LOCUS       HUMCALPASK               849 bp    mRNA    linear   HUM 09-NOV-1994
DEFINITION  Homo sapiens calpastatin (CAST) mRNA, 5' end.
ACCESSION   M86258
VERSION     M86258.1
KEYWORDS    calpain inhibitor; calpastatin; protease inhibitor.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Lee,W.J., Ma,H., Takano,E., Yang,H.Q., Hatanaka,M. and Maki,M.
  TITLE     Molecular diversity in amino-terminal domains of human calpastatin
            by exon skipping
  JOURNAL   J. Biol. Chem. 267 (12), 8437-8442 (1992)
   PUBMED   1569094
COMMENT     Original source text: Homo sapiens male lung cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..849
                     /db_xref="H-InvDB:HIT000196618"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="5q15-q21"
                     /haplotype="diploid"
                     /sex="male"
                     /cell_line="WI-38"
                     /cell_type="fibroblast"
                     /tissue_type="lung"
     gene            1..849
                     /gene="CAST"
     CDS             1..>849
                     /gene="CAST"
                     /codon_start=1
                     /product="calpastatin"
                     /protein_id="AAB59398.1"
                     /db_xref="GDB:G00-125-210"
                     /translation="MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKL
                     SVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTK
                     PQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDL
                     IDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGP
                     PADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQE
                     KKRKVEK"
     misc_feature    1..450
                     /gene="CAST"
                     /note="functionally unknown domain (domain L);
                     G00-125-210"
     misc_difference 22..87
                     /gene="CAST"
                     /note="deletion in subtype (pWICS41) and (pWICS38)...a;
                     G00-125-210"
                     /replace=""
     misc_difference 130..186
                     /gene="CAST"
                     /note="deletion in subtype (pWICS38)...b; G00-125-210"
                     /replace=""
     misc_feature    451..849
                     /gene="CAST"
                     /note="calpain inhibition domain (domain 1); G00-125-210"
BASE COUNT          328 a          181 c          190 g          150 t
ORIGIN      
        1 atgaatccca cagaaaccaa ggccattcca gtcagccaac agatggaagg accacatctt
       61 cctaacaaga aaaaacacaa aaaacaggct gtaaaaacag aacctgagaa gaagtcacag
      121 tcaaccaagc tgtctgtggt tcatgagaaa aaatcccaag aaggaaagcc aaaagaacac
      181 acagagccaa aaagcctacc caagcaggca tcagatacag gaagtaacga tgctcacaat
      241 aaaaaagcag tttccagatc agctgaacag cagccatcag agaaatcaac agaaccaaag
      301 actaaaccac aagacatgat ttctgctggt ggagagagtg ttgctggtat cactgcaata
      361 tctggcaagc cgggtgacaa gaaaaaagaa aagaaatcat taaccccagc tgtgccagtt
      421 gaatctaaac cggataaacc atcgggaaag tcaggcatgg atgctgcttt ggatgactta
      481 atagatactt taggaggacc tgaagaaact gaagaagaaa atacaacgta tactggacca
      541 gaagtttcag atccaatgag ttccacctac atagaggaat tgggtaaaag agaagtcaca
      601 attcctccaa aatataggga actattggct aaaaaggaag ggatcacagg gcctcctgca
      661 gactcttcga aacccatagg tccagatgat gctatagacg ccttgtcatc tgacttcacc
      721 tgtgggtcgc ctacagctgc tggaaagaaa actgaaaaag aggaatctac agaagtttta
      781 aaagctcagt ctgcagggac agtcagaagt gctgctccac cccaagagaa gaaaagaaag
      841 gtggagaag
//