LOCUS AH005427 7447 bp DNA linear HUM 01-AUG-2016
DEFINITION Homo sapiens NAD(P)H:quinone oxireductase (NQO1) gene, complete
cds.
ACCESSION AH005427 J05348 M81596 M81597 M81598 M81599 M81600
VERSION AH005427.2
KEYWORDS NAD(P)H:quinone oxireductase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7447)
AUTHORS Jaiswal,A.K.
TITLE Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and
induction by dioxin
JOURNAL Biochemistry 30 (44), 10647-10653 (1991)
PUBMED 1657151
REFERENCE 2 (sites)
AUTHORS Li,Y. and Jaiswal,A.K.
TITLE Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of
AP1 binding site contained within human antioxidant response
element
JOURNAL J. Biol. Chem. 267 (21), 15097-15104 (1992)
PUBMED 1340765
COMMENT On or before Aug 1, 2016 this sequence version replaced M81596.1,
M81597.1, M81598.1, M81599.1, M81600.1, AH005427.1.
FEATURES Location/Qualifiers
source 1..7447
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/tissue_type="liver"
gene 1184..7379
/gene="NQO1"
regulatory 1184..1188
/regulatory_class="CAAT_signal"
/gene="NQO1"
regulatory 1787..1791
/regulatory_class="TATA_box"
/gene="NQO1"
mRNA join(1824..1941,3059..3223,3340..3470,4144..4257,
4797..4898,5498..7379)
/gene="NQO1"
/product="NAD(P)H:quinone oxireductase"
exon 1824..1941
/gene="NQO1"
/number=1
CDS join(1935..1941,3059..3223,3340..3470,4144..4257,
4797..4898,5498..5803)
/gene="NQO1"
/codon_start=1
/product="NAD(P)H:quinone oxireductase"
/protein_id="AAB60701.1"
/translation="MVGRRALIVLAHSERTSFNYAMKEAAAAALKKKGWEVVESDLYA
MNFNPIISRKDITGKLKDPANFQYPAESVLAYKEGHLSPDIVAEQKKLEAADLVIFQF
PLQWFGVPAILKGWFERVFIGEFAYTYAAMYDKGPFRSKKAVLSITTGGSGSMYSLQG
IHGDMNVILWPIQSGILHFCGFQVLEPQLTYSIGHTPADARIQILEGWKKRLENIWDE
TPLYFAPSSLFDLNFQAGFLMKKEVQDEEKNKKFGLSVGHHLGKSIPTDNQIKARK"
intron order(1942..2646,2747..3058)
/gene="NQO1"
/number=1
gap 2647..2746
/estimated_length=unknown
exon 3059..3223
/gene="NQO1"
/number=2
intron 3224..3339
/gene="NQO1"
/number=2
exon 3340..3470
/gene="NQO1"
/number=3
intron order(3471..3634,3735..4143)
/gene="NQO1"
/number=3
gap 3635..3734
/estimated_length=unknown
exon 4144..4257
/gene="NQO1"
/number=4
gap 4258..4357
/estimated_length=unknown
intron <4358..4796
/gene="NQO1"
/number=4
exon 4797..4898
/gene="NQO1"
/number=5
intron order(4899..5246,5347..5497)
/gene="NQO1"
/number=5
gap 5247..5346
/estimated_length=unknown
exon 5498..7379
/gene="NQO1"
/number=6
BASE COUNT 1710 a 1739 c 1603 g 1995 t
ORIGIN
1 tgccactgca ctccagcctg ggcgacacag tgaaaccccg cctcaaaaaa taaattttta
61 aaaaattaat ttaattacaa ttaaaacttc acttcctcag tccactggcc actttttttt
121 ttttaatttc catttttttt cttttattga gtccaccact gcggccttga attcctgggc
181 tcaagcgatc tttttgcctc agatcctgag tagctgggac acaggcgcct gccaccacgc
241 ctggctgctg gccacatttc caggctcaat agctacttga agcttgtggc taccttactt
