LOCUS HUMARGNP 2736 bp mRNA linear HUM 27-APR-1993
DEFINITION Human arginine-rich nuclear protein mRNA, complete cds.
ACCESSION M74002
VERSION M74002.1
KEYWORDS U1-snRNP; arginine/serine-rich; spliceosome; transformer protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2736)
AUTHORS Chaudhary,N., McMahon,C. and Blobel,G.
TITLE Primary structure of a human arginine-rich nuclear protein that
colocalizes with spliceosome components
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (18), 8189-8193 (1991)
PUBMED 1896467
COMMENT Original source text: Homo sapiens (library: lambda gt11 (Mike
Mueckler)) liver cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..2736
/db_xref="H-InvDB:HIT000196291"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/haplotype="2N"
/cell_line="HepG2 cells"
/tissue_type="liver"
/tissue_lib="lambda gt11 (Mike Mueckler)"
CDS 84..1538
/note="Gene product is 54 kDa but migrates aberrantly on
SDS gels as a
70 kDa protein.; In mammalian cells, the protein
colocalizes with many components of the pre-mRNA splicing
machinery in the nucleus."
/codon_start=1
/product="arginine-rich nuclear protein"
/protein_id="AAA35554.1"
/translation="MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSA
SSEQMRTLFGFLGKIDELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVD
RALIVVPYAEGVIPDEAKALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGA
PTLDPALAALGLPGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKE
IEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRR
SHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTAR
RSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERE
RSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSP
KTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD"
regulatory 2718..2723
/regulatory_class="polyA_signal_sequence"
BASE COUNT 867 a 521 c 608 g 740 t
ORIGIN
1 gagagaagcc ttttccgttg ccggtgccgg cctagcgtcc tggaattact tcaatcaaca
61 ggagcgagaa cccgagcagc gccatgagca acactaccgt cgtccccagc actgcaggtc
121 cgggccccag cggcgggccc ggtggcggag gtggtggtgg cggcggaggc ggcggcaccg
181 aggtaatcca ggtgactaat gtctccccga gcgctagctc tgagcagatg cggactctct
241 tcggtttcct aggcaagatc gacgaactgc gcctcttccc gccggatgat tcgcctttgc
301 cagtctcatc tcgtgtctgc tttgttaagt tccatgatcc agactcagca gttgtggcac
361 agcatctgac aaacactgta ttcgttgaca gagctttgat agtcgtacca tatgcagaag
421 gagttattcc tgatgaagct aaagctttgt ctctgttggc accagctaat gcagtggcag
481 gtcttctgcc tggtggtgga ctcctgccta ctcctaaccc acttacccag attggcgctg
541 ttccactggc tgctttgggg gctcctactc ttgatcctgc ccttgctgca cttgggcttc
601 ctggagcaaa cttgaactct cagtctcttg ctgcagatca gttgctgaag cttatgagta
661 ctgttgatcc caagttgaat catgtagctg ctggtctcgt ttcaccaagt ctgaaatcgg
721 atacctctag taaagaaata gaggaagcta tgaaaagagt acgagaagca cagtccctaa
781 tttctgctgc tatagaacca gataagaaag aagaaaaaag aaggcattca agatcaagat
841 cacgttctag gaggaggagg actccctcat cttctagaca caggcggtca agaagcagat
901 cgagacggcg gtcacattct aagtctagga gtcggcgacg atccaaaagc ccaaggcgga
961 gaagatctca ttccagagaa agaggtagaa ggtcaaggag cacatcaaaa acaagagaca
1021 aaaagaaaga agacaaagaa aagaaacgtt ctaaaacacc accaaaaagt tacagcacag
1081 ccagacgttc tagaagtgca agcagagaga gacgacgacg aagaagcagg agtggcacaa
1141 gatctcctaa aaagcctcgg tctcctaaaa gaaaattgtc ccgctcacca tcccctagga
1201 gacataaaaa ggagaagaag aaagataaag acaaagaaag aagtagggat gaaagagaac
1261 gatcaacaag caagaagaag aagagtaaag ataaggaaaa ggaccgggaa agaaaatcag
1321 agagtgataa agatgtaaaa caggttacac gggattatga tgaagaggaa caggggtatg
1381 acagtgagaa agagaaaaaa gaagagaaga aaccaataga aacaggttcc cctaaaacaa
1441 aggaatgttc tgtggaaaag ggaactggtg attcactaag agaatccaaa gtgaatgggg
1501 atgatcatca tgaagaagac atggatatga gtgactgaat attgcctctg agggagtcca
1561 actgtatacc tgcatcagtg tcattccttt gtgtgatttc ttaatgctgt atttgttcat
1621 ctcaaaccta gatgtataca gctctgagtt ataaatggtt ataaagctcc tgttactcat
1681 attagttatt tacatcaaaa agcttttaga aaatggtacg aggtaaccaa ttcttgtcat
1741 ggtgaaatct gattgagtaa ccaagcagtt ttactattct ggtgctgctt cataacaaaa
1801 atgaaaagct gcatgcatct acagcaggca tggattgttt atgtcgtatg atatccttta
1861 ttaagtaagt tcacttatag tatttctata atttgattca ttgccgtaat agagccatgt
1921 aggaaatgca ctgattgcat gttattgtgg caagaatatc ctaaatgtca ttaaaatcct
1981 ccaacatgat ggatctactt atggtcttgt ttgttgacat gacaaattaa cattcttata
2041 gttacatctg gaaatgagca tttgaaatag ataatccttt aagccttgtg gcaaaatttt
2101 tgtggctttt gtttaacttt gaaaggttat tatgcactaa ccttttttgg tggctaatta
2161 gggtttaaat acagaaacaa gatttcaaat aaaactgtct ttgggcagtg agtaaatagc
2221 atattttgaa gtagagttgt atactttttc ataagatgtt tgggaatttt tttcctgaag
2281 taataattta ttcccacatc tacatcagtg aaagctatct acctatcctg agtctatctt
2341 aaaggaaaaa aagaaaaaaa ccttatctct tgcccttatt ttgaattttc cactctttca
2401 ttaatttgtt ttaagctcct gttggaaaaa aaggggtagt gcattttaaa ttgaccttca
2461 tacgctttta aaataagaca aatctacttg ataatgtacc tttatttgat ctcaagttgt
2521 ataaaaccaa taaatttgtg ttactgcagt agtaatctta tgcacacggt gatttcatgt
2581 tatatatgca aagtaggcaa ctgttttctt agttacagaa gtttcaagct tcacttttgt
2641 gcagtagaaa caaaagtagg ctacagtctg tgccatgttg atgtacagtt tctgaaattg
2701 ttttacaaga ctttgataat aaaaccctta aactta
//