LOCUS HUMHSPG2B 14327 bp mRNA linear HUM 08-NOV-1994 DEFINITION Human heparan sulfate proteoglycan (HSPG2) mRNA, complete cds. ACCESSION M85289 VERSION M85289.1 KEYWORDS HSPG2 gene; heparan sulfate proteoglycan. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 14327) AUTHORS Dodge,G.R., Kovalszky,I., Chu,M.L., Hassell,J.R., McBride,O.W., Yi,H.F. and Iozzo,R.V. TITLE Heparan sulfate proteoglycan of human colon: partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1 JOURNAL Genomics 10 (3), 673-680 (1991) PUBMED 1679749 REFERENCE 2 (bases 1 to 14327) AUTHORS Murdoch,A.D., Dodge,G.R., Cohen,I., Tuan,R.S. and Iozzo,R.V. TITLE Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor JOURNAL J. Biol. Chem. 267 (12), 8544-8557 (1992) PUBMED 1569102 COMMENT Original source text: Homo sapiens skin; colon cDNA to mRNA. FEATURES Location/Qualifiers source 1..14327 /db_xref="H-InvDB:HIT000196616" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="1p36.1-p35" /cell_line="WiDr; CRL 1262" /cell_type="fibroblast; amnion" /tissue_type="skin; colon" gene 1..14327 /gene="HSPG2" CDS 81..13256 /gene="HSPG2" /codon_start=1 /product="heparan sulfate proteoglycan" /protein_id="AAA52700.1" /db_xref="GDB:G00-126-372" /translation="MGWRAPGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTAS QMRWTHSYLSDDEYMLADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLED AGSREFREVSEAVVDTLESEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQ IQEMLLRVISSGSVASYVTSPQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYR CDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLL PGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGN GHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES DCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDG HFYLEHSAACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPGTPPL SSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELAR GMLEPVQRPDVVLVGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRPVQRAEL LQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGL SCESCDAHFTRVPGGPYLGTCSGCSCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAG FFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAP GYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLS TRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIFSPT PGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLV VLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLL IRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTR TPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQ DCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQP CQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPE GAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQ ITGNNIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIR ATFSSVPLVASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTG SGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDC QPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQC LPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH QGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVR PGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTG SNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWT GGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRV QVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAIT TADAGFYLCVATSPAGTAQARMQVVVLSASDASPPGVKIESSSPSVTEGQTLDLNCVV AGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITV SVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVR IESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADA GQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVV PGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLV TIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRI ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSG EYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVA RQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVIS VSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSH HQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPA DSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDL NCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQE ASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLP EGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCS ATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATII LHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELL HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQL ETKSIGASVEFHCAVPSDQGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYIC QAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ EVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYV CTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSAD GMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGH FHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSS GFIGCVRELRIQGEEIVFHDLNLTAHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCP AGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTP SLSGAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGH LEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGL NLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYD SSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGT RCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFS RSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSG EARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGG APDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTRPCPS" sig_peptide 81..143 /gene="HSPG2" /note="G00-126-372" mat_peptide 144..13253 /gene="HSPG2" /product="heparan sulfate proteoglycan" /note="G00-126-372" misc_feature 144..659 /gene="HSPG2" /note="unique region with 3 glycosamnioglycan attachment sites (domain I); G00-126-372" misc_feature 660..1289 /gene="HSPG2" /note="shares homology with low density lipoprotein (LDL) receptor (domain II); G00-126-372" misc_feature 1593..5108 /gene="HSPG2" /note="shares