LOCUS HUMAPNH1A 3989 bp mRNA linear HUM 13-OCT-2000
DEFINITION Human Na/H antiporter (APNH1) mRNA, complete cds.
ACCESSION M81768 J03163
VERSION M81768.1
KEYWORDS Na+/H+ antiporter; sodium/proton antiporter.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3989)
AUTHORS Sardet,C., Franchi,A. and Pouyssegur,J.
TITLE Molecular cloning, primary structure, and expression of the human
growth factor-activatable Na+/H+ antiporter
JOURNAL Cell 56 (2), 271-280 (1989)
PUBMED 2536298
REFERENCE 2 (bases 1 to 3989)
AUTHORS Sardet,C., Counillon,L., Franchi,A. and Pouyssegur,J.
TITLE Growth factors induce phosphorylation of the Na+/H+ antiporter,
glycoprotein of 110 kD
JOURNAL Science 247 (4943), 723-726 (1990)
PUBMED 2154036
REFERENCE 3 (bases 1 to 3989)
AUTHORS Takaichi,K., Wang,D., Balkovetz,D.F. and Warnock,D.G.
TITLE Cloning, sequencing and expression of Na+/H+ antiporter cDNAs from
human tissues
JOURNAL Am. J. Physiol. 262, 1069-1076 (1992)
COMMENT On Oct 13, 2000 this sequence version replaced J03163.1.
FEATURES Location/Qualifiers
source 1..3989
/db_xref="H-InvDB:HIT000196484"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="1p36.1-p35"
/tissue_type="kidney"
gene 1..3989
/gene="APNH"
CDS 54..2501
/gene="APNH"
/function="electrically-neutral Na/H exchange"
/note="putative"
/citation=[1]
/citation=[3]
/codon_start=1
/product="Na/H antiporter"
/protein_id="AAB59460.1"
/db_xref="GDB:G00-119-683"
/translation="MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTAS
TIRSSEPPRERSIGDVTTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTP
FEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDV
FFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNASFLGGLMYAVCLVGGEQ
INNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHL
FEEFANYEHCGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFV
FLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSET
LIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQF
IIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAV
KKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGE
RSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALS
KDNEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINN
YLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVDLVNEELKGK
VLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTPAPSDSPSSQRIQRCLSDP
GPHPEPGEGEPSFPKGQ"
misc_difference 2495
/gene="APNH"
/note="conflict; confirms corrected sequence reported in
reference #3"
/citation=[3]
/replace=""
3'UTR 2502..3989
/gene="APNH"
/experiment="experimental evidence, no additional details
recorded"
/note="G00-119-683"
/citation=[1]
/citation=[3]
regulatory 3969..3975
/regulatory_class="polyA_signal_sequence"
/gene="APNH"
/experiment="experimental evidence, no additional details
recorded"
/note="G00-119-683"
/citation=[3]
polyA_site 3989
/gene="APNH"
/experiment="experimental evidence, no additional details
recorded"
/note="G00-119-683"
/citation=[3]
BASE COUNT 756 a 1318 c 1043 g 872 t
ORIGIN
1 cccggtttta ctctcatttg ggtaaggtcg aggctggctc tggaagcagc accatggttc
61 tgcggtctgg catctgtggc ctctctccac atcggatctt cccttcctta ctcgtggtgg
121 ttgctttggt ggggctgctg cctgttctca ggagccatgg cctccagctc agcccaactg
181 ccagcaccat tcgaagctca gagccaccac gagaacgctc gattggggat gtcaccaccg
241 ctccaccgga ggtcacccca gagagccgcc ctgttaatca ttccgtcact gatcatggca
301 tgaagccgcg caaggccttt ccagtcctgg gcatcgacta cacacacgtg cgcaccccct
361 tcgagatctc cctctggatc cttctggcct gcctcatgaa gataggtttc catgtgatcc
421 ccactatctc aagcatcgtc ccggagagct gcctgctgat cgtggtgggg ctgctggtgg
481 ggggcctgat caagggtgta ggcgagacac cccccttcct gcagtccgac gtcttcttcc
541 tcttcctgct gccgcccatc atcctggatg cgggctactt cctgccactg cggcagttca
601 cagaaaacct gggcaccatc ctgatctttg ccgtggtggg cacgctgtgg aacgcctcct
661 tcctgggcgg cctcatgtac gccgtgtgcc tggtgggcgg tgagcagatc aacaacatcg
