LOCUS HUMCSPA 4770 bp DNA linear HUM 25-AUG-1995
DEFINITION Human cytotoxic serine proteinase gene, complete cds.
ACCESSION M72150
VERSION M72150.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4770)
AUTHORS Caputo,T. and Rowe,P.B.
JOURNAL Unpublished
COMMENT On Aug 25, 1995 this sequence version replaced gi:181156.
FEATURES Location/Qualifiers
source 1..4770
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/tissue_type="blood"
/clone_lib="D-SECT2"
misc_feature 1..875
/note="5' flanking region"
regulatory 846..849
/regulatory_class="TATA_box"
/note="TAAA Box"
mRNA join(876..960,2107..2254,2772..2907,3113..3370,3773..4029)
/product="cytotoxic serine proteinase"
exon 876..960
/number=1
5'UTR 876..905
CDS join(906..960,2107..2254,2772..2907,3113..3370,3773..3916)
/codon_start=1
/product="cytotoxic serine proteinase"
/protein_id="AAA74885.1"
/translation="MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEK
SRKRCGGILVRKDFVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNP
KNFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQ
EVLLTVQKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSY
GNKKGTPPGVYIKVSHFLPWIKRTMKRL"
intron 961..2106
/number=1
exon 2107..2254
/number=2
intron 2255..2771
/number=2
exon 2772..2907
/number=3
intron 2908..3112
/number=3
exon 3113..3370
/number=4
intron 3371..3772
/number=4
exon 3773..4029
/number=5
3'UTR 3917..4029
regulatory 4012..4017
/regulatory_class="polyA_signal_sequence"
misc_feature 4030..4770
/note="3' flanking region"
BASE COUNT 1208 a 1328 c 1076 g 1158 t
ORIGIN
1 aaccaggatg gtctcgatct cctgacctcg tgatccaccc gtcttggcct cccaaagtgc
61 taggattaca ggcatgagcc accgcgcccg gccttagtga acaattatta tcaggatgat
121 cagcatccat ttttccatca cctggcaaca acaactagca tttctcaagg gaaatcccct
181 cctcattcat aagcaccata gatggagtgg aacagtcccc acctcagctt aaggagggct
241 aaataaccaa agcataaagc aatcagtcca ctacacttca gtggacccaa tgatgactca
301 ttttggttca ataaatatca agtccagaac ttttgtgcag aactgtggaa taaaaaaagt
361 tatctttgtc acagaatatt tatatttaaa gaggggattc taaatatccc aaaaatatga
421 atctgagata gtggtaagat aggaatgggt tgccatttgc agtatttgtt gggtgtgtgc
481 aactctgcat actgctaagg caagtccagc ctccgtctca caccaacagg cagatttccc
541 caccacggcc cttaccatct tgtgctctaa ccccagattt tcagtctact cttgctaacc
601 atcaattctt caagggcaag agccatgtct ctcatatccc tggatctggc ttgctaaata
661 attattcatg attttatctg agtagaaaaa gagccaagaa ctgagaaaag gagacattct
721 tggttctcag tcactgagga gcttctgcag taccagcctt tctgctagct gcagccacag
781 cttcaacagc tccacctcct tgttctttat tcttgctttc accttgttac tcagcagcag
841 gggtgtaaat gtgacagtgc catgtcaaca ccaacagctc tgacctgggc agccttcctg
901 agaaaatgca gccattcctc ctcctgttgg cctttcttct gacccctggg gctgggacag
961 gtaagtgact atccctattc cagaggcctg aacccatctt ataagatacc ctgtacccat
1021 gagcactggt caggaatttt cctcaatctg agcccacctc ccattccaca cccagactta
1081 taaatctgag gctagataga cactcagcaa agatcgaaaa atgaagggtg ttccctaaaa
1141 ggtttaatgg gtgttagcct ctccctagac ctctccttta tgacctggag tgtggattgt
1201 tcttagaaag gcatttggta gggaatgtga agctaaaaaa gataagtaat tattactcta
1261 cactccaacc caggaaagag gagctcagac accaagttgc agtcatagga gttgttactg
1321 gactcagctt aagaaccact tattcagtgc ccccacccag tcacccctgc caggagggaa
1381 gcccatggtg caactgatct cagagatggc aagatgactg tgtccatagc tctcccatta
1441 ccttggctcc acctgggctt tgcgattcat ttttagttga tttctccact tccttctgcc
1501 tttgcaggcc ctcagctact ccactgacct ggtgataacc ccctctaaca tccctgaggt
1561 cctgaatccc accagcacta cccccactaa acctcagcca aaggctaatt ggaggctatt
1621 catttatgca ccaaacaaca cttactgaga acctagaatg tgttcagccc tggcacatga
1681 gaattttaga aaatccaact ccagaagctc atgggtagat cattagaaaa tggcaccaat