homology with the short arm of laminin A chain (domain III); G00-126-372" repeat_region 5109..11138 /gene="HSPG2" /note="shares homology with immunoglobulin repeats of N-CAM (domain IV); G00-126-372" misc_feature 11139..13253 /gene="HSPG2" /note="shares homology with G-domain of laminin A chain and EGF (domain V); G00-126-372" polyA_site 14327 /gene="HSPG2" /note="G00-126-372" BASE COUNT 2615 a 4940 c 4299 g 2473 t ORIGIN 1 ggccggcgag cgggcggctg cgggcggcgc ggagcgggcg gcgcggagcg agcgagcgag 61 agagcggcgc gggccgggcc atggggtggc gggcgccggg cgcgctgctg ctggcgctgc 121 tgctgcacgg gcggctgctg gcggtgaccc atgggctgag ggcatacgat ggcttgtctc 181 tgcctgagga catagagacc gtcacagcaa gccaaatgcg ctggacacat tcgtaccttt 241 ctgatgatga gtacatgctg gctgacagca tctcaggaga cgacctgggc agtggggacc 301 tgggcagcgg ggacttccag atggtttatt tccgagccct ggtgaatttc actcgctcca 361 tcgagtacag ccctcagctg gaggatgcag gctccagaga gtttcgagag gtgtccgagg 421 ctgtggtaga cacgctggag tcggagtact tgaaaattcc cggagaccag gttgtcagtg 481 tggtgttcat caaggagctg gatggctggg tttttgtgga gctcgatgtg ggctcggaag 541 ggaatgcgga tggtgctcag attcaggaga tgctgctcag ggtcatctcc agcggctctg 601 tggcctccta cgtcacctct ccccagggat tccagttccg acgcctgggc acagtgcccc 661 agttcccaag agcctgcacg gaggccgagt ttgcctgcca cagctacaat gagtgtgtgg 721 ccctggagta tcgctgtgac cggcggcccg actgcaggga catgtctgat gagctcaatt 781 gtgaggagcc agtcctgggt atcagcccca cattctctct ccttgtggag acgacatctt 841 taccgccccg gccagagaca accatcatgc gacagccacc agtcacccac gctcctcagc 901 ccctgcttcc cggttccgtc aggcccctgc cctgtgggcc ccaggaggcc gcatgccgca 961 atgggcactg catccccaga gactacctct gcgacggaca ggaggactgc gaggacggca 1021 gcgatgagct agactgtggc cccccgccac cctgtgagcc caacgagttc ccctgcggga 1081 atggacattg tgccctcaag ctgtggcgct gcgatggtga ctttgactgt gaggaccgaa 1141 ctgatgaagc caactgcccc accaagcgtc ctgaggaagt gtgcgggccc acacagttcc 1201 gatgcgtctc taccaacatg tgcatcccag ccagcttcca ctgtgacgag gagagcgact 1261 gtcctgaccg gagcgacgag tttggctgca tgccccccca ggtggtgaca cctccccggg 1321 agtccatcca ggcttcccgg ggccagacag tgaccttcac ctgcgtggcc attggcgtcc 1381 ccacccccat catcaattgg aggctcaact ggggccacat cccctctcat cccagggtga 1441 cagtgaccag cgagggtggc cgtggcacac tgatcatccg tgatgtgaag gagtcagacc 1501 agggtgccta cacctgtgag gccatgaacg cccggggcat ggtgtttggc attcctgacg 1561 gtgtccttga gctcgtccca caacgaggcc cctgccctga cggccacttc tacctggagc 1621 acagcgccgc ctgcctgccc tgcttctgct ttggcatcac cagcgtgtgc cagagcaccc 1681 gccgcttccg ggaccagatc aggctgcgct ttgaccaacc cgatgacttc aagggtgtga 1741 atgtgacaat gcctgcgcag cccggcacgc cacccctctc ctccacgcag ctgcagatcg 1801 acccatccct gcacgagttc cagctagtag acctgtcccg ccgcttcctc gtccacgact 1861 ccttctgggc tctgcctgaa cagttcctgg gcaacaaggt ggactcctat ggcggctccc 1921 tgcgttacaa cgtgcgctac gagttggccc gtggcatgct ggagccagtg cagcggccgg 1981 acgtggtcct cgtgggtgcc gggtaccgcc tcctctcccg aggccacaca cccacccaac 2041 ctggtgctct gaaccagcgc caggtccagt tctctgagga gcactgggtc catgagtctg 2101 