LOCUS       HUMGAD67A               3610 bp    mRNA    linear   HUM 23-FEB-1995
DEFINITION  Human glutamate decarboxylase (GAD67) mRNA, complete cds.
ACCESSION   M81883
VERSION     M81883.1
KEYWORDS    glutamate decarboxylase; pyridoxal phosphate coenzyme.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3610)
  AUTHORS   Bu,D.F., Erlander,M.G., Hitz,B.C., Tillakaratne,N.J., Kaufman,D.L.,
            Wagner-McPherson,C.B., Evans,G.A. and Tobin,A.J.
  TITLE     Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are
            each encoded by a single gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (6), 2115-2119 (1992)
   PUBMED   1549570
REFERENCE   2  (bases 1 to 3610)
  AUTHORS   Bu,D.F. and Tobin,A.J.
  TITLE     The exon-intron organization of the genes (GAD1 and GAD2) encoding
            two human glutamate decarboxylases (GAD67 and GAD65) suggests that
            they derive from a common ancestral GAD
  JOURNAL   Genomics 21 (1), 222-228 (1994)
   PUBMED   8088791
COMMENT     Original source text: Homo sapiens cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..3610
                     /db_xref="H-InvDB:HIT000196495"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /dev_stage="22 week fetus"
                     /tissue_lib="whole brain, lambda gt11"
     gene            1..3610
                     /gene="GAD67"
     mRNA            <1..>3610
                     /gene="GAD67"
                     /experiment="experimental evidence, no additional details
                     recorded"
     CDS             551..2335
                     /gene="GAD67"
                     /EC_number="4.1.1.15"
                     /function="directs the synthesis of enzymatically active
                     proteins in prokaryotic and eukaryotic expression systems"
                     /note="67-kDa isoenzyme"
                     /codon_start=1
                     /product="glutamate decarboxylase"
                     /protein_id="AAA62368.1"
                     /translation="MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLG
                     LKICGFLQRTNSLEEKSRLVSAFRERQSSKNLLSCENSDRDARFRRTETDFSNLFARD
                     LLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSD
                     HPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEI
                     APVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGM
                     AAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQK
                     GYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNG
                     IERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGD
                     KAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEP
                     EHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFF
                     RMVISNPAATQSDIDFLIEEIERLGQDL"
BASE COUNT          985 a          838 c          861 g          926 t
ORIGIN      chromosome 2q31.
        1 gaattcttcg taggaattat cttttccctc ctctcacccg acagcctgcc tatttccaaa
       61 ggaaaaaaaa aaagcgtgtt gagtacgttc tggattactc ataagacctt ttttttttcc
      121 ttccgggcgc aaaaccgtga gctggattta taatcgccct ataaagctcc agaggcggtc
      181 aggcacctgc agaggagccc cgccgctccg ccgactagct gcccccgcga gcaacggcct
      241 cgtgatttcc ccgccgatcc ggtccccgcc tccccactct gcccccgcct accccggagc
      301 cgtgcagccg cctctccgaa tctctctctt ctcctggcgc tcgcgtgcga gagggaacta
      361 gcgagaacga ggaagcagct ggaggtgacg ccgggcagat tacgcctgtc agggccgagc
      421 cgagcggatc gctgggcgct gtgcagagga aaggcgggag tgcccggctc gctgtcgcag
      481 agccgagcct gtttctgcgc cggaccagtc gaggactctg gacagtagag gccccgggac
      541 gaccgagctg atggcgtctt cgaccccatc ttcgtccgca acctcctcga acgcgggagc
      601 ggaccccaat accactaacc tgcgccccac aacgtacgat acctggtgcg gcgtggccca
