LOCUS HUMPROP 1543 bp mRNA linear HUM 11-FEB-2002
DEFINITION Homo sapiens complement omponent properdin mRNA, complete cds.
ACCESSION M83652 S49355
VERSION M83652.1
KEYWORDS complement component; properdin.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS Nolan,K.F., Schwaeble,W., Kaluz,S., Dierich,M.P. and Reid,K.B.
TITLE Molecular cloning of the cDNA coding for properdin, a positive
regulator of the alternative pathway of human complement
JOURNAL Eur. J. Immunol. 21 (3), 771-776 (1991)
PUBMED 2009915
REFERENCE 2 (bases 1 to 1543)
AUTHORS Maves,K.K. and Weiler,J.M.
TITLE Detection of properdin mRNA in human peripheral blood monocytes and
spleen
JOURNAL J. Lab. Clin. Med. 120 (5), 762-766 (1992)
PUBMED 1431505
COMMENT On Feb 8, 2002 this sequence version replaced S49355.1.
FEATURES Location/Qualifiers
source 1..1543
/db_xref="H-InvDB:HIT000196540"
/organism="Homo sapiens"
/mol_type="mRNA"
/isolate="PD89"
/db_xref="taxon:9606"
/chromosome="X"
/map="Xp11.23-Xp21.1"
/tissue_type="spleen"
CDS 73..1482
/note="potential N-linked glycosylation site (401..401)"
/codon_start=1
/product="complement omponent properdin"
/protein_id="AAA36489.1"
/translation="MITEGAQAPRLLLPPLLLLLTLPATGSDPVLCFTQYEESSGKCK
GLLGGGVSVEDCCLNTAFAYQKRSGGLCQPCRSPRWSLWSTWAPCSVTCSEGSQLRYR
RCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCSVTCSKGTRTRR
RACNHPAPKCGGHCPGQAQESEACDTQQVCPTHGAWATWGPWTPCSASCHGGPHEPKE
TRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLPPCPVAGGWGPWGPVSPCPVTCGLG
QTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWDSWGEWSPCIRRNMKS
ISCQEIPGQQSRGRTCRGRKFDGHRCAGQQQDIRHCYSIQHCPLKGSWSEWSTWGLCM
PPCGPNPTRARQRLCTPLLPKYPPTVSMVEGQGEKNVTFWGRPLPRCEELQGQKLVVE
EKRPCLHVPACKDPEEEEL"
sig_peptide 73..153
mat_peptide 154..1479
/product="properdin"
/function="stabilises alternative pathway C3 convertase
(C3b, Bb)"
variation 103
/citation=[1]
variation 582
/citation=[1]
variation 747
/citation=[1]
variation 1442
/citation=[1]
variation 1507
/citation=[1]
regulatory 1526..1531
/regulatory_class="polyA_signal_sequence"
polyA_site 1543
BASE COUNT 291 a 505 c 478 g 269 t
ORIGIN
1 attccaggag cctatcaacc cagataaagc gggacctcct ctctggtaga ggtgcagggg
61 gcagtactca acatgatcac agagggagcg caggcccctc gactgttgct gccgccgctg
121 ctcctgctgc tcaccctgcc agccacaggc tcagaccccg tgctctgctt cacccagtat
181 gaagaatcct ccggcaagtg caagggcctc ctggggggtg gtgtcagcgt ggaagactgc
241 tgtctcaaca ctgcctttgc ctaccagaaa cgtagtggtg ggctctgtca gccttgcagg
301 tccccacgat ggtccctgtg gtccacatgg gccccctgtt cggtgacgtg ctctgagggc
361 tcccagctgc ggtaccggcg ctgtgtgggc tggaatgggc agtgctctgg aaaggtggca
421 cctgggaccc tggagtggca gctccaggcc tgtgaggacc agcagtgctg tcctgagatg
481 ggcggctggt ctggctgggg gccctgggag ccttgctctg tcacctgctc caaagggacc
541 cggacccgca ggcgagcctg taatcaccct gctcccaagt gcgggggcca ctgcccagga
601 caggcacagg aatcagaggc ctgtgacacc cagcaggtct gccccacaca cggggcctgg
661 gccacctggg gcccctggac cccctgctca gcctcctgcc acggtggacc ccacgaacct
721 aaggagacac gaagccgcaa gtgttccgca cctgagccct cccagaaacc tcctgggaag
781 ccctgcccgg ggctagccta cgagcagcgg aggtgcaccg gcctgccacc ctgcccagtg
841 gctgggggct gggggccttg gggccctgtg agcccctgcc ctgtgacctg tggcctgggc
901 cagaccatgg aacaacggac gtgcaatcac cctgtgcccc agcatggggg ccccttctgt
961 gctggcgatg ccacccggac ccacatctgc aacacagctg tgccctgccc tgtggatggg
1021 gagtgggact cgtgggggga gtggagcccc tgtatccgac ggaacatgaa gtccatcagc
1081 tgtcaagaaa tcccgggcca gcagtcacgc gggaggacct gcaggggccg caagtttgac
1141 ggacatcgat gtgccgggca acagcaggat atccggcact gctacagcat ccagcactgc
1201 cccttgaaag gatcatggtc agagtggagt acctgggggc tgtgcatgcc cccctgtgga
1261 cctaatccta cccgtgcccg ccagcgcctc tgcacaccct tgctccccaa gtacccgccc
1321 accgtttcca tggtcgaagg tcagggcgag aagaacgtga ccttctgggg gagaccgctg
1381 ccacggtgtg aggagctaca agggcagaag ctggtggtgg aggagaaacg accatgtcta
1441 cacgtgcctg cttgcaaaga ccctgaggaa gaggaactct aacacttctc tcctccactc
1501 tgagccccct gaccttccaa acctcaataa actagcctct tcg
//