gccggccggt gcagcgcgcg gagctgctgc aggtgctgca gagcctggag gccgtgctca 2161 tccagaccgt gtacaacacc aagatggcta gcgtgggact tagcgacatc gccatggata 2221 ccaccgtcac ccatgccacc agccatggcc gtgcccacag tgtggaggag tgcagatgcc 2281 ccattggcta ttctggcttg tcctgcgaga gctgtgatgc ccacttcact cgggtgcctg 2341 gtgggcccta cctgggcacc tgctctggtt gcagttgcaa tggccatgcc agctcctgtg 2401 accctgtgta tggccactgc ctgaattgcc agcacaacac ggaggggcca cagtgcaaca 2461 agtgcaaggc tggcttcttt ggggacgcca tgaaggccac ggccacttcc tgccggccct 2521 gcccttgccc atacatcgat gcctcccgca gattctcaga cacttgcttc ctggacacgg 2581 atggccaagc cacatgtgac gcctgtgccc caggctacac tggccgccgc tgtgagagct 2641 gtgcccccgg atacgagggc aaccccatcc agcccggcgg gaagtgcagg cccgtcaacc 2701 aggagattgt gcgctgtgac gagcgtggca gcatggggac ctccggggag gcctgccgct 2761 gtaagaacaa tgtggtgggg cgcttgtgca atgaatgtgc tgacggctct ttccacctga 2821 gtacccgaaa ccccgatggc tgcctcaagt gcttctgcat gggtgtcagt cgccactgca 2881 ccagctcttc atggagccgt gcccagttgc atggggcctc tgaggagcct ggtcacttca 2941 gcctgaccaa cgccgcaagc acccacacca ccaacgaggg catcttctcc cccacgcccg 3001 gggaactggg attctcctcc ttccacagac tcttatctgg accctacttc tggagcctcc 3061 cttcacgctt cctgggggac aaggtgacct cctatggagg agagctgcgc ttcacagtga 3121 cccagaggtc ccagccgggc tccacacccc tgcacgggca gccgttggtg gtgctgcaag 3181 gtaacaacat catcctagag caccatgtgg cccaggagcc cagccccggc cagcccagca 3241 ccttcattgt gcctttccgg gagcaagcat ggcagcggcc cgatgggcag ccagccacac 3301 gggagcacct gctgatggca ctggcaggca tcgacaccct cctgatccga gcatcctacg 3361 cccagcagcc cgctgagagc agggtctctg gcatcagcat ggacgtggct gtgcccgagg 3421 aaaccggcca ggaccccgcg ctggaagtgg aacagtgctc ctgcccaccc gggtaccgtg 3481 ggccgtcctg ccaggactgt gacacaggct acacacgcac gcccagtggc ctctacctgg 3541 gtacctgtga acgctgcagc tgccatggcc actcagaggc ctgcgagcca gaaacaggtg 3601 cctgccaggg ctgccagcat cacacggagg gccctcggtg tgagcagtgc cagccaggat 3661 actacgggga cgcccagcgg gggacaccac aggactgcca gctgtgcccc tgctacggag 3721 accctgctgc cggccaggct gcccacactt gttttctgga cacagacggc caccccacct 3781 gtgatgcgtg ctccccaggc cacagtgggc gtcactgtga gaggtgcgcc cctggctact 3841 atggcaaccc cagccagggc cagccatgcc agagagacag ccaggtgcca gggcccatag 3901 gctgcaactg tgacccccaa ggcagcgtca gcagccagtg tgatgctgct ggtcagtgcc 3961 agtgcaaggc ccaggtagaa ggcctcactt gcagccactg ccggccccac cacttccacc 4021 tgagtgccag caacccagac ggctgcctgc cctgcttctg tatgggcatc acccagcagt 4081 gcgccagctc tgcctacaca cgccacctga tctccaccca ctttgcccct ggggacttcc 4141 aaggctttgc cctggtgaac ccacagcgaa acagccgcct gacaggagaa ttcactgtgg 4201 aacccgtgcc cgagggtgcc cagctctctt ttggcaactt tgcccaactc ggccatgagt 4261 ccttctactg gcagctgccg gagacatacc agggagacaa ggtggcggcc tacggtggga 4321 agttgcgata caccctctcc tacacagcag gcccacaggg cagcccactc tcggaccccg 4381 atgtgcagat cacgggcaac aacatcatgc tagtggcctc ccagccagcg ctgcagggcc 4441 cagagaggag gagctacgag atcatgttcc gagaggaatt ctggcgccgg cccgatgggc 4501 agccggccac acgcgagcac ctcctgatgg cactggccga cctggatgag ctcctgatcc 4561 