301 gggcagcaca gatagggaaa gttctattgg acagggctgc ctacctagcc cttttttaaa
361 acgtcctttt atactatttt gtcagatggg gtctcacttt gttgctcagg cttttctcaa
421 actcttgggc tcaagtgatc ctcctgcctc agcctcccaa agtaatttgt aaatacgtgt
481 aaataatata gtcctctctt gttgcatcaa aatgaatgca aaaatgtcac gatggggccg
541 ggcgcggtgg ctcatgcctg taatcccagc acttcgggag gccgaggcgg taggatcacc
601 tgaggtcggg agttggaaac cagttttctg gtgcctcctt aacttttctg gtgcctcctt
661 aacttttgca ctggagggac aacggaaggg ccctgtgtca tcctcacctc ccccatctgt
721 aattcttctg atggttaatt accacttaaa gctctagttc tttttccttc acctactgag
781 agtatatctc cttctttaca gtaactttta ctttatagag ttttttttga gacggagtct
841 cacttcgtca cccaggcggg agtgcagtgg cacgatctcg acccactgca acctccgcct
901 tccgggttca agcgattctc ctgcctcagc ctcccgagta gctgggactt acaggcgccc
961 gccatcacgc ccagctaatt tttcagtaca gacggggctt caccaggttg gccaggctgg
1021 tctcgaactc ctgacctcag gtgatccacc cacctcggcc tcccatattg ctgggattac
1081 aggcgtgagc accgcgcctg gtcccgtttt ggctattctt taatatgctt ccctataact
1141 gctatctcca caccagcctt gccttagctc atgggaaaca aaaccaatta gttccccatt
1201 acctgccttg aggagcaggg gtggtgcagt ggcatgcacc cagggaagtg tgttgtatgg
1261 gcccccaagt gcagaatctg aatcttgcaa aggaagaaac aaattcgtct ccacggagca
1321 tgtctcccca ggactctcag ccttccaaat cgcagtcaca gtgactcagc agaatctgag
1381 cctagggcac cacagtaatc gcatcggctc tttttctgct ccatttcgtg ccaaggctaa
1441 aagggcatgc ccacttgatc ctggactctc ttgggacgac ttccaccctg catcctcttg
1501 cacctcaggg cacagtgcgc agatgggctt gccttagcac ccccagccag atttttgagg
1561 cctctgtcac acacacccct acaatcccct cccccagccc cgagagactt ttcttgactt
1621 ccaccagttg ctccggcggg tgagagtgga gaggcccctc cttcatcccc caggctccct
1681 cccttcctgg agctgcagcc tcagcatcct ccgcccagca ccccaggatt caggcgttgg
1741 gtcccgccct tgtaggctgt ccacctcaaa cgggccggac aggatatata agagagaatg
1801 caccgtgcac tacacacgcg actcccacaa ggttgcagcc ggagccgccc agctcaccga
1861 gagcctagtt ccggccaggg tcgccccggc aaccacgagc ccagccaatc agcgccccgg
1921 actgcaccag agccatggtc ggtgagtgct gcaaagggcg gggtgcttgg cggtcgtctc
1981 tcgagcactg gtgcctgtgg aggaggttgt aggggcttgg cctgaatttt gttccttgac
2041 tcaaaaccca caaagggaag agattaggga cctgggatga gccttgatcg gactccggga
2101 gaaggagagc ttctgtttgt atccggtgtc gcggatcctt cctcactcca ccccacgaac
2161 tctagtgggc atttaggaga aacttgacct tggaagcaga aattccctcc aaaactgtgg
2221 tcagaaactg gccgtcagag gccaaatcag gcttacggtc acagcccata cctcttttgg
2281 tctatagtat ctaaaacact ttgaaataag ttgctaacat taaaatgggt gatttcactt
2341 aaaaatgtgg attccgagct tctgaagaaa atgagaatat ctggcgattg gtggacagga
2401 gtggaggaaa ctgatgcctt tggtttgacg gagaccagaa ccggctccag gctgccaggc
2461 acaggttttg ttttgttttg ttttgttttg tttgagacgg agttttgctc ttgtcaccca
2521 ggtgtagtgc aatggcgcta tctcagctca gcgaaacttc cgcctcccgg gttcaagcga
2581 ttctcccatc tcagcctccc gagtagctgg gattacagga gtgcgccatc atgcgcggct
