LOCUS HUMHIOMT 1257 bp mRNA linear HUM 28-MAR-1994
DEFINITION Homo sapiens (clone 179 or 217) hydroxyindole-O-methyltransferase
(HIOMT) mRNA, complete cds.
ACCESSION M83779
VERSION M83779.1
KEYWORDS hydroxyindole-O-methyltransferase; methyltransferase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1257)
AUTHORS Donohue,S.J., Roseboom,P.H., Illnerova,H., Weller,J.L. and
Klein,D.C.
TITLE Human hydroxyindole-O-methyltransferase: presence of LINE-1
fragment in a cDNA clone and pineal mRNA
JOURNAL DNA Cell Biol. 12 (8), 715-727 (1993)
PUBMED 8397829
COMMENT Original source text: Homo sapiens (library: pineal lambda-gt11 in
pBluescript SK+) cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1257
/db_xref="H-InvDB:HIT000196553_03"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
gene 1..1257
/gene="HIOMT"
CDS 70..1191
/gene="HIOMT"
/EC_number="2.1.1.4"
/function="O-methylates N-acetylserotonin using
S-adenosyl-L-methionine as the methyl donor"
/codon_start=1
/product="hydroxyindole-O-methyltransferase"
/protein_id="AAA17020.1"
/translation="MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPL
DVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQ
CSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQAL
QEVWSVNGRSVLTAFDLSVFPLMCDLGGTRIKLETIILSKLSQGQKTKHRVFSLIGGA
GALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLY
ILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQ
TEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK"
regulatory 1239..1244
/regulatory_class="polyA_signal_sequence"
/gene="HIOMT"
BASE COUNT 303 a 337 c 355 g 262 t
ORIGIN
1 agcaggctct gtgctccttg aagcaagcgc tccagaggct ccggaagcca cggctggatt
61 ggagacaaga tgggatcctc agaggaccag gcctatcgcc tccttaatga ctacgccaac
121 ggcttcatgg tgtcccaggt tctcttcgcc gcctgcgagc tgggcgtgtt tgaccttctc
181 gccgaggccc cagggcccct ggacgtggcg gcagtggctg caggtgtgag ggccagcgcc
241 catgggacag agctcctgct ggacatctgt gtgtccctga agctgctgaa agtggagacg
301 aggggaggaa aagctttcta tcgaaacaca gagctgtcca gcgactacct gaccacggtc
361 agcccgacgt cacaatgcag catgctgaag tacatgggca ggaccagcta ccggtgctgg
421 ggccacctgg cagacgccgt gagagaagga aggaaccagt acctggagac gtttggcgtt
481 cccgctgaag agctttttac ggccatctac aggtccgagg gcgagcggct acagttcatg
541 caagctctgc aggaggtctg gagcgtcaac gggagaagcg tgctgaccgc ctttgacctg
601 tcagtgttcc cacttatgtg tgaccttggt gggacacgga taaagctgga aaccatcatt
661 ctcagcaaac tatcgcaagg acagaaaacc aaacaccgcg tgttctcact cataggtggg
721 gctggagctc tggctaagga atgcatgtct ctgtaccctg gatgtaagat caccgttttt
781 gacatcccag aagtggtgtg gacggcaaag cagcacttct cattccagga ggaagaacag
841 attgacttcc aggaagggga tttcttcaaa gaccctcttc cggaagctga tctgtacatc
901 ctggccaggg tcctccatga ctgggcagac ggaaagtgct cacacctgct ggagaggatc
961 taccacactt gcaagccagg tggtggcatt ctggtaattg aaagcctcct ggatgaagac
1021 aggcgaggtc ctctgctcac gcagctctac tctctgaaca tgcttgtgca gacggaaggg
1081 caggagagga cccccaccca ctaccacatg ctcctctctt ctgctggctt cagagacttc
1141 cagtttaaga aaacaggagc catttatgat gccattttag ccaggaaata actgtttctt
1201 gtgacctgga actaacgtca aagcacacaa gacataataa taaagacatg tacctcc
//