gggccacgtt ctcctccgtg ccgctggtgg ccagcatcag cgcagtcagc ctggaggtcg 4621 cccagccggg gccctcaaac agaccccgcg ccctcgaggt ggaggagtgc cgctgcccgc 4681 caggctacat cggtctgtcc tgccaggact gtgcccccgg ctacacgcgc accgggagtg 4741 ggctctacct cggccactgc gagctatgtg aatgcaatgg ccactcagac ctgtgccacc 4801 cagagactgg ggcctgctcg caatgccagc acaacgccgc aggggagttc tgcgagcttt 4861 gtgcccctgg ctactacgga gatgccacag ccgggacgcc tgaggactgc cagccctgtg 4921 cctgcccact gaccaaccca gagaacatgt tttcccgcac ctgtgagagc ctgggagccg 4981 gcgggtaccg ctgcacggcc tgcgaacccg gctacactgg ccagtactgt gagcagtgtg 5041 gcccaggtta cgtgggtaac cccagtgtgc aagggggcca gtgcctgcca gagacaaacc 5101 aagccccact ggtggtcgag gtccatcctg ctcgaagcat agtgccccaa ggtggctccc 5161 actccctgcg gtgtcaggtc agtgggagcc caccccacta cttctattgg tcccgtgagg 5221 atgggcggcc tgtgcccagc ggcacccagc agcgacatca aggctccgag ctccacttcc 5281 ccagcgtcca gccctcggat gctggggtct acatttgcac ctgccgtaat ctccaccaat 5341 ccaataccag ccgggcagag ctgctggtca ctgaggctcc aagcaagccc atcacagtga 5401 ctgtggagga gcagcggagc cagagcgtgc gccccggagc tgacgtcacc ttcatctgca 5461 cagccaaaag caagtcccca gcctataccc tggtgtggac ccgcctgcac aacgggaaac 5521 tgcccacccg agccatggat ttcaatggca tcctgaccat tcgcaacgtc cagctgagtg 5581 atgcaggcac ctacgtgtgc accggctcca acatgtttgc catggaccag ggcacagcca 5641 ctctacatgt gcaggcctcg ggcaccttgt ccgcccccgt ggtctccatc catccgccac 5701 agctcacagt gcagcccggg caactggcgg agttccgctg cagcgccaca gggagcccca 5761 cgcccaccct cgagtggaca gggggccccg gcggccagct ccctgcgaag gcacaaatcc 5821 acggcggcat cctgcgcctg ccagctgtcg agcccacgga tcaggcccag tacttgtgcc 5881 gagcccacag cagcgctggg cagcaggtgg ccagggctgt gctccacgtg catgggggcg 5941 gtgggcccag agtccaagtg agcccagaga ggacccaggt ccacgcaggc cggaccgtca 6001 ggctgtactg cagggctgca ggcgtgccta gcgccaccat cacctggagg aaggaagggg 6061 gcagcctccc accacaggcc cggtcagagc gcacagacat cgcgacactg ctcatcccag 6121 ccatcacgac tgctgacgcc ggcttctacc tctgcgtggc caccagccct gcaggcactg 6181 cccaggcccg gatgcaagtg gttgtccttt cagcctcaga tgccagccca ccgggggtca 6241 agattgagtc ctcatcgcct tctgtgacag aagggcaaac actcgacctc aactgtgtgg 6301 tggcagggtc agcccatgcc caggtcacct ggtacaggcg agggggtagc ctgcctcccc 6361 acacccaggt gcacggctcc cgtctgcggc tcccccaggt ctcaccagct gattctggag 6421 aatatgtgtg ccgtgtggag aatggatcgg gccccaagga ggcctccatt actgtgtctg 6481 tgctccacgg cacccattct ggccccagct acaccccagt gcccggcagc acccggccca 6541 tccgcatcga gccctcctcc tcacacgtgg cggaagggca gaccctggat ctgaactgcg 6601 tggtgcccgg gcaggcccac gcccaggtca cgtggcacaa gcgtgggggc agcctccctg 6661 cccggcacca gacccacggc tcgctgctgc ggctgcacca ggtgaccccg gccgactcag 6721 gcgagtatgt gtgccatgtg gtgggcacct ccggccccct agaggcctca gtcctggtca 6781 ccatcgaagc ctctgtcatc cctggaccca tcccacctgt caggatcgag tcttcatcct 6841 ccacagtggc cgagggccag accctggatc tgagctgcgt ggtggcaggg caggcccacg 6901 cccaggtcac atggtacaag cgtgggggca gcctccctgc ccggcaccag gttcgtggct 6961 cccgcctgta catcttccag gcctcacctg ccgatgcggg acagtacgtc tgccgggcca 