721 gcctcctgga caacctgctc ttcggcagca tcatctcggc cgtggacccc gtggcggttc
781 tggctgtctt tgaggaaatt cacatcaatg agctgctgca catccttgtt tttggggagt
841 ccttgctcaa tgacgccgtc actgtggtcc tgtatcacct ctttgaggag tttgccaact
901 acgaacactg tggcatcgtg gacatcttcc tcggcttcct gagcttcttc gtggtggccc
961 tgggcggggt gcttgtgggc gtggtctacg gggtcatcgc agccttcacc tcccgattta
1021 cctcccacat ccgggtcatc gagccgctct tcgtcttcct ctacagctac atggcctact
1081 tgtcagccga gctcttccac ctgtcaggca tcatggcgct catagcctca ggagtggtga
1141 tgcgccccta tgtggaggcc aacatctccc acaagtccca caccaccatc aaatacttcc
1201 tgaagatgtg gagcagcgtc agcgagaccc tcatcttcat cttcctcggc gtctccacgg
1261 tggccggctc ccaccactgg aactggacct tcgtcatcag caccctgctc ttctgcctca
1321 tcgcccgcgt gctgggggtg ctgggcctga cctggttcat caacaagttc cgtatcgtga
1381 agctgacccc caaggaccag ttcatcatcg cctatggggg cctgcgaggg gccatcgcct
1441 tctctctggg ctacctcctg gacaagaagc acttccccat gtgtgacctg ttcctcactg
1501 ccatcatcac tgtcatcttc ttcaccgtct ttgtgcaggg catgaccatt cggcccctgg
1561 tagacctgtt ggctgtgaag aaaaagcaag agacgaagcg ctccatcaac gaagagatcc
1621 acacacagtt cctggaccac cttctgacag gcatcgaaga catctgtggc cactacggtc
1681 accaccactg gaaggacaag ctcaaccggt ttaataagaa atatgtgaag aagtgtctga
1741 tagctggcga gcgctccaag gagccccagc tcattgcctt ctaccacaag atggagatga
1801 agcaggccat cgagctggtg gagagcgggg gcatgggcaa gatcccctct gccgtctcca
1861 ccgtctccat gcagaacatc caccccaagt ccctgccttc cgagcgcatc ctgccagcac
1921 tgtccaagga caacgaggag gagatccgca aaatcctgag gaacaacttg cagaagacca
1981 ggcagcggct gcggtcctac aacagacaca cgctggtggc agacccctac gaggaagcct
2041 ggaaccagat gctgctccgg aggcagaagg cccggcagct ggagcagaag atcaacaact
2101 acctgacggt gccagcccac aagctggact cacccaccat gtctcgggcc cgcatcggct
2161 cagacccact ggcctatgag ccgaaggagg acctgcctgt catcaccatc gacccggctt
2221 ccccgcagtc acccgagtct gtggacctgg tgaatgagga gctgaagggc aaagtcttag
2281 ggttgagccg ggatcctgca aaggtggctg aggaggacga ggacgacgat gggggcatca
2341 tgatgcggag caaggagact tcgtccccag gaaccgacga tgtcttcacc cccgcgccca
2401 gtgacagccc cagctcccag aggatacagc gctgcctcag tgacccaggc ccacaccctg
2461 agcctgggga gggagaaccg tccttcccca aggggcagta acgccagggc cagcaggcag
2521 cgcctgtccc ctcacagact cttccaccag agcaggggct gctgggggct ccccttgccc
2581 ttcctgaccc ggattggccc tgcccctccc cctaccgcat ggcagctggg cccacagccc
2641 ccaccccagc acagctcctc ccctgccgcc tcccgggaag catcctcccc accagagctg
2701 cctccccaat ccatttggca gaactgctgg ggctggtgag gccggccctg cccctcccta
2761 gatccaggct tctcccggac ctggactagg gcctcggagg ctcctccctc tgcctcatcc
2821 tcctcctcat tcagaccaat cttagtttct aaccaaagag tctctggctc agctgtggtc
2881 ccacccagga agggagggag ctgaggcctc ccttgagtag gccctgcttt atcaggggac
2941 aaaccagggg taccaggcac atggctgggg gagggactgc tgacccacca aggtctcaca
3001 ctcctcctgc cagctctgtc accctggcca ccacccaacc tgtccttact cagagctgcg
3061 ggctgagggc atctctgagt gtctctgcct ggagcagggg tggtttctac ggtgacagtg
3121 acgtgactca gagcttttcg aactgtgctc ccacggggac cactgggccc ctcaggggaa
3181 gctgctaggg gaaggactgg ccgtggctcc agaatgtgct gcctttttaa gttttgtttg
3241 ttcacactcc tatatatgat tgtttgcaca gagggcgctc ctgtttctaa aacattttga
3301 aaacccctgg ctgaacagtg ctctgcctct aactccctcc tcacactcca gaattaccct
3361 tcctcatctg tgcctgtctg tccaacccct cccccacgtc tctctgcctg ctgggctctt
3421 aactgttgct gaagactgtg acatcagaag taactcccac tcctaatcaa gagtctctcc
3481 agcctcacag atgctggcct cttggcacct gcctagctct tgggcctgac ctccagtcct
3541 gctggcctgc tcttacttcc cccaccctgg gtttggcccc tggaaccttt cccttgtgtg
3601 taccacaccc tgcctgctgt ggagcccatt gtggaggcgg tgggggggag aaggcctccc
3661 ctgaggatcc cctgtcccct ggggctggtg gattgggcag aatcctgggc ccccagagac
3721 ctttgcccac acacactcct tccccttgtc cctggggcac tcccccagga ttgtgcaata
3781 gtcagagtgt ccctttttgc agggactggg ccatggtcct cggcccatct gtccatcctc
3841 ctctccatgc aagtgctgtt tgggcaggag tcaccatgca agggtgacat cgacaaccac
3901 gtaccaagcc accgcagctg cgccactctg ctgcctgtac agaagaaact gaatcttttt
3961 catattctaa taaatcaatg tgagttttt
//