LOCUS HUMUGT1D 1197 bp DNA linear HUM 14-JAN-1995
DEFINITION Human UDP-glucuronosyltransferase (UGT1D) gene isozyme, exon 1.
ACCESSION M84128
VERSION M84128.1
KEYWORDS UDP-glucuronosyltransferase; bilirubin; isozyme.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1197)
AUTHORS Ritter,J.K., Crawford,J.M. and Owens,I.S.
TITLE Cloning of two human liver bilirubin UDP-glucuronosyltransferase
cDNAs with expression in COS-1 cells
JOURNAL J. Biol. Chem. 266 (2), 1043-1047 (1991)
PUBMED 1898728
REFERENCE 2 (bases 1 to 1197)
AUTHORS Ritter,J.K., Chen,F., Sheen,Y.Y., Tran,H.M., Kimura,S.,
Yeatman,M.T. and Owens,I.S.
TITLE A novel complex locus UGT1 encodes human bilirubin, phenol, and
other UDP-glucuronosyltransferase isozymes with identical carboxyl
termini
JOURNAL J. Biol. Chem. 267 (5), 3257-3261 (1992)
PUBMED 1339448
COMMENT Original source text: Homo sapiens (tissue library: cosmid) liver
DNA.
FEATURES Location/Qualifiers
source 1..1197
/organism="Homo sapiens"
/mol_type="genomic DNA"
/host="XL1-Blue"
/db_xref="taxon:9606"
/map="2"
/tissue_type="liver"
/tissue_lib="cosmid"
gene 155..1197
/gene="UGT1"
regulatory 155..161
/regulatory_class="TATA_box"
/gene="UGT1"
/note="G00-120-007"
exon 186..1096
/gene="UGT1"
/note="G00-120-007"
/number=1
CDS 230..>1096
/gene="UGT1"
/codon_start=1
/product="UDP-glucuronosyltransferase"
/protein_id="AAA61249.1"
/db_xref="GDB:G00-120-007"
/translation="MARGLQVPLPRLATGLLLLLSVQPWAESGKVLVVPTDGSPWLSM
REALRELHARGHQAVVLTPEVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFE
TEHLLKRYSRSMAIMNNVSLALHRCCVELLHNEALIRHLNATSFDVVLTDPVNLCGAV
LAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPL
ALSYICHTFSAPYASLASELFQREVSVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFI
GGINCANGKPLSQ"
intron 1097..1197
/gene="UGT1"
/note="G00-120-007"
/number=1
BASE COUNT 280 a 287 c 303 g 327 t
ORIGIN
1 gtcagatgag cttttcaaga taggcgtgat tggtctttcc cagggttggg cccataacga
61 aaggcagtta tacattaatg ggtaataagt aactggagga gggcactttg tcttccaatt
121 acatgctgat ttgctaggtg gctcaatgac aaggtaatta aggcgaagga aacaaatgta
181 gcaggcacag cgtggggtgg acagtcagct gtcggtggct tctgctgaga tggccagagg
241 actccaggtt cccctgccgc ggctggccac aggactgctg ctcctcctca gtgtccagcc
301 ctgggctgag agtggaaagg tgttggtggt gcccactgat ggcagcccct ggctcagcat
361 gcgggaggcc ttgcgggagc tccatgccag aggccaccag gcggtggtcc tcaccccaga
421 ggtgaatatg cacatcaaag aagagaaatt tttcaccctg acagcctatg ctgttccatg
481 gacccagaag gaatttgatc gcgttacgct gggctacact caagggttct ttgaaacaga
541 acatcttctg aagagatatt ctagaagtat ggcaattatg aacaatgtat ctttggccct
601 tcataggtgt tgtgtggagc tactgcataa tgaggccctg atcaggcacc tgaatgctac
661 ttcctttgat gtggttttaa cagaccccgt taacctctgt ggggcggtgc tggctaagta
721 cctgtcgatt cctgctgtgt ttttttggag gtacattcca tgtgacttag actttaaggg
781 cacacagtgt ccaaatcctt cctcctatat tcctaagtta ctaacgacca attcagacca
841 catgacattc ctgcaaaggg tcaagaacat gctctaccct ctggccctgt cctacatttg
901 ccatactttt tctgcccctt atgcaagtct tgcctctgag ctttttcaga gagaggtgtc
961 agtggtggat cttgtcagct atgcatccgt gtggctgttc cgaggggact ttgtgatgga
1021 ctaccccagg ccgatcatgc ccaacatggt cttcattggg ggcatcaact gtgccaacgg
1081 gaagccacta tctcaggtct gtattggtgc cttcatccaa tcaatgttcc aggcaaaaca
1141 ctttttaaaa aatgtattta cttacaagtg cttccatatc tacttatctt tccaaag
//