LOCUS HUMGRF1A 3233 bp mRNA linear HUM 31-DEC-1994
DEFINITION Human glucocorticoid receptor repression factor 1 (GRF-1) mRNA,
complete cds.
ACCESSION M73077
VERSION M73077.1
KEYWORDS glucocorticoid receptor repression factor 1.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3233)
AUTHORS LeClerc,S., Palaniswami,R., Xie,B.X. and Govindan,M.V.
TITLE Molecular cloning and characterization of a factor that binds the
human glucocorticoid receptor gene and represses its expression
JOURNAL J. Biol. Chem. 266 (26), 17333-17340 (1991)
PUBMED 1894621
COMMENT Original source text: Homo sapiens (tissue library: lambda-GT11,
lambda-GT10) breast cDNA to mRNA.
FEATURES Location/Qualifiers
source 1..3233
/db_xref="H-InvDB:HIT000196257"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="MCF-7"
/tissue_type="breast"
/tissue_lib="lambda-GT11, lambda-GT10"
gene 1..3233
/gene="GRF-1"
CDS 34..2541
/gene="GRF-1"
/codon_start=1
/product="glucocorticoid receptor repression factor 1"
/protein_id="AAA58618.1"
/translation="MDATSHIDNMENERIPFDLMDTVPAEALYEAHLEKLRNERKRVE
MRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYTDIYGKHQKQIIDKAK
EEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKAIYKSSKQSVDALILK
HIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILG
KDALPESWPMEIRALCTNDDKYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHGCL
CLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQ
GQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLA
DVDLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELS
VLSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVD
VLDNDLSREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATH
MYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPSYSLFREDTSLPSLSKDHS
KLSMELEGNDGLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQR
KSVSSSPWLPQDGFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQ
SNGSGNGSDSEMDTSSLERGRKVSIVSKPVLYRTRCTRLGGLLVTGPASAWGVMMSWG
PSGRKRRIRHPRVIKGTMLSFHTKQTKTRGGGIFFAA"
BASE COUNT 929 a 751 c 771 g 782 t
ORIGIN
1 cttgaagtgg tttgttgtgc ttgaagagac cccatggatg ccaccagtca cattgacaac
61 atggaaaacg aacggattcc ctttgattta atggataccg tccctgcaga ggcactatac
121 gaggcccact tagagaagct gaggaacgaa aggaaaagag ttgagatgcg aagggcgttt
181 aaagaaaacc tggagacttc tcctttcata actcccggaa agccttggga agaggcccgt
241 agttttatta tgaatgagga tttctaccag tggctggagg aatctgtata cacggatatt
301 tatggcaaac accaaaagca aattatagat aaagcaaagg aagaatttca ggagttgctt
361 ttggaatatt cagaattgtt ttatgaactg gagctggatg ctaagcccag caaggagaag
421 atgggtgtta ttcaggatgt tctgggagag gaacagcgat ttaaagccat ttacaaaagc
481 tccaagcaga gcgttgatgc ccttattctg aaacacattc attttgtgta ccacccaaca
541 aaggagacat gccccagctg cccagcttgt gtggacgcta agattgagca cttgattagt
601 tctcggttta tccggccgtc tgaccggaat cagaaaaatt cactctctga ccctaacatt
661 gatagaatca acttggttat attgggcaaa gacgccttgc ccgagagttg gccaatggag
721 attagagctc tttgtacaaa tgatgacaag tatgtgatag atggtaaaat gtatgagctt
