LOCUS       HUMUGT1F                1220 bp    DNA     linear   HUM 14-JAN-1995
DEFINITION  Human phenol UDP-glucuronosyltransferase (UGT1F) gene isozyme, exon
            1.
ACCESSION   M84130
VERSION     M84130.1
KEYWORDS    UDP-glucuronosyltransferase; isozyme; phenol.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Harding,D., Fournel-Gigleux,S., Jackson,M.R. and Burchell,B.
  TITLE     Cloning and substrate specificity of a human phenol
            UDP-glucuronosyltransferase expressed in COS-7 cells
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 85 (22), 8381-8385 (1988)
   PUBMED   3141926
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Harding,D., Jeremiah,S.J., Povey,S. and Burchell,B.
  TITLE     Chromosomal mapping of a human phenol UDP-glucuronosyltransferase,
            GNT1
  JOURNAL   Ann. Hum. Genet. 54 (Pt 1), 17-21 (1990)
   PUBMED   2108603
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Ritter,J.K., Chen,F., Sheen,Y.Y., Tran,H.M., Kimura,S.,
            Yeatman,M.T. and Owens,I.S.
  TITLE     A novel complex locus UGT1 encodes human bilirubin, phenol, and
            other UDP-glucuronosyltransferase isozymes with identical carboxyl
            termini
  JOURNAL   J. Biol. Chem. 267 (5), 3257-3261 (1992)
   PUBMED   1339448
COMMENT     Original source text: Homo sapiens (tissue library: cosmid) liver
            DNA.
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /map="2"
                     /tissue_type="liver"
                     /lab_host="XL1-Blue"
                     /tissue_lib="cosmid"
     gene            71..1220
                     /gene="UGT1"
     regulatory      71..77
                     /regulatory_class="TATA_box"
                     /gene="UGT1"
                     /note="G00-120-007"
     exon            102..1074
                     /gene="UGT1"
                     /note="G00-120-007"
                     /number=1
     CDS             214..>1074
                     /gene="UGT1"
                     /codon_start=1
                     /product="UDP-glucuronosyltransferase"
                     /protein_id="AAC41717.1"
                     /db_xref="GDB:G00-120-007"
                     /translation="MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKD
                     IVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAER
                     SFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILA
                     EYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLE
                     PYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGG
                     INCKKRKDLSQ"
     intron          1075..1220
                     /gene="UGT1"
                     /note="G00-120-007; does not fit consensus"
                     /number=1
BASE COUNT          302 a          259 c          296 g          363 t
ORIGIN      
        1 tgacacggcc atagttggtt catattaacc atgtgattaa aatggttaaa tattaatttg
       61 ggttcttaca tatcaaaggg taaaattcag agcaagggag aggtagacag gacctgtgaa
      121 aagcagtggt tagtttaggg aaaataccta ggagccctgt gatttggaga gtgaaaactc
      181 tttattaccg ttgttacttt aactctttcc aggatggcct gcctccttcg ctcatttcag
      241 agaatttctg caggggtttt cttcttagca ctttggggca tggttgtagg tgacaagctg
      301 ctggtggtcc ctcaggacgg aagccactgg cttagtatga aggatatagt tgaggttctc
      361 agtgaccggg gtcatgagat tgtagtggtg gtgcctgaag ttaatttgct tttgaaagaa
      421 tccaaatact acacaagaaa aatctatcca gtgccgtatg accaagaaga gctgaagaac
      481 cgttaccaat catttggaaa caatcacttt gctgagcgat cattcctaac tgctcctcag
      541 acagagtaca ggaataacat gattgttatt ggcctgtact tcatcaactg ccagagcctc
      601 ctgcaggaca gggacaccct gaacttcttt aaggagagca agtttgatgc tcttttcaca
      661 gacccagcct taccctgtgg ggtgatcctg gctgagtatt tgggcctacc atctgtgtac
      721 ctcttcaggg gttttccgtg ttccctggag catacattca gcagaagccc agaccctgtg
      781 tcctacattc ccaggtgcta cacaaagttt tcagaccaca tgactttttc ccaacgagtg
      841 gccaacttcc ttgttaattt gttggagccc tatctatttt attgtctgtt ttcaaagtat
      901 gaagaactcg catcagctgt cctcaagaga gatgtggata taatcacctt atatcagaag
      961 gtctctgttt ggctgttaag atatgacttt gtgcttgaat atcctaggcc ggtcatgccc
     1021 aacatggtct tcattggagg tatcaactgt aagaagagga aagacttgtc tcaggttggt
     1081 gggtttattt cttttggact gccttgtttc ttccaggctc tgtcctccct cactcatttg
     1141 gctccttgag ccgactgtcc cttggaggat ttcctggaga acggtggggg gaagtgatac
     1201 ccggctcgga gcagcgggaa
//