LOCUS HUMTYRKINR 3227 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human tyrosine kinase receptor (axl) mRNA, complete cds.
ACCESSION M76125
VERSION M76125.1
KEYWORDS tyrosine kinase receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
AUTHORS O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
Prokop,C., Espinosa,R. III, Le Beau,M.M., Earp,H.S. and Liu,E.T.
TITLE axl, a transforming gene isolated from primary human myeloid
leukemia cells, encodes a novel receptor tyrosine kinase
JOURNAL Mol. Cell. Biol. 11 (10), 5016-5031 (1991)
PUBMED 1656220
REFERENCE 2 (bases 1 to 3227)
AUTHORS Bergsagel,P.L., Victor-Kobrin,C., Timblin,C.R., Trepel,J. and
Kuehl,W.M.
TITLE A murine cDNA encodes a pan-epithelial glycoprotein that is also
expressed on plasma cells
JOURNAL J. Immunol. 148 (2), 590-596 (1992)
PUBMED 1729376
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3227
/db_xref="H-InvDB:HIT000196362"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="19q, map"
/cell_type="fibroblast"
gene 1..3227
/gene="axl"
CDS 159..2816
/gene="axl"
/codon_start=1
/product="tyrosine kinase receptor"
/protein_id="AAA61243.1"
/translation="MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNI
TGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQL
RITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSC
QAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRT
ATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEP
DPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPL
GPPKNISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLE
LQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVV
AAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLG
ISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICT
RSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLL
YSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADF
GLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTP
YPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTL
KALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGR
YVLCPSTTPSPAQPADRGSPAAPGQEDGA"
mat_peptide 159..2813
/gene="axl"
/product="tyrosine kinase receptor"
regulatory 3183..3188
/regulatory_class="polyA_signal_sequence"
/gene="axl"
BASE COUNT 698 a 972 c 931 g 626 t
ORIGIN chromosome 19q, map position 13.2.
1 gctgggcaaa gccggtggca agggcctccc ctgccgctgt gccaggcagg cagtgccaaa
61 tccggggagc ctggagctgg ggggagggcc ggggacagcc cggccctgcc ccctcccccg
121 ctgggagccc agcaacttct gaggaaagtt tggcacccat ggcgtggcgg tgccccagga
181 tgggcagggt cccgctggcc tggtgcttgg cgctgtgcgg ctgggcgtgc atggccccca
241 ggggcacgca ggctgaagaa agtcccttcg tgggcaaccc agggaatatc acaggtgccc
301 ggggactcac gggcaccctt cggtgtcagc tccaggttca gggagagccc cccgaggtac
361 attggcttcg ggatggacag atcctggagc tcgcggacag cacccagacc caggtgcccc
421 tgggtgagga tgaacaggat gactggatag tggtcagcca gctcagaatc acctccctgc
481 agctttccga cacgggacag taccagtgtt tggtgtttct gggacatcag accttcgtgt
541 cccagcctgg ctatgttggg ctggagggct tgccttactt cctggaggag cccgaagaca
601 ggactgtggc cgccaacacc cccttcaacc tgagctgcca agctcaggga cccccagagc
