LOCUS HUMCACNLB 3600 bp mRNA linear HUM 31-OCT-1994
DEFINITION Human neuronal DHP-sensitive, voltage-dependent, calcium channel
alpha-2b subunit mRNA, complete cds.
ACCESSION M76559
VERSION M76559.1
KEYWORDS neuronal DHP-sensitive calcium channel; transmembrane protein;
voltage-dependent calcium channel alpha-2b subunit; voltage-gated
calcium channel.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3600)
AUTHORS Williams,M.E., Feldman,D.H., McCue,A.F., Brenner,R., Velicelebi,G.,
Ellis,S.B. and Harpold,M.M.
TITLE Structure and functional expression of alpha 1, alpha 2, and beta
subunits of a novel human neuronal calcium channel subtype
JOURNAL Neuron 8 (1), 71-84 (1992)
PUBMED 1309651
COMMENT Original source text: Homo sapiens (tissue library: lambda gt11
cDNA) central nervous system cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3600
/db_xref="H-InvDB:HIT000196371"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Unassigned"
/tissue_type="central nervous system"
/tissue_lib="lambda gt11 cDNA"
gene 1..3600
/gene="CCHL1A2"
CDS 35..3310
/gene="CCHL1A2"
/codon_start=1
/product="calcium channel alpha-2b subunit"
/protein_id="AAA51903.1"
/db_xref="GDB:G00-128-872"
/translation="MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDL
VTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVSLAL
EAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQIS
YQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYY
PASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSV
SEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYK
KGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFNKYNKDKKVRVFRFSVGQH
NYERGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVY
LDALELGLVITGTLPVFNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCP
NGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGE
KTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQAR
SKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNN
PSCNADLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENW
QENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPA
VVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYT
NQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVAD
ILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFD
NDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPN
PCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTH
RLL"
BASE COUNT 1139 a 680 c 805 g 976 t
ORIGIN
1 gcgggggagg gggcattgat cttcgatcgc gaagatggct gctggctgcc tgctggcctt
61 gactctgaca cttttccaat ctttgctcat cggcccctcg tcggaggagc cgttcccttc
121 ggccgtcact atcaaatcat gggtggataa gatgcaagaa gaccttgtca cactggcaaa
181 aacagcaagt ggagtcaatc agcttgttga tatttatgag aaatatcaag atttgtatac
241 tgtggaacca aataatgcac gccagctggt agaaattgca gccagggata ttgagaaact
301 tctgagcaac agatctaaag ccctggtgag cctggcattg gaagcggaga aagttcaagc
361 agctcaccag tggagagaag attttgcaag caatgaagtt gtctactaca atgcaaagga
421 tgatctcgat cctgagaaaa atgacagtga gccaggcagc cagaggataa aacctgtttt
481 cattgaagat gctaattttg gacgacaaat atcttatcag cacgcagcag tccatattcc
541 tactgacatc tatgagggct caacaattgt gttaaatgaa ctcaactgga caagtgcctt
601 agatgaagtt ttcaaaaaga atcgcgagga agacccttca ttattgtggc aggtttttgg
661 cagtgccact ggcctagctc gatattatcc agcttcacca tgggttgata atagtagaac
721 tccaaataag attgaccttt atgatgtacg cagaagacca tggtacatcc aaggagctgc
