LOCUS HUMINTLEU8 1510 bp mRNA linear HUM 08-DEC-1995
DEFINITION Human interleukin-8 receptor type B (IL8RB) mRNA, complete cds.
ACCESSION M73969
VERSION M73969.1
KEYWORDS interleukin 8 receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1510)
AUTHORS Murphy,P.M. and Tiffany,H.L.
TITLE Cloning of complementary DNA encoding a functional human
interleukin-8 receptor
JOURNAL Science 253 (5025), 1280-1283 (1991)
PUBMED 1891716
REFERENCE 2 (bases 1 to 1510)
AUTHORS Ahuja,S.K., Ozcelik,T., Milatovitch,A., Francke,U. and Murphy,P.M.
TITLE Molecular evolution of the human interleukin-8 receptor gene
cluster
JOURNAL Nat. Genet. 2 (1), 31-36 (1992)
PUBMED 1303245
REFERENCE 3 (bases 1 to 1510)
AUTHORS Murphy,P.M.
TITLE Direct Submission
JOURNAL Submitted (25-JUL-1991) Philip M. Murphy, NIAID, NIH, Bethesda, MD
20892, USA
COMMENT Original source text: Homo sapiens cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..1510
/db_xref="H-InvDB:HIT000196288"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q34-q35"
/cell_type="neutrophil"
gene 1..1510
/gene="IL8RB"
CDS 26..1108
/gene="IL8RB"
/note="potential translation initiation codons begin at
nucleotide position 26 or 41; high affinity ligands for
this receptor include the CXC chemokines interleukin-8,
GROalpha, GRObeta, GROgamma, NAP-2 and ENA-78"
/codon_start=1
/product="interleukin-8 receptor type B"
/protein_id="AAA83148.1"
/db_xref="GDB:G00-120-099"
/translation="MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESL
EINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLP
IWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRY
LVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSF
GFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTL
MRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGL
ISKDSLPKDSRPSFVGSSSGHTSTTL"
BASE COUNT 337 a 442 c 333 g 398 t
ORIGIN
1 gtcaggattt aagtttacct caaaaatgga agattttaac atggagagtg acagctttga
61 agatttctgg aaaggtgaag atcttagtaa ttacagttac agctctaccc tgcccccttt
121 tctactagat gccgccccat gtgaaccaga atccctggaa atcaacaagt attttgtggt
181 cattatctat gccctggtat tcctgctgag cctgctggga aactccctcg tgatgctggt
241 catcttatac agcagggtcg gccgctccgt cactgatgtc tacctgctga acctagcctt
301 ggccgaccta ctctttgccc tgaccttgcc catctgggcc gcctccaagg tgaatggctg
361 gatttttggc acattcctgt gcaaggtggt ctcactcctg aaggaagtca acttctatag
421 tggcatcctg ctactggcct gcatcagtgt ggaccgttac ctggccattg tccatgccac
481 acgcacactg acccagaagc gctacttggt caaattcata tgtctcagca tctggggtct
541 gtccttgctc ctggccctgc ctgtcttact tttccgaagg accgtctact catccaatgt
601 tagcccagcc tgctatgagg acatgggcaa caatacagca aactggcgga tgctgttacg
661 gatcctgccc cagtcctttg gcttcatcgt gccactgctg atcatgctgt tctgctacgg
721 attcaccctg cgtacgctgt ttaaggccca catggggcag aagcaccggg ccatgcgggt
781 catctttgct gtcgtcctca tcttcctgct ttgctggctg ccctacaacc tggtcctgct
841 ggcagacacc ctcatgagga cccaggtgat ccaggagacc tgtgagcgcc gcaatcacat
901 cgaccgggct ctggatgcca ccgagattct gggcatcctt cacagctgcc tcaaccccct
961 catctacgcc ttcattggcc agaagtttcg ccatggactc ctcaagattc tagctataca
1021 tggcttgatc agcaaggact ccctgcccaa agacagcagg ccttcctttg ttggctcttc
1081 ttcagggcac acttccacta ctctctaaga cctcctgcct aagtgcagcc cgtggggttc
1141 ctcccttctc ttcacagtca cattccaagc ctcatgtcca ctggttcttc ttggtctcag
1201 tgtcaatgca gcccccattg tggtcacagg aagcagagga ggccacgttc ttactagttt
1261 cccttgcatg gtttagaaag cttgccctgg tgcctcaccc cttgccataa ttactatgtc
1321 atttgctgga gctctgccca tcctgcccct gagcccatgg cactctatgt tctaagaagt
1381 gaaaatctac actccagtga gacagctctg catactcatt aggatggcta gtatcaaaag
1441 aaagaaaatc aggctggcca acgggatgaa accctgtctc tactaaaaat acaaaaaaaa
1501 aaaaaaaaaa
//