LOCUS HUMPVA 3336 bp mRNA linear HUM 08-JAN-1995
DEFINITION Human 130-kD pemphigus vulgaris antigen mRNA, complete cds.
ACCESSION M76482
VERSION M76482.1
KEYWORDS autoantibody; cadherin; pemphigus vulgaris antigen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3336)
AUTHORS Amagai,M., Klaus-Kovtun,V. and Stanley,J.R.
TITLE Autoantibodies against a novel epithelial cadherin in pemphigus
vulgaris, a disease of cell adhesion
JOURNAL Cell 67 (5), 869-877 (1991)
PUBMED 1720352
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3336
/db_xref="H-InvDB:HIT000196368"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="18"
/cell_type="epidermal keratinocyte"
gene 1..3336
/gene="NCAD"
CDS 84..3083
/gene="NCAD"
/note="130-kD"
/codon_start=1
/product="pemphigus vulgaris antigen"
/protein_id="AAA60230.1"
/translation="MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAK
RRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVV
DKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQ
IFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEV
RTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARI
EENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKA
LDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTV
QKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNM
NRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPS
VVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISL
VLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLL
LLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEIT
NICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATG
TVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAF
ACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKL
AEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSASG
SVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSV
PGNLAGPTQLRGSHTMLCTEDPCSRLI"
BASE COUNT 998 a 730 c 754 g 854 t
ORIGIN
1 ttttcttaga cattaactgc agacggctgg caggatagaa gcagcggctc acttggactt
61 tttcaccagg gaaatcagag acaatgatgg ggctcttccc cagaactaca ggggctctgg
121 ccatcttcgt ggtggtcata ttggttcatg gagaattgcg aatagagact aaaggtcaat
181 atgatgaaga agagatgact atgcaacaag ctaaaagaag gcaaaaacgt gaatgggtga
241 aatttgccaa accctgcaga gaaggagaag ataactcaaa aagaaaccca attgccaaga
301 ttacttcaga ttaccaagca acccagaaaa tcacctaccg aatctctgga gtgggaatcg
361 atcagccgcc ttttggaatc tttgttgttg acaaaaacac tggagatatt aacataacag
421 ctatagtcga ccgggaggaa actccaagct tcctgatcac atgtcgggct ctaaatgccc
481 aaggactaga tgtagagaaa ccacttatac taacggttaa aattttggat attaatgata
541 atcctccagt attttcacaa caaattttca tgggtgaaat tgaagaaaat agtgcctcaa
601 actcactggt gatgatacta aatgccacag atgcagatga accaaaccac ttgaattcta
661 aaattgcctt caaaattgtc tctcaggaac cagcaggcac acccatgttc ctcctaagca
721 gaaacactgg ggaagtccgt actttgacca attctcttga ccgagagcaa gctagcagct
781 atcgtctggt tgtgagtggt gcagacaaag atggagaagg actatcaact caatgtgaat
841 gtaatattaa agtgaaagat gtcaacgata acttcccaat gtttagagac tctcagtatt
901 cagcacgtat tgaagaaaat attttaagtt ctgaattact tcgatttcaa gtaacagatt
961 tggatgaaga gtacacagat aattggcttg cagtatattt ctttacctct gggaatgaag
1021 gaaattggtt tgaaatacaa actgatccta gaactaatga aggcatcctg aaagtggtga
1081 aggctctaga ttatgaacaa ctacaaagcg tgaaacttag tattgctgtc aaaaacaaag
1141 ctgaatttca ccaatcagtt atctctcgat accgagttca gtcaacccca gtcacaattc
1201 aggtaataaa tgtaagagaa ggaattgcat tccgtcctgc ttccaagaca tttactgtgc
1261 aaaaaggcat aagtagcaaa aaattggtgg attatatcct gggaacatat caagccatcg
1321 atgaggacac taacaaagct gcctcaaatg tcaaatatgt catgggacgt aacgatggtg
1381 gatacctaat gattgattca aaaactgctg aaatcaaatt tgtcaaaaat atgaaccgag
1441 attctacttt catagttaac aaaacaatca cagctgaggt tctggccata gatgaataca
1501 cgggtaaaac ttctacaggc acggtatatg ttagagtacc cgatttcaat gacaattgtc
1561 caacagctgt cctcgaaaaa gatgcagttt gcagttcttc accttccgtg gttgtctccg
1621 ctagaacact gaataataga tacactggcc cctatacatt tgcactggaa gatcaacctg
1681 taaagttgcc tgccgtatgg agtatcacaa ccctcaatgc tacctcggcc ctcctcagag
1741 cccaggaaca gatacctcct ggagtatacc acatctccct ggtacttaca gacagtcaga
1801 acaatcggtg tgagatgcca cgcagcttga cactggaagt ctgtcagtgt gacaacaggg
1861 gcatctgtgg aacttcttac ccaaccacaa gccctgggac caggtatggc aggccgcact
1921 cagggaggct ggggcctgcc gccatcggcc tgctgctcct tggtctcctg ctgctgctgt
1981 tggcccccct tctgctgttg acctgtgact gtggggcagg ttctactggg ggagtgacag
2041 gtggttttat cccagttcct gatggctcag aaggaacaat tcatcagtgg ggaattgaag
2101 gagcccatcc tgaagacaag gaaatcacaa atatttgtgt gcctcctgta acagccaatg
2161 gagccgattt catggaaagt tctgaagttt gtacaaatac gtatgccaga ggcacagcgg
2221 tggaaggcac ttcaggaatg gaaatgacca ctaagcttgg agcagccact gaatctggag
2281 gtgctgcagg ctttgcaaca gggacagtgt caggagctgc ttcaggattc ggagcagcca
2341 ctggagttgg catctgttcc tcagggcagt ctggaaccat gagaacaagg cattccactg
2401 gaggaaccaa taaggactac gctgatgggg cgataagcat gaattttctg gactcctact
2461 tttctcagaa agcatttgcc tgtgcggagg aagacgatgg ccaggaagca aatgactgct
2521 tgttgatcta tgataatgaa ggcgcagatg ccactggttc tcctgtgggc tccgtgggtt
2581 gttgcagttt tattgctgat gacctggatg acagcttctt ggactcactt ggacccaaat
2641 ttaaaaaact tgcagagata agccttggtg ttgatggtga aggcaaagaa gttcagccac
2701 cctctaaaga cagcggttat gggattgaat cctgtggcca tcccatagaa gtccagcaga
2761 caggatttgt taagtgccag actttgtcag gaagtcaagg agcttctgct ttgtccgcct
2821 ctgggtctgt ccagccagct gtttccatcc ctgaccctct gcagcatggt aactatttag
2881 taacggagac ttactcggct tctggttccc tcgtgcaacc ttccactgca ggctttgatc
2941 cacttctcac acaaaatgtg atagtgacag aaagggtgat ctgtcccatt tccagtgttc
3001 ctggcaacct agctggccca acgcagctac gagggtcaca tactatgctc tgtacagagg
3061 atccttgctc ccgtctaata tgaccagaat gagctggaat accacactga ccaaatctgg
3121 atctttggac taaagtattc aaaatagcat agcaaagctc actgtattgg gctaataatt
3181 tggcacttat tagcttctct cataaactga tcacgattat aaattaaatg tttgggttca
3241 taccccaaaa gcaatatgtt gtcactccta attctcaagt actattcaaa ttgtagtaaa
3301 tcttaaagtt tttcaaaacc ctaaaatcat attcgc
//