LOCUS HUMGAD67A 3610 bp mRNA linear HUM 23-FEB-1995 DEFINITION Human glutamate decarboxylase (GAD67) mRNA, complete cds. ACCESSION M81883 VERSION M81883.1 KEYWORDS glutamate decarboxylase; pyridoxal phosphate coenzyme. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3610) AUTHORS Bu,D.F., Erlander,M.G., Hitz,B.C., Tillakaratne,N.J., Kaufman,D.L., Wagner-McPherson,C.B., Evans,G.A. and Tobin,A.J. TITLE Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 89 (6), 2115-2119 (1992) PUBMED 1549570 REFERENCE 2 (bases 1 to 3610) AUTHORS Bu,D.F. and Tobin,A.J. TITLE The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD JOURNAL Genomics 21 (1), 222-228 (1994) PUBMED 8088791 COMMENT Original source text: Homo sapiens cDNA to mRNA. FEATURES Location/Qualifiers source 1..3610 /db_xref="H-InvDB:HIT000196495" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /dev_stage="22 week fetus" /tissue_lib="whole brain, lambda gt11" gene 1..3610 /gene="GAD67" mRNA <1..>3610 /gene="GAD67" /experiment="experimental evidence, no additional details recorded" CDS 551..2335 /gene="GAD67" /EC_number="4.1.1.15" /function="directs the synthesis of enzymatically active proteins in prokaryotic and eukaryotic expression systems" /note="67-kDa isoenzyme" /codon_start=1 /product="glutamate decarboxylase" /protein_id="AAA62368.1" /translation="MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLG LKICGFLQRTNSLEEKSRLVSAFRERQSSKNLLSCENSDRDARFRRTETDFSNLFARD LLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSD HPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEI APVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGM AAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQK GYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNG IERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGD KAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEP EHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFF RMVISNPAATQSDIDFLIEEIERLGQDL" BASE COUNT 985 a 838 c 861 g 926 t ORIGIN chromosome 2q31. 1 gaattcttcg taggaattat cttttccctc ctctcacccg acagcctgcc tatttccaaa 61 ggaaaaaaaa aaagcgtgtt gagtacgttc tggattactc ataagacctt ttttttttcc 121 ttccgggcgc aaaaccgtga gctggattta taatcgccct ataaagctcc agaggcggtc 181 aggcacctgc agaggagccc cgccgctccg ccgactagct gcccccgcga gcaacggcct 241 cgtgatttcc ccgccgatcc ggtccccgcc tccccactct gcccccgcct accccggagc 301 cgtgcagccg cctctccgaa tctctctctt ctcctggcgc tcgcgtgcga gagggaacta 361 gcgagaacga ggaagcagct ggaggtgacg ccgggcagat tacgcctgtc agggccgagc 421 cgagcggatc gctgggcgct gtgcagagga aaggcgggag tgcccggctc gctgtcgcag 481 agccgagcct gtttctgcgc cggaccagtc gaggactctg gacagtagag gccccgggac 541 gaccgagctg atggcgtctt cgaccccatc ttcgtccgca acctcctcga acgcgggagc 601 ggaccccaat accactaacc tgcgccccac aacgtacgat acctggtgcg gcgtggccca 661 tggatgcacc agaaaactgg ggctcaagat ctgcggcttc ttgcaaagga ccaacagcct 721 ggaagagaag agtcgccttg tgagtgcctt cagggagagg caatcctcca agaacctgct 781 ttcctgtgaa aacagcgacc gggatgcccg cttccggcgc acagagactg acttctctaa 841 tctgtttgct agagatctgc ttccggctaa gaacggtgag gagcaaaccg tgcaattcct 901 cctggaagtg gtggacatac tcctcaacta tgtccgcaag acatttgatc gctccaccaa 961 