LOCUS HUMFAPAPC 8972 bp mRNA linear HUM 09-DEC-1993
DEFINITION Human APC gene mRNA, complete cds.
ACCESSION M74088
VERSION M74088.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8972)
AUTHORS Kinzler,K.W., Nilbert,M.C., Su,L.K., Vogelstein,B., Bryan,T.M.,
Levy,D.B., Smith,K.J., Preisinger,A.C., Hedge,P., McKechnie,D.,
Finniear,R., Markham,A., Groffen,J., Boguski,M.S., Altschul,S.F.,
Horii,A.K., Ando,H., Miyoshi,Y., Miki,Y., Nishisho,I. and
Nakamura,Y.
TITLE Identification of FAP locus genes from chromosome 5q21
JOURNAL Science 253 (5020), 661-665 (1991)
PUBMED 1651562
REFERENCE 2 (sites)
AUTHORS Nishisho,I., Nakamura,Y., Miyoshi,Y., Miki,Y., Ando,H., Horii,A.,
Koyama,K., Utsunomiya,J., Baba,S. and Hedge,P.
TITLE Mutations of chromosome 5q21 genes in FAP and colorectal cancer
patients
JOURNAL Science 253 (5020), 665-669 (1991)
PUBMED 1651563
REFERENCE 3 (bases 1 to 8972)
AUTHORS Kinzler,K.W.
TITLE Direct Submission
JOURNAL Submitted (31-JUL-1991) K.W. Kinzler, Molecular Genetics
Laboratory, Johns Hopkins University School of Medicine, Baltimore,
MD 21231 USA
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..8972
/db_xref="H-InvDB:HIT000196299"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="5q21"
gene 1..8972
/gene="APC"
CDS 19..8550
/gene="APC"
/codon_start=1
/protein_id="AAA03586.1"
/translation="MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNM
KEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGS
VSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYA
QLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRI
ARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGN
GQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTL
LAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIH
SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAV
CVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNL
TFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREV
GSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRS
QTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACG
TLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDA
NIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGD
YVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERER
GIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHC
VTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDG
YGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLK
YSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLK
FQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSER
YSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQ
SSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTY
CVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPV
SEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQ
ETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRS
KTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATE
STPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKE
AEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPS
QLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNE
LAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAE
CINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTE
YRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKDFNDKLPNNEDRVRGSFAFDS
PHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTEL
TSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIEN
TPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVED
TPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGE
DLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDS
DSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKG
GKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSK
KGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRD
STPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKM
SYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSST
KSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQ
TPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSR
LPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSIS
GTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKT
EDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVP
MRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKH
SSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGT
QSPKRHSGSYLVTSV"
BASE COUNT 3095 a 1827 c 1821 g 2229 t
ORIGIN
1 gtccaagggt agccaaggat ggctgcagct tcatatgatc agttgttaaa gcaagttgag
61 gcactgaaga tggagaactc aaatcttcga caagagctag aagataattc caatcatctt
121 acaaaactgg aaactgaggc atctaatatg aaggaagtac ttaaacaact acaaggaagt
181 attgaagatg aagctatggc ttcttctgga cagattgatt tattagagcg tcttaaagag
241 cttaacttag atagcagtaa tttccctgga gtaaaactgc ggtcaaaaat gtccctccgt
301 tcttatggaa gccgggaagg atctgtatca agccgttctg gagagtgcag tcctgttcct
361 atgggttcat ttccaagaag agggtttgta aatggaagca gagaaagtac tggatattta
421 gaagaacttg agaaagagag gtcattgctt cttgctgatc ttgacaaaga agaaaaggaa
481 aaagactggt attacgctca acttcagaat ctcactaaaa gaatagatag tcttccttta
541 actgaaaatt tttccttaca aacagatatg accagaaggc aattggaata tgaagcaagg
601 caaatcagag ttgcgatgga agaacaacta ggtacctgcc aggatatgga aaaacgagca
661 cagcgaagaa tagccagaat tcagcaaatc gaaaaggaca tacttcgtat acgacagctt
721 ttacagtccc aagcaacaga agcagagagg tcatctcaga acaagcatga aaccggctca
781 catgatgctg agcggcagaa tgaaggtcaa ggagtgggag aaatcaacat ggcaacttct
841 ggtaatggtc agggttcaac tacacgaatg gaccatgaaa cagccagtgt tttgagttct
901 agtagcacac actctgcacc tcgaaggctg acaagtcatc tgggaaccaa ggtggaaatg
961 gtgtattcat tgttgtcaat gcttggtact catgataagg atgatatgtc gcgaactttg
1021 ctagctatgt ctagctccca agacagctgt atatccatgc gacagtctgg atgtcttcct
1081 ctcctcatcc agcttttaca tggcaatgac aaagactctg tattgttggg aaattcccgg
1141 ggcagtaaag aggctcgggc cagggccagt gcagcactcc acaacatcat tcactcacag
1201 cctgatgaca agagaggcag gcgtgaaatc cgagtccttc atcttttgga acagatacgc
1261 gcttactgtg aaacctgttg ggagtggcag gaagctcatg aaccaggcat ggaccaggac
1321 aaaaatccaa tgccagctcc tgttgaacat cagatctgtc ctgctgtgtg tgttctaatg
1381 aaactttcat ttgatgaaga gcatagacat gcaatgaatg aactaggggg actacaggcc