781 atctcctaaa gacatgctta ttctggtgga tgtgagtgga agtgttagtg gattgacact
841 taaactgatc cgaacatctg tctccgaaat gttagaaacc ctctcagatg atgatttcgt
901 gaatgtagct tcatttaaca gcaatgctca ggatgtaagc tgttttcagc accttgtcca
961 agcaaatgta agaaataaaa aagtgttgaa agacgcggtg aataatatca cagccaaagg
1021 aattacagat tataagaagg gctttagttt tgcttttgaa cagctgctta attataatgt
1081 ttccagagca aactgcaata agattattat gctattcacg gatggaggag aagagagagc
1141 ccaggagata tttaacaaat acaataaaga taaaaaagta cgtgtattca ggttttcagt
1201 tggtcaacac aattatgaga gaggacctat tcagtggatg gcctgtgaaa acaaaggtta
1261 ttattatgaa attccttcca ttggtgcaat aagaatcaat actcaggaat atttggatgt
1321 tttgggaaga ccaatggttt tagcaggaga caaagctaag caagtccaat ggacaaatgt
1381 gtacctggat gcattggaac tgggacttgt cattactgga actcttccgg tcttcaacat
1441 aaccggccaa tttgaaaata agacaaactt aaagaaccag ctgattcttg gtgtgatggg
1501 agtagatgtg tctttggaag atattaaaag actgacacca cgttttacac tgtgccccaa
1561 tgggtattac tttgcaatcg atcctaatgg ttatgtttta ttacatccaa atcttcagcc
1621 aaagaacccc aaatctcagg agccagtaac attggatttc cttgatgcag agttagagaa
1681 tgatattaaa gtggagattc gaaataagat gattgatggg gaaagtggag aaaaaacatt
1741 cagaactctg gttaaatctc aagatgagag atatattgac aaaggaaaca ggacatacac
1801 atggacacct gtcaatggca cagattacag tttggccttg gtattaccaa cctacagttt
1861 ttactatata aaagccaaac tagaagagac aataactcag gccagatcaa aaaagggcaa
1921 aatgaaggat tcggaaaccc tgaagccaga taattttgaa gaatctggct atacattcat
1981 agcaccaaga gattactgca atgacctgaa aatatcggat aataacactg aatttctttt
2041 aaatttcaac gagtttattg atagaaaaac tccaaacaac ccatcatgta acgcggattt
2101 gattaataga gtcttgcttg atgcaggctt tacaaatgaa cttgtccaaa attactggag
2161 taagcagaaa aatatcaagg gagtgaaagc acgatttgtt gtgactgatg gtgggattac
2221 cagagtttat cccaaagagg ctggagaaaa ttggcaagaa aacccagaga catatgagga
2281 cagcttctat aaaaggagcc tagataatga taactatgtt ttcactgctc cctactttaa
2341 caaaagtgga cctggtgcct atgaatcggg cattatggta agcaaagctg tagaaatata
2401 tattcaaggg aaacttctta aacctgcagt tgttggaatt aaaattgatg taaattcctg
2461 gatagagaat ttcaccaaaa cctcaatcag agatccgtgt gctggtccag tttgtgactg
2521 caaaagaaac agtgacgtaa tggattgtgt gattctggat gatggtgggt ttcttctgat
2581 ggcaaatcat gatgattata ctaatcagat tggaagattt tttggagaga ttgatcccag
2641 cttgatgaga cacctggtta atatatcagt ttatgctttt aacaaatctt atgattatca
2701 gtcagtatgt gagcccggtg ctgcaccaaa acaaggagca ggacatcgct cagcatatgt
2761 gccatcagta gcagacatat tacaaattgg ctggtgggcc actgctgctg cctggtctat
2821 tctacagcag tttctcttga gtttgacctt tccacgactc cttgaggcag ttgagatgga
2881 ggatgatgac ttcacggcct ccctgtccaa gcagagctgc attactgaac aaacccagta
2941 tttcttcgat aacgacagta aatcattcag tggtgtatta gactgtggaa actgttccag
3001 aatctttcat ggagaaaagc ttatgaacac caacttaata ttcataatgg ttgagagcaa
3061 agggacatgt ccatgtgaca cacgactgct catacaagcg gagcagactt ctgacggtcc
3121 aaatccttgt gacatggtta agcaacctag ataccgaaaa gggcctgatg tctgctttga
3181 taacaatgtc ttggaggatt atactgactg tggtggtgtt tctggattaa atccctccct
3241 gtggtatatc attggaatcc agtttctact actttggctg gtatctggca gcacacaccg
3301 gctgttatga ccttctaaaa accaaatctg catagttaaa ctccagaccc tgccaaaaca
3361 tgagccctgc cctcaattac agtaacgtag ggtcagctat aaaatcagac aaacattagc
3421 tgggcctgtt ccatggcata acactaaggc gcagactcct aaggcaccca ctggctgcat
3481 gtcagggtgt cagatcctta aacgtgtgtg aatgctgcat catctatgtg taacatcaaa
3541 gcaaaatcct atacgtgtcc tctattggaa aatttgggcg tttgttgttg cattgttggt
//