      661 tggatgcacc agaaaactgg ggctcaagat ctgcggcttc ttgcaaagga ccaacagcct
      721 ggaagagaag agtcgccttg tgagtgcctt cagggagagg caatcctcca agaacctgct
      781 ttcctgtgaa aacagcgacc gggatgcccg cttccggcgc acagagactg acttctctaa
      841 tctgtttgct agagatctgc ttccggctaa gaacggtgag gagcaaaccg tgcaattcct
      901 cctggaagtg gtggacatac tcctcaacta tgtccgcaag acatttgatc gctccaccaa
      961 ggtgctggac tttcatcacc cacaccagtt gctggaaggc atggagggct tcaacttgga
     1021 gctctctgac caccccgagt ccctggagca gatcctggtt gactgcagag acaccttgaa
     1081 gtatggggtt cgcacaggtc atcctcgatt tttcaaccag ctctccactg gattggatat
     1141 tattggccta gctggagaat ggctgacatc aacggccaat accaacatgt ttacatatga
     1201 aattgcacca gtgtttgtcc tcatggaaca aataacactt aagaagatga gagagatagt
     1261 tggatggtca agtaaagatg gtgatgggat attttctcct gggggcgcca tatccaacat
     1321 gtacagcatc atggctgctc gctacaagta cttcccggaa gttaagacaa agggcatggc
     1381 ggctgtgcct aaactggtcc tcttcacctc agaacagagt cactattcca taaagaaagc
     1441 tggggctgca cttggctttg gaactgacaa tgtgattttg ataaagtgca atgaaagggg
     1501 gaaaataatt ccagctgatt ttgaggcaaa aattcttgaa gccaaacaga agggatatgt
     1561 tcccttttat gtcaatgcaa ctgctggcac gactgtttat ggagcttttg atccgataca
     1621 agagattgca gatatatgtg agaaatataa cctttggttg catgtcgatg ctgcctgggg
     1681 aggtgggctg ctcatgtcca ggaagcaccg ccataaactc aacggcatag aaagggccaa
     1741 ctcagtcacc tggaaccctc acaagatgat gggcgtgctg ttgcagtgct ctgccattct
     1801 cgtcaaggaa aagggtatac tccaaggatg caaccagatg tgtgcaggat atctcttcca
     1861 gccagacaag cagtatgatg tctcctacga caccggggac aaggcaattc agtgtggccg
     1921 ccacgtggat atcttcaagt tctggctgat gtggaaagca aagggcacag tgggatttga
     1981 aaaccagatc aacaaatgcc tggaactggc tgaatacctc tatgccaaga ttaaaaacag
     2041 agaagaattt gagatggttt tcaatggcga gcctgagcac acaaacgtct gtttttggta
     2101 tattccacaa agcctcaggg gtgtgccaga cagccctcaa cgacgggaaa agctacacaa
     2161 ggtggctcca aaaatcaaag ccctgatgat ggagtcaggt acgaccatgg ttggctacca
     2221 gccccaaggg gacaaggcca acttcttccg gatggtcatc tccaacccag ccgctaccca
     2281 gtctgacatt gacttcctca ttgaggagat agaaagactg ggccaggatc tgtaatcatc
     2341 cttcgcagaa catgagttta tgggaatgcc ttttccctct ggcactccag aacaaacctc
     2401 tatatgttgc tgaaacacac aggccatttc attgagggaa aacataatat cttgaagaat
     2461 attgttaaaa ccttacttaa agcttgtttg ttctagttag caggaaatag tgttcttttt
     2521 aaaaagttgc acattaggaa cagagtatat atgtacagtt atacatacct ctctctatat
     2581 atacatgtat agtgagtgtg gcttagtaat agatcacggc atgtttcccg ctccaagaga
     2641 attcacttta ccttcagcag ttaccgagga gctaaacatg ctgccaacca gcttgtccaa
     2701 caactccagg aaaactgttt ttcaaaacgc catgtcctag gggccaaggg aaatgctgtt
     2761 ggtgagaatc gacctcactg tcagcgtttc tccacctgaa gtgatgatgg atgagaaaaa
     2821 acaccaccaa atgacaagtc acaccctccc cattagtatc ctgttagggg aaaatagtag
     2881 cagagtcatt gttacaggtg tactatggct gtattttaga gattaatttg tgtagattgt
     2941 gtaaattcct gttgtctgac cttggtggtg ggaggggaga ctatgtgtca tgatttcaat
     3001 gattgtttaa ttgtaggtca atgaaatatt tgcttattta tattcagaga tgtaccatgt
     3061 taaagaggcg tcttgtattt tcttcccatt tgtaatgtat cttatttata tatgaagtaa
     3121 gttctgaaaa ctgtttatgg tattttcgtg catttgtgag ccaaagagaa aagattaaaa
     3181 ttagtgagat ttgtatttat attagagtgc ccttaaaata atgatttaag cattttactg
     3241 tctgtaagag aattctaaga ttgtacatga cataagttat agtaatcatg gcaaatcctg
     3301 ttacttaaat agcatctgct cttctcttac gctctctgtc tggctgtacg tctggtgttc
     3361 tcaatgcttt tctagcaact gttggataat aactagatct cctgtaattt tgtagtagtt
     3421 gatgaccaat ctctgtgact cgcttagctg aaacctaagg caacatttcc gaagaccttc
     3481 tgaagatctc agataaagtg accaggctca caactgtttt tgaagaaggg aaattcacac
     3541 tgtgcgtttt gagtatgcaa gaagaatata aataaataaa atatctcatg gagattgaca
     3601 aaaaaaaaaa
//