LOCUS HUMIMMPHLN 2156 bp mRNA linear HUM 27-APR-1993 DEFINITION Human immunophilin (FKBP52) mRNA, complete cds. ACCESSION M88279 VERSION M88279.1 KEYWORDS FK506 binding protein; immunophilin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2156) AUTHORS Sanchez,E.R., Faber,L.E., Henzel,W.J. and Pratt,W.B. TITLE The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins JOURNAL Biochemistry 29 (21), 5145-5152 (1990) PUBMED 2378870 REFERENCE 2 (bases 1 to 2156) AUTHORS Yem,A.W., Tomasselli,A.G., Heinrikson,R.L., Zurcher-Neely,H., Ruff,V.A., Johnson,R.A. and Deibel,M.R. Jr. TITLE The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13 JOURNAL J. Biol. Chem. 267 (5), 2868-2871 (1992) PUBMED 1371107 REFERENCE 3 (bases 1 to 2156) AUTHORS Peattie,D.A., Harding,M.W., Fleming,M.A., DeCenzo,M.T., Lippke,J.A., Livingston,D.J. and Benasutti,M. TITLE Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (22), 10974-10978 (1992) PUBMED 1279700 COMMENT Original source text: Homo sapiens placenta cDNA to mRNA. FEATURES Location/Qualifiers source 1..2156 /db_xref="H-InvDB:HIT000196695" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="placenta" 5'UTR 1..99 CDS 100..1479 /function="'binds the immunosuppressants FK506 and rapamycin'" /note="FKBP52; 52 kD FK506 binding protein" /codon_start=1 /product="immunophilin" /protein_id="AAA36111.1" /translation="MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGT EMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEV CHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEG YAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSI VYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKER GTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQA FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQ LAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAG SQSQVETEA" 3'UTR 1480..2156 regulatory 2143..2148 /regulatory_class="polyA_signal_sequence" polyA_site 2156 BASE COUNT 530 a 551 c 606 g 469 t ORIGIN 1 cccggcctcc cgcacgcccc gcaggtagcg cccccgcccg cggcccagag tgcgctcgcg 61 ccggcaccag ctcccggata aacggcgcgc cgcgcggaga tgacagccga ggagatgaag 121 gcgaccgaga gcggggcgca gtcggcgccg ctgcccatgg agggagtgga catcagcccc 181 aaacaggacg aaggcgtgct gaaggtcatc aagagagagg gcacaggtac agagatgccc 241 atgattgggg accgagtctt tgtccactac actggctggc tattagatgg cacaaagttt 301 gactccagtc tggatcgcaa ggacaaattc tcctttgacc tgggaaaagg ggaggtcatc 361 aaggcttggg acattgccat agccaccatg aaggtggggg aggtgtgcca catcacctgc 421 aaaccagaat atgcctacgg ttcagcaggc agtcctccaa agattccccc caatgccacg 481 cttgtatttg aggtggagtt gtttgagttt aagggagaag atctgacgga agaggaagat 541 ggcggaatca ttcgcagaat acagactcgc ggtgaaggct atgctaagcc caatgagggt 601 gctatcgtgg aggttgcact ggaagggtac tacaaggaca agctctttga ccagcgggag 661 ctccgctttg agattggcga gggggagaac ctggatctgc cttatggtct ggagagggcc 721 attcagcgca tggagaaagg agaacattcc atcgtgtacc tcaagcccag ctatgctttt 781 ggcagtgttg ggaaggaaaa gttccaaatc ccaccaaatg ctgagctgaa atatgaatta 841 cacctcaaga gttttgaaaa ggccaaggag tcttgggaga tgaattcaga agagaagctg 901 gaacagagca ccatagtgaa agagcggggc actgtgtact tcaaggaagg taaatacaag 961 caagctttac tacagtataa gaagatcgtg tcttggctgg aatatgagtc tagtttttcc 1021 aatgaggaag cacagaaagc acaggccctt cgactggcct ctcacctcaa cctggccatg 1081 tgtcatctga aactacaggc cttctctgct gccattgaaa gctgtaacaa ggccctagaa 1141 ctggacagca acaacgagaa gggcctcttc cgccggggag aggcccacct ggccgtgaat 1201 gactttgaac tggcacgggc tgatttccag aaggtcctgc agctctaccc caacaacaaa 1261 gccgccaaga cccagctggc tgtgtgccag cagcggatcc gaaggcagct tgcccgggag 1321 aagaagctct atgccaatat gtttgagagg ctggctgagg aggagaacaa ggccaaggca 1381 gaggcttcct caggagacca tcccactgac acagagatga aggaggagca gaagagcaac 1441 acggcaggga gccagtctca ggtggagaca gaagcatagc ccctctccac cagccctact 1501 cctgcggctg cctgcccccc agtctcccca ctccaccctg ttagttttgt aaaaactgaa 1561 gaattttgag tgaattagac ctttattttt ctatctggtt ggatggtggc tttaggggaa 1621 gggggaaagg tgtaggctgg gggattgagg tggggaatca ttttagctgg tgtcagcccc 1681 tcttcccttc ctccattgca catgaacata tgtccatcca tatatattca tcagaatgtt 1741 aatttatttt gctccctctg ttaggtccat tttctaaggg tagaagaggc aagtggtagg 1801 gatgaggtct gataagaacc cagggtggag agggagactc ctgggcagcc gttttcctca 1861 tcctttccct ctcccagtcc atttccaaat gtggcctcca tgtgggtgct agggacatgg 1921 gaaaaaccac tgctatgcca tttcttctct ctgttccctt cctcaccccc gacggtgtgg 1981 ctgatgatgt cttctggtgt catggtgacc accccctgtt ccctgttctg gtatttcccc 2041 tgtcagtttc ccctctcggc caggttgtgt cccaaaatcc cctcagcctc ttctctgcac 2101 gttgctgaag gtccaggctt gcctcaagtt ccatgcttga gcaataaagt ggaaac //