2641 aattttnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnntggc aggtggtctc
2761 aaactcctga cctcaggtga tctgcccgcc ttggcctccc aaagtagctg ggattacagt
2821 tatgagccac agagcccagt tgtcaacatt atttattaaa tcagccactg atttaaatgc
2881 ttcctttaat cttcagtgct tttaagggaa aatacatttc tggctacagg agatggaatg
2941 caataaccta atgtcaaaca aagccgcccc ctcctttaca gactgcaact cccctgtagc
3001 tgaaggtttg ctggttggta atgggttttc cctgtgtgct ttgtgtgtgt ctctgtaggc
3061 agaagagcac tgatcgtact ggctcactca gagaggacgt ccttcaacta tgccatgaag
3121 gaggctgctg cagcggcttt gaagaagaaa ggatgggagg tggtggagtc ggacctctat
3181 gccatgaact tcaatcccat catttccaga aaggacatca caggtaggag gagttcctcc
3241 tcccctcttt aattagttct ttgcggatct ccttgcctgt gggtcctctg gcccagcttt
3301 ggcccctctg gccccagcct ctctttttct tctctgcagg taaactgaag gaccctgcga
3361 actttcagta tcctgccgag tctgttctgg cttataaaga aggccatctg agcccagata
3421 ttgtggctga acaaaagaag ctggaagccg cagaccttgt gatattccag gtatgggggg
3481 acatcggaag gggtgtcagg gacatttgcg tgcttattgt cctagacatg tacctaatta
3541 gctatgagat cttaaacagt tacccacttt actgcattct ctgcaaataa gggtgattac
3601 tttaaaggtg cagtattact ggatttcacg atatnnnnnn nnnnnnnnnn nnnnnnnnnn
3661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
3721 nnnnnnnnnn nnnnccaaca gtcatattgt tgataccaca cctactaaag caaactcttg
3781 gaaaatactg attgaagcaa cagcatgaag caaaccttgt ttgcaatcct tgctatttag
3841 actttgctgc caaatgtgat ttcatacaaa caagtttcat atcaacaagt cttctgtgta
3901 tctagcttta ctcggaccca ctcaatattt gcattttcag ggaaaaagaa gactgtcaag
3961 ttggctgacc aaggacaata atgatctctt tccttaaagt gctaactccc caggaggaat
4021 gggaaaggtg tgaagagggg cttcccacac agtgccatca tggggagcgg ctcagcactc
4081 cgagccacct tctgggcttg gggagcccct ggtcttacct caatgatgtc ttctgtccca
4141 cagttccccc tgcagtggtt tggagtccct gccattctga aaggctggtt tgagcgagtg
4201 ttcataggag agtttgctta cacttacgct gccatgtatg acaaaggacc cttccggnnn
4261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
4321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnngta ggtggatggt tctgaatgct
4381 ctgacagcca gcttctgggt ggtctgtact gatgcagggg tgtttgtttg tttgtttgtt
4441 tgagatggag cttccctctt agtccagccc gtgggaggat ggataagaac aaccaataac
4501 tccacctagg cagccagcag ccagcactga ttttggatat ggtgacagcc tcgtcctaag
4561 ccacatgtgg gggtttggaa tccttcattt gccccaggcc accggtctgt agaccatcta
4621 ggctggcact cctgcagagt catattatgt agctcagggg agccaaagta tgaagtaata
4681 taaacagcaa ataggacaga cttgtgtgtt cttttccctg gagctgtttg attaacttct
4741 tgtcaccaag gggatgtgga gggaagtgaa gtttgttatt gctttttctt ttgcagagta
4801 agaaggcagt gctttccatc accactggtg gcagtggctc catgtactct ctgcaaggga
4861 tccacgggga catgaatgtc attctctggc caattcaggt acctcatttt cttttctttt
4921 cttttttttc tttgagacgg agttactctg tcatctaggc tggagtgcag tgacaccatc
4981 ttagttcact acaagctccg cccgctgggt tcgagcaatt ctcctgcctc agcctactga
