LOCUS HUMCOL4A5X 2933 bp mRNA linear HUM 01-NOV-1994
DEFINITION Human collagen type IV alpha 5 chain (COL4A5) gene, 5' end.
ACCESSION M90464
VERSION M90464.1
KEYWORDS collagen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2933)
AUTHORS Zhou,J., Hertz,J.M., Leinonen,A. and Tryggvason,K.
TITLE Complete amino acid sequence of the human alpha 5 (IV) collagen
chain and identification of a single-base mutation in exon 23
converting glycine 521 in the collagenous domain to cysteine in an
Alport syndrome patient
JOURNAL J. Biol. Chem. 267 (18), 12475-12481 (1992)
PUBMED 1352287
COMMENT Original source text: Homo sapiens kidney cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2933
/db_xref="H-InvDB:HIT000196773"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Xq22"
/tissue_type="kidney"
gene 1..2933
/gene="COL4A5"
CDS 203..2933
/gene="COL4A5"
/codon_start=1
/product="alpha-5 type IV collagen"
/protein_id="AAA52046.1"
/db_xref="GDB:G00-120-596"
/translation="MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIK
GEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPG
TPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGS
IIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNM
GLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRG
PPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGYPGEPGRDGEKGQKG
DTGPPGPPGLVIPRPGTGITIGEKGNIGLPGLPGEKGERGFPGIQGPPGLPGPPGAAV
MGPPGPPGFPGERGQKGDEGPPGISIPGPPGLDGQPGAPGLPGPPGPAGPHIPPSDEI
CEPGPPGPPGSPGDKGLQGEQGVKGDKGDTCFNCIGTGISGPPGQPGLPGLPGPPGSL
GFPGQKGEKGQAGATGPKGLPGIPGAPGAPGFPGSKGEPGDILTFPGMKGDKGELGSP
GAPGLPGLPGTPGQDGLPGLPGPKGEPGGITFKGERGPPGNPGLPGLPGNIGPMGPPG
FGPPGPVGEKGIQGVAGNPGQPGIPGPKGDPGQTITQPGKPGLPGNPGRDGDVGLPGD
PGLPGQPGLPGIPGSKGEPGIPGIGLPGPPGPKGFPGIPGPPGAPGTPGRIGLEGPPG
PPGFPGPKGEPGFALPGPPGPPGLPGFKGALGPKGDRGFPGPPGPPGRTGLDGLPGPK
GDVGPNGQPGPMGPPGLPGIGVQGPPGPPGIPGPIGQPGLHGIPGEKGDPGPPGLDVP
GPPGERGSPGIPGAPGPIGPPGSPGLPGKAGASGFPGTKGEMGMMGPPGPPGPL"
sig_peptide 203..322
/gene="COL4A5"
/note="G00-120-596; putative"
BASE COUNT 703 a 754 c 875 g 601 t
ORIGIN
1 aggggggaag gaagagtagc tccttcttct tcttcttttt tttttcttcc actcttaaaa
61 agcttctttc tcttcaccca agcctcactg tccctctccg gctctagctc tctccatata
121 aaccctcaag attatgtcaa ttggttagag ccagccggga atttcgtgcg ggtgctgaag
181 gagctgcggg agccggagaa gaatgaaact gcgtggagtc agcctggctg ccggcttgtt
241 cttactggcc ctgagtcttt gggggcagcc tgcagaggct gcggcttgct atgggtgttc
301 tccaggatca aagtgtgact gcagtggcat aaaaggggaa aagggagaga gagggtttcc
361 aggtttggaa ggacacccag gattgcctgg atttccaggt ccagaagggc ctccggggcc
421 tcggggacaa aagggtgatg atggaattcc agggccacca ggaccaaaag gaatcagagg
481 tcctcctgga cttcctggat ttccagggac accaggtctt cctggaatgc caggccacga
541 tggggcccca ggacctcaag gtattcccgg atgcaatgga accaagggag aacgtggatt