7021 gcaacggcat ggaggcctcc atcacggtca cagtaactgg gacccagggg gccaacttag 7081 cctaccctgc cggcagcacc cagcccatcc gcatcgagcc ctcctcctcg caagtggcgg 7141 aagggcagac cctggatctg aactgcgtgg tgcccgggca gtcccatgcc caggtcacgt 7201 ggcacaagcg tgggggcagc ctccctgtcc ggcaccagac ccacggctcc ctgctgagac 7261 tctaccaagc gtcccccgcc gactcgggcg agtacgtgtg ccgagtgttg ggcagctccg 7321 tgcctctaga ggcctctgtc ctggtcacca ttgagcctgc gggctcagtg cctgcacttg 7381 gggtcacccc cacggtccgg atcgagtcat cgtcttcgca agtggccgag gggcagaccc 7441 tggacctgaa ctgcctcgtt gctggtcagg cccatgccca ggtcacgtgg cacaagcgcg 7501 ggggcagcct cccggcccgg caccaggtgc atggctcgag gctacgcctg ctccaggtga 7561 ccccagctga ttcaggggag tacgtgtgcc gtgtggtcgg cagctcaggt acccaggaag 7621 cctcagtcct tgtcaccatc cagcagcgcc ttagtggctc ccactcccag ggtgtggcgt 7681 accccgtccg catcgagtcc tcctcagcct ccctggccaa tggacacacc ctggacctca 7741 actgcctggt tgccagccag gctccccaca ccatcacctg gtataagcgt ggaggcagct 7801 tacccagccg gcaccagatc gtgggctccc ggctgcggat ccctcaggtg actccggcag 7861 actcgggcga gtacgtgtgt cacgtcagta acggtgcagg ctcccgggag acctcgctca 7921 tcgtcaccat ccagggcagc ggttcctccc acgtgcccag cgtctcccca ccgatcagga 7981 tcgagtcgtc ttcccccacg gtggtggaag ggcagacctt ggatctgaac tgcgtggtcg 8041 ccaggcagcc ccaggctatc atcacatggt acaagcgtgg gggcagcctt ccctcccgac 8101 accagaccca tggctcccac ctgcggttgc accaaatgtc tgtggctgac tcgggcgagt 8161 atgtgtgccg ggccaacaac aacatcgatg ccctggaggc ctccatcgtc atctccgtct 8221 cccctagcgc cggcagcccc tccgcccctg gcagctccat gcccatcaga attgagtcat 8281 cctcctcaca cgtggccgaa ggggagaccc tggatctgaa ctgcgtggtc cccgggcagg 8341 cccatgccca ggtcacttgg cacaagcgtg ggggcagcct ccccagtcac catcagaccc 8401 gcggctcacg gctgcggctg caccatgtgt ccccggccga ctcgggtgaa tacgtgtgcc 8461 gggtgatggg cagctctggc cccctggagg cctcagtcct ggtcaccatc gaagcctctg 8521 gctcaagtgc tgtccacgtc cccgccccag gtggagcccc acccatccgc atcgagccct 8581 cctcctcccg agtggcagaa gggcagaccc tggatctgaa gtgcgtggtg cccgggcagg 8641 cccacgccca ggtcacatgg cacaagcgtg gaggaaacct ccctgcccgg caccaggtcc 8701 acggcccact gctgaggctg aaccaggtgt ccccggctga ctctggcgag tactcgtgcc 8761 aagtgaccgg aagctcaggc accctggagg catctgtcct ggtcacaatt gagccctcca 8821 gcccaggacc cattcctgct ccaggactgg cccagcccat ctacatcgag gcctcctctt 8881 cacacgtgac tgaagggcag actctggatc tgaactgtgt ggtgcccggg caggcccatg 8941 cccaggtcac gtggtacaag cgcgggggca gcctccccgc ccggcaccag acccatggct 9001 cccagctgcg gctccacctc gtctcccctg ccgactcagg cgagtatgtg tgtcgtgcag 9061 ccagcggccc aggccctgag caagaagcct ccttcacagt caccgtcccg cccagtgagg 9121 ggtcttccta ccgccttagg agcccggtca tctccatcga cccgcccagc agcaccgtgc 9181 agcagggcca ggatgccagc ttcaagtgcc tcatccatga cggggcagcc cccatcagcc 9241 tcgagtggaa gacccggaac caggagctgg aggacaacgt ccacatcagt cccaatggct 9301 ccatcatcac catcgtgggc acccggccca gcaaccacgg tacctaccgc tgcgtggcct 9361 ccaatgccta cggtgtggcc cagagtgtgg tgaacctcag tgtgcacggg ccccctacag 9421 tgtccgtgct ccccgagggc cccgtgtggg tgaaagtggg aaaggctgtc accctggagt 