LOCUS       HUMLIPCHL               2493 bp    mRNA    linear   HUM 07-JAN-1995
DEFINITION  Human lysosomal acid lipase/cholesteryl esterase mRNA, complete
            cds.
ACCESSION   M74775
VERSION     M74775.1
KEYWORDS    lysosomal acid lipase/cholesteryl esterase.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2493)
  AUTHORS   Anderson,R.A. and Sando,G.N.
  TITLE     Cloning and expression of cDNA encoding human lysosomal acid
            lipase/cholesteryl ester hydrolase. Similarities to gastric and
            lingual lipases
  JOURNAL   J. Biol. Chem. 266 (33), 22479-22484 (1991)
   PUBMED   1718995
COMMENT     Original source text: Homo sapiens fibroblast cDNA to mRNA.
FEATURES             Location/Qualifiers
     source          1..2493
                     /db_xref="H-InvDB:HIT000196338"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="10"
                     /tissue_type="fibroblast"
     gene            1..2493
                     /gene="LIPA"
     mRNA            <1..2493
                     /gene="LIPA"
                     /note="G00-120-153"
     CDS             41..1240
                     /gene="LIPA"
                     /EC_number="3.1.1.13"
                     /note="alternate initiator ATG may be at position 47"
                     /codon_start=1
                     /product="lysosomal acid lipase/cholesteryl esterase"
                     /protein_id="AAA59519.1"
                     /db_xref="GDB:G00-120-153"
                     /translation="MKMRFLGLVVCLVLWPLHSEGSGGKLTAVDPETNMNVSEIISYW
                     GFPSEEYLVETEDGYILCLNRIPHGRKNHSDKGPKPVVFLQHGLLADSSNWVTNLANS
                     SLGFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEFWAFSYDEMAKYDLPASINFIL
                     NKTGQEQVYYVGHSQGTTIGFIAFSQIPELAKRIKMFFALGPVASVAFCTSPMAKLGR
                     LPDHLIKDLFGDKEFLPQSAFLKWLGTHVCTHVILKELCGNLCFLLCGFNERNLNMSR
                     VDVYTTHSPAGTSVQNMLHWSQAVKFQKFQAFDWGSSAKNYFHYNQSYPPTYNVKDML
                     VPTAVWSGGHDWLADVYDVNILLTQITNLVFHESIPEWEHLDFIWGLDAPWRLYNKII
                     NLMRKYQ"
     sig_peptide     41..103
                     /gene="LIPA"
                     /note="alternate signal peptide may begin at position 47;
                     as predicted from von Heijne, G. (1986) Nucl. Acids Res.
                     14,4683-4690; G00-120-153"
     mat_peptide     104..1237
                     /gene="LIPA"
                     /product="lysosomal acid lipase/cholesteryl esterase"
                     /EC_number="3.1.1.13"
                     /note="G00-120-153"
     regulatory      2466..2471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LIPA"
                     /note="G00-120-153"
     polyA_site      2493
                     /gene="LIPA"
                     /note="G00-120-153"
BASE COUNT          692 a          484 c          516 g          801 t
ORIGIN      
        1 actgcgactc gagacagcgg cccggcagga cagctccaga atgaaaatgc ggttcttggg
       61 gttggtggtc tgtttggttc tctggcccct gcattctgag gggtctggag ggaaactgac