1441 attgcagaat tattgcaagt ggactgtgaa atgtacgggc ttactaatga ccactacagt
1501 attacactaa gacgatatgc tggaatggct ttgacaaact tgacttttgg agatgtagcc
1561 aacaaggcta cgctatgctc tatgaaaggc tgcatgagag cacttgtggc ccaactaaaa
1621 tctgaaagtg aagacttaca gcaggttatt gcaagtgttt tgaggaattt gtcttggcga
1681 gcagatgtaa atagtaaaaa gacgttgcga gaagttggaa gtgtgaaagc attgatggaa
1741 tgtgctttag aagttaaaaa ggaatcaacc ctcaaaagcg tattgagtgc cttatggaat
1801 ttgtcagcac attgcactga gaataaagct gatatatgtg ctgtagatgg tgcacttgca
1861 tttttggttg gcactcttac ttaccggagc cagacaaaca ctttagccat tattgaaagt
1921 ggaggtggga tattacggaa tgtgtccagc ttgatagcta caaatgagga ccacaggcaa
1981 atcctaagag agaacaactg tctacaaact ttattacaac acttaaaatc tcatagtttg
2041 acaatagtca gtaatgcatg tggaactttg tggaatctct cagcaagaaa tcctaaagac
2101 caggaagcat tatgggacat gggggcagtt agcatgctca agaacctcat tcattcaaag
2161 cacaaaatga ttgctatggg aagtgctgca gctttaagga atctcatggc aaataggcct
2221 gcgaagtaca aggatgccaa tattatgtct cctggctcaa gcttgccatc tcttcatgtt
2281 aggaaacaaa aagccctaga agcagaatta gatgctcagc acttatcaga aacttttgac
2341 aatatagaca atttaagtcc caaggcatct catcgtagta agcagagaca caagcaaagt
2401 ctctatggtg attatgtttt tgacaccaat cgacatgatg ataataggtc agacaatttt
2461 aatactggca acatgactgt cctttcacca tatttgaata ctacagtgtt acccagctcc
2521 tcttcatcaa gaggaagctt agatagttct cgttctgaaa aagatagaag tttggagaga
2581 gaacgcggaa ttggtctagg caactaccat ccagcaacag aaaatccagg aacttcttca
2641 aagcgaggtt tgcagatctc caccactgca gcccagattg ccaaagtcat ggaagaagtg
2701 tcagccattc atacctctca ggaagacaga agttctgggt ctaccactga attacattgt
2761 gtgacagatg agagaaatgc acttagaaga agctctgctg cccatacaca ttcaaacact
2821 tacaatttca ctaagtcgga aaattcaaat aggacatgtt ctatgcctta tgccaaatta
2881 gaatacaaga gatcttcaaa tgatagttta aatagtgtca gtagtagtga tggttatggt
2941 aaaagaggtc aaatgaaacc ctcgattgaa tcctattctg aagatgatga aagtaagttt
3001 tgcagttatg gtcaataccc agccgaccta gcccataaaa tacatagtgc aaatcatatg
3061 gatgataatg atggagaact agatacacca ataaattata gtcttaaata ttcagatgag
3121 cagttgaact ctggaaggca aagtccttca cagaatgaaa gatgggcaag acccaaacac
3181 ataatagaag atgaaataaa acaaagtgag caaagacaat caaggaatca aagtacaact
3241 tatcctgttt atactgagag cactgatgat aaacacctca agttccaacc acattttgga
3301 cagcaggaat gtgtttctcc atacaggtca cggggagcca atggttcaga aacaaatcga
3361 gtgggttcta atcatggaat taatcaaaat gtaagccagt ctttgtgtca agaagatgac
3421 tatgaagatg ataagcctac caattatagt gaacgttact ctgaagaaga acagcatgaa
3481 gaagaagaga gaccaacaaa ttatagcata aaatataatg aagagaaacg tcatgtggat
3541 cagcctattg attatagttt aaaatatgcc acagatattc cttcatcaca gaaacagtca
3601 ttttcattct caaagagttc atctggacaa agcagtaaaa ccgaacatat gtcttcaagc
3661 agtgagaata cgtccacacc ttcatctaat gccaagaggc agaatcagct ccatccaagt
3721 tctgcacaga gtagaagtgg tcagcctcaa aaggctgcca cttgcaaagt ttcttctatt
3781 aaccaagaaa caatacagac ttattgtgta gaagatactc caatatgttt ttcaagatgt
3841 agttcattat catctttgtc atcagctgaa gatgaaatag gatgtaatca gacgacacag
3901 gaagcagatt ctgctaatac cctgcaaata gcagaaataa aagaaaagat tggaactagg