9481 gtgtcagtgc cggggagccc cgctcctctg ctcgttggac ccggatcagc agcacccctg 9541 ccaagttgga gcagcggaca tatgggctca tggacagcca cgcggtgctg cagatttcat 9601 cagctaaacc atcagatgcg ggcacttatg tgtgccttgc tcagaatgca ctaggcacag 9661 cacagaagca ggtggaggtg atcgtggaca cgggcgccat ggccccaggg gcccctcagg 9721 tccaagctga agaagctgag ctgactgtgg aggctggaca cacggccacc ttgcgctgct 9781 cagccacagg cagccccgcg cccaccatcc actggtccaa gctgcgttcc ccactgccct 9841 ggcagcaccg gctggaaggt gacacactca tcataccccg ggtagcccag caggactcgg 9901 gccagtacat ctgcaatgcc actagccctg ctgggcacgc tgaggccacc atcatcctgc 9961 acgtggagag cccaccatat gccaccacgg tcccagagca cgcttcggtg caggcagggg 10021 agacggtgca gctccagtgc ctggctcacg ggacaccccc actcaccttc cagtggagcc 10081 gcgtgggcag cagccttcct gggagggcga ccgccaggaa cgagctgctg cactttgagc 10141 gtgcagcccc tgaggactca ggccgctacc gctgccgggt caccaacaag gtgggctcag 10201 ccgaggcctt tgcccagctg ctcgtccaag gccctcccgg ctctctccct gccacctcca 10261 tcccagcagg gtccacgccc accgtgcagg tcacgcctca gctagagacc aagagcattg 10321 gggccagcgt tgagttccac tgtgctgtgc ccagcgacca gggtacccag ctccgttggt 10381 tcaaggaagg gggtcagctg cctccgggtc acagcgtgca ggatggggtg ctccgaatcc 10441 agaacttgga ccagagctgc caagggacgt atatatgcca ggcccatgga ccttggggga 10501 aggcccaggc cagtgcccag ctggttatcc aagccctgcc ctcggtgctc atcaacatcc 10561 ggacctctgt gcagaccgtg gtggttggcc acgccgtgga gttcgaatgc ctggcactgg 10621 gtgaccccaa gcctcaggtg acatggagca aagttggagg gcacctgcgg ccaggcattg 10681 tgcagagcgg aggtgtcgtc aggatcgccc acgtagagct ggctgatgcg ggacagtatc 10741 gctgcactgc caccaacgca gctggcacca cacaatccca cgtcctgctg cttgtgcaag 10801 ccttgcccca gatctcaatg ccccaagaag tccgtgtgcc tgctggttct gcagctgtct 10861 tcccctgcat agcctcaggc taccccactc ctgacatcag ctggagcaag ctggatggca 10921 gcctgccacc tgacagccgc ctggagaaca acatgctgat gctgccctca gtccgacccc 10981 aggacgcagg tacctacgtc tgcaccgcca ctaaccgcca gggcaaggtc aaagcctttg 11041 cccacctgca ggtgccagag cgggtggtgc cctacttcac gcagaccccc tactccttcc 11101 taccgctgcc caccatcaag gatgcctaca ggaagttcga gatcaagatc accttccggc 11161 ccgactcagc cgatgggatg ctgctgtaca atgggcagaa gcgagtccca gggagcccca 11221 ccaacctggc caaccggcag cccgacttca tctccttcgg cctcgtgggg ggaaggcccg 11281 agttccggtt cgatgcaggc tcaggcatgg ccaccatccg ccatcccaca ccactggccc 11341 tgggccattt ccacaccgtg accctgctgc gcagcctcac ccagggctcc ctgattgtgg 11401 gtgacctggc cccggtcaat gggacctccc agggcaagtt ccagggcctg gatctgaacg 11461 aggaactcta cctgggtggc tatcctgact atggtgccat ccccaaggcg gggctgagca 11521 gcggcttcat aggctgtgtc cgggagctgc gcatccaggg cgaggagatc gtcttccatg 11581 acctcaacct cacggcgcac ggcatctccc actgccccac ctgtcgggac cggccctgcc 11641 agaatggcgg tcagtgccat gactctgaga gcagcagcta cgtgtgcgtc tgcccagctg 11701 gcttcaccgg gagccgctgt gagcactcgc aggccctgca ctgccatcca gaggcctgtg 11761 ggcccgacgc cacctgtgtg aaccggcctg acggtcgagg ctacacctgc cgctgccacc 11821 tgggccgctc ggggttgcgg tgtgaggaag gtgtgacagt gaccaccccc tcgctgtcgg 11881 gtgctggctc ctacctggca