ggtgctggac tttcatcacc cacaccagtt gctggaaggc atggagggct tcaacttgga 1021 gctctctgac caccccgagt ccctggagca gatcctggtt gactgcagag acaccttgaa 1081 gtatggggtt cgcacaggtc atcctcgatt tttcaaccag ctctccactg gattggatat 1141 tattggccta gctggagaat ggctgacatc aacggccaat accaacatgt ttacatatga 1201 aattgcacca gtgtttgtcc tcatggaaca aataacactt aagaagatga gagagatagt 1261 tggatggtca agtaaagatg gtgatgggat attttctcct gggggcgcca tatccaacat 1321 gtacagcatc atggctgctc gctacaagta cttcccggaa gttaagacaa agggcatggc 1381 ggctgtgcct aaactggtcc tcttcacctc agaacagagt cactattcca taaagaaagc 1441 tggggctgca cttggctttg gaactgacaa tgtgattttg ataaagtgca atgaaagggg 1501 gaaaataatt ccagctgatt ttgaggcaaa aattcttgaa gccaaacaga agggatatgt 1561 tcccttttat gtcaatgcaa ctgctggcac gactgtttat ggagcttttg atccgataca 1621 agagattgca gatatatgtg agaaatataa cctttggttg catgtcgatg ctgcctgggg 1681 aggtgggctg ctcatgtcca ggaagcaccg ccataaactc aacggcatag aaagggccaa 1741 ctcagtcacc tggaaccctc acaagatgat gggcgtgctg ttgcagtgct ctgccattct 1801 cgtcaaggaa aagggtatac tccaaggatg caaccagatg tgtgcaggat atctcttcca 1861 gccagacaag cagtatgatg tctcctacga caccggggac aaggcaattc agtgtggccg 1921 ccacgtggat atcttcaagt tctggctgat gtggaaagca aagggcacag tgggatttga 1981 aaaccagatc aacaaatgcc tggaactggc tgaatacctc tatgccaaga ttaaaaacag 2041 agaagaattt gagatggttt tcaatggcga gcctgagcac acaaacgtct gtttttggta 2101 tattccacaa agcctcaggg gtgtgccaga cagccctcaa cgacgggaaa agctacacaa 2161 ggtggctcca aaaatcaaag ccctgatgat ggagtcaggt acgaccatgg ttggctacca 2221 gccccaaggg gacaaggcca acttcttccg gatggtcatc tccaacccag ccgctaccca 2281 gtctgacatt gacttcctca ttgaggagat agaaagactg ggccaggatc tgtaatcatc 2341 cttcgcagaa catgagttta tgggaatgcc ttttccctct ggcactccag aacaaacctc 2401 tatatgttgc tgaaacacac aggccatttc attgagggaa aacataatat cttgaagaat 2461 attgttaaaa ccttacttaa agcttgtttg ttctagttag caggaaatag tgttcttttt 2521 aaaaagttgc acattaggaa cagagtatat atgtacagtt atacatacct ctctctatat 2581 atacatgtat agtgagtgtg gcttagtaat agatcacggc atgtttcccg ctccaagaga 2641 attcacttta ccttcagcag ttaccgagga gctaaacatg ctgccaacca gcttgtccaa 2701 caactccagg aaaactgttt ttcaaaacgc catgtcctag gggccaaggg aaatgctgtt 2761 ggtgagaatc gacctcactg tcagcgtttc tccacctgaa gtgatgatgg atgagaaaaa 2821 acaccaccaa atgacaagtc acaccctccc cattagtatc ctgttagggg aaaatagtag 2881 cagagtcatt gttacaggtg tactatggct gtattttaga gattaatttg tgtagattgt 2941 gtaaattcct gttgtctgac cttggtggtg ggaggggaga ctatgtgtca tgatttcaat 3001 gattgtttaa ttgtaggtca atgaaatatt tgcttattta tattcagaga tgtaccatgt 3061 taaagaggcg tcttgtattt tcttcccatt tgtaatgtat cttatttata tatgaagtaa 3121 gttctgaaaa ctgtttatgg tattttcgtg catttgtgag ccaaagagaa aagattaaaa 3181 ttagtgagat ttgtatttat attagagtgc ccttaaaata atgatttaag cattttactg 3241 tctgtaagag aattctaaga ttgtacatga cataagttat agtaatcatg gcaaatcctg 3301 ttacttaaat agcatctgct cttctcttac gctctctgtc tggctgtacg tctggtgttc 3361 tcaatgcttt tctagcaact gttggataat aactagatct cctgtaattt tgtagtagtt 3421 gatgaccaat ctctgtgact cgcttagctg aaacctaagg caacatttcc gaagaccttc 3481 tgaagatctc agataaagtg accaggctca caactgtttt tgaagaaggg aaattcacac 3541 tgtgcgtttt gagtatgcaa gaagaatata aataaataaa atatctcatg gagattgaca 3601 aaaaaaaaaa //