601 tccaggcagt cccggttttc ctggtttaca gggtcctcca ggaccccctg ggatcccagg
661 tatgaagggt gaaccaggta gtataattat gtcatcactg ccaggaccaa agggtaatcc
721 aggatatcca ggtcctcctg gaatacaagg cctacctggt cccactggta taccagggcc
781 aattggtccc ccaggaccac caggtttgat gggccctcct ggtccaccag gacttccagg
841 acctaagggg aatatgggct taaatttcca gggacccaaa ggtgaaaaag gtgagcaagg
901 tcttcagggc ccacctgggc cacctgggca gatcagtgaa cagaaaagac caattgatgt
961 agagtttcag aaaggagatc agggacttcc tggtgaccga gggcctcctg gacctccagg
1021 gatacgtggt cctccaggtc ccccaggtgg tgagaaaggt gagaagggtg agcaaggaga
1081 gccaggcaaa agaggtaaac caggcaaaga tggagaaaat ggccaaccag gaattcctgg
1141 tttgcctggt gatcctggtt accctggtga acccggaagg gatggtgaaa agggccaaaa
1201 aggtgacact ggcccacctg gacctcctgg acttgtaatt cctagacctg ggactggtat
1261 aactatagga gaaaaaggaa acattgggtt gcctgggttg cctggagaaa aaggagagcg
1321 aggatttcct ggaatacagg gtccacctgg ccttcctgga cctccagggg ctgcagttat
1381 gggtcctcct ggccctcctg gatttcctgg agaaaggggt cagaaaggtg atgaaggacc
1441 acctggaatt tccattcctg gacctcctgg acttgacgga cagcctgggg ctcctgggct
1501 tccagggcct cctggccctg ctggccctca cattcctcct agtgatgaga tatgtgaacc
1561 aggccctcca ggccccccag gatctccagg tgataaagga ctccaaggag aacaaggagt
1621 gaaaggtgac aaaggtgaca cttgcttcaa ctgcattgga actggtattt cagggcctcc
1681 aggtcaacct ggtttgccag gtctcccagg tcctccagga tctcttggtt tccctggaca
1741 gaaaggggaa aaaggacaag ctggtgcaac tggtcccaaa ggattaccag gcattccagg
1801 agctccaggt gctccaggct ttcctggatc taaaggtgaa cctggtgata tcctcacttt
1861 tccaggaatg aagggtgaca aaggagagtt gggttcccct ggagctccag ggcttcctgg
1921 tttacctggc actcctggac aggatggatt gccagggctt cctggcccga aaggagagcc
1981 tggtggaatt acttttaagg gtgaaagagg tccccctggg aacccaggtt taccaggcct
2041 cccagggaat atagggccta tgggtccccc tggtttcggc cctccaggcc cagtaggtga
2101 aaaaggcata caaggtgtgg caggaaatcc aggccagcca ggaataccag gtcctaaagg
2161 ggatccaggt cagactataa cccagccggg gaagcctggc ttgcctggta acccaggcag
2221 agatggtgat gtaggtcttc caggtgaccc tggacttcca gggcaaccag gcttgccagg
2281 gatacctggt agcaaaggag aaccaggtat ccctggaatt gggcttcctg gaccacctgg
2341 tcccaaaggc tttcctggaa ttccaggacc tccaggagca cctgggacac ctggaagaat
2401 tggtctagaa ggccctcctg ggccacccgg ctttccagga ccaaagggtg aaccaggatt
2461 tgcattacct gggccacctg ggccaccagg acttccaggt ttcaaaggag cacttggtcc
2521 aaaaggtgat cgtggtttcc caggacctcc gggtcctcca ggacgcactg gcttagatgg
2581 gctccctgga ccaaaaggtg atgttggacc aaatggacaa cctggaccaa tgggacctcc
2641 tgggctgcca ggaataggtg ttcagggacc accaggacca ccagggattc ctgggccaat
2701 aggtcaacct ggtttacatg gaataccagg agagaagggg gatccaggac ctcctggact
2761 tgatgttcca ggacccccag gtgaaagagg cagtccaggg atccccggag cacctggtcc
2821 tataggacct ccaggatcac cagggcttcc aggaaaagca ggtgcctctg gatttccagg
2881 taccaaaggt gaaatgggta tgatgggacc tccaggccca ccaggacctt tgg
//