LOCUS HUMSAP1B 1976 bp mRNA linear HUM 17-DEC-1993
DEFINITION Homo sapiens SRF accessory protein 1B (SAP-1) mRNA, complete cds.
ACCESSION M85164
VERSION M85164.1
KEYWORDS serum response factor; SAP-1; Elk-1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1976)
AUTHORS Dalton,S. and Treisman,R.
TITLE Characterization of SAP-1, a protein recruited by serum response
factor to the c-fos serum response element
JOURNAL Cell 68 (3), 597-612 (1992)
PUBMED 1339307
REFERENCE 2 (bases 1 to 1976)
AUTHORS Treisman,R.
TITLE Direct Submission
JOURNAL Submitted (05-MAR-1992) Richard Treisman, Transcription Laboratory,
Imperial Cancer Research Fund, London, England
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1976
/db_xref="H-InvDB:HIT000196606"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1976
/gene="SAP-1"
CDS 150..1367
/gene="SAP-1"
/note="Homology region A with Elk-1 protein (Ets domain)
is bp 150-417, amino acids 1-89; Homology region B with
Elk-1 protein, required for cooperative ternary complex
formation with SRF is bp 565-617, amino acids 136-157;
Sequence diverges from SAP-1A at bp 1229, amino acid 360;
Homology region C with Elk-1 protein is truncated such
that only the TP motif at amino acid T354, bp 1209-1214,
is conserved"
/codon_start=1
/product="SAP-1B protein"
/protein_id="AAA03632.1"
/translation="MDSAITLWQFLLQLLQKPQNKHMICWTSNDGQFKLLQAEEVARL
WGIRKNKPNMNYDKLSRALRYYYVKNIIKKVNGQKFVYKFVSYPEILNMDPMTVGRIE
GDCESLNFSEVSSSSKDVENGGKDKPPQPGAKTSSRNDYIHSGLYSSFTLNSLNSSNV
KLFKLIKTENPAEKLAEKKSPQEPTPSVIKFVTTPSKKPPVEPVAATISIGPSISPSS
EETIQALETLVSPKLPSLEAPTSASNVMTAFATTPPISSIPPLQEPPRTPSPPLSSHP
DIDTDIDSVASQPMELPENLSLEPKDQDSVLLEKDKVNNSSRSKKPKGLELAPTLVIT
SSDPSPLGILSPSLPTASLTPAFFSQVACSLFMVSPLLSFICPFKQIQNLYTQVCFLL
LRFVLERLCVTVM"
BASE COUNT 615 a 454 c 376 g 531 t
ORIGIN
1 ccgccgcctt ctactccgcc gcgggggtcg cagcggctgc cgcgccgtcc tcgagtttcc
61 agcgtgagga ggaggctgag ggcggagagg cgcatcgtgt tcgaggcgga gaccgagggg
121 gagccccgcg cgcggcgtcg ctcattgcta tggacagtgc tatcaccctg tggcagttcc
181 ttcttcagct cctgcagaag cctcagaaca agcacatgat ctgttggacc tctaatgatg
241 ggcagtttaa gcttttgcag gcagaagagg tggctcgtct ctgggggatt cgcaagaaca
301 agcctaacat gaattatgac aaactcagcc gagccctcag atactattat gtaaagaata
361 tcatcaaaaa agtgaatggt cagaagtttg tgtacaagtt tgtctcttat ccagagattt
421 tgaacatgga tccaatgaca gtgggcagga ttgagggtga ctgtgaaagt ttaaacttca
481 gtgaagtcag cagcagttcc aaagatgtgg agaatggagg gaaagataaa ccacctcagc
541 ctggtgccaa gacctctagc cgcaatgact acatacactc tggcttatat tcttcattta
601 ctctcaactc tttgaactcc tccaatgtaa agcttttcaa attgataaag actgagaatc
661 cagccgagaa actggcagag aaaaaatctc ctcaggagcc cacaccatct gtcatcaaat
721 ttgtcacgac accttccaaa aagccaccag ttgaacctgt tgctgccacc atttcaattg
781 gcccaagtat ttctccatct tcagaagaaa ctatccaagc tttggagaca ttggtttccc
841 caaaactgcc ttccctggaa gccccaacct ctgcctctaa cgtaatgact gcttttgcca
901 ccacaccacc catttcgtcc ataccccctt tgcaggaacc tcccagaaca ccttcaccac
961 cactgagttc tcacccagac atcgacacag acattgattc agtggcttct cagccaatgg
1021 aacttccaga gaatttgtca ctggagccta aagaccagga ttcagtcttg ctagaaaagg
1081 acaaagtaaa taattcatca agatccaaga aacccaaagg gttagaactg gcacccaccc
1141 ttgtgatcac gagcagtgat ccaagcccac tgggaatact gagcccatct ctccctacag
1201 cttctcttac accagcattt ttttcacagg tagcttgctc gctctttatg gtgtcaccat
1261 tgctttcatt tatttgccct tttaagcaaa tccagaattt atacactcaa gtttgctttc
1321 tgttacttag gtttgtctta gaaaggttat gtgtgactgt catgtgaaag ttaccccatt
1381 tctcatctta attaggattg ctaaaataga aagtttggag tattttctta aaaaattcat
1441 tgctctacaa gtaaataaat attttgattt ttctatttcc tcctaaagaa agtacacaca
1501 ctctctcgct ctctctcggt cttataaaac tcgttggtgt cttataaaac aaacagtgat
1561 aatctcaagt tagaaaacag taggtcctga gaaccataag aaaaatgact ggtgtgatgt
1621 tgagtaacaa gttggtacag ttactttagc tatttattaa cttgctcatc tcatagaaca
1681 ttttaataga tttttcacac acctcattat taaaaaaaaa caaacatgct ggtgtcttgg
1741 ttacccatta ttcctctgta cctgaattca ggttggtttt tctatttgga aaagacttta
1801 taaatgttgg cttaaaaaga ggttgagcac cagaatctca gaatttacca ccaaagaact
1861 catccatgta accaaaaacc acttgtaggg ggaaaaacta ttgaaataaa aatttaaaaa
1921 attttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//