LOCUS HUMPEDF 1490 bp mRNA linear HUM 07-JAN-1995
DEFINITION H.sapiens pigment epithelium-differentiation factor (PEDF) mRNA,
complete cds.
ACCESSION M76979
VERSION M76979.1
KEYWORDS pigment epithelium-differentiation factor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1490)
AUTHORS Steele,F.R., Chader,G.J., Johnson,L.V. and Tombran-Tink,J.
TITLE Pigment epithelium-derived factor: neurotrophic activity and
identification as a member of the serine protease inhibitor gene
family
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (4), 1526-1530 (1993)
PUBMED 8434014
COMMENT Original source text: Homo sapiens (tissue library: charon BS from
A. Swaroop) Fetus Eye cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1490
/db_xref="H-InvDB:HIT000196384"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="Eye"
/dev_stage="Fetus"
/tissue_lib="charon BS from A. Swaroop"
gene 1..1490
/gene="PEDF"
mRNA 1..1490
/gene="PEDF"
CDS 117..1373
/gene="PEDF"
/codon_start=1
/product="pigment epithelial-differentiating factor"
/protein_id="AAA60058.1"
/translation="MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEED
PFFKVPVNKLAAAVSNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTES
IIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEK
SYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWV
TKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIF
FLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKL
QSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQ
PFIFVLRDTDTGALLFIGKILDPRGP"
sig_peptide 117..170
/gene="PEDF"
mat_peptide 171..1370
/gene="PEDF"
/product="pigment epithelial-differentiating factor"
regulatory 1471..1476
/regulatory_class="polyA_signal_sequence"
/gene="PEDF"
polyA_site 1490
/gene="PEDF"
BASE COUNT 360 a 439 c 393 g 297 t
ORIGIN
1 ggacgctgga ttagaaggca gcaaaaaaag atctgtgctg gctggagccc cctcagtgtg
61 caggcttaga gggactaggc tgggtgtgga gctgcagcgt atccacaggc cccaggatgc
121 aggccctggt gctactcctc tgcattggag ccctcctcgg gcacagcagc tgccagaacc
181 ctgccagccc cccggaggag ggctccccag accccgacag cacaggggcg ctggtggagg
241 aggaggatcc tttcttcaaa gtccccgtga acaagctggc agcggctgtc tccaacttcg
301 gctatgacct gtaccgggtg cgatccagca tgagccccac gaccaacgtg ctcctgtctc
361 ctctcagtgt ggccacggcc ctctcggccc tctcgctggg agcggacgag cgaacagaat
421 ccatcattca ccgggctctc tactatgact tgatcagcag cccagacatc catggtacct
481 ataaggagct ccttgacacg gtcactgccc cccagaagaa cctcaagagt gcctcccgga
541 tcgtctttga gaagaagctr cgcataaaat ccagctttgt ggcacctctg gaaaagtcat
601 atgggaccag gcccagagtc ctgacgggca accctcgctt ggacctgcaa gagatcaaca
661 actgggtgca ggcgcagatg aaagggaagc tcgccaggtc cacaaaggaa attcccgatg
721 agatcagcat tctccttctc ggtgtggcgc acttcaaggg gcagtgggta acaaagtttg
781 actccagaaa gacttccctc gaggatttct acttggatga agagaggacc gtgagggtcc
841 ccatgatgtc ggaccctaag gctgttttac gctatggctt ggattcagat ctcagctgca
901 agattgccca gctgcccttg accggaagca tgagtatcat cttcttcctg cccctgaaag
961 tgacccagaa tttgaccttg atagaggaga gcctcacctc cgagttcatt catgacatag
1021 accgagaact gaagaccgtg caggcggtcc tcactgtccc caagctgaag ctgagttacg
1081 aaggcgaagt caccaagtcc ctgcaggaga tgaagctgca atccttgttt gattcaccag
1141 actttagcaa gatcacaggc aaacccatca agctgactca ggtggaacac cgggctggct
1201 ttgagtggaa cgaggatggg gcgggaacca cccccagccc agggctgcag cctgcccacc
1261 tcaccttccc gctggactat caccttaacc agcctttcat cttcgtactg agggacacag
1321 acacaggggc ccttctcttc attggcaaga ttctggaccc caggggcccc taatatccca
1381 gtttaatatt ccaataccct agaagaaaac ccgagggaca gcagattcca caggacacga
1441 aggctgcccc tgtaaggttt caatgcatac aataaaagag ctttatccct
//