3961 tcagctgaag atcctgtgag cgaagttcca gcagtgtcac agcaccctag aaccaaatcc
4021 agcagactgc agggttctag tttatcttca gaatcagcca ggcacaaagc tgttgaattt
4081 tcttcaggag cgaaatctcc ctccaaaagt ggtgctcaga cacccaaaag tccacctgaa
4141 cactatgttc aggagacccc actcatgttt agcagatgta cttctgtcag ttcacttgat
4201 agttttgaga gtcgttcgat tgccagctcc gttcagagtg aaccatgcag tggaatggta
4261 agtggcatta taagccccag tgatcttcca gatagccctg gacaaaccat gccaccaagc
4321 agaagtaaaa cacctccacc acctcctcaa acagctcaaa ccaagcgaga agtacctaaa
4381 aataaagcac ctactgctga aaagagagag agtggaccta agcaagctgc agtaaatgct
4441 gcagttcaga gggtccaggt tcttccagat gctgatactt tattacattt tgccacggaa
4501 agtactccag atggattttc ttgttcatcc agcctgagtg ctctgagcct cgatgagcca
4561 tttatacaga aagatgtgga attaagaata atgcctccag ttcaggaaaa tgacaatggg
4621 aatgaaacag aatcagagca gcctaaagaa tcaaatgaaa accaagagaa agaggcagaa
4681 aaaactattg attctgaaaa ggacctatta gatgattcag atgatgatga tattgaaata
4741 ctagaagaat gtattatttc tgccatgcca acaaagtcat cacgtaaagc aaaaaagcca
4801 gcccagactg cttcaaaatt acctccacct gtggcaagga aaccaagtca gctgcctgtg
4861 tacaaacttc taccatcaca aaacaggttg caaccccaaa agcatgttag ttttacaccg
4921 ggggatgata tgccacgggt gtattgtgtt gaagggacac ctataaactt ttccacagct
4981 acatctctaa gtgatctaac aatcgaatcc cctccaaatg agttagctgc tggagaagga
5041 gttagaggag gagcacagtc aggtgaattt gaaaaacgag ataccattcc tacagaaggc
5101 agaagtacag atgaggctca aggaggaaaa acctcatctg taaccatacc tgaattggat
5161 gacaataaag cagaggaagg tgatattctt gcagaatgca ttaattctgc tatgcccaaa
5221 gggaaaagtc acaagccttt ccgtgtgaaa aagataatgg accaggtcca gcaagcatct
5281 gcgtcgtctt ctgcacccaa caaaaatcag ttagatggta agaaaaagaa accaacttca
5341 ccagtaaaac ctataccaca aaatactgaa tataggacac gtgtaagaaa aaatgcagac
5401 tcaaaaaata atttaaatgc tgagagagtt ttctcagaca acaaagattc aaagaaacag
5461 aatttgaaaa ataattccaa ggacttcaat gataagctcc caaataatga agatagagtc
5521 agaggaagtt ttgcttttga ttcacctcat cattacacgc ctattgaagg aactccttac
5581 tgtttttcac gaaatgattc tttgagttct ctagattttg atgatgatga tgttgacctt
5641 tccagggaaa aggctgaatt aagaaaggca aaagaaaata aggaatcaga ggctaaagtt
5701 accagccaca cagaactaac ctccaaccaa caatcagcta ataagacaca agctattgca
5761 aagcagccaa taaatcgagg tcagcctaaa cccatacttc agaaacaatc cacttttccc
5821 cagtcatcca aagacatacc agacagaggg gcagcaactg atgaaaagtt acagaatttt
5881 gctattgaaa atactccagt ttgcttttct cataattcct ctctgagttc tctcagtgac
5941 attgaccaag aaaacaacaa taaagaaaat gaacctatca aagagactga gccccctgac
6001 tcacagggag aaccaagtaa acctcaagca tcaggctatg ctcctaaatc atttcatgtt
6061 gaagataccc cagtttgttt ctcaagaaac agttctctca gttctcttag tattgactct
6121 gaagatgacc tgttgcagga atgtataagc tccgcaatgc caaaaaagaa aaagccttca
6181 agactcaagg gtgataatga aaaacatagt cccagaaata tgggtggcat attaggtgaa
6241 gatctgacac ttgatttgaa agatatacag agaccagatt cagaacatgg tctatcccct
6301 gattcagaaa attttgattg gaaagctatt caggaaggtg caaattccat agtaagtagt
6361 ttacatcaag ctgctgctgc tgcatgttta tctagacaag cttcgtctga ttcagattcc
6421 atcctttccc tgaaatcagg aatctctctg ggatcaccat ttcatcttac acctgatcaa