ctgcccgccc tcaccaacac acaccacgag ctacgcctgg 11941 acgtggagtt caagccactc gcccctgacg gggtcctgct gttcagcggg gggaagagcg 12001 ggcctgtgga ggacttcgtg tccctggcga tggtgggcgg ccacctggag ttccgctatg 12061 agttggggtc agggctggcc gttctgcgga gcgccgagcc gctggccctg ggccgctggc 12121 accgtgtgtc tgcagagcgt ctcaacaagg acggcagcct gcgggtgaat ggtggacgcc 12181 ctgtgctgcg ctcctcgccc ggcaagagcc agggcctcaa cctgcacacc ctgctctacc 12241 tggggggtgt ggagccttcc gtgccactgt ccccggccac caacatgagc gctcacttcc 12301 gcggctgtgt gggcgaggtg tcagtgaatg gcaaacggct ggacctcacc tacagtttcc 12361 taggcagcca gggcatcggg caatgctatg atagctcccc atgtgagcgc cagccttgcc 12421 aacatggtgc cacgtgcatg cccgctggcg agtatgagtt ccagtgcctg tgtcgagatg 12481 gattcaaagg agacctgtgt gagcacgagg agaacccctg ccagctccgt gaaccctgtc 12541 tgcatggggg cacctgccag ggcacccgct gcctctgcct ccctggcttc tctggcccac 12601 gctgccaaca aggctctgga catggcatag cagagtccga ctggcatctt gaaggcagcg 12661 ggggcaatga tgcccctggg cagtacggag cctatttcca cgatgatggc ttcctcgcct 12721 tccctggcca tgtcttctcc aggagcctgc ccgaggtgcc cgagaccatc gagctggagg 12781 ttcggaccag cacagccagt ggcctcctgc tctggcaggg tgtggaggtg ggagaggccg 12841 gccaaggcaa ggacttcatc agcctcgggc ttcaagacgg gcaccttgtc ttcaggtacc 12901 agctgggtag tggggaggcc cgcctggtct ctgaggaccc catcaatgac ggcgagtggc 12961 accgggtgac agcactgcgg gagggccgca gaggttccat ccaagtcgac ggtgaggagc 13021 tggtcagcgg ccggtcccca ggtcccaacg tggcagtcaa cgccaagggc agcgtctaca 13081 tcggcggagc ccctgacgtg gccacgctga ccgggggcag attctcctcg ggcatcacag 13141 gctgtgtcaa gaacctggtg ctgcactcgg cccgacccgg cgccccgccc ccacagcccc 13201 tggacctgca gcaccgcgcc caggccgggg ccaacacacg cccctgcccc tcgtaggcac 13261 ctgcctgccc cacacggact cccgggccac gccccagccc gacaatgtcg agtatattat 13321 tattaatatt attatgaatt tttgtaagaa accgaggcga tgccacgctt tgctgctacc 13381 gccctgggct ggactggagg tgggcatgcc accctcacac acacagctgg gcaaagccac 13441 aaggctggcc agcaaggcag gttggatggg agtgggcacc tcagaaagtc accaggactt 13501 ggggtcagga acagtggctg ggtgggccca gaactgcccc cactgtcccc ctacccaccg 13561 atggagcccc cagatagagc tgggtggcct gtttctgcag cccttgggca gttctcactc 13621 ctaggagagc caacctcggc ttgtgggctg gtgccccaca gctacctgag acgggcatcg 13681 caggagtctc tgccacccac tcaggattgg gaattgtctt tagtgccggc tgtggagcaa 13741 aaggcagctc acccctgggc aggcggtccc catccccacc agctcgtttt tcagcacccc 13801 cacccacctc cacccagccc ctggcacctc ctctggcaga ctccccctcc taccacgtcc 13861 tcctggcctg cattcccacc ccctcctgcc agcacacagc ctggggtccc tccctcaggg 13921 gctgtaaggg aaggcccacc ccaactctta ccaggagctg ctacaggcag agcccagcac 13981 tgatagggcc ccgcccaccg ggccccgccc accccaggcc acatccccac ccatctggaa 14041 gtgaaggccc agggactcct ccaacagaca acggacggac ggatgccgct ggtgctcagg 14101 aagagctagt gccttaggtg ggggaaggca ggactcacga ctgagagaga gaggaggggg 14161 atatgaccac cctgccccat ctgcaggagc ctgaagatcc agctcaagtg ccatcctgcc 14221 agtggccccc agactgtggg gttgggacgc ctggcctctg tgtcctagaa gggaccctcc 14281 tgtggtcttt gtcttgattt ttcttaataa acggtgctat ccccgcc //