LOCUS       HUMNEPPON               1278 bp    mRNA    linear   HUM 10-JUN-2002
DEFINITION  Homo sapiens nephropontin precursor, mRNA, complete cds.
ACCESSION   M83248
VERSION     M83248.1
KEYWORDS    nephropontin, osteopontin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Shiraga,H., Min,W., VanDusen,W.J., Clayman,M.D., Miner,D.,
            Terrell,C.H., Sherbotie,J.R., Foreman,J.W., Przysiecki,C.,
            Neilson,E.G. and Hoyer,J.R.
  TITLE     Inhibition of calcium oxalate crystal growth in vitro by uropontin:
            another member of the aspartic acid-rich protein superfamily
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (1), 426-430 (1992)
   PUBMED   1729712
COMMENT     Original source text: Homo sapiens (library: lambda gt10
            (Clontech)) adult kidney cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..1278
                     /db_xref="H-InvDB:HIT000196526"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /tissue_type="kidney"
                     /dev_stage="adult"
     CDS             98..1042
                     /codon_start=1
                     /product="nephropontin precursor"
                     /protein_id="AAA17675.1"
                     /translation="MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWL
                     NPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDS
                     IDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRG
                     DSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWD
                     SRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSH
                     EFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN"
     sig_peptide     98..145
     mat_peptide     146..1039
                     /product="nephropontin"
     variation       265
                     /note="single base difference from clone NP3; 't' in
                     variation"
                     /replace=""
     misc_feature    272..313
                     /note="The 5' portion of NP3 sequence was determined from
                     base 236 to 964 of NP1 and differs from NP1 only in 2
                     single base substitutons and the 42 base deletion.; This
                     42 base sequence is also deleted in an isoform of
                     humanosteopontin mRNA (Genomics 7:491-502(1990) X13694.;
                     encodes 14 AA sequence homologous to exon 4 of mouse
                     osteopontingene(J.Biol.Chem. 265:14432-14438(1990) X51834.
                     Author suggests NP3 lacks thissequence due to alternative
                     splicing.; this 42 base sequence is deleted in another
                     clone NP3 from samekidneycDNA library as NP1"
     variation       319
                     /note="single base difference from human osteopontin cDNA
                     (NucleicAcids Res.17:3306-3306(1989) X13694); 't' in
                     variation"
                     /replace=""
     variation       379
                     /note="single base difference from X13694.; 't' in
                     variation"
                     /replace=""
     variation       847
                     /note="single base difference from X13694.; 'c' in
                     variation"
                     /replace=""
     variation       1180
                     /note="single base difference from X13694; 'a' in
                     variation"
                     /replace=""
BASE COUNT          397 a          283 c          287 g          311 t
ORIGIN      
        1 gcaggaggag gcagagcaca gcatcgtcgg gaccagactc gtctcaggcc agttgcagcc
       61 ttctcagcca aacgccgacc aaggaaaact cactaccatg agaattgcag tgatttgctt
      121 ttgcctccta ggcatcacct gtgccatacc agttaaacag gctgattctg gaagttctga
      181 ggaaaagcag ctttacaaca aatacccaga tgctgtggcc acatggctaa accctgaccc
      241 atctcagaag cagaatctcc tagccccaca gaatgctgtg tcctctgaag aaaccaatga
      301 ctttaaacaa gagaccctcc caagtaagtc caacgaaagc catgaccaca tggatgatat
      361 ggatgatgaa gatgatgacg accatgtgga cagccaggac tccattgact cgaacgactc
      421 tgatgatgta gatgacactg atgattctca ccagtctgat gagtctcacc attctgatga
      481 atctgatgaa ctggtcactg attttcccac ggacctgcca gcaaccgaag ttttcactcc
      541 agttgtcccc acagtagaca catatgatgg ccgaggtgat agtgtggttt atggactgag
      601 gtcaaaatct aagaagtttc gcagacctga catccagtac cctgatgcta cagacgagga
      661 catcacctca cacatggaaa gcgaggagtt gaatggtgca tacaaggcca tccccgttgc
      721 ccaggacctg aacgcgcctt ctgattggga cagccgtggg aaggacagtt atgaaacgag
      781 tcagctggat gaccagagtg ctgaaaccca cagccacaag cagtccagat tatataagcg
      841 gaaagctaat gatgagagca atgagcattc cgatgtgatt gatagtcagg aactttccaa
      901 agtcagccgt gaattccaca gccatgaatt tcacagccat gaagatatgc tggttgtaga
      961 ccccaaaagt aaggaagaag ataaacacct gaaatttcgt atttctcatg aattagatag
     1021 tgcatcttct gaggtcaatt aaaaggagaa aaaatacaat ttctcacttt gcatttagtc
     1081 aaaagaaaaa atgctttata gcaaaatgaa agagaacatg aaatgcttct ttctcagttt
     1141 attggttgaa tgtgtatcta tttgagtctg gaaataactg atgtgtttga taattagttt
     1201 agtttgtggc ttcatggaaa ctccctgtaa actaaaagct tcagggttat gtctatgttc
     1261 attctataga agaaatgc
//