6481 gaagaaaaac cctttacaag taataaaggc ccacgaattc taaaaccagg ggagaaaagt
6541 acattggaaa ctaaaaagat agaatctgaa agtaaaggaa tcaaaggagg aaaaaaagtt
6601 tataaaagtt tgattactgg aaaagttcga tctaattcag aaatttcagg ccaaatgaaa
6661 cagccccttc aagcaaacat gccttcaatc tctcgaggca ggacaatgat tcatattcca
6721 ggagttcgaa atagctcctc aagtacaagt cctgtttcta aaaaaggccc accccttaag
6781 actccagcct ccaaaagccc tagtgaaggt caaacagcca ccacttctcc tagaggagcc
6841 aagccatctg tgaaatcaga attaagccct gttgccaggc agacatccca aataggtggg
6901 tcaagtaaag caccttctag atcaggatct agagattcga ccccttcaag acctgcccag
6961 caaccattaa gtagacctat acagtctcct ggccgaaact caatttcccc tggtagaaat
7021 ggaataagtc ctcctaacaa attatctcaa cttccaagga catcatcccc tagtactgct
7081 tcaactaagt cctcaggttc tggaaaaatg tcatatacat ctccaggtag acagatgagc
7141 caacagaacc ttaccaaaca aacaggttta tccaagaatg ccagtagtat tccaagaagt
7201 gagtctgcct ccaaaggact aaatcagatg aataatggta atggagccaa taaaaaggta
7261 gaactttcta gaatgtcttc aactaaatca agtggaagtg aatctgatag atcagaaaga
7321 cctgtattag tacgccagtc aactttcatc aaagaagctc caagcccaac cttaagaaga
7381 aaattggagg aatctgcttc atttgaatct ctttctccat catctagacc agcttctccc
7441 actaggtccc aggcacaaac tccagtttta agtccttccc ttcctgatat gtctctatcc
7501 acacattcgt ctgttcaggc tggtggatgg cgaaaactcc cacctaatct cagtcccact
7561 atagagtata atgatggaag accagcaaag cgccatgata ttgcacggtc tcattctgaa
7621 agtccttcta gacttccaat caataggtca ggaacctgga aacgtgagca cagcaaacat
7681 tcatcatccc ttcctcgagt aagcacttgg agaagaactg gaagttcatc ttcaattctt
7741 tctgcttcat cagaatccag tgaaaaagca aaaagtgagg atgaaaaaca tgtgaactct
7801 atttcaggaa ccaaacaaag taaagaaaac caagtatccg caaaaggaac atggagaaaa
7861 ataaaagaaa atgaattttc tcccacaaat agtacttctc agaccgtttc ctcaggtgct
7921 acaaatggtg ctgaatcaaa gactctaatt tatcaaatgg cacctgctgt ttctaaaaca
7981 gaggatgttt gggtgagaat tgaggactgt cccattaaca atcctagatc tggaagatct
8041 cccacaggta atactccccc ggtgattgac agtgtttcag aaaaggcaaa tccaaacatt
8101 aaagattcaa aagataatca ggcaaaacaa aatgtgggta atggcagtgt tcccatgcgt
8161 accgtgggtt tggaaaatcg cctgaactcc tttattcagg tggatgcccc tgaccaaaaa
8221 ggaactgaga taaaaccagg acaaaataat cctgtccctg tatcagagac taatgaaagt
8281 tctatagtgg aacgtacccc attcagttct agcagctcaa gcaaacacag ttcacctagt
8341 gggactgttg ctgccagagt gactcctttt aattacaacc caagccctag gaaaagcagc
8401 gcagatagca cttcagctcg gccatctcag atcccaactc cagtgaataa caacacaaag
8461 aagcgagatt ccaaaactga cagcacagaa tccagtggaa cccaaagtcc taagcgccat
8521 tctgggtctt accttgtgac atctgtttaa aagagaggaa gaatgaaact aagaaaattc
8581 tatgttaatt acaactgcta tatagacatt ttgtttcaaa tgaaacttta aaagactgaa
8641 aaattttgta aataggtttg attcttgtta gagggttttt gttctggaag ccatatttga
8701 tagtatactt tgtcttcact ggtcttattt tgggaggcac tcttgatggt taggaaaaaa
8761 atagtaaagc caagtatgtt tgtacagtat gttttacatg tatttaaagt agcacccatc
8821 ccaacttcct ttaattattg cttgtcttaa aataatgaac actacagata gaaaatatga
8881 tatattgctg ttatcaatca tttctagatt ataaactgac taaacttaca tcagggaaaa
8941 attggtattt atgcaaaaaa aaatgttttt gt
//