5041 caggcacccc gccaccacac tcggctaatt tttgtatttt ttagtagaga cggggtcttg
5101 ccatgttagc caggctggtt tcaaacactt gacctcaaat gattctcctg cctcagcctc
5161 ccaaagtgct gtgattacag gcgtgagcac tgcacctggc caggacctca tttttcaacg
5221 aaccttcagg ggaattattc attgagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
5341 nnnnnngaga gagacgctag ctctgaactg attctctagt gtgcctgagg cctccttatc
5401 agagtgtctt actgagaagc ccagaccaac ttctgttgtt atagtacaac tgcatggaat
5461 tggttgactt acctctctgt gctttctgta tcctcagagt ggcattctgc atttctgtgg
5521 cttccaagtc ttagaacctc aactgacata tagcattggg cacactccag cagacgcccg
5581 aattcaaatc ctggaaggat ggaagaaacg cctggagaat atttgggatg agacaccact
5641 gtattttgct ccaagcagcc tctttgacct aaacttccag gcaggattct taatgaaaaa
5701 agaggtacag gatgaggaga aaaacaagaa atttggcctt tctgtgggcc atcacttggg
5761 caagtccatc ccaactgaca accagatcaa agctagaaaa tgagattcct tagcctggat
5821 ttccttctaa catgttatca aatctgggta tctttccagg cttccctgac ttgctttagt
5881 ttttaagatt tgtgtttttc tttttccaca aggaataaat gagagggaat cgaccgtatt
5941 cgtgcatttt tggatgcatt tttaactgat tcttatgatt actatcatgg catataacca
6001 aaatccgact gggctcaaga ggccacttag ggaaagatgt agaaagatgc tagaaaaatg
6061 ttctttaaag gcatctacac aatttaattc ctctttttag ggctaaagtt ttagggtaca
6121 gtttggctag gtatcattca actctccaat gttctattaa tcacctctct gtagtttatg
6181 gcagaaggga attgctcaga gaaggtaaaa gactgaatct acctgcccta agggacttaa
6241 cttgtttggt agttagccat ctaatgcttg tttatgatat ttcttgcttt caattacaaa
6301 gcagttacta atatgcctag cacaagtacc actcttggtc agcttttgtt gtttatatac
6361 agtacacaga taccttgaaa ggaagagcta ataaatctct tctttgctgc agtcatctac
6421 ttttttttta attaaaaaaa attttttttt gaagcagtct tgctctgtta cccaggctgg
6481 agtgcagtgg tgtgatctcg gctcactgca acctctgcct cccaggttcc agcaattctc
6541 ctgcctcagc ctccctagta gctgggatga caggcgcctg ccatcatgcc tgactaattt
6601 ttgtattttt agtagagacg gcgtttcacc atgttggcca ggctggtctc aaactcctga
6661 cctcaggtga tccgcctacc tcagcctccc aaagtgctgg gattacaggc gtgactccac
6721 cacacctggc ccttgcaatc ttctacttta aggtttgcag agataaacca ataaatccac
6781 accgtacatc tgcaatatga attccaagaa aggaaatagt accttcaata cttaaaaata
6841 gtcttccaca aaaaatactt tatttctgat ctatacaaat tttcagaagg ttattttctt
6901 tatcattgct aaactgatga cttaccatgg gatggggtcc agtcccatga ccttggggta
6961 caattgtaaa cctagagttt tatcaacttt ggtgaacagt tttggcataa tagtcaattt
7021 ctacttctgg aagtcatctc attccactgt tggtattata taattcaagg agaatatgat
7081 aaaacactgc cctcttgtgg tgcattgaaa gaagagatga gaaatgatga aaaggttgcc
7141 tgaaaaatgg gagacagcct cttacttgcc aagaaaatga agggattgga ccgagctgga
7201 aaacctcctt taccagatgc tgactggcac tggtggtttt tgctctcgac agtatccaca
7261 atagctgacg gctgggtgtt tcagtttgaa aatattttgt tgccttcatc ttcactgcaa
7321 ttttgtgtaa atttctcaaa gatctgaatt aaataaataa aattcatttc tacagaccca
7381 cactcattgg tatcagtgaa gctaatgata gtggaatcta gtgggaggca gatccgttga
7441 cctgcag
//