1741 caggaggaca gcagaggctc agaggaatca gagagactca ctaaaaagga ggagcctggg
1801 aagtcctgtc caggatcctc tggggctcta ccactgtgaa aatagatctt tcttcctcca
1861 tgtgtgtttc tgcagtagga tgcagaagtc aagcactgtc cattctttct gagagaaggt
1921 tctgagactt aaagttcaga aaagcttgct ctgcctgcaa ggagtactgc ctgcagagct
1981 caggaggacc cctccctcac tgtctgcagc acacaaaaca cttcaccctc aatcactgtc
2041 gtcctaagcc ttctctcctg actgcagcca tccccagcta ctttatcttc cagtctttcc
2101 tttcagagga gatcatcggg ggccatgagg ccaagcccca ctcccgcccc tacatggcct
2161 ttgttcagtt tctgcaagag aagagtcgga agaggtgtgg cggcatccta gtgagaaagg
2221 actttgtgct gacagctgct cactgccagg gaaggtaagg agcagcacca gctcacctcc
2281 tgagttcccc ctacagggac ccttgttttc tcctggggac tgcagcccag gggagcttcc
2341 agagttcctg gtaacacaag cccatgaaag ctcatcggag cagccacctg ggaataggac
2401 taagatgatg aaaggctgag aaataggaca gggtcagagg gtcagagggt cagaggtcag
2461 agcaagtggc atggtttcac acactggccc aataaggcag tagtaaaggt tgaatccatg
2521 cattaaggat caaaatgcaa actcgagcaa tttcatgata tttcctgaag gcaagagaga
2581 gcccccagaa gccctactct tcatgtcttt gtgaagtaga gggcacagtc actcagccct
2641 ggagccctcc tgtcccttca acttcccctc agctgcagcc ctaccctgcc acagctgtca
2701 tctgctcttc actgctcctg ggctctatcc cctgtgactc cacccccatc ctcactctgc
2761 tctctgtgca gctccataaa tgtcaccttg ggggcccaca atatcaagga acaggagcgg
2821 acccagcagt ttatccctgt gaaaagaccc atcccccatc cagcctataa tcctaagaac
2881 ttctccaacg acatcatgct actgcaggtg aggcacactc ctgccactct tgctcttctt
2941 ggtccagttg gttccactcc cactgggatg ccggcccttt cctcctttcc atcctgacct
3001 cttggtcagt tcctgtgcct tagaggagag ggaagattgt gcagccccat cactgtgtcg
3061 gggcccagaa ggccattgcc tgacctggac tttcttgctt cttccccacc agctggagag
3121 aaaggccaag tggaccacag ctgtgcggcc tctcaggcta cctagcagca aggcccaggt
3181 gaagccaggg cagctgtgca gtgtggctgg ctggggttat gtctcaatga gcactttagc
3241 aaccacactg caggaagtgt tgctgacagt gcagaaggac tgccagtgtg aacgtctctt
3301 ccatggcaat tacagcagag ccactgagat ttgtgtgggg gatccaaaga agacacagac
3361 cggtttcaag gttgggtttc cagcctctac ccagaaagac cacagggaga gaggaacttg
3421 agggagttct ggggtatgac agtggccaga tctttatgct ctcagcccag agcttgggca
3481 gcctgtgtcc ccctggaatc tagtctttag tccactcctt gggaggactg gggtggctgg
3541 aggggaagga tctgtcatcc gacagtcact tatcaccaaa gtgtccgtga gaattgcaga
3601 gaaaggcttg gtctggggag agccagaaag cacagccagg gccatgctgg agacccagga
3661 ctgagggagg tgagtgacaa ggcctgcctg gcactgatgt cacacaaaat ccataacaga
3721 gaccacccat cccagggaac actagctcag tctttcctct ctctgttcac agggggactc
3781 cggggggccc ctcgtgtgta aggacgtagc ccaaggtatt ctctcctatg gaaacaaaaa
3841 agggacacct ccaggagtct acatcaaggt ctcacacttc ctgccctgga taaagagaac
3901 aatgaagcgc ctctaacagc aggcatgaga ctaaccttcc tctgggcctg accatctctg
3961 ggacagaggc aagaatcccc aaggggtggg cagtcggggt tgcaggactg taataaatgg
4021 atctctggtg taaatatgac tgaagtctta tttattcact gaaccatctt caatatgcaa
4081 caacactgct ccaggcagcc gtctgctgtc agttctggct tttgcttctt cctttctccc
4141 ccagccctcc ctcctcccta aaccccatgc tgtacagttt tttcactaat ttctcaatca
4201 catgtctttg atactgaacc ctctgttaga gctggtttga actccattat aaacaacaat
4261 cttcaacccc tctacccttc acaaaaaaaa ataaacctct ctggacgtta ggaatttctt
4321 atcgcctcta aaccaactac ctactcccct aacaacgtag cagagaatgg agcagggcag
4381 tagcagatgg agtggaaagg aaataactcc agggactcag aaggccaggg gcatgccatg
4441 agtactcagt ttcctatttt cagggcctgt ccctccaatg ggggcaggct tctcccacag
4501 ccaggtctgc ctgcagctta ggaggttgag atgctcctct gcacctaggt ccctcttccc
4561 tgccctgggc ccagccctga gctcagtcaa ccttcttcct tcctggccgg ccttcccagc
4621 tcccaagagt ttttcaccca agtgcctggc taccagtttc tttcccttct agatcaccct
4681 gttctgaagc cagcctctct ctcatgtccc taacagagtt cccagctctg tgtgaattca
4741 cacacccttt gaaagaagca ggacactgct
//