LOCUS HUMLIPCHL 2493 bp mRNA linear HUM 07-JAN-1995 DEFINITION Human lysosomal acid lipase/cholesteryl esterase mRNA, complete cds. ACCESSION M74775 VERSION M74775.1 KEYWORDS lysosomal acid lipase/cholesteryl esterase. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2493) AUTHORS Anderson,R.A. and Sando,G.N. TITLE Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases JOURNAL J. Biol. Chem. 266 (33), 22479-22484 (1991) PUBMED 1718995 COMMENT Original source text: Homo sapiens fibroblast cDNA to mRNA. FEATURES Location/Qualifiers source 1..2493 /db_xref="H-InvDB:HIT000196338" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="10" /tissue_type="fibroblast" gene 1..2493 /gene="LIPA" mRNA <1..2493 /gene="LIPA" /note="G00-120-153" CDS 41..1240 /gene="LIPA" /EC_number="3.1.1.13" /note="alternate initiator ATG may be at position 47" /codon_start=1 /product="lysosomal acid lipase/cholesteryl esterase" /protein_id="AAA59519.1" /db_xref="GDB:G00-120-153" /translation="MKMRFLGLVVCLVLWPLHSEGSGGKLTAVDPETNMNVSEIISYW GFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANS SLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFIL NKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGR LPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSR VDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDML VPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKII NLMRKYQ" sig_peptide 41..103 /gene="LIPA" /note="alternate signal peptide may begin at position 47; as predicted from von Heijne, G. (1986) Nucl. Acids Res. 14,4683-4690; G00-120-153" mat_peptide 104..1237 /gene="LIPA" /product="lysosomal acid lipase/cholesteryl esterase" /EC_number="3.1.1.13" /note="G00-120-153" regulatory 2466..2471 /regulatory_class="polyA_signal_sequence" /gene="LIPA" /note="G00-120-153" polyA_site 2493 /gene="LIPA" /note="G00-120-153" BASE COUNT 692 a 484 c 516 g 801 t ORIGIN 1 actgcgactc gagacagcgg cccggcagga cagctccaga atgaaaatgc ggttcttggg 61 gttggtggtc tgtttggttc tctggcccct gcattctgag gggtctggag ggaaactgac 121 agctgtggat cctgaaacaa acatgaatgt gagtgaaatt atctcttact ggggattccc 181 tagtgaggaa tacctagttg agacagaaga tggatatatt ctgtgcctta accgaattcc 241 tcatgggagg aagaaccatt ctgacaaagg tcccaaacca gttgtcttcc tgcaacatgg 301 cttgctggca gattctagta actgggtcac aaaccttgcc aacagcagcc tgggcttcat 361 tcttgctgat gctggttttg acgtgtggat gggcaacagc agaggaaata cctggtctcg 421 gaaacataag acactctcag tttctcagga tgaattctgg gctttcagtt atgatgagat 481 ggcaaaatat gacctaccag cttccattaa cttcattctg aataaaactg gccaagaaca 541 agtgtattat gtgggtcatt ctcaaggcac cactataggt tttatagcat tttcacagat 601 ccctgagctg gctaaaagga ttaaaatgtt ttttgccctg ggtcctgtgg cttccgtcgc 661 cttctgtact agccctatgg ccaaattagg acgattacca gatcatctca ttaaggactt 721 atttggagac aaagaatttc ttccccagag tgcgtttttg aagtggctgg gtacccacgt 781 ttgcactcat gtcatactga aggagctctg tggaaatctc tgttttcttc tgtgtggatt 841 taatgagaga aatttaaata tgtctagagt ggatgtatat acaacacatt ctcctgctgg 901 aacttctgtg caaaacatgt tacactggag ccaggctgtt aaattccaaa agtttcaagc 961 ctttgactgg ggaagcagtg ccaagaatta ttttcattac aaccagagtt atcctcccac 1021 atacaatgtg aaggacatgc ttgtgccgac tgcagtctgg agcgggggtc acgactggct 1081 tgcagatgtc tacgacgtca atatcttact gactcagatc accaacttgg tgttccatga 1141 gagcattccg gaatgggagc atcttgactt catttggggc ctggatgccc cttggaggct 1201 ttataataaa attattaatc taatgaggaa atatcagtga aagctggact tgagctgtgt 1261 accaccaagt caatgattat gtcatgtgaa aatgtgtttg cttcatttct gtaaaacact 1321 tgtttttctt tcccaggtct tttgtttttt tatatccaag aaaatgataa ctttgaagat 1381 gcccagttca ctctagtttc aattagaaac atactagcta ttttttcttt aattagggct 1441 ggaataggaa gccagtgtct caaccatagt attgtctctt taagtctttt aaatatcact 1501 gatgtgtaaa aaggtcatta tatccattct gtttttaaaa tttaaaatat attgactttt 1561 tgcccttcat aggacaaagt aatatatgtg ttggaatttt aaaattgtgt tgtcattggt 1621 aaatctgtca ctgacttaag cgaggtataa aagtacgcag ttttcatgtc cttgccttaa 1681 agagctctct agtctaacgg tcttgtagtt agagatctaa atgacatttt atcatgtttt 1741 cctgcagcag gtgcatagtc aaatccagaa atatcacagc tgtgccagta ataaggatgc 1801 taacaattaa ttttatcaaa cctaactgtg acagctgtga tttgacacgt tttaattgct 1861 caggttaaat gaaatagttt tccggcgtct tcaaaaacaa attgcactga taaaacaaaa 1921 acaaaagtat gttttaaatg ctttgaagac tgatacactc aaccatctat attcatgagc 1981 tctcaatttc atggcaggcc atagttctac ttatctgaga agcaaatccc tgtggagact 2041 ataccactat tttttctgag attaatgtac tcttggagcc cgctactgtc gttattgatc 2101 acatctgtgt gaagccaaag ccccgtggtt gcccatgaga agtgtccttg ttcattttca 2161 cccaaatgaa gtgtgaacgt gatgttttcg gatgcaaact cagctcaggg attcattttg 2221 tgtcttagtt ttatatgcat ccttattttt aatacacctg cttcacgtcc ctatgttggg 2281 aagtccatat ttgtctgctt ttcttgcagc atcatttcct tacaatactg tccggtggac 2341 aaaatgacaa ttgatatgtt tttctgatat aattacttta gctgcactaa cagtacaatg 2401 cttgttaatg gttaatatag gcagggcgaa tactactttg taacttttaa agtcttaaac 2461 ttttcaataa aattgagtga gacttatagg ccc //