781 tccctgaggc caatagaggg gaatgtcagg cttcctgtga actctttcca gacgccaaca
841 tttcagcccc acggctgtct ctgcctttac aattcaaagg aatcgctatc ctatgtagtg
901 gaaagtatag agaagagtag agagtccacg ctgggccggc gggataatca tttagtccat
961 ctccccctta cattaatttt ggttaacaag agaggagaca ccagtggaga gactctgcat
1021 agcttaatac agcaaggtca acaaattgct agcaaacttc agtgtgtctt tctcgaccct
1081 gcttctgctg gcattggtta cggacgcaac attaatgaaa agcaaatcag tcaagttttg
1141 aagggactcc tggactctaa gcgtaactta aacctggtca gttctactgc tagcatcaaa
1201 gatttggctg atgttgatct gcgaattgtt atgtgtctga tgtgtggaga tccttttagt
1261 gcagatgata tactttttcc tgtccttcag tcccaaacct gtaaatcttc ccattgtgga
1321 agcaacaact ctgttttact tgaactacca atcggactgc acaagaagcg gattgaactg
1381 tctgttcttt cataccattc ctcctttagc atcagaaaga gccggttggt tcatgggtac
1441 attgtttttt attcagccaa acgtaaggcc tctttggcta tgttacgtgc ctttctttgt
1501 gaagtgcagg atattatccc tattcagctt gtagcactca ctgatggcgc tgtagatgtc
1561 ctggacaatg acttaagtag ggaacagcta actgaggggg aggagattgc tcaagaaatt
1621 gacggaaggt tcacaagcat cccctgtagc caaccccagc ataaacttga gatctttcac
1681 ccatttttta aagatgtggt ggaaaaaaag aacataatcg aggctactca tatgtacgat
1741 aatgctgccg aggcctgtag caccaccgaa gaggtgttta actccccccg ggcaggatca
1801 ccgctctgca actcaaacct gcaggattca gaagaagata tcgagccatc ttacagcctg
1861 tttcgagaag acacatcact gccttctctg tccaaagacc attctaagct ctctatggaa
1921 ctggagggaa atgatgggct gtctttcatt atgagcaatt ttgagagtaa actgaacaac
1981 aaagtacctc cgccagtcaa accaaagcct cctgtccatt ttgaaattac aaagggggat
2041 ctatcttatt tagaccaagg ccatagggat ggacagagga agtctgtgtc ttctagcccc
2101 tggctgcctc aggatgggtt tgatccttct gactatgctg aacccatgga tgctgtggtg
2161 aagccaagga atgaagaaga aaacatatac tccgtgcccc atgacagcac ccaaggcaaa
2221 atcatcacca ttcggaatat caacaaagcc cagtccaacg gcagcgggaa tggttctgac
2281 agtgaaatgg acaccagctc tctagagcga gggcgcaagg tttccatcgt gagcaagcca
2341 gtgctgtaca ggacgagatg cacccggctg ggcggtttgc tagttaccgg accagcttca
2401 gcgtggggag tgatgatgag ctggggccca tccggaagaa agaggaggat caggcatccc
2461 agggttataa aggggacaat gctgtcattc catacgaaac agacgaagac ccgcggagga
2521 ggaatattct tcgcagccta aggaggaaca ctaagaaacc aaagcccaaa ccccggccat
2581 ccatcacaaa ggccaacctg ggagagtaac tattttgggg tgcccttaac aactgtcgtg
2641 actccagaga agccgatccc catttttatt gaaagatgta ttgagtacat tgaagccaca
2701 ggactgagca cggaaggcat ctaccgggtc agcgggaaca agtctgagat ggagagtctg
2761 cagagacagt ttgatcaaga ccacaacctg gacctggcag agaaagactt tacggtgaat
2821 accgtggctg gtgccatgaa gagctttttc tcagaactgc ctgaccccct ggtccgtata
2881 acatgcagat cgacttggtg gaagcacaca aaatcaacga ccgggagcag aagttgcatg
2941 cccttaagga ggtattaaag aaatttccaa aggaaaacca cgaagtcttc aagtatgtca
3001 tctctcacct aaacaaggtc agccacaaca acaaggtgaa tctcatgacc agcgagaacc
3061 tctccatctg cttctggccc accttgatga gacctgattt cagcactatg gacgccctca
3121 cagccacgcg cacctaccag acaatcattg aactctttat ccagcagtgc cccttcttct
3181 tctacaatcg gcccatcacc gagcccccgg cgccaggccc agctcccgga att
//