LOCUS HUMGLCKNS 2731 bp mRNA linear HUM 08-NOV-1994 DEFINITION Human glucokinase (GCK) mRNA, complete cds. ACCESSION M90299 VERSION M90299.1 KEYWORDS D-hexose 6-phosphotransferase; glucokinase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2731) AUTHORS Koranyi,L.I., Tanizawa,Y., Welling,C.M., Rabin,D.U. and Permutt,M.A. TITLE Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA JOURNAL Diabetes 41 (7), 807-811 (1992) PUBMED 1612194 COMMENT Original source text: Homo sapiens (tissue library: lambda gt11; lambda ZAP) adult pancreatic islets cDNA to mRNA. FEATURES Location/Qualifiers source 1..2731 /db_xref="H-InvDB:HIT000196765" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="Unassigned" /tissue_type="pancreatic islets" /dev_stage="adult" /tissue_lib="lambda gt11; lambda ZAP" gene 1..2731 /gene="GCK" mRNA 1..2731 /gene="GCK" /experiment="experimental evidence, no additional details recorded" /note="G00-127-550" 5'UTR 1..458 /gene="GCK" /note="G00-127-550; putative" CDS 459..1856 /gene="GCK" /EC_number="2.7.1.1" /standard_name="ATP:D-hexose 6-phosphotransferase" /note="putative" /codon_start=1 /product="glucokinase" /protein_id="AAA52562.1" /db_xref="GDB:G00-127-550" /translation="MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRG LRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVK TKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDID KGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDH QCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRL VDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRF VSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINR MRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAA LVSAVACKKACMLGQ" 3'UTR 1857..2723 /gene="GCK" /note="G00-127-550" regulatory 2695..2701 /regulatory_class="polyA_signal_sequence" /gene="GCK" /note="G00-127-550" polyA_site 2723 /gene="GCK" /experiment="experimental evidence, no additional details recorded" /note="G00-127-550" BASE COUNT 626 a 778 c 864 g 463 t ORIGIN 1 ccgagcggcg cctgagcccc agggaagcag gctaggatgt gagagacaca gtcacctgca 61 gcctaattac tcaaaagctg tccccaggtc acagaaggga gaggacattt cccactgaat 121 ctgtctgaag gacactaagc cccacagctc aacacaacca ggagagaaag cgctgaggac 181 gccacccaag cgcccagcaa tggccctgcc tggagaacat ccaggctcag tgaggaaggg 241 tccagaaggg aatgcttgcc gactcgttgg agaacaatga aaaggaggaa actgtgactg 301 aacctcaaac cccaaaccag cccgaggaga accacattct cccagggacc cagggcgggc 361 cgtgacccct gcggcggaga agccttggat atttccactt cagaagccta ctggggaagg 421 ctgaggggtc ccagctcccc acgctggctg ctgtgcagat gctggacgac agagccagga 481 tggaggccgc caagaaggag aaggtagagc agatcctggc agagttccag ctgcaggagg 541 aggacctgaa gaaggtgatg agacggatgc agaaggagat ggaccgcggc ctgaggctgg 601 agacccatga agaggccagt gtgaagatgc tgcccaccta cgtgcgctcc accccagaag 661 gctcagaagt cggggacttc ctctccctgg acctgggtgg cactaacttc agggtgatgc 721 tggtgaaggt gggagaaggt gaggaggggc agtggagcgt gaagaccaaa caccagatgt 781 actccatccc cgaggacgcc atgaccggca ctgctgagat gctcttcgac tacatctctg 841 agtgcatctc cgacttcctg gacaagcatc agatgaaaca caagaagctg cccctgggct 901 tcaccttctc ctttcctgtg aggcacgaag acatcgataa gggcatcctt ctcaactgga 961 ccaagggctt caaggcctca ggagcagaag ggaacaatgt cgtggggctt ctgcgagacg 1021 ctatcaaacg gagaggggac tttgaaatgg atgtggtggc aatggtgaat gacacggtgg 1081 ccacgatgat ctcctgctac tacgaagacc atcagtgcga ggtcggcatg atcgtgggca 1141 cgggctgcaa tgcctgctac atggaggaga tgcagaatgt ggagctggtg gagggggacg 1201 agggccgcat gtgcgtcaat accgagtggg gcgccttcgg ggactccggc gagctggacg 1261 agttcctgct ggagtatgac cgcctggtgg acgagagctc tgcaaacccc ggtcagcagc 1321 tgtatgagaa gctcataggt ggcaagtaca tgggcgagct ggtgcggctt gtgctgctca 1381 ggctcgtgga cgaaaacctg ctcttccacg gggaggcctc cgagcagctg cgcacacgcg 1441 gagccttcga gacgcgcttc gtgtcgcagg tggagagcga cacgggcgac cgcaagcaga 1501 tctacaacat cctgagcacg ctggggctgc gaccctcgac caccgactgc gacatcgtgc 1561 gccgcgcctg cgagagcgtg tctacgcgcg ctgcgcacat gtgctcggcg gggctggcgg 1621 gcgtcatcaa ccgcatgcgc gagagccgca gcgaggacgt aatgcgcatc actgtgggcg 1681 tggatggctc cgtgtacaag ctgcacccca gcttcaagga gcggttccat gccagcgtgc 1741 gcaggctgac gcccagctgc gagatcacct tcatcgagtc ggaggagggc agtggccggg 1801 gcgcggccct ggtctcggcg gtggcctgta agaaggcctg tatgctgggc cagtgagagc 1861 agtggccgca agcgcaggga ggatgccaca gccccacagc acccaggctc catggggaag 1921 tgctccccac acgtgctcgc agcctggcgg ggcaggaggc ctggccttgt caggacccag 1981 gccgcctgcc ataccgctgg ggaacagagc gggcctcttc cctcagtttt tcggtgggac 2041 agccccaggg ccctaacggg ggtgcggcag gagcaggaac agagactctg gaagcccccc 2101 acctttctcg ctggaatcaa tttcccagaa gggagttgct cactcaggac tttgatgcat 2161 ttccacactg tcagagctgt tggcctcgcc tgggcccagg ctctgggaag gggtgccctc 2221 tggatcctgc tgtggcctca cttccctggg aactcatcct gtgtggggag gcagctccaa 2281 cagcttgacc agacctagac ctgggccaaa agggcaggcc aggggctgct catcacccag 2341 tcctggccat tttcttgcct gaggctcaag aggcccaggg agcaatggga gggggctcca 2401 tggaggaggt gtcccaagct ttgaataccc cccagagacc ttttctctcc cataccatca 2461 ctgagtggct tgtgattctg ggatggaccc tcgcagcagg tgcaagagac agagccccca 2521 agcctctgcc ccaaggggcc cacaaagggg agaagggcca gccctacatc ttcagctccc 2581 atagcgctgg ctcaggaaga aaccccaagc agcattcagc acaccccaag ggacaacccc 2641 atcatatgac atgccaccct ctccatgccc aacctaagat tgtgtgggtt ttttaattaa 2701 aaatgttaaa agttttaaac atgaaaaaaa a //