      121 agctgtggat cctgaaacaa acatgaatgt gagtgaaatt atctcttact ggggattccc
      181 tagtgaggaa tacctagttg agacagaaga tggatatatt ctgtgcctta accgaattcc
      241 tcatgggagg aagaaccatt ctgacaaagg tcccaaacca gttgtcttcc tgcaacatgg
      301 cttgctggca gattctagta actgggtcac aaaccttgcc aacagcagcc tgggcttcat
      361 tcttgctgat gctggttttg acgtgtggat gggcaacagc agaggaaata cctggtctcg
      421 gaaacataag acactctcag tttctcagga tgaattctgg gctttcagtt atgatgagat
      481 ggcaaaatat gacctaccag cttccattaa cttcattctg aataaaactg gccaagaaca
      541 agtgtattat gtgggtcatt ctcaaggcac cactataggt tttatagcat tttcacagat
      601 ccctgagctg gctaaaagga ttaaaatgtt ttttgccctg ggtcctgtgg cttccgtcgc
      661 cttctgtact agccctatgg ccaaattagg acgattacca gatcatctca ttaaggactt
      721 atttggagac aaagaatttc ttccccagag tgcgtttttg aagtggctgg gtacccacgt
      781 ttgcactcat gtcatactga aggagctctg tggaaatctc tgttttcttc tgtgtggatt
      841 taatgagaga aatttaaata tgtctagagt ggatgtatat acaacacatt ctcctgctgg
      901 aacttctgtg caaaacatgt tacactggag ccaggctgtt aaattccaaa agtttcaagc
      961 ctttgactgg ggaagcagtg ccaagaatta ttttcattac aaccagagtt atcctcccac
     1021 atacaatgtg aaggacatgc ttgtgccgac tgcagtctgg agcgggggtc acgactggct
     1081 tgcagatgtc tacgacgtca atatcttact gactcagatc accaacttgg tgttccatga
     1141 gagcattccg gaatgggagc atcttgactt catttggggc ctggatgccc cttggaggct
     1201 ttataataaa attattaatc taatgaggaa atatcagtga aagctggact tgagctgtgt
     1261 accaccaagt caatgattat gtcatgtgaa aatgtgtttg cttcatttct gtaaaacact
     1321 tgtttttctt tcccaggtct tttgtttttt tatatccaag aaaatgataa ctttgaagat
     1381 gcccagttca ctctagtttc aattagaaac atactagcta ttttttcttt aattagggct
     1441 ggaataggaa gccagtgtct caaccatagt attgtctctt taagtctttt aaatatcact
     1501 gatgtgtaaa aaggtcatta tatccattct gtttttaaaa tttaaaatat attgactttt
     1561 tgcccttcat aggacaaagt aatatatgtg ttggaatttt aaaattgtgt tgtcattggt
     1621 aaatctgtca ctgacttaag cgaggtataa aagtacgcag ttttcatgtc cttgccttaa
     1681 agagctctct agtctaacgg tcttgtagtt agagatctaa atgacatttt atcatgtttt
     1741 cctgcagcag gtgcatagtc aaatccagaa atatcacagc tgtgccagta ataaggatgc
     1801 taacaattaa ttttatcaaa cctaactgtg acagctgtga tttgacacgt tttaattgct
     1861 caggttaaat gaaatagttt tccggcgtct tcaaaaacaa attgcactga taaaacaaaa
     1921 acaaaagtat gttttaaatg ctttgaagac tgatacactc aaccatctat attcatgagc
     1981 tctcaatttc atggcaggcc atagttctac ttatctgaga agcaaatccc tgtggagact
     2041 ataccactat tttttctgag attaatgtac tcttggagcc cgctactgtc gttattgatc
     2101 acatctgtgt gaagccaaag ccccgtggtt gcccatgaga agtgtccttg ttcattttca
     2161 cccaaatgaa gtgtgaacgt gatgttttcg gatgcaaact cagctcaggg attcattttg
     2221 tgtcttagtt ttatatgcat ccttattttt aatacacctg cttcacgtcc ctatgttggg
     2281 aagtccatat ttgtctgctt ttcttgcagc atcatttcct tacaatactg tccggtggac
     2341 aaaatgacaa ttgatatgtt tttctgatat aattacttta gctgcactaa cagtacaatg
     2401 cttgttaatg gttaatatag gcagggcgaa tactactttg taacttttaa agtcttaaac
     2461 ttttcaataa aattgagtga gacttatagg ccc
//