LOCUS HUMNEPPON 1278 bp mRNA linear HUM 10-JUN-2002 DEFINITION Homo sapiens nephropontin precursor, mRNA, complete cds. ACCESSION M83248 VERSION M83248.1 KEYWORDS nephropontin, osteopontin. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1278) AUTHORS Shiraga,H., Min,W., VanDusen,W.J., Clayman,M.D., Miner,D., Terrell,C.H., Sherbotie,J.R., Foreman,J.W., Przysiecki,C., Neilson,E.G. and Hoyer,J.R. TITLE Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (1), 426-430 (1992) PUBMED 1729712 COMMENT Original source text: Homo sapiens (library: lambda gt10 (Clontech)) adult kidney cDNA to mRNA. FEATURES Location/Qualifiers source 1..1278 /db_xref="H-InvDB:HIT000196526" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /tissue_type="kidney" /dev_stage="adult" CDS 98..1042 /codon_start=1 /product="nephropontin precursor" /protein_id="AAA17675.1" /translation="MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWL NPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDS IDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRG DSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWD SRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSH EFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN" sig_peptide 98..145 mat_peptide 146..1039 /product="nephropontin" variation 265 /note="single base difference from clone NP3; 't' in variation" /replace="" misc_feature 272..313 /note="The 5' portion of NP3 sequence was determined from base 236 to 964 of NP1 and differs from NP1 only in 2 single base substitutons and the 42 base deletion.; This 42 base sequence is also deleted in an isoform of humanosteopontin mRNA (Genomics 7:491-502(1990) X13694.; encodes 14 AA sequence homologous to exon 4 of mouse osteopontingene(J.Biol.Chem. 265:14432-14438(1990) X51834. Author suggests NP3 lacks thissequence due to alternative splicing.; this 42 base sequence is deleted in another clone NP3 from samekidneycDNA library as NP1" variation 319 /note="single base difference from human osteopontin cDNA (NucleicAcids Res.17:3306-3306(1989) X13694); 't' in variation" /replace="" variation 379 /note="single base difference from X13694.; 't' in variation" /replace="" variation 847 /note="single base difference from X13694.; 'c' in variation" /replace="" variation 1180 /note="single base difference from X13694; 'a' in variation" /replace="" BASE COUNT 397 a 283 c 287 g 311 t ORIGIN 1 gcaggaggag gcagagcaca gcatcgtcgg gaccagactc gtctcaggcc agttgcagcc 61 ttctcagcca aacgccgacc aaggaaaact cactaccatg agaattgcag tgatttgctt 121 ttgcctccta ggcatcacct gtgccatacc agttaaacag gctgattctg gaagttctga 181 ggaaaagcag ctttacaaca aatacccaga tgctgtggcc acatggctaa accctgaccc 241 atctcagaag cagaatctcc tagccccaca gaatgctgtg tcctctgaag aaaccaatga 301 ctttaaacaa gagaccctcc caagtaagtc caacgaaagc catgaccaca tggatgatat 361 ggatgatgaa gatgatgacg accatgtgga cagccaggac tccattgact cgaacgactc 421 tgatgatgta gatgacactg atgattctca ccagtctgat gagtctcacc attctgatga 481 atctgatgaa ctggtcactg attttcccac ggacctgcca gcaaccgaag ttttcactcc 541 agttgtcccc acagtagaca catatgatgg ccgaggtgat agtgtggttt atggactgag 601 gtcaaaatct aagaagtttc gcagacctga catccagtac cctgatgcta cagacgagga 661 catcacctca cacatggaaa gcgaggagtt gaatggtgca tacaaggcca tccccgttgc 721 ccaggacctg aacgcgcctt ctgattggga cagccgtggg aaggacagtt atgaaacgag 781 tcagctggat gaccagagtg ctgaaaccca cagccacaag cagtccagat tatataagcg 841 gaaagctaat gatgagagca atgagcattc cgatgtgatt gatagtcagg aactttccaa 901 agtcagccgt gaattccaca gccatgaatt tcacagccat gaagatatgc tggttgtaga 961 ccccaaaagt aaggaagaag ataaacacct gaaatttcgt atttctcatg aattagatag 1021 tgcatcttct gaggtcaatt aaaaggagaa aaaatacaat ttctcacttt gcatttagtc 1081 aaaagaaaaa atgctttata gcaaaatgaa agagaacatg aaatgcttct ttctcagttt 1141 attggttgaa tgtgtatcta tttgagtctg gaaataactg atgtgtttga taattagttt 1201 agtttgtggc ttcatggaaa ctccctgtaa actaaaagct tcagggttat gtctatgttc 1261 attctataga agaaatgc //