt atggcagaga
841 agatgtcctg aaagaagctg tggccaataa aggcccagtg tctgttggtg tagatgcgcg
901 tcatccttct ttcttcctct acagaagtgg tgtctactat gaaccatcct gtactcagaa
961 tgtgaatcat ggtgtacttg tggttggcta tggtgatctt aatgggaaag aatactggct
1021 tgtgaaaaac agctggggcc acaactttgg tgaagaagga tatattcgga tggcaagaaa
1081 taaaggaaat cattgtggga ttgctagctt tccctcttac ccagaaatct agaggatctc
1141 tcctttttat aacaaatcaa tgaaatatga agcactttct cttaacttaa tttttcctgc
1201 tgtatccaga agaaataatt gtgtcatgat taatgtgtat ttactgtact aattagaaaa
1261 tatagtttga ggccgggcac gtggctcacg cgtaatcccg ttacttggga ggccaaggca
1321 ggcattatca atcttgaggc caggagttaa agagcagcct ggctaacatg gtgaaacccc
1381 atctctacta aaaatacaaa aaattagccg agcacggtgg tgcatgcctg taatcccagc
1441 tacttgggag gctgaggcac gagattcctt gaacccaaga ggttgaggct atgttgagct
1501 gagatcacac cactgtactc cagcctggat gacagagtgg agactctgtt tcaaaaaaac
1561 agaaaagaaa atatagtttg attcttcatt tttttaaatt tgcaaatctc aggataaagt
1621 ttgctaagta aattagtaat gtactataga tataactgta caaaaattgt tcaacctaaa
1681 acaatctgta attgcttatt gttttattgt cccgaattca gttggtttaa tatattgtcc
1741 tctgtaattt cgatccttct taa
//