661 ccgtggacct actctggctc caggatgctg tccccctggc cacggctcca ggtcacggcc
721 cccagcgcag cctgcatgtt ccagggctga acaagacatc ctctttctcc tgcgaagccc
781 ataacgccaa gggggtcacc acatcccgca cagccaccat cacagtgctc ccccagcagc
841 cccgtaacct ccacctggtc tcccgccaac ccacggagct ggaggtggct tggactccag
901 gcctgagcgg catctacccc ctgacccact gcaccctgca ggctgtgctg tcagacgatg
961 ggatgggcat ccaggcggga gaaccagacc ccccagagga gcccctcacc tcgcaagcat
1021 ccgtgccccc ccatcagctt cggctaggca gcctccatcc tcacacccct tatcacatcc
1081 gcgtggcatg caccagcagc cagggcccct catcctggac ccactggctt cctgtggaga
1141 cgccggaggg agtgcccctg ggccccccta agaacattag tgctacgcgg aatgggagcc
1201 aggccttcgt gcattggcaa gagccccggg cgcccctgca gggtaccctg ttagggtacc
1261 ggctggcgta tcaaggccag gacaccccag aggtgctaat ggacataggg ctaaggcaag
1321 aggtgaccct ggagctgcag ggggacgggt ctgtgtccaa tctgacagtg tgtgtggcag
1381 cctacactgc tgctggggat ggaccctgga gcctcccagt acccctggag gcctggcgcc
1441 cagtgaagga accttcaact cctgccttct cgtggccctg gtggtatgta ctgctaggag
1501 cagtcgtggc cgctgcctgt gtcctcatct tggctctctt ccttgtccac cggcgaaaga
1561 aggagacccg ttatggagaa gtgtttgaac caacagtgga aagaggtgaa ctggtagtca
1621 ggtaccgcgt gcgcaagtcc tacagtcgtc ggaccactga agctaccttg aacagcctgg
1681 gcatcagtga agagctgaag gagaagctgc gggatgtgat ggtggaccgg cacaaggtgg
1741 ccctggggaa gactctggga gagggagagt ttggagctgt gatggaaggc cagctcaacc
1801 aggacgactc catcctcaag gtggctgtga agacgatgaa gattgccatc tgcacgaggt
1861 cagagctgga ggatttcctg agtgaagcgg tctgcatgaa ggaatttgac catcccaacg
1921 tcatgaggct catcggtgtc tgtttccagg gttctgaacg agagagcttc ccagcacctg
1981 tggtcatctt acctttcatg aaacatggag acctacacag cttcctcctc tattcccggc
2041 tcggggacca gccagtgtac ctgcccactc agatgctagt gaagttcatg gcagacatcg
2101 ccagtggcat ggagtatctg agtaccaaga gattcataca ccgggacctg gcggccagga
2161 actgcatgct gaatgagaac atgtccgtgt gtgtggcgga cttcgggctc tccaagaaga
2221 tctacaatgg ggactactac cgccagggac gtatcgccaa gatgccagtc aagtggattg
2281 ccattgagag tctagctgac cgtgtctaca ccagcaagag cgatgtgtgg tccttcgggg
2341 tgacaatgtg ggagattgcc acaagaggcc aaaccccata tccgggcgtg gagaacagcg
2401 agatttatga ctatctgcgc cagggaaatc gcctgaagca gcctgcggac tgtctggatg
2461 gactgtatgc cttgatgtcg cggtgctggg agctaaatcc ccaggaccgg ccaagtttta
2521 cagagctgcg ggaagatttg gagaacacac tgaaggcctt gcctcctgcc caggagcctg
2581 acgaaatcct ctatgtcaac atggatgagg gtggaggtta tcctgaaccc cctggagctg
2641 caggaggagc tgacccccca acccagccag accctaagga ttcctgtagc tgcctcactg
2701 cggctgaggt ccatcctgct ggacgctatg tcctctgccc ttccacaacc cctagccccg
2761 ctcagcctgc tgataggggc tccccagcag ccccagggca ggaggatggt gcctgagaca
2821 accctccacc tggtactccc tctcaggatc caagctaagc actgccactg gggaaaactc
2881 caccttccca cttttccacc ccacgcctta tccccacttg cagccctgtc ttcctaccta
2941 tcccacctcc atcccagaca ggtccctccc cttctctgtg cagtagcatc accttgaaag
3001 cagtagcatc accatctgta aaaggaaggg gttggattgc aatatctgaa gccctcccag
3061 gtgttaacat tccaagactc tagagtccaa ggtttaaaga gtctagattc aaaggttcta
3121 ggtttcaaag atgctgtgag tctttggttc taaggacctg aaattccaaa gtctctaatt
3181 ctattaaagt gctaaggttc taaggcaaaa aaaaaaaaaa aaaaaaa
//