LOCUS HUMGAPJUNC 2311 bp mRNA linear HUM 23-MAR-1999
DEFINITION Homo sapiens connexin 26 (GJB2) mRNA, complete cds.
ACCESSION M86849
VERSION M86849.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2311)
AUTHORS Lee,S.W., Tomasetto,C., Paul,D., Keyomarsi,K. and Sager,R.
TITLE Transcriptional downregulation of gap-junction proteins blocks
junctional communication in human mammary tumor cell lines
JOURNAL J. Cell Biol. 118 (5), 1213-1221 (1992)
PUBMED 1324944
COMMENT On Mar 23, 1999 this sequence version replaced M86849.1.
Sequence updated by NCBI staff based on sequence published in
journal article.
FEATURES Location/Qualifiers
source 1..2311
/db_xref="H-InvDB:HIT000196649"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/sex="female"
/cell_type="epithelial"
/tissue_type="breast"
/dev_stage="adult"
gene 1..2311
/gene="GJB2"
CDS 199..879
/gene="GJB2"
/note="gap junction protein"
/codon_start=1
/product="connexin 26"
/protein_id="AAD21314.1"
/translation="MDWGTLQTILGGVNKHSTSIGKIWLTVLFIFRIMILVVAAKEVW
GDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSSPALLVAMHVAYRRHEK
KRKFIKGEIKSEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVIFEAAFMYVFYVMYDG
FSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYC
SGKSKKPV"
BASE COUNT 638 a 470 c 522 g 681 t
ORIGIN
1 gatttaatcc tatgacaaac taagttggtt ctgtcttcac ctgttttggt gaggttgtgt
61 aagagttggt gtttgctcag gaagagattt aagcatgctt gcttacccag actcagagaa
121 gtctccctgt tctgtcctag ctatgttcct gtgttgtgtg cattcgtctt ttccagagca
181 aaccgcccag agtagaagat ggattggggc acgctgcaga cgatcctggg gggtgtgaac
241 aaacactcca ccagcattgg aaagatctgg ctcaccgtcc tcttcatttt tcgcattatg
301 atcctcgttg tggctgcaaa ggaggtgtgg ggagatgagc aggccgactt tgtctgcaac
361 accctgcagc caggctgcaa gaacgtgtgc tacgatcact acttccccat ctcccacatc
421 cggctatggg ccctgcagct gatcttcgtg tccagcccag cgctcctagt ggccatgcac
481 gtggcctacc ggagacatga gaagaagagg aagttcatca agggggagat aaagagtgaa
541 tttaaggaca tcgaggagat caaaacccag aaggtccgca tcgaaggctc cctgtggtgg
601 acctacacaa gcagcatctt cttccgggtc atcttcgaag ccgccttcat gtacgtcttc
661 tatgtcatgt acgacggctt ctccatgcag cggctggtga agtgcaacgc ctggccttgt
721 cccaacactg tggactgctt tgtgtcccgg cccacggaga agactgtctt cacagtgttc
781 atgattgcag tgtctggaat ttgcatcctg ctgaatgtca ctgaattgtg ttatttgcta
841 attagatatt gttctgggaa gtcaaaaaag ccagtttaac gcattgccca gttgttagat
901 taagaaatag acagcatgag agggatgagg caacccgtgc tcagctgtca aggctcagtc
961 gccagcattt cccaacacaa agattctgac cttaaatgca accatttgaa acccctgtag
1021 gcctcaggtg aaactccaga tgccacaatg agctctgctc ccctaaagcc tcaaaacaaa
1081 ggcctaattc tatgcctgtc ttaattttct ttcacttaag ttagttccac tgagacccca
1141 ggctgttagg ggttattggt gtaaggtact ttcatatttt aaacagagga tatcggcatt
1201 tgtttctttc tctgaggaca agagaaaaaa gccaggttcc acagaggaca cagagaaggt
1261 ttgggtgtcc tcctggggtt ctttttgcca actttcccca cgttaaaggt gaacattggt
1321 tctttcattt gctttggaag ttttaatctc taacagtgga caaagttacc agtgccttaa
1381 actctgttac actttttgga agtgaaaact ttgtagtatg ataggttatt ttgatgtaaa
1441 gatgttctgg ataccattat atgttccccc tgtttcagag gctcagattg taatatgtaa
1501 atggtatgtc attcgctact atgatttaat ttgaaatatg gtcttttggt tatgaatact
1561 ttgcagcaca gctgagagag gctgtctgtt gtattcattg tggtcatagc acctaacaac
1621 attgtagcct caatcgagtg agacagacta gaagttccta gttggcttat gatagcaaat
1681 ggcctcatgt caaatattag atgtaatttt gtgtaagaaa tacagactgg atgtaccacc
1741 aactactacc tgtaatgaca ggcctgtcca acacatctcc cttttccatg ctgtggtagc
1801 cagcatcgga aagaacgctg atttaaagag gtgagcttgg gaattttatt gacacagtac
1861 catttaatgg ggagacaaaa atgggggcca ggggagggag aagtttctgt cgttaaaaac
1921 gagtttggaa agactggact ctaaattctg ttgattaaag atgagctttg tctaccttca
1981 aaagtttgtt tggcttaccc ccttcagcct ccaatttttt aagtgaaaat ataactaata
2041 acatgtgaaa agaatagaag ctaaggttta gataaatatt gagcagatct ataggaagat
2101 tgaacctgaa tattgccatt atgcttgaca tggtttccaa aaaatggtac tccacatact
2161 tcagtgaggg taagtatttt cctgttgtca agaatagcat tgtaaaagca ttttgtaata
2221 ataaagaata gctttaatga tatgcttgta actaaaataa ttttgtaatg tatcaaatac
2281 atttaaaaca